- About
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- Research Disciplines
- Socio-Economic Objectives
- Publications
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These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.
- Journal Articles
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- Dobson G, Morris J and Letson H (in press) Pathophysiology of severe burn injuries: new therapeutic opportunities from a systems perspective. Journal of Burn Care and Research,
- Chequer de Souza J, Letson H, Gibbs C and Dobson G (in press) The burden of head trauma in rural and remote North Queensland, Australia. Injury,
- Davenport L, Letson H and Dobson G (in press) Lung protection after severe thermal burns with adenosine, lidocaine, and magnesium (ALM) resuscitation and importance of shams in a rat model. Journal of Burn Care and Research,
- Dobson G, Morris J and Letson H (2023) Adenosine, lidocaine and Mg2+ update: teaching old drugs new tricks. Frontiers in Medicine, 10.
- Hoeger N, Mittlmeier T, Vollmar B, Stratos I, Dobson G and Rotter R (2023) ALM Therapy Promotes Functional and Histologic Regeneration of Traumatized Peripheral Skeletal Muscle. Biology, 12.
- Letson H, Morris J and Dobson G (2023) Changes in plasma alpha-1 acid glycoprotein following hemorrhagic trauma: Possible role in dose differences of ALM drug therapy in rat and pig resuscitation. Pharmacology Research & Perspectives, 11 (5).
- Morris J, McEwen P, Letson H and Dobson G (2023) Adenosine, Lidocaine and Magnesium (ALM) therapy modulates early sex-specific inflammatory and immune responses following experimental anterior cruciate ligament rupture and reconstruction. Translational Medicine Communications, 8.
- Dobson G, Morris J and Letson H (2022) Why are bleeding trauma patients still dying? Towards a systems hypothesis of trauma. Frontiers in Physiology, 13.
- Dobson G (2022) Wired to Doubt: Why People Fear Vaccines and Climate Change and Mistrust Science. Frontiers in Medicine, 8.
- Engstrom N, Dobson G, Ng K, Lander K, Win K, Gupta A and Letson H (2022) Validation of CalECG software for primary prevention heart failure patients: Reducing inter-observer measurement variability. Journal of Electrocardiology, 74. pp. 128-133
- Engstrom N, Letson H, Ng K and Dobson G (2022) Predicting arrhythmias in primary prevention heart failure patients: picking up the fragments. Open Heart, 9 (2).
- Engstrom N, Dobson G, Kevin N and Letson H (2022) Fragmented QRS is associated with ventricular arrhythmias in heart failure patients: a systematic review and meta-analysis. Annals of Noninvasive Electrocardiology, 27 (1).
- More
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ResearchOnline@JCU stores 120+ research outputs authored by Prof Geoffrey Dobson from 2001 onwards.
- Current Funding
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Current and recent Research Funding to JCU is shown by funding source and project.
United States Department of Defence - Traumatic Brain Injury and Psychological Health, Investigator Initiated Research Award
Point-of-injury intranasal ALM drug therapy to reduce secondary injury and improve outcomes after TBI in civilian and military resource-limited environments
- Indicative Funding
- $932,919 over 3 years
- Summary
- Currently there is no effective drug therapy to treat traumatic brain injury (TBI) in combat and other military and civilian settings immediately after the injury has occurred that can protect the brain and the whole body by reducing secondary injury progression and TBI-associated complications. ALM therapy is a neuroprotective fluid therapy that significantly improves survival, rescues cardiac function, reduces local bleeding, and blunts secondary injury processes including inflammation after trauma. This project will evaluate the efficacy and protective benefits of ALM therapy administered intravenously (injectable) and intranasally (via spray) in a rat model of TBI.
- Investigators
- Geoffrey Dobson, Hayley Letson and Jodie Morris (College of Medicine & Dentistry)
- Keywords
- Traumatic Brain Injury; intranasal; Blood brain barrier; Military; Immune; ALM
United States Department of Defence - DoD Peer Reviewed Orthopaedic Research Program (PRORP) - Applied Research Award
ALM Drug Therapy to reduce inflammation and scar formation after ACL reconstruction surgery: Targeting earlier return to active duty.
- Indicative Funding
- $1,061,864 over 4 years
- Summary
- Two complications of anterior cruciate ligament (ACL) reconstruction surgery are cartilage degeneration and scarring within the joint, which can prolong healing, promote pain and restrict knee movement. Our project will evaluate a new therapy known as ALM solution that can be administrered during ACL reconstruction surgery to dampen inflammation, protect cartilage and promote tissue healing within the joint. Our study has the potential to expedite a patient's return to an active duty with fewer complications.
- Investigators
- Geoffrey Dobson, Peter McEwen, Jodie Morris, Hayley Letson and Erik Biros (College of Medicine & Dentistry)
- Keywords
- ACL Injury; ACL Reconstruction surgery; Scarring; Osteoarthritis; Inflammation; Therapeutics
Emergency Medicine Foundation - Leading Edge
Classifying the Type and Severtiy of Traumatic Injury in North Queensland: A Multicentre Retrospective Study
- Indicative Funding
- $97,580 over 2 years (administered by Queensland Health)
- Summary
- Queenslanders living in regional, rural and remote areas having a higher incidence of traumatic injury and are disadvantaged by prolonged prehospital times. The aim of this project is to define and describe trauma patients transported by aeromedical emergency services to and between Townsville, Cairns, Mt Isa and Mackay hospitals over a 3 - year period (2016-2018). A key objective is to conduct a comprehensive analysis of clinical interventions and therapies from point-of-injury to hospital admission, and patient outcomes to hospital discharge. This data will help inform all stakeholders on the current state of emergency trauma care in the tropics.
- Investigators
- Clinton Gibbs, Hayley Letson, Geoffrey Dobson, Luke Lawton, Brett Hoggard and Ben Butson in collaboration with Erik Biros, Daniel Lindsay, Richard Murray and Ulrich Orda (Queensland Health, College of Medicine & Dentistry, College of Public Health, Medical & Vet Sciences, Townsville Hospital and Health Service and North West Hospital and Health Service)
- Keywords
- Injury; Trauma; Prehospital emergency care; Patient transfer; Rural Health; Aeromedical
Townsville Hospital and Health Service - Study Education Research Trust Account (SERTA)
Trauma Care in the Tropics: A Multi-centre Retrospective Analysis.
- Indicative Funding
- $9,110 over 2 years (administered by Townsville Hospital and Health Service)
- Summary
- High quality pre-hospital trauma care and timely access to emergency aeromedical retrieval services is paramount for an efficient, sustainable healthcare system in North Queensland. We propose to identify and classify trauma patients in the North Queensland since 2016 to assess the magnitude of the total injury burden and evaluate the chain-of-care from the prehospital environment, through patient transfer, to hospital discharge. The dataset generated will provide valuable insights into patterns of primary retrieval, trauma distribution, and service provisions and gaps.
- Investigators
- Clinton Gibbs, Geoffrey Dobson and Hayley Letson (Retrieval Services Queensland and College of Medicine & Dentistry)
- Keywords
- Injury; Trauma; Prehospital Emergency Care; Patient Transfer; Rural Health; Aeromedical
United States Department of Defence - Broad Agency Award
Optimisation of Ultra-Small Volume Adenosine, Lidocaine and Mg2+ (ALM) Fluid Resuscitation and 72hr Stabilisation Drip for Uncontrolled Haemorrhage and TBI
- Indicative Funding
- $1,746,795 over 4 years
- Summary
- The resuscitation and stabilisation properties of ALM 'one-two treatment' will be investigated in rats after uncontrolled blood loss ? traumatic brain injury, and a translational arm in pigs followed for 72hrs to mimic prolonged far-forward retrieval delays. The aim is to show improved survival is associated with improved cardiac function, reduced inflammation, less coagulopathy and less secondary 'it' complications. The ALM therapy has the potential to reduce morbidity and mortality on the battlefield by buying time for treatment, stabilisation and preparedness of causalities for safer evacuation. The study also has broad-spectrum public purpose for pre-hospital trauma and aeromedical transport.
- Investigators
- Geoffrey Dobson and Hayley Letson in collaboration with Asger Granfeldt (College of Medicine & Dentistry and The Aarhus School of Business)
- Keywords
- Haemorrhage; Traumatic Brain / Head Injury; Pre-hospital; Trauma; Haemorrhagic shock; Inflammation
- Supervision
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Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.
These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.
- Current
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- Primary Prevention Implantable Cardiac Defribrillators: A North Queensland Perspective (PhD , Primary Advisor/AM/Adv)
- Completed
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- Adenosine and lidocaine (AL) as a vasodilator in cardiac procedures and a storage solution for vascular banking (2019, PhD , Primary Advisor/AM/Adv)
- Data
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These are the most recent metadata records associated with this researcher. To see a detailed description of all dataset records, visit Research Data Australia.
- Letson, H. (2017) Adenosine, Lidocaine and Mg2+ (ALM) fluid therapy for treatment of non-compressible uncontrolled haemorrhage. James Cook University
- Collaboration
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The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.- 5+ collaborations
- 4 collaborations
- 3 collaborations
- 2 collaborations
- 1 collaboration
- Indicates the Tropics (Torrid Zone)
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