Dr Mark Pearson ~ Research Fellow
Australian Institute of Tropical Health & Medicine
- Mark’s major research focus involves looking at the functions of proteins from human parasites (specifically helminths, or worms) and how these molecules interact with the host immune system.I am particularly interested in understanding these processes in the context of developing vaccines against parasites of third world populations and finding novel therapies for autoimmune disorders such as asthma.
- 2011 to present - Research Fellow, James Cook University (Cairns, Qld, Australia)
- 2009 to 2011 - Research Fellow, University of Edinburgh (Edinburgh, UK)
- 2006 to 2010 - Research Officer, Queensland institute of Medical Research (Brisbane, Qld, Australia)
- 2001 to 2005 - PhD Student, Queensland institute of Medical Research (Brisbane, Qld, Australia)
- Research Disciplines
- Medical Microbiology (1108)
- Socio-Economic Objectives
- Clinical Health (9201)
After the completion of a PhD in 2005, Mark was appointed the senior research scientist of the Queensland Institute of Medical Research arm of the Human Helminth Vaccine Initiative, a multi-national collaborative effort funded by the Bill and Melinda Gates Foundation to develop recombinant vaccines against the human parasitic worms, Necator americanus and Schistosoma mansoni.
In 2009, Mark was granted an NHMRC training fellowship to study how molecules in parasite secretions and on the parasite surface influence the host-parasite relationship with a view to develop anti-worm vaccines and novel therapies for autoimmune disorders. Mid-way through 2011 Mark completed part of this work at the Institute of Infection and Immunology Research at the University of Edinburgh and is now continuing this research at James Cook University.
- 2011 - Finalist - Australian Museum Eureka Prizes
- 2010 - Research Australia Griffith University Discovery Award
- 2009 to 2013 - NHMRC Early Career Training Fellowship
These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.
- Journal Articles
- Gaze Jangola ST, Driguez P, Pearson MS, Mendes T, Doolan D, Trieu A, McManus DP, Gobert G, Periago MV, Correa Oliveira RC, Cardoso FC, Oliveira G, Nakajima R, Jasinskas A, Hung C, Liang L, Pablo J, Bethony J, Felgner PL and Loukas AC (2014) An immunomics approach to schistosome antigen discovery: antibody signatures of naturally resistant and chronically infected individuals from endemic areas. PLoS Pathogens, 10 (3). pp. 1-16
- Jia X, Schulte L, Loukas AC, Pickering DA, Pearson MS, Mobli M, Jones A, Rosengren KJoha, Daly NL, Gobert G, Jones M, Craik DJ and Mulvenna JP (2014) Solution structure, membrane interactions and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni. Journal of Biological Chemistry, 289 (10). pp. 7151-7163
- Kline K, McCarthy J, Pearson MS, Loukas AC and Hotez P (2013) Neglected tropical diseases of oceania: review of their prevalence, distribution, and opportunities for control. PLoS Neglected Tropical Disease, 7 (1). pp. 1-9
- Pearson MS, Tribolet L, Cantacessi C, Periago MV, Adela Valerio M, Jariwala AR, Hotez P, Diemert DJ, Loukas AC and Bethony J (2012) Molecular mechanisms of hookworm disease: stealth, virulence, and vaccines. Journal of Allergy and Clinical Immunology, 130 (1). pp. 13-21
- Pearson MS, Pickering DA, McSorley H, Bethony J, Tribolet L, Dougall AM, Hotez P and Loukas AC (2012) Enhanced protective efficacy of a chimeric form of the schistosomiasis vaccine antigen Sm-TSP-2. PLoS Neglected Tropical Diseases, 6 (3). pp. 1-10
- Skwarczynski M, Dougall AM, Khoshnejad M, Chandrudu S, Pearson MS, Loukas AC and Toth I (2012) Peptide-based subunit vaccine against hookworm infection. PLoS One, 7 (10). pp. 1-7
- Hewitson JP, Filbey KJ, Grainger JR, Dowle AA, Pearson MS, Murray J, Harcus Y and Maizels RM (2011) Heligmosomoides polygyrus elicits a dominant, non-protective antibody response directed against restricted glycan and peptide epitopes. Journal of Immunology, 187 (9). pp. 4764-4777
- Amante FH, Haque A, Stanley AC, de Labastida Rivera F, Randall LM, Wilson YA, Yeo G, Pieper C, Crabb BS, de Koning-Ward TF, Lundie RJ, Good MF, Pinzon-Charry A, Pearson MS, Duke MG, McManus DP, Loukas AC, Hill GR and Engwerda CR (2010) Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria. Journal of Immunology, 185 (6). pp. 3632-3642
- Hotez P, Bethony J, Diemert DJ, Pearson MS and Loukas AC (2010) Developing vaccines to combat hookworm infection and intestinal schistosomiasis. Nature Reviews Microbiology , 8 (11). pp. 814-826
- Pearson MS, Ranjit N and Loukas AC (2010) Blunting the knife: development of vaccines targeting digestive proteases of blood-feeding helminth parasites. Biological Chemistry, 391 (8). pp. 901-911
- Book Chapters
- Loukas AC, Gaze Jangola ST, Pearson MS, Doolan D, Felgner PL, Diemert DJ, McManus DP, Driguez P and Bethony J (2012) Schistosomiasis vaccines: new approaches to antigen discovery and promising new candidates. In: Parasitic Helminths: targets, screens, drugs and vaccines. Drug Discovery in Infectious Diseases. Wiley-Blackwell, Weinheim, Germany, pp. 421-433
- Loukas AC, Ranjit N, Pickering DA and Pearson MS (2012) Blood-feeding human hookworm proteases. In: Proteinases as Drug Targets. Royal Society of Chemistry, Cambridge, UK, pp. 186-198
ResearchOnline@JCU stores a total of 26 research outputs authored by Dr Mark Pearson from 2002 onwards.
- Current Funding
Current and recent Research Funding is shown by funding source and project.
Sabin Vaccine Institute - Vaccine Development Program
Development of a vaccine for human hookworm disease
- Indicative Funding
- $45,509 over 3 years
- Hookworms infect 600 million people in developing countries but there is no vaccine available. We are developing recombinant vaccines for human hookworm disease using animal models of infection and human correlates of protective immunity. We are focusing particularly on vaccines which induce antibody responses which target the digestive enzymes the worms use to break down host blood in the parasite's gut. This project is aimed at developing assays to support product development for the Na-APR-1 human hookworm vaccine.
- Alex Loukas and Mark Pearson, with the help of Darren Pickering (Australian Institute of Tropical Health & Medicine)
- Hookworm; Vaccine; neglected tropical disease; Control; Protease; Blood
Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor as long as there is also a Level 1 Advisor on the Panel.
These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.
- Hookworm Na-ASP-2- Putative Functions, Allergenicity and Implications for Vaccine Development (PhD, Associate Advisor)
The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.
- 5+ collaborations
- 4 collaborations
- 3 collaborations
- 2 collaborations
- 1 collaboration
- Indicates the Tropics (Torrid Zone)
Connect with me
My research areas
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Mr Darren PickeringAustralian Institute of Tropical Health & Medicine
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Prof Nick SmithAustralian Institute of Tropical Health & Medicine