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Adjunct Professor John Croese

Experience

Croese is a gastroenterologist with an interest in hookworm infection that is now focused on the immunobiology of Necator americanus. He successfully completed a clinical trial in which people with coeliac disease were inoculated with N. americanus and challenged with gluten. We have established that after infection, host homeostasis was preserved despite up-regulation of innately anti-bacterial and pro-inflammatory genes including interleukin (IL)-15, IL-22 and interferon (IFN)-γ. Hookworm infection suppressed the Th1/Th17 response to gluten. Current research aims to develop the therapeutic potential of helminths and helminth derivatives to address the rapid increases in autoimmune and atopic diseases.

Research Projects

  • Low-dose gluten challenge in coeliac disease after Necator americanus infection  – a clinical trial
  • The effects of Necator americanus on innate and adaptive immune responses in coeliac disease

    Grants

    1. $50,000.00 The Townsville Hospital Private Practice Fund, 2006.
    2. $475,000.00 The Broad Medical Research Program, The Broad Foundation, 2008-9.

    Awards and Honours

    • Clinical Professor of Medicine, University of Queensland (1998).
    • Adjunct Professor of Medicine, James Cook University (2005).
    • Gastroenterology Society of Australia Outstanding Clinician Award (2008)

    Key Publications

    1. Croese J. Eosinophilic enteritis - a recent North Queensland experience. Aust NZ J Med, 1988. 18: 848-53.
    2. Prociv P, Croese J. Human eosinophilic enteritis caused by Ancylostoma caninum, a common dog hookworm. Lancet, 1990. 355: 1299-302.
    3. Croese J, Loukas A, Opdebeeck J, Prociv P. Occult enteric infection by Ancylostoma caninum: a previously unrecognised zoonosis. Gastroenterology, 1994. 106:3-13.
    4. Croese J, Loukas A, Opdebeeck J, Fairley S, Prociv P. Human enteric infection by canine hookworms. Ann Intern Med, 1994. 120:369-74.
    5. Croese J, …… Walker NI. The Clinical and Endoscopes Features of Adults with Eosinophilic Esophagitis. Gastrointest Endosc, 2003.  4:516-22.
    6. Croese J, O’Neil J, Masson J, Melrose W, Pritchard D, Speare R. A proof of concept study establishing Necator americanus in Crohn's patients and reservoir donors. Gut. 2006, 55:136-7.
    7. Croese J, Wood, MJ, Melrose W, Speare R. Allergy controls the population density of Necator americanus in the small intestine. Gastroenterology, 2006. 131:402-9.
    8. Daveson AJ, …. Croese, J. Effect of hookworm infection on wheat challenge in celiac disease – a randomized double-blinded placebo controlled trial. PLoS One, 2011. 8;6(3):e17366.
    9. Gaze S, ... Croese J, Loukas A. Characterising the mucosal and systemic immune responses to experimental human hookworm infection. PLoS Pathog, 2012. 8(2):e1002520.
    10. McSorley HJ, .... Croese J, Loukas A. Suppression of inflammatory immune responses in celiac disease by experimental hookworm infection. PLoS One, 2011. 6(9):e24092.

    Contact Information

    Address: Dr John Croese,

    Department of Gastroenterology and Hepatology, The Prince Charles Hospital, Rode Road, Chermside, Qld. 4032 AUSTRALIA

    Email: jcroese@bigpond.com