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Dr. Kate Miller

Experience

millerI received my PhD from the Australian National University in April 1992. I have worked as a research fellow at the Universities of Bern and Zurich in Switzerland, the Queensland Institute of Medical Research, The University of Queensland and the University of Technology, Sydney. In 2010 I accepted a one-year, full time teaching-only position at the MacKillop campus of Australian Catholic University before joining JCU Cairns in as an Associate Lecturer in the School of Veterinary and Biomedical Sciences in May, 2011.

Research Projects

My research focuses on understanding and manipulating the host’s intestinal immune response to parasites. My research tests two hypotheses.

  • The first hypothesis is that the immune cell receptor, P2X7R, plays a critical role in preventing intestinal inflammation caused by the protozoan parasite, Toxoplasma gondii.
  • The second hypothesis is that that secretory molecules from helminth parasites can modulate inflammation in the intestine.

Grants

Miller, C.M. and Walker R.A. Immune effects of helminth proteins. JCU Faculty of Medicine, Health and Molecular Science Research Grant, 2012-2-13

Key Publications

  1. LeesMP, FullerSJ, McLeodR, BoulterNR, MillerCM, ZakrzewskiAM, MuiEJ, WitolaWH, CoyneJJ, HargraveAC, JamiesonSE, BlackwellJM, WileyJS, and SmithNC (2010) P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages. Journal of Immunology 184; 7040-7046
  2. Miller CM, Zakrzewski AM, Ikin RJ, Boulter NR, Katrib M, Lees MP, Fuller SJ, Wiley JS and Smith NC. (2010) Dysregulation of the inflammatory response to the parasite Toxoplasma gondii in P2X7 receptor-deficient mice. International Journal for Parasitology 41(3-4):301-8.
  3. Pissuwan D, Valenzuela SM, Miller CM, Killingworth MC and Cortie MB (2009) Destruction and control of Toxoplasma gondii tachyzoites using gold nanosphere/antibody conjugates. Small 5(9): 1030-1034
  4. Miller CM, Smith NC, Ikin RJ, Boulter NR, Dalton JP and Donnelly S. (2009) Immunological interactions between the Th1-inducing protozoan Toxoplasma gondii and the Th2-inducing helminth Fasciola hepatica. PLoS ONE 4(5): e5692
  5. Miller CMD, Boulter N, Ikin R and Smith NC (2008) The immunobiology of the innate response to Toxoplasma gondii. International Journal for Parasitology 39; 23-39
  6. Miller CM, Quinn HE, Ryce C, Reichel MP and Ellis JT (2005) Reduction in transplacental transmission of Neospora caninum in outbred mice by vaccination. International Journal for Parasitology 35: 821-828
  7. Miller, C.M.D., Quinn, H.E., Windsor, P.A. and Ellis, J.T. (2002)  Characterisation of the first Australian isolate of Neospora caninum from cattle. Australian Veterinary Journal 80: 620-625
  8. Wallach M, Smith NC, Petracca M, Miller CMD, Eckert J and Braun R (1995) Eimeria maxima gametocyte antigens: potential use in a subunit maternal vaccine against coccidiosis in chickens. Vaccine 13: 347-354
  9. Smith NC, Wallach M, Miller CMD, Morgenstern R, Braun R and Eckert J (1994) Maternal transmission of immunity to Eimeria maxima: ELISA analysis of protective antibodies induced by infection. Infection and Immunity 62: 1348-1357
  10. Miller CMD, Howell MJ & Boray JC  (1994) Glutathione S-transferase as a marker for drug resistance in Fasciola hepatica. International Journal for Parasitology 24: 533-542

JCU eResearch Publication List

Contact Information

Phone:

(07) 4042 1670

Email:

kate.miller1@jcu.edu.au