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Professor Istvan Toth

Experience

Professor Istvan Toth (The University of Queensland) is a chemical engineer with a significant international reputation as a medicinal chemist. Professor Toth's research has focused on the development of versatile delivery mechanisms that can be adapted to suit a broad range of drug and vaccine candidates. His expertise lies in drug delivery, immunoadjuvants, vaccine delivery, peptides, carbohydrates, lipids, nucleosides, and nucleotides. Professor Toth has a strong track record in research commercialisation as a key founder of Alchemia (listed on the Australian Stock Exchange), Implicit Biosciences Pty. Ltd., and Neurotide Pty. Ltd. He is also a key partner in the Queensland Preclinical Drug Development Facility (TetraQ), established in 2005 as a world-class facility to provide integrated preclinical drug development services to Queensland and Australian biotechnology companies engaged in human therapeutics development.

Research/Projects

  • Novel immunoadjuvants for vaccine delivery
  • Oral drug/vaccine delivery strategies
  • Nanovaccine delivery systems
  • Charged liposaccharide-based drug delivery systems
  • Gene delivery systems
  • Chemo-enzymatic synthesis of drug/vaccine delivery systems

    Grants

    Current Grants

    NHMRC Program Grant 2013-2017 - Tropical Disease – Immunity, pathogenesis and vaccine development: global translation. $17, 100, 585

    ARC Discovery Grant 2011-2015 - Liposaccharide based peptide and vaccine delivery systems: improving the bioavailability and immunogenicity of LHRH. $1, 030, 000

    NHMRC Program Grant 2004-2012 - Tropical Infectious Diseases – Pathogenesis and vaccine research. $22, 000, 000

    ARC Discovery Project Grant 2010-2012 - Lipid and carbohydrate based systems to target and deliver peptide drug candidates to specific cells. $750, 000

    Previous Grants

    NHMRC Development Grant 2009-2010 - Neuropathic pain drugs based on the endogenous opioid peptide Endomorphin 1. $203,000

    NHMRC Program Grant 2008-2012 - Immunity and pathology in tropical and infectious diseases: implications for vaccines and drug development. $14,902,357

    ARC Discovery Project Grant 2008-2010 - Synthesis, biological interactions and toxicity studies of precisely engineered nanoparticles. $475,000

    ARC Linkage, Infrastructure, Equipment and Facilities Grant 2008 - Analytical and preparative enantioselective chromatography. $600,000

    Awards and Honours

    • ARC Australian Professorial Fellowship
    • Fellow of the Queensland Academy of Arts and Sciences (2009)
    • Adrien Albert Award (2009)
    • Business/Higher Education Award for Outstanding Achievement in Collaborative Research & Development (2002)
    • Fellow of the Royal Australian Chemical Institute

    Key Publications

    1. Zaman M, Abdel-Aal ABM, Fujita Y, Phillipps KSM, Batzloff MR, Good MF, Toth I, Immunological evaluation of lipopeptide Group A streptococcus (GAS) vaccine: structure-activity relationship. PLoS ONE. 2012;7(1):e30146. IF: 4.411
    2. Lin IC, Liang M, Liu TY, Monteiro MJ, Toth I. Cellular transport of polymer coated gold nanoparticles. The Journal of Nanomedicine and Nanotechnology 2012;8(1):8-11. IF: 5.44
    3. Deng ZJ, Liang M, Toth I, Monteiro M, Rodney F, Minchin, Plasma protein binding of positively and negatively charged polymer-coated gold nanoparticles elicits different biological responses. Nanotoxicology. Online 06-Mar-2012 (doi:10.3109/17435390.2012.655342). IF: 5.758
    4. Zaman M, Skwarczynski M, Malcolm JM, Urbani CN, Jia ZF, Batzloff MR, Good MF, Montiero MJ, Toth I. Self-adjuvanting polyacrylic nanoparticulate delivery system for group A streptococcus (GAS) vaccine. The Journal of Nanomedicine and Nanotechnology. 2011;7(2):168-73. IF: 5.44
    5. Simerska P, Moyle PM, Toth I. Modern Lipid-, Carbohydrate-, and Peptide-Based Delivery Systems for Peptide, Vaccine, and Gene Products. Medicinal Research Reviews. 2011;31(4):520-47. (Review) IF: 10.228
    6. Lin IC, Liang M, Liu TY, Ziora ZM, Monteiro MJ, Toth I. Interaction of densely polymer-coated gold nanoparticles with epithelial Caco-2 monolayers. Biomacromolecules. 2011;12(4):1339-48. IF: 4.409
    7. Deng ZJ, Liang MT, Monteiro M, Toth I, Minchin RF. Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 (CD11b/CD18) receptor activation and inflammation. Nature Nanotechnology. 2011;6(1):39-44. IF: 26.309
    8. Skwarczynski M, Ziora ZM, Coles DJ, Lin IC, Toth I. Thymine, adenine and lipoamino acid based gene delivery systems. Chemical Communications. 2010;46(18):3140-2. IF: 5.504
    9. Skwarczynski M, Zaman M, Urbani CN, Lin IC, Jia ZF, Batzloff MR, Good MF, Montiero MG, Toth I. Novel self-adjuvanting vaccine delivery system: polyacrylate dendrimer nanoparticles. Angewandte Chemie International Edition. 2010;49:5742-5. IF: 11.829
    10. Liang M, Lin IC, Whittaker MR, Minchin RF, Monteiro M, Toth I. Preparation and cellular uptake of functionalized gold nanoparticles with different sizes and surface properties. ACS Nano. 2010;4(1):403-13. IF 7.493

    Contact Information

    Room: 1121 Building: 68 Chemistry  Building
    Phone: +61 7 336 69892
    Email: i.toth@uq.edu.au

    Profile Page at UQ.