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Evaluation of bacteriophage in a rat model of PJI

Investigation of the in vivo efficacy of single or combination therapy using a bacteriophage cocktail and vancomycin for reducing S. aureus burden within the implanted knee of the rat model of S. aureus biofilm-associated PJI (periprosthetic joint infection). 

This dataset consists of 6 PRISM (.pzfz) projects containing data tables, results of statistical analyses and graphs. The data tables for each project are also saved in comma-separated values (.csv) format, for preservation purposes.

The projects can be opened using the GraphPad Prism software if owned, otherwise they can be opened using the Prism view utility. More details on the free viewer are available from the GraphPad website.

The files consists of:

PRISM projects:

  • Bacterial Loads.pzfx - Bacterial load in implanted knees from treated and untreated rats
  • In vitro vancomycin sensitivity.pzfx - In vitro vancomycin sensitivity for S. aureus isolates recovered from implants from knees of treated and untreated rats
  • In vitro phage sensitivity.pzfx - In vitro phage sensitivity for S. aureus isolates recovered from implants from knees of treated and untreated rats
  • Joint pathology.pzfx - Macroscopic changes in implanted knees from treated and untreated rats
  • Joint cytokines.pzfx - Inflammatory cytokines in implanted knees from treated and untreated rats
  • Plasma cytokines.pzfx - Inflammatory cytokines in treated and untreated rats

Data Tables (exported from Prism in .csv format):

  • Bacterial loads_DataTables.zip
  • In vitro vancomycin sensitivity_DataTables.zip
  • In vitro phage sensitivity_DataTables.zip
  • Joint pathology_DataTables.zip
  • Plasma cytokines_DataTables.zip

 The full methodology is available in the Open Access publication from the Related Publications link below.

 
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    Data Record Details
    Data record related to this publication Evaluation of bacteriophage in a rat model of PJI
    Data Publication title Evaluation of bacteriophage in a rat model of PJI
  • Description

    Investigation of the in vivo efficacy of single or combination therapy using a bacteriophage cocktail and vancomycin for reducing S. aureus burden within the implanted knee of the rat model of S. aureus biofilm-associated PJI (periprosthetic joint infection). 

    This dataset consists of 6 PRISM (.pzfz) projects containing data tables, results of statistical analyses and graphs. The data tables for each project are also saved in comma-separated values (.csv) format, for preservation purposes.

    The projects can be opened using the GraphPad Prism software if owned, otherwise they can be opened using the Prism view utility. More details on the free viewer are available from the GraphPad website.

    The files consists of:

    PRISM projects:

    • Bacterial Loads.pzfx - Bacterial load in implanted knees from treated and untreated rats
    • In vitro vancomycin sensitivity.pzfx - In vitro vancomycin sensitivity for S. aureus isolates recovered from implants from knees of treated and untreated rats
    • In vitro phage sensitivity.pzfx - In vitro phage sensitivity for S. aureus isolates recovered from implants from knees of treated and untreated rats
    • Joint pathology.pzfx - Macroscopic changes in implanted knees from treated and untreated rats
    • Joint cytokines.pzfx - Inflammatory cytokines in implanted knees from treated and untreated rats
    • Plasma cytokines.pzfx - Inflammatory cytokines in treated and untreated rats

    Data Tables (exported from Prism in .csv format):

    • Bacterial loads_DataTables.zip
    • In vitro vancomycin sensitivity_DataTables.zip
    • In vitro phage sensitivity_DataTables.zip
    • Joint pathology_DataTables.zip
    • Plasma cytokines_DataTables.zip

     The full methodology is available in the Open Access publication from the Related Publications link below.

     

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  • Other Descriptors
    • Data type dataset
  • Keywords
    • total knee arthroplasty
    • prosthetic joint infection
    • Staphylococcus aureus
    • biofilm
    • bacteriophage therapy
    • treatment
  • Funding source
  • Research grant(s)/Scheme name(s)
    • 2017_102 - Australian Orthopaedic Association Research Foundation
    • Research themes
    Tropical Health, Medicine and Biosecurity
    FoR Codes (*)
    SEO Codes
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    Temporal (time) coverage
  • Start Date 2018/01/08
  • End Date 2019/01/08
    • Time Period
    Spatial (location) coverage
  • Locations
    • James Cook University
- Data
- Related resources
  • Related publications
      Name Morris, Jodie L., Letson, Hayley L., Elliot, Lisa, Grant, Andrea L., Hazratwala, Kaushik and McEwen, Peter. (2019) Evaluation of bacteriophage as an adjunct therapy for treatment of peri-prosthetic joint infection caused by Staphylococcus aureus. PLoS One. 14(2): e0226574.
    • URL https://dx.doi.org/10.1371%2Fjournal.pone.0226574
    • Notes Open Access
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- Citation
    Citation Morris, Jodie (2019): Evaluation of bacteriophage in a rat model of PJI. James Cook University. https://doi.org/10.25903/5dd21c638f492