Adenosine, Lidocaine and Mg2+ (ALM) fluid therapy for treatment of non-compressible uncontrolled haemorrhage

Systemic inflammation and coagulopathy are major drivers of injury progression following haemorrhagic trauma. Our aim was to examine the effect of small-volume 3% NaCl adenosine, lidocaine and Mg2+ (ALM) bolus and 0.9% NaCl/ALM 'drip' on inflammation and coagulation in a rat model of haemorrhagic shock. Male Sprague-Dawley rats were randomly assisned to: 1) shams, 2) no-treatment, 3) saline controls, 4) ALM therapy, and 5) Hextend. Haemorrhage was induced in anaesthetized and ventilated animals by liver resection (60% left lateral lobe and 50% medial lobe). After 15 min, a bolus of 3% NaCl +/- ALM (0.7 ml/kg) was administered intravenously (Phase 1) followed 60 min later by 4 hours infusion of 0.9% NaCl +/- ALM (0.5 ml/kg/hr) with 60 min monitoring (Phase 2). Plasma cytokines were measured on Magpix and coagulation using Stago/Rotational Thromboelastometry.

    Data Record Details
    Data record related to this publication Adenosine, Lidocaine and Mg2+ (ALM) fluid therapy for treatment of non-compressible uncontrolled haemorrhage
    Data Publication title Adenosine, Lidocaine and Mg2+ (ALM) fluid therapy for treatment of non-compressible uncontrolled haemorrhage
  • Description

    Systemic inflammation and coagulopathy are major drivers of injury progression following haemorrhagic trauma. Our aim was to examine the effect of small-volume 3% NaCl adenosine, lidocaine and Mg2+ (ALM) bolus and 0.9% NaCl/ALM 'drip' on inflammation and coagulation in a rat model of haemorrhagic shock. Male Sprague-Dawley rats were randomly assisned to: 1) shams, 2) no-treatment, 3) saline controls, 4) ALM therapy, and 5) Hextend. Haemorrhage was induced in anaesthetized and ventilated animals by liver resection (60% left lateral lobe and 50% medial lobe). After 15 min, a bolus of 3% NaCl +/- ALM (0.7 ml/kg) was administered intravenously (Phase 1) followed 60 min later by 4 hours infusion of 0.9% NaCl +/- ALM (0.5 ml/kg/hr) with 60 min monitoring (Phase 2). Plasma cytokines were measured on Magpix and coagulation using Stago/Rotational Thromboelastometry.

  • Other Descriptors
    • Descriptor

      This dataset is available as 7 files saved in .sav (SPSS) and comma-separated values (CSV) formats.

    • Descriptor type Note
  • Data type dataset
  • Keywords
    • non-compressible hemorrhage
    • surgery
    • truncal
    • inflammation
    • shock
    • immune
    • platelet
    • coagulopathy
    • ROTEM
    • trauma
  • Funding source
  • Research grant(s)/Scheme name(s)
    • W81XWH-15-1-0002 - A New Ultra-Small Volume Fluid for Far-Forward, Non-Compressible Hemorrhage and Traumatic Brain Injury
  • Research themes
    Tropical Health, Medicine and Biosecurity
    FoR Codes (*)
    • 119999 - Medical and Health Sciences not elsewhere classified
    SEO Codes
    • 920199 - Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
    Specify spatial or temporal setting of the data
    Temporal (time) coverage
  • Start Date 2015/09/01
  • End Date 2016/11/30
  • Time Period
    Spatial (location) coverage
  • Locations
    Data Locations

    Type Location Notes
    Attachment Hem_Stago.sav SPSS Statistics Data File (.sav) format
    Attachment Hem_Luminex.sav SPSS Statistics Data File (.sav) format
    Attachment Hem_Luminex.csv Comma-separated values (.csv) format
    Attachment Hem_ROTEM_Phase_1.csv Comma-separated values (.csv) format
    Attachment Hem_RBC.csv Comma-separated values (.csv) format
    Attachment Hem_PAP.csv Comma-separated values (.csv) format
    Attachment Hem_Stago.csv Comma-separated values (.csv) format
    Attachment Hem_PLT.sav SPSS Statistics Data File (.sav) format
    Attachment Hem_RBC.sav SPSS Statistics Data File (.sav) format
    Attachment Hem_PAP.sav SPSS Statistics Data File (.sav) format
    Attachment Hem_ROTEM_Phase_2.csv Comma-separated values (.csv) format
    Attachment Hem_ROTEM_Phase_1.sav SPSS Statistics Data File (.sav) format
    Attachment Hem_ROTEM_Phase_2.sav SPSS Statistics Data File (.sav) format
    Attachment Hem_PLT.csv Comma-separated values (.csv) format
    The Data Manager is: Hayley Letson
    College or Centre
    Access conditions Open
  • Alternative access conditions
  • Data record size 14 files: 146 KB
  • Related publications
      Name Letson, Hayley, and Dobson, Geoffrey (2017) 3% NaCl adenosine, lidocaine, Mg2+ (ALM) bolus and 4 hours "drip" infusion reduces noncompressible hemorrhage by 60% in a rat model. Journal of Trauma and Acute Care Surgery, 82 (6). pp. 1063-1072.
    • URL http://dx.doi.org/10.1097/TA.0000000000001454
    • Notes
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    Citation Letson, Hayley; Dobson, Geoffrey (2017): Adenosine, Lidocaine and Mg2+ (ALM) fluid therapy for treatment of non-compressible uncontrolled haemorrhage. James Cook University. https://doi.org/10.4225/28/59c446100467b