Detecting sub-clinical change in tissue compressibility and free fluid in the lower limbs of young people living in an LF endemic area in Myanmar

SPSS data set for physical measures taken at 3 time points using 4 devices and publications relating to the data analysis.

Abstract [Related Publication]: When normal lymphatic function is hampered, imperceptible subcutaneous edema can develop and progress to overt lymphedema. Low-cost reliable devices for objective assessment of lymphedema are well accepted in clinical practice and research on breast-cancer related lymphedema but are untested in populations with lymphatic filariasis (LF). This is a cross-sectional analysis of baseline data in a longitudinal study on asymptomatic, LF antigen-positive and -negative young people in Myanmar. Rapid field screening was used to identify antigen-positive cases and a group of antigen-negative controls of similar age and gender were invited to continue in the study. Tissue compressibility was assessed with three tissue tonometers, and free fluids were assessed using bio-impedance spectroscopy (BIS). Infection status was confirmed by Og4C3 antigen assay. At baseline (n= 98), antigen-positive cases had clinically relevant increases in tissue compressibilityat the calf using a digital Indurometer (11.1%, p = 0.021), and in whole-leg free fluid using BIS (9.2%, p = 0.053). Regression analysis for moderating factors (age, gender, hydration) reinforced the between-infection group differences. Results demonstrate that sub-clinical changes associated with infection can be detected in asymptomatic cases. Further exploration of these low-cost devices in clinical and research settings on filariasis-related lymphedema are warranted.

The full methodology is available in the publications from the Related Publications links below.

 

    Data Record Details
    Data record related to this publication Detecting sub-clinical change in tissue compressibility and free fluid in the lower limbs of young people living in an LF endemic area in Myanmar
    Data Publication title Detecting sub-clinical change in tissue compressibility and free fluid in the lower limbs of young people living in an LF endemic area in Myanmar
  • Description

    SPSS data set for physical measures taken at 3 time points using 4 devices and publications relating to the data analysis.

    Abstract [Related Publication]: When normal lymphatic function is hampered, imperceptible subcutaneous edema can develop and progress to overt lymphedema. Low-cost reliable devices for objective assessment of lymphedema are well accepted in clinical practice and research on breast-cancer related lymphedema but are untested in populations with lymphatic filariasis (LF). This is a cross-sectional analysis of baseline data in a longitudinal study on asymptomatic, LF antigen-positive and -negative young people in Myanmar. Rapid field screening was used to identify antigen-positive cases and a group of antigen-negative controls of similar age and gender were invited to continue in the study. Tissue compressibility was assessed with three tissue tonometers, and free fluids were assessed using bio-impedance spectroscopy (BIS). Infection status was confirmed by Og4C3 antigen assay. At baseline (n= 98), antigen-positive cases had clinically relevant increases in tissue compressibilityat the calf using a digital Indurometer (11.1%, p = 0.021), and in whole-leg free fluid using BIS (9.2%, p = 0.053). Regression analysis for moderating factors (age, gender, hydration) reinforced the between-infection group differences. Results demonstrate that sub-clinical changes associated with infection can be detected in asymptomatic cases. Further exploration of these low-cost devices in clinical and research settings on filariasis-related lymphedema are warranted.

    The full methodology is available in the publications from the Related Publications links below.

     

  • Other Descriptors
  • Data type dataset
  • Keywords
    • lymphoedema
    • lymphedema
    • filariasis
    • indurometer
    • bio-impedance spectroscopy
  • Funding source
  • Research grant(s)/Scheme name(s)
  • Research themes
    People and Societies in the Tropics
    FoR Codes (*)
    • 1117 - Public Health and Health Services
    SEO Codes
    Specify spatial or temporal setting of the data
    Temporal (time) coverage
  • Start Date 2014/10/14
  • End Date 2015/06/17
  • Time Period
    Spatial (location) coverage
  • Locations
    • Central Myanmar
  • Related publications
      Name Douglass, Janet, Graves, Patricia, and Gordon, Susan (2017) Intrarater reliability of tonometry and bio-impedance spectroscopy to measure tissue compressibility and extracellular fluid in the legs of healthy young people in Australia and Myanmar. Lymphatic Biology and Research, 15 (1). pp. 57-63.
    • URL http://dx.doi.org/10.1089/lrb.2016.0021
    • Notes Reliability study includes a detailed description of data collection methods
    • Name Douglass, Janet, Graves, Patricia, Lindsay, Daniel, Becker, Luke, Mason, Jesse, Aye, Ni Ni, Win, San San, Wai, Tint, Win, Yi Yi, and Gordon, Susan (2017) Lymphatic filariasis increases tissue compressibility and extracellular fluid in lower limbs of asymptomatic young people in Central Myanmar. Tropical Medicine and Infectious Disease, 2 (4).
    • URL http://dx.doi.org/10.3390/tropicalmed2040050
    • Notes Open Access
  • Related websites
      Name
    • URL
    • Notes
  • Related metadata (including standards, codebooks, vocabularies, thesauri, ontologies)
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    • Notes
    Citation Douglass, Janet (2020): Detecting sub-clinical change in tissue compressibility and free fluid in the lower limbs of young people living in an LF endemic area in Myanmar. James Cook University. https://doi.org/10.25903/5f221ac564641