About

Professor Alan Baxter is a medical graduate who completed a PhD in immunogenetics at the Walter and Eliza Hall Institute under the supervision of Tom Mandel. He has worked as a Research Fellow at Harvard Medical School and at Cambridge University, where he was a Supervisor in Pathology for Trinity College. He was president of the Australasian Society for Immunology from 2006-2008, a member of the Council of the Federation of Immunological Societies of Asia-Oceania 2012-2015, the Council of the International Union of Immunological Societies 2013-2017, and the MSRA Research Management Council since 2013. He established the Autoimmunity Research Group at the Centenary Institute, where he worked for nine years before taking up his current appointment as Professor of Biochemistry and Molecular Cell Biology and Director of the Comparative Genomics Centre of James Cook University. His work is funded by James Cook University,  the MSRA, Townsville Hospital and Health Service and the Queensland Department of Health.

Specialties

He is known internationally for his contributions to the genetics of autoimmune disease and has published on the genetics of gastritis, lupus, type 1 diabetes, multiple sclerosis and the role of NKT cells in autoimmunity, and made major contributions to our understanding of gene/environment interactions in autoimmune disease.

 

Interests
Research
  • Immunogenetics of autoimmune disease
  • Innate immunity
  • Genetics of immune regulation
  • Multiple sclerosis
  • Type 1 diabetes
  • Systemic lupus erythematosus
  • Autoimmune gastritis
Research Disciplines
Socio-Economic Objectives
Honours
Awards
  • 2011 to 2015 - NHMRC Senior Research Fellowship (B)
  • 2006 to 2010 - NHMRC Senior Research Fellowship (B)
  • 2001 to 2005 - NHMRC Senior Research Fellowship (A)
  • 1997 to 2000 - NHMRC RD Wright Fellowship
  • 1992 to 1995 - NHMRC CJ Martin Fellowship
Memberships
  • 2013 - Elected member of the Council for the International Union of Immunological Societies.
  • 2012 - Elected member of the Council for the Federation of Immunological Societies for Asia/Oceania.
  • 2012 - Senior Editorial Board, American J Clinical and Experimental Immunology
  • 2010 - Multiple Sclerosis Research Australia Research Management Council
  • 2006 - Board of the Australian Institute of Tropical Medicine
  • 2004 to 2007 - Professional Review Panel, Juvenile Diabetes Research Foundation
  • 1999 to 2003 - Professional Advisory Panel, Juvenile Diabetes Research Foundation Australia
  • 1997 to 2002 - Editorial Board, Autoimmunity
Other
  • 2007 - Associate Editor, Immunology and Cell Biology
  • 2004 - Associate Editor, The Review of Diabetic Studies
  • 2006 to 2008 - President, Australasian Society for Immunology
  • 2004 to 2008 - Associate Editor, Journal of Immunology
  • 2005 to 2006 - Vice-President, Australasian Society for Immunology
Publications

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles
  • Lelliott E, Ramsbottom K, Dowling M, Shembrey C, Noori T, Kearney C, Michie J, Parish I, Jordan M, Baxter A, Young N, Brennan A and Oliaro J (2022) NKG7 enhances CD8+ T cell synapse efficiency to limit inflammation. Frontiers in Immunology, 13.
  • Dinh X, Stanley D, Smith L, Moreau M, Berzins S, Gemiarto A, Baxter A and Jordan M (2021) Modulation of TCR signalling components occurs prior to positive selection and lineage commitment in iNKT cells. Scientific Reports, 11.
  • Gresle M, Jordan M, Stankovich J, Spelman T, Johnson L, Laverick L, Hamlett A, Smith L, Jokubaitis V, Baker J, Haartsen J, Taylor B, Charlesworth J, Bahlo M, Speed T, Brown M, Field J, Baxter A and Butzkueven H (2020) Multiple Sclerosis risk variants regulate gene expression in innate and adaptive immune cells. Life Science Alliance, 3 (7).
  • Ng S, Rivera F, Yan J, Corvino D, Das I, Zhang P, Kuns R, Chauhan S, Hou J, Li X, Frame T, McEnroe B, Moore E, Na J, Engel J, Soon M, Singh B, Kueh A, Herold M, de Oca M, Singh S, Bunn P, Aguilera A, Casey M, Braun M, Ghazanfari N, Wani S, Wang Y, Amante F, Edwards C, Haque A, Dougall W, Singh O, Baxter A, Teng M, Loukas A, Daly N, Cloonan N, Degli-esposti M, Uzonna J, Heath W, Bald T, Tey S, Nakamura K, Hill G, Kumar R, Sundar S, Smyth M and Engwerda C (2020) The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nature Immunology, 21. pp. 1205-1217
  • Patsopoulos N, Baranzini S, Santaniello A, Shoostari P, Cotsapas C, Wong G, Beecham A, James T, Replogle J, Vlachos I, McCabe C, Pers T, Brandes A, White C, Keenan B, Cimpean M, Winn P, Panteliadis I, Robbins A, Andlauer T, Zarzycki O, Dubois B, Goris A, Sondergaard H, Sellebjerg F, Sorensen P, Ullum H, Thorner L, Saarela J, Cournu-Rebeix I, Damotte V, Fontaine B, Guillot-Noel L, Lathrop M, Vukusic S, Berthele A, Pongratz V, Pongratz V, Gasperi C, Graetz C, Grummel V, Hemmer B, Hoshi M, Knier B, Korn T, Lill C, Luessi F, Muehlau M, Zipp F, Dardiotis E, Agliardi C, Amoroso A, Barizzone N, Benedetti M, Bernardinelli L, Cavalla P, Clarelli F, Comi G, Cusi D, Esposito F, Ferre L, Galimberti D, Guaschino C, Leone M, Martinelli V, Moiola L, Salvetti M, Sorosina M, Vecchio D, Zauli A, Santoro S, Mancini N, Zuccala M, Mescheriakova J, van Duijn C, Bos S, Celius E, Spurkland A, Comabella M, Montalban X, Alfredsson L, Bomfim I, Gomez-Cabrero D, Hillert J, Jagodic M, Linden M, Piehl F, Jelcic I, Martin R, Sospedra M, Baker A, Ban M, Hawkins C, Hysi P, Kalra S, Karpe F, Khadake J, Lachance G, Molyneux P, Neville M, Thorpe J, Bradshaw E, Caillier S, Calabresi P, Cree B, Cross A, Davis M, de Bakker P, Delgado S, Dembele M, Edwards K, Fitzgerald K, Frohlich I, Gourraud P, Haines J, Hakonarson H, Kimbrough D, Isobe N, Konidari I, Lathi E, Lee M, Li T, An D, Zimmer A, Madireddy L, Manrique C, Mitrovic M, Olah M, Patrick E, Pericak-Vance M, Piccio L, Schaefer C, Weiner H, Lage K, Scott R, Lechner-Scott J, Leal R, Moscato P, Booth D, Stewart G, Vucic S, Pame G, BamettO M, Mason D, GriffithS L, Broadley S, Tajouri L, Baxter A, Slee M, Taylor B, Charlesworth J, Kilpatrick T, Rubio J, Jokubaitis V, Wiley J, Butzkueven H, Leslie S, Motyer A, Stankovich J, Carroll W, Kermode A, Edrin M, Barclay M, Peyrin-Biroulet L, Chamaillard M, Colombe J, Cottone M, Croft A, D'Inca R, Halfvarson J, Hanigan K, Henderson P, Hugot J, Karban A, Kennedy N, Khan M, Lemann M, Levine A, Massey D, Milla M, Motoey G, Ng S, Oikonomnou J, Peeters H, Proctor D, Rahier J, Roberts R, Rutgeerts P, Seibold F, Stronati L, Taylor K, Torkvist L, Ublick K, Van Limbergen J, Van Gossum A, Vatn M, Zhang H, Zhang W, Donnelly P, Barroso I, Blackwe J, Bramon E, Brown M, Casas J, Corvin A, Deloukas P, Duncanson A, Jankowski J, Markus H, Mathew C, Palmer C, Plomin R, Rautanen A, Sawcer S, Trembath R, Viswanathan A, Wood N, Spencer C, Band G, Bellenguez C, Freeman C, Hellenthal G, Giannoulatou E, Pirinen M, Pearson R, Strange A, Sul Z, Vukcevic D, Donnelly P, Langford C, Hunt S, Edkins S, Gwilliam R, Blackburn H, Bumpstead S, Dronov S, Gillman M, Gray E, Hammond N, Jayakumar A, McCann O, Liddle J, Potter S, Ravindrarajah R, Ricketts M, Waller M, Weston P, Widaa S, Whittaker P, Barroso I, Deloukas P, Mathew C, Blackwe J, , Corvin A, Spencer C, Compston A, Hafler D, Harbo H, Hauser S, D'Alfonso S, Hadjigeorgiou G, Barcellos L, Booth D, Hintzen R, Kockum I, Martinelli-Boneschi F, McCauley J, Oksenberg J, Oturai A, Ivinson A, Olsson T and De Jager P (2019) Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science, 365 (6460).
  • Too L, Yau B, Baxter A, McGregor I and Hunt N (2019) Double deficiency of toll-like receptors 2 and 4 alters long-term neurological sequelae in mice cured of pneumococcal meningitis. Scientific Reports, 9.
  • Wiede F, Brodnicki T, Goh P, Leong Y, Jones G, Yu D, Baxter A, Jones S, Kay T and Tiganis T (2019) T-Cell-specific PTPN2 deficiency in NOD mice accelerates the development of type 1 diabetes and autoimmune comorbidities. Diabetes, 68 (6). pp. 1251-1266
  • Kling J, Jordan M, Pitt L, Meiners J, Thanh-Tran T, Son Tran L, Nguyen T, Mittal D, Villani R, Steptoe R, Khosrotehrani K, Berzins S, Baxter A, Godfrey D, Blumenthal A and (2018) Temporal regulation of natural killer T cell interferon gamma responses by β-catenin-dependent and -independent Wnt signaling. Frontiers in Immunology, 9.
  • Schultz T, Wiesmueller K, Lucas M, Dobos K, Baxter A and Blumenthal A (2018) The N-terminal peptide moiety of the Mycobacterium tuberculosis 19 kDa lipoprotein harbors RP105-agonistic properties. Journal of Leukocyte Biology, 103 (2). pp. 311-319
  • Zeng B, Middelberg A, Gemiarto A, Macdonald K, Baxter A, Talekar M, Moi D, Tullett K, Caminschi I, Lahoud M, Mazzieri R, Dolcetti R and Thomas R (2018) Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy. Journal of Clinical Investigation, 128 (5). pp. 1971-1984
  • Field J, Fox A, Jordan M, Baxter A, Spelman T, Gresle M, Butzkueven H, Kilpatrick T and Rubio J (2017) Interleukin-2 receptor-alpha proximal promoter hypomethylation is associated with multiple sclerosis. Genes and Immunity, 18. pp. 59-66
Book Chapters
More

ResearchOnline@JCU stores 112+ research outputs authored by Prof Alan Baxter from 1989 onwards.

Current Funding

Current and recent Research Funding to JCU is shown by funding source and project.

Tropical Australian Academic Health Centre Limited - Contract Research

Genomics of lung cancer in Indigenous people of North Queensland

Indicative Funding
$50,000 over 1 year
Summary
Cancer genomic profiling is a major determinant of chemotherapy selection for non-small cell lung cancer and is widely used internationally. Indigenous genomes carry ~10X more uncharacterised DNA sequence variation than people of European heritage. THHS is currently trialling the use of whole exome sequencing, instead of the existing 4 gene panel, to base choice of targeted therapies in lung cancer. This creates an opportunity to study whether the cancer-associated variation currently being used to select therapies is adequate, and if not, these data will form the foundation for an NHMRC funding application to identify improved markers.
Investigators
Alan Baxter, Sabe Sabesan, Martin Nakata, Margaret Jordan, Justin Lee and Letitia Smith in collaboration with Matt Brown and Trevor Prior (College of Public Health, Medical & Vet Sciences, Townsville Hospital and Health Service, Indigenous Education & Research Centre and Queensland University of Technology)
Keywords
Cancer; Non-small cell lung cancer; Genomics; Whole exome sequencing; Indigenous health care; Closing The Gap
Supervision

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Completed
  • Ketogenic diet as a potential novel treatment for schizophrenia in translational animal models (2019, PhD , Secondary Advisor/AM)
Collaboration

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.

  • 5+ collaborations
  • 4 collaborations
  • 3 collaborations
  • 2 collaborations
  • 1 collaboration
  • Indicates the Tropics (Torrid Zone)

Connect with me
Share my profile
Share my profile:
jcu.me/alan.baxter

Email
Location
  • 142.306, The Science Place (Townsville campus)
Advisory Accreditation
Advisor Mentor
Find me on…
Icon for Google Scholar profile Icon for ResearcherID page Icon for Scopus Author page Icon for LinkedIn profile page

Similar to me

  1. Dr Margaret Jordan
    Biomedical Sciences and Molecular Biology
  2. Prof Alex Loukas
    Australian Institute of Tropical Health & Medicine
  3. Dr Paul Giacomin
    Australian Institute of Tropical Health & Medicine
  4. A/Prof Andreas Kupz
    Australian Institute of Tropical Health & Medicine
  5. A/Prof Matt Field
    Biomedical Sciences and Molecular Biology