JCU > Research Portfolio > Prof Alan Baxter

About

Professor Alan Baxter is a medical graduate who completed a PhD in immunogenetics at the Walter and Eliza Hall Institute under the supervision of Tom Mandel. He has worked as a Research Fellow at Harvard Medical School and at Cambridge University, where he was a Supervisor in Pathology for Trinity College. He was president of the Australasian Society for Immunology from 2006-2008, a member of the Council of the Federation of Immunological Societies of Asia-Oceania 2012-2015, the Council of the International Union of Immunological Societies 2013-2017, and the MSRA Research Management Council since 2013. He established the Autoimmunity Research Group at the Centenary Institute, where he worked for nine years before taking up his current appointment as Professor of Biochemistry and Molecular Cell Biology and Director of the Comparative Genomics Centre of James Cook University. His work is funded by James Cook University, the MSRA, Townsville Hospital and Health Service and the Queensland Department of Health.

Specialties

He is known internationally for his contributions to the genetics of autoimmune disease and has published on the genetics of gastritis, lupus, type 1 diabetes, multiple sclerosis and the role of NKT cells in autoimmunity, and made major contributions to our understanding of gene/environment interactions in autoimmune disease.

Teaching

BC5001: Advanced Readings in Molecular and Cell Biology (Level 5; TSV)
BC5002: Advanced Research in Molecular and Cell Biology 1 of 2 (Level 5; TSV)
BC5003: Advanced Research in Molecular and Cell Biology 2 of 2 (Level 5; TSV)
BC5312: Research and Dissertation in Molecular and Cell Biology (Level 5; TSV)

Interests

Research

Immunogenetics of autoimmune disease
Innate immunity
Genetics of immune regulation
Multiple sclerosis
Type 1 diabetes
Systemic lupus erythematosus
Autoimmune gastritis

Research Disciplines

Socio-Economic Objectives

Honours

Awards

2011 to 2015 - NHMRC Senior Research Fellowship (B)
2006 to 2010 - NHMRC Senior Research Fellowship (B)
2001 to 2005 - NHMRC Senior Research Fellowship (A)
1997 to 2000 - NHMRC RD Wright Fellowship
1992 to 1995 - NHMRC CJ Martin Fellowship

Memberships

2013 - Elected member of the Council for the International Union of Immunological Societies.
2012 - Elected member of the Council for the Federation of Immunological Societies for Asia/Oceania.
2012 - Senior Editorial Board, American J Clinical and Experimental Immunology
2010 - Multiple Sclerosis Research Australia Research Management Council
2006 - Board of the Australian Institute of Tropical Medicine
2004 to 2007 - Professional Review Panel, Juvenile Diabetes Research Foundation
1999 to 2003 - Professional Advisory Panel, Juvenile Diabetes Research Foundation Australia
1997 to 2002 - Editorial Board, Autoimmunity

Other

2007 - Associate Editor, Immunology and Cell Biology
2004 - Associate Editor, The Review of Diabetic Studies
2006 to 2008 - President, Australasian Society for Immunology
2004 to 2008 - Associate Editor, Journal of Immunology
2005 to 2006 - Vice-President, Australasian Society for Immunology

Publications

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

Kling J, Jordan M, Pitt L, Meiners J, Thanh-Tran T, Son Tran L, Nguyen T, Mittal D, Villani R, Steptoe R, Khosrotehrani K, Berzins S, Baxter A, Godfrey D, Blumenthal A and (2018) Temporal regulation of natural killer T cell interferon gamma responses by β-catenin-dependent and -independent Wnt signaling. Frontiers in Immunology, 9.
Schultz T, Wiesmueller K, Lucas M, Dobos K, Baxter A and Blumenthal A (2018) The N-terminal peptide moiety of the Mycobacterium tuberculosis 19 kDa lipoprotein harbors RP105-agonistic properties. Journal of Leukocyte Biology, 103 (2). pp. 311-319
Zeng B, Middelberg A, Gemiarto A, Macdonald K, Baxter A, Talekar M, Moi D, Tullett K, Caminschi I, Lahoud M, Mazzieri R, Dolcetti R and Thomas R (2018) Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy. Journal of Clinical Investigation, 128 (5). pp. 1971-1984
Field J, Fox A, Jordan M, Baxter A, Spelman T, Gresle M, Butzkueven H, Kilpatrick T and Rubio J (2017) Interleukin-2 receptor-alpha proximal promoter hypomethylation is associated with multiple sclerosis. Genes and Immunity, 18. pp. 59-66
Mariño E, Richards J, McLeod K, Stanley D, Yap Y, Knight J, Mckenzie C, Kranich J, Oliveira A, Rossello F, Krishnamurthy B, Nefzger C, Macia L, Thorburn A, Baxter A, Morohan G, Wong L, Polo J, Moore R, Lockett T, Clarke J, Topping D, Harrison L and Mackay C (2017) Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nature Immunology, 18. pp. 552-562
Modhiran N, Watterson D, Blumenthal A, Baxter A, Young P and Stacey K (2017) Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6. Immunology and Cell Biology, 95. pp. 491-495
Binder M, Fox A, Merlo D, Johnson L, Giuffrida L, Calvert S, Akkermann R, Ma G, Perera A, Gresle M, Laverick L, Foo G, Fabis-Pedrini M, Spelman T, Jordan M, Baxter A, Foote S, Butzkueven H, Kilpatrick T and Field J (2016) Common and low Frequency variants in MERTK are independently associated with multiple sclerosis susceptibility with discordant association dependent upon HLA-DRB1*15:01 status. PLoS Genetics, 12 (3). pp. 1-25
Too L, McGregor I, Baxter A and Hunt N (2016) Altered behaviour and cognitive function following combined deletion of Toll-like receptors 2 and 4 in mice. Behavioural Brain Research, 303. pp. 1-8
Gu B, Field J, Dutertre S, Ou A, Kilpatrick T, Lechner-Scott J, Scott R, Lea R, Taylor B, Stankovich J, Butzkueven H, Gresle M, Laws S, Petrou S, Hoffjan S, Akkad D, Graham C, Hawkins S, Bedri S, Glaser A, Hillert J, Matute C, Antiguedad A, Wiley J and ANZgene Consortium inlcuding Alan G. Baxter (2015) A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis. Human Molecular Genetics, 24 (19). pp. 5644-5654
Johnson L, Widi A, Rowarth S and Baxter A (2015) Abdominal distension and Escherichia coli peritonitis in mice lacking myeloid differentiation factor 88. Comparative medicine, 65 (2). pp. 123-126
Gresle M, Schulz K, Jonas A, Perreau V, Cipriani T, Baxter A, Miranda-Hernandez S, Field J, Jokubaitis V, Cherny R, Volitakis I, David S, Kilpatrick T and Butzkueven H (2014) Ceruloplasmin gene-deficient mice with experimental autoimmune encephalomyelitis show attenuated early disease evolution. Journal of Neuroscience Research, 92 (6). pp. 732-742

Book Chapters

Jordan M, Field J, Butzkueven H and Baxter A (2014) Genetic predisposition: humans. In: The Autoimmune Diseases. Elsevier, Boston, pp. 341-364

More: ResearchOnline@JCU stores 103+ research outputs authored by Prof Alan Baxter from 1989 onwards.

Current Funding

Current and recent Research Funding to JCU is shown by funding source and project.

Tropical Australian Academic Health Centre Limited - Contract Research

Genomics of lung cancer in Indigenous people of North Queensland

Indicative Funding: $50,000
Summary: Cancer genomic profiling is a major determinant of chemotherapy selection for non-small cell lung cancer and is widely used internationally. Indigenous genomes carry ~10X more uncharacterised DNA sequence variation than people of European heritage. THHS is currently trialling the use of whole exome sequencing, instead of the existing 4 gene panel, to base choice of targeted therapies in lung cancer. This creates an opportunity to study whether the cancer-associated variation currently being used to select therapies is adequate, and if not, these data will form the foundation for an NHMRC funding application to identify improved markers.
Investigators: Alan Baxter, Sabe Sabesan, Martin Nakata, Margaret Jordan, Justin Lee and Letitia Smith in collaboration with Matt Brown and Trevor Prior (College of Public Health, Medical & Vet Sciences, Townsville Hospital and Health Services, Indigenous Education & Research Centre and Queensland University of Technology)
Keywords: Cancer; Non-small cell lung cancer; Genomics; Whole exome sequencing; Indigenous health care; Closing The Gap

Queensland Health - Queensland Genomics Health Alliance Project Fund

Bringing Modern Genomics to the Management of Lung Cancer in Queensland

Indicative Funding: $221,388 over 2 years (administered by QUT)
Summary: Our project will overcome many of the issues slowing the implementation of cancer genomics and personalised medicine in the state, including (and where relevant, in partnership with the QGHA capability projects): ? We will develop models of care covering all aspects from consent, sample collection and handling, genomic profiling, data analysis and reporting of both somatic and heritable variants, to enable clinical uptake. ? We will develop education programs for health care workers and patients. ? We will establish protocols for cancer genomics in Indigenous populations in consensus with Indigenous communities. ? We will perform a comprehensive analysis of the performance of all aspects of the upgraded model of care and compare it with the current standard of care to identify areas for improvement, and to establish the case for its broader implementation. A system of performance analysis and systems improvement will be built into the care pathways developed, to ensure continuous service improvement beyond the life of this project.
Investigators: Paul Leo, Ken O'Byrne, Fong Kwun, Ian Yang, Stephen Fox, Jayesh Desai, Alan Baxter, Emily Callander, Sabe Sabesan, Jacinta Elston and Nick Graves (Queensland University of Technology, Princess Alexandra Hospital, The Prince Charles Hospital, The University of Queensland, Peter MacCallum Cancer Institute, College of Public Health, Medical & Vet Sciences, Australian Institute of Tropical Health & Medicine, College of Medicine & Dentistry and Division of Tropical Health & Medicine)
Keywords: Genomics; Lung Cancer; Clinical care

Multiple Sclerosis Research Australia - Project Grant

An immune transcriptional regulatory network approach to Multiple Sclerosis

Indicative Funding: $240,000 over 3 years
Summary: Multiple Sclerosis (MS) is an autoimmune disease resulting from a complex interaction between genetic and environmental factors. In an attempt to understand the integration of both sets of risk factors, we have compared mRNA transcripts between relapsing/remitting (RR) MS patients and healthy controls in 5 leukocyte subsets: CD4 and CD8 T cells, B cells, NK cells and monocytes. A gene co-expression network was generated based on correlation of expression levels across >700 gene expression microarrays, and a major co-ordinately regulated sub-network (module) of mRNA transcripts that is differentially expressed in the monocytes of RR-MS patients was identified. This project validates, characterizes and attempts to manipulate this transcriptional module in human cells ex-vivo and in the experimental autoimmune encephalomyelitis (EAE) model of central nervous system (CNS) autoimmunity. These results should provide greater explanatory power than the analyses of individual risk factors separately and may provide a multi-faceted target for intervention.
Investigators: Alan Baxter, Margaret Jordan, Helmut Butzkueven and Louise Laverick in collaboration with Letitia Smith (College of Public Health, Medical & Vet Sciences and The University of Melbourne)
Keywords: Autoimmunity; Cellular Immunology; Immunogenetics; Multiple Sclerosis; mouse models; humans

Supervision

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current

Causes of Multiple Sclerosis: A Functional Genomics Approach. (PhD , Primary Advisor/AM/Adv)

Completed

Transcriptional analysis of natural killer T cell development (2018, PhD , Primary Advisor)
Ketogenic diet as a potential novel treatment for schizophrenia in translational animal models (2019, PhD , Secondary Advisor/AM)

Collaboration

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.