Professor Mallett leads the first and largest renal genetics clinical service and program in Australia. Having been a Churchill Fellow, an RACP Foundation Jacquot Research Establishment Fellow and Metro North HHS Clinical Research Fellow, he has a strongly emerging profile in the clinical care and research of inherited kidney disease and nephrogenetics nationally, regionally and internationally. The clinical and translational research he is undertaking includes the epidemiology of inherited kidney diseases, subspecialist models of clinical care for these diseases, and new and novel genetic sequencing for nephrogenetic diagnosis and discovery including approaches to functional validation. 

Currently, Professor of Medicine (College of Medicine, James Cook University) and Director of Clinical Research & Nephrologist (Townsville University Hospital & THHS), he is also Clinical Fellow (Institute for Molecular Bioscience, The University of Queensland), Co-Lead Queensland Renal Genetics Program (Genetic Health Queensland, Townsville HHS, MNHHS Genomics Institute), National Director of the KidGen Collaborative and Lead for two Rare Disease Flagships (Australian Genomics Health Alliance), having previously been a recurrent visiting fellow at the Cambridge Institute for Medical Research and Addenbrooke’s Hospital, The University of Cambridge. Professor Mallett is the Global Lead for the IMPEDE-PKD Clinical Trial funded by the MRFF ($2.6million, 2021-2025) and delivered by the Australasian Kidney Trials Network (https://aktn.org.au/trials/trials-in-development/impede-pkd/). He is committed to improving the understanding of inherited kidney disease as well as the clinical care and outcomes of Australians affected by it.

Professor Mallett is an active supervisor and mentor for emerging clinician-researchers at both undergraduate and postgraduate career stages across a broad range of topics and contemporary health research fields. Whilst currently supervising 6 Research Higher Degree students (6 UQ (3 as Primary Supervisor) & 1 at Monash), Professor Mallett is excited to invite any interested students, trainees and clinicians in North Queensland to reach out if interested in developing research ideas, projects or future Research Higher Degrees. 

  • MD6010: Advanced Clinical Medicine Part 1 of 3 (Level 6; TSV)
  • MD6020: Advanced Clinical Medicine Part 2 of 3 (Level 6; TSV)
  • MD6030: Advanced Clinical Medicine Part 3 of 3 (Level 6; TSV)
  • Genetic Kidney Disease & Nephrogenetics
  • Kidney Health, Kidney Disease & Nephrology
  • 2021 to present - Co-Chair, Queensland Health Research Forum (HIIRO, ODG)
  • 2020 to present - Professor of Medicine & Head of Discipline (Internal Medicine), College of Medicine and Dentistry, James Cook University (Douglas)
  • 2020 to present - Director of Clinical Research & Nephrologist, Townsville University Hospital (Douglas)
  • 2018 to present - Clinical Fellow, Institute for Molecular Bioscience, The University of Queensland (St Lucia)
  • 2016 to present - National Director, KidGen Collaborative
  • 2016 to present - Rare Disease Flagship Lead, Australian Genomics
  • 2013 to present - Co-Lead, QLD Conjoint Renal Genetics Service
  • 2020 - Medical Advisor, Genomics Institute, Metro North Hospital and Health Service (Herston)
  • 2018 to 2020 - Co-Chair, RBWH Staff Council (Herston)
  • 2014 to 2020 - Nephrologist, Royal Brisbane and Women's Hospital (Herston)
Research Disciplines
Socio-Economic Objectives
  • 2021 - Outstanding Alumni Award, JCU College of Medicine & Dentistry
  • 2021 - Mid-Career Clinical Science Award, Australia & New Zealand Society of Nephrology
  • 2021 - MNHHS Staff Excellence Award (Excellence in Training & Education) - "Development of decision aids to support mainstreaming of genomic testing in renal medicine"
  • 2019 - Rising Star Research Excellence Award - Metro North HHS
  • 2019 - Distinguished Young Alumnus Award - The University of Queensland
  • 2021 to 2025 - Advancing Clinical Research Fellowship (Mid-Career), QLD Health
  • 2019 to 2020 - MNHHS Clinical Research Fellowship
  • 2018 - RACP Jacquot Research Establishment Fellowship
  • 2012 to 2013 - Churchill Fellowship https://www.churchilltrust.com.au/fellow/andrew-mallett-qld-2012/
  • 2021 - National Examining Panel, Royal Australasian College of Physicians

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

ResearchOnline@JCU stores 98+ research outputs authored by Prof Andrew Mallett from 2015 onwards.

Current Funding

Current and recent Research Funding to JCU is shown by funding source and project.

Commonwealth Department of Health - Medical Research Future Fund - Genomic Health Futures Mission

The KidGen National Kidney Genomics Program ? improving genomic outcomes for Australian families with genetic kidney disease

Indicative Funding
$2,999,537 over 5 years
The KidGen National Kidney Genomic Program is an Australian national and translational genomics program addressing the clinical need to urgently improve identification and diagnosis of novel monogenic rare kidney diseases. Our vision is to improve the diagnostic and clinical outcomes of Australian patients and families affected by genetic kidney disease (GKD) through personalised application of novel genomic approaches at national scale and within a multidisciplinary context. We will materially increase the genetic diagnosis rate in this space towards 70% by 2025 whilst enabling earlier and more efficient genomic diagnosis of rare kidney disorders. World-leading genomic approaches will be utilised to improve connection and capacity, including the application of advanced research and functional genomics to identify and validate novel gene variants in our extensive patient cohort. Through our established national network of multidisciplinary clinics this will inform clinical options and pathways for affected Australian families and accelerate translation and integration of genomics knowledge and technology into kidney clinical practice.
Andrew Mallett, Stephen Alexander, Melissa Little, Cas Simons, Ian Smyth, Amali Mallawaarachchi, Catherine Quinlan, Ira Deveson, Thomas Forbes and Kushani Jayasinghe in collaboration with Daniel MacArthur, Zomitza Stark, Jirag Patel, Jeffrey Braithwaite, Bruce Bennets, Hugh McCarthy, Madhivanan Sundaram, Randall Faull, Matthew Jose and Aron Chakera (College of Medicine & Dentistry, The University of Sydney, Murdoch Childrens Research Institute, Monash University, The Garvan Institute of Medical Research, Queensland Health, Macquarie University, Westmead Hospital, Sydney Childrens Hospitals Network, Royal Darwin Hospital, University of Adelaide, University of Tasmania and Sir Charles Gairdner Hospital)
Genetic disorders; Kidney Disease; Clinical Genetics; Medical Genomics; Disease Modelling

Commonwealth Department of Health - Medical Research Future Fund - Genomic Health Futures Mission

TRIAGE: A disease agnostic computational and modelling platform to accelerate variant classification

Indicative Funding
$180,333 over 3 years (administered by The University of Queensland)
This proposal develops a disease-agnostic, high throughput and scalable functional genomics platform integrating computational variant prediction and disease modelling to increase the diagnostic rate of unresolved cases and accelerate development of experimental therapeutics. We implement a novel unsupervised, disease agnostic, genome-wide computational analysis method called TRIAGE which provides predictions at single base resolution across the human genome, revealing the likelihood of a variant being pathogenic. No other methods compare with TRIAGE in identifying genes associated with developmental process and cell differentiation where variants in these loci are associated with congenital disease and multi-organ syndromes. Our team of experts across Australia?s research and clinical sectors bring skills in bioinformatics, statistical genetics, clinical genetics, and disease modelling. In Aim 1 we incorporate tested genome-wide metrics, such as TRIAGE, to build open access machine learning methods that enhance variant prediction in clinical data. Aim 2 implements TRIAGE in Australian Genomic cohorts and registries to identify prioritised and novel candidates for disease modelling and develop strategies and guidelines for advancing TRIAGE in clinical genetic diagnostics and functional genomics networks. Aim 3 uses TRIAGE to prioritise variants for disease modelling across a multi-institutional phenotyping platform. Disease modelling includes innovative genome-wide molecular phenotyping coupled with physiological assays in cell and animal models. At the completion of the grant, we aim to implement TRIAGE in standard clinical genetic analysis protocols and deliver phenotyping data to assist in classification of unresolved genetic diseases. These achievements will result in diagnoses and mechanism of disease that will directly benefit patients in obtaining medical and psychosocial support and create pathways to new therapies.
Nathan Palpant, Andrew Mallett, Zornitza Stark, Julie McGaughran, Adam Hill, Mikael Boden, Diane Fatkin, Alexander Combes, Richard Harvey, Tatiane Yanes, Sonia Shah, Robert Bryson-Richardson, John Atherton, Richard Bagnall and Jodie Ingles (The University of Queensland, College of Medicine & Dentistry, Murdoch Childrens Research Institute, Royal Brisbane Womens Hospital, University of New South Wales, Victor Chang Cardiac Research Institute, Monash University, Centenary Institute of Cancer Research and The Garvan Institute of Medical Research)
Congenital disease; Functional Genomics; Embryonic stem cells; Disease modelling; Bioinformatics

Tropical Australian Academic Health Centre Limited - Research Seed Grants

Using portable long-read sequencing to diagnose Chronic Kidney Disease in regional North QLD Using portable long-read sequencing to diagnose Chronic Kidney Disease in regional North Using portable long-read sequencing to diagnose Chronic Kidney Disease

Indicative Funding
$50,000 over 2 years
This project addresses the early diagnosis of genetic predispositions for Chronic Kidney Disease (CKD), which poses an increasing burden on the North Queensland population and unequally affects the Indigenous Australian peoples. We will develop a mobile diagnostic pipeline that allows a rapid and cost-efficient screening for genetic CKD predispositions and circulating biomarkers using a targeted, DNA/RNA long-read sequencing approach.
Ulf Schmitz, Andrew Mallett, Matt Field, Paul Horwood, Helen Wright, Chirag Patel, Ira Cooke and Ben Lundie (College of Public Health, Medical & Vet Sciences, College of Medicine & Dentistry, College of Healthcare Sciences, Queensland Clinical Genetics Service and Pathology Queensland)
long-read sequencing; Nanopore; Chronic Kidney Disease; Genetic Testing; targeted sequencing; transcriptomic complexity

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These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

  • Utility of arterial reflection measures as a risk and monitoring tool for cardiovascular disease in Australians with and without chronic disease (PhD , Secondary Advisor)
  • Clinical applications of genetic testing, sequencing and information to promote kidney health (PhD , Primary Advisor)
  • Psychological intervention for reducing emergency department (ED) representations ?? A randomised controlled trial (RCT) (PhD , Primary Advisor)
  • Pharmacist-led Prescribing Education to final year Medical Students (PhD , Primary Advisor)
  • Design, Implementation and Evaluation of an Intervention for a Kidney Transplant Service in Northern Queensland utilising a prospective Cohort study (PhD , Primary Advisor)

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.

  • 5+ collaborations
  • 4 collaborations
  • 3 collaborations
  • 2 collaborations
  • 1 collaboration
  • Indicates the Tropics (Torrid Zone)

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