Dr Moran began his training in vascular research within the Centre for Research in Vascular Biology, University of Queensland. The two-year research project for the award of Master of Science investigated the effect of human leukemia inhibitory factor on the development of experimental atherosclerosis in an animal model of carotid artery occlusive disease. Project outcomes were recognized with Dr Moran awarded the Australian Vascular Biology Society's inaugural Young Investigator Prize for this work. Dr Moran received his PhD from James Cook University in 2006 after completing a research program investigating the role of Osteoprotegerin in the development of abdominal aortic aneurysm (AAA). He then undertook consecutive postdoctoral appointments within the Vascular Biology Unit at JCU after winning the National Heart Foundation of Australia’s John Shaw and the Queensland Government Smart Futures Fellowships. Dr Moran continues as a Senior Research Scientist (preclinical) within the Queensland Research Centre for Peripheral Vascular Disease (QRC-PVD) at JCU.

Research: 

 Dr Moran’s research focuses upon cellular mechanisms involved in AAA initiation and progression. Dr Moran’s expertise in this field is evidenced by a numerous publications in quality cardiovascular journals including Arteriosclerosis, Thrombosis and Vascular Biology, European Heart Journal, and Circulation. He has developed an extensive skill base and high-level proficiency in the development, characterization, and assessment of in vitro and in vivo pre-clinical models of vascular disease. His scientific training to date has been geared to develop a solid research foundation in the field of artery disease, with a primary focus on understanding pathological weakening of the human aorta, identifying potential drug-based intervention strategies, and in vivo drug delivery systems for the treatment of AAA. A developing area of interest for Dr Moran is the role of mitochondrial dysfunction in accelerated senescence and impaired growth of vascular smooth muscle cells associated with aortic wall degeneration, and can how this can be targeted as early intervention to limit expansion of small AAA.  

 Student Supervision:

 Dr Moran has (co)-supervised 2 PhD students to completion.  The success of these students is evidenced by publication of multiple papers, conference presentations, and academic awards during their candidatures, and their current professional appointments as Immunologist at Addenbrookes Hospital, Cambridge, UK, and Associate Professor at Dalian University, China. Dr Moran currently co-supervises 1 Masters and 1 PhD student.

Other Academic Activities:

 ·    Editorial board member for Scientific Reports (Nature Publishing Group)

·     Reviewer for a range of journals including Arteriosclerosis, Thrombosis, and Vascular  Biology, Circulation Research, PloS, and International Journal of Molecular Sciences

·     Grant reviewer for a range of funding bodies including Diabetes Australia, the National Health  and Medical Research Council, the National Centre for the Replacement, Refinement, and Reduction of Animals in Research (NC3R, London), and JCU funding schemes.

Interests

Research

• Interests: Professional • Cell Biology, Metabolism & Bioenergetics Research • Abdominal Aortic Aneurysm • Peripheral Artery Disease • Cell Proliferation, Degeneration, & Ageing • Mitochondrial Biogenesis & Function • Molecular Pathology • Nutrition • Cardiovascular complications • Pre-clinical research

Experience

• 2014 to present - Senior Research Scientist (preclinical), College of Medicine and Dentistry, James Cook University (Australia)
• 2010 to 2013 - Smart Futures Fellow, College of Medicine and Dentistry, James Cook University (Australia)
• 2007 to 2009 - National Heart Foundation Fellow, School of Medicine & Dentistry, James Cook University (Australia)
• 2002 to 2006 - PhD Candidate, School of Medicine & Dentistry, James Cook University (Australia)

Research Disciplines

• Cardiovascular medicine and haematology (3201)

Socio-Economic Objectives

• Clinical health (2001)

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU.

Journal Articles

• Moran C, Biros E, Krishna S, Morton S, Sexton D and Golledge J (2021) Kallikrein-1 blockade inhibits aortic expansion in a mouse model and reduces prostaglandin E2 secretion from human aortic aneurysm explants. Journal of the American Heart Association, 10 (5), DOI:10.1161/JAHA.120.019372.
• Biros E and Moran C (2020) Mini tryptophanyl-tRNA synthetase is required for a synthetic phenotype in vascular smooth muscle cells induced by IFN-gamma-mediated beta 2-adrenoceptor signaling. Cytokine, 127, Article: 154940, DOI:10.1016/j.cyto.2019.154940.
• Moran C, Seto S, Biros E, Krishna S, Morton S, Kleinschnitz C, Panousis C and Golledge J (2020) Factor XII blockade inhibits aortic dilatation in angiotensin II-infused apolipoprotein E-deficient mice. Clinical Science, 134 (9), pp. 1049-1061, DOI:10.1042/CS20191020.
• Moxon J, Rowbotham S, Pinchbeck J, Lazzaroni S, Morton S, Moran C, Quigley F, Jenkins J, Reid C, Cavaye D, Jaeggi R and Golledge J (2020) A randomised controlled trial assessing the effects of peri-operative fenofibrate administration on abdominal aortic aneurysm pathology: outcomes from the FAME trial. European Journal of Vascular and Endovascular Surgery, 60 (3), pp. 452-460, DOI:10.1016/j.ejvs.2020.06.006.
• Nsengiyumva V, Krishna S, Moran C, Moxon J, Morton S, Clarke M, Seto S and Golledge J (2020) Vitamin D deficiency promotes large rupture-prone abdominal aortic aneurysms and cholecalciferol supplementation limits progression of aneurysms in a mouse model. Clinical Science, 134 (18), pp. 2521-2534, DOI:10.1042/CS20200980.
• Krishna S, Moran C, Jose R, Lazzaroni S, Huynh P and Golledge J (2019) Depletion of CD11c+ dendritic cells in apolipoprotein E-deficient mice limits angiotensin II-induced abdominal aortic aneurysm formation and growth. Clinical Science, 133 (21), Article: 7, pp. 2203-2215, DOI:10.1042/CS20190924.
• Rowbotham S, Krishna S, Moran C and Golledge J (2018) Fenofibrate and telmisartan in the management of abdominal aortic aneurysm. Current Drug Targets, 19 (11), pp. 1241-1246, DOI:10.2174/1389450119666171227224655.
• Biros E, Moran C, Maguire J, Holliday E, Levi C and Golledge J (2017) Upregulation of arylsulfatase B in carotid atherosclerosis is associated with symptoms of cerebral embolization. Scientific Reports, 7 (1), DOI:10.1038/s41598-017-04497-9.
• Moran C, Biros E, Krishna S, Wang Y, Tikellis C, Moxon J, Cooper M, Norman P, Burrell L, Thomas M and Golledge J (2017) Resveratrol inhibits growth of experimental abdominal aortic aneurysm associated with upregulation of angiotensin-converting enzyme 2. Arteriosclerosis Thrombosis and Vascular Biology, 37 (11), pp. 2195-2218, DOI:10.1161/ATVBAHA.117.310129.
• Moran C, Seto S, Krishna S, Sharma S, Jose R, Biros E, Wang Y, Morton S and Golledge J (2017) Parenteral administration of factor Xa/IIa inhibitors limits experimental aortic aneurysm and atherosclerosis. Scientific Reports, 7, Article: 43079, pp. 1-12, DOI:10.1038/srep43079.
• Rowbotham S, Pinchbeck J, Anderson G, Bourke B, Bourke M, Gasser T, Jaeggi R, Jenkins J, Moran C, Morton S, Reid C, Velu R, Yip L, Moxon J and Golledge J (2017) Inositol in the MAnaGemENt of abdominal aortic aneurysm (IMAGEN): study protocol for a randomised controlled trial. Trials, 18, DOI:10.1186/s13063-017-2304-x.
• Rowbotham S, Cavaye D, Jaeggi R, Jenkins J, Moran C, Moxon J, Pinchbeck J, Quigley F, Reid C and Golledge J (2017) Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME): study protocol for a randomised controlled trial. Trials, 18 (1), pp. 1-8, DOI:10.1186/s13063-016-1752-z.

More

ResearchOnline@JCU stores 46+ research outputs authored by Dr Corey Moran from 2005 onwards.

Current and recent Research Funding to JCU is shown by funding source and project.

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Completed

• Utilising novel clinically relevant mouse models to test new therapeutic interventions for peripheral artery diseases (2020, PhD , Secondary Advisor)
• A small animal model for the creation of pre-aneurysmal change in the intracranial vasculature (2020, Masters , Secondary Advisor)
• The role of vitamin D in the development and progression of experimental abdominal aortic aneurysm (2020, PhD , Secondary Advisor)

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.