JCU > Research Portfolio > Prof Geoffrey Dobson

About

Research Disciplines: Clinical sciences (3202)

Cardiovascular medicine and haematology (3201)
Socio-Economic Objectives: Clinical health (2001)

Publications

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

Letson H, Morris J, Biros E and Dobson G (2022) ALM induces cellular quiescence in the surgical margin 3 d following liver resection, hemorrhage, and shock. Journal of Surgical Research, 275. pp. 16-28
Conner J, Lammers D, Holtestaul T, Jones I, Kuckelman J, Letson H, Dobson G, Eckert M and Bingham J (2021) Combatting ischemia reperfusion injury from resuscitative endovascular balloon occlusion of the aorta (REBOA) using adenosine, lidocaine and magnesium: a pilot study. Journal of Trauma and Acute Care Surgery, 91 (6). pp. 995-1001
Dobson G, Morris J, Biros E, Davenport L and Letson H (2021) Major surgery leads to a proinflammatory phenotype: differential gene expression following a laparotomy. Annals Of Medicine And Surgery, 71.
Dobson G, Biros E, Letson H and Morris J (2021) Living in a hostile world: inflammation, new drug development, and coronavirus. Frontiers in Immunology, 11.
Engstrom N, Dobson G, Kevin N and Letson H (in press) Fragmented QRS is associated with ventricular arrhythmias in heart failure patients: a systematic review and meta-analysis. Annals of Noninvasive Electrocardiology,
Francica A, Vaccarin A, Dobson G, Rossetti C, Gardellini J, Faggian G and Onorati F (in press) Short-term outcome of adenosine–lidocaine–magnesium polarizing cardioplegia in humans. European Journal of Cardio-Thoracic Surgery,
Francica A, Tonelli F, Rossetti C, Tropea I, Luciani G, Faggian G, Dobson G and Onorati F (2021) Cardioplegia between evolution and revolution: from depolarized to polarized cardiac arrest in adult cardiac surgery. Journal of Clinical Medicine, 10 (19). p. 4485
Letson H and Dobson G (in press) The role of nitric oxide in the efficacy of adenosine, lidocaine and magnesium (ALM) treatment of experimental hemorrhagic shock in rats. Current Therapeutic Research,
Letson H, Biros E, Morris J and Dobson G (in press) ALM fluid therapy shifts sympathetic hyperactivity to parasympathetic dominance in the rat model of non-compressible hemorrhagic shock. Shock,
Letson H and Dobson G (2021) Buprenorphine analgesia reduces survival with ALM resuscitation in a rat model of uncontrolled hemorrhage: concerns for trauma-related research. Shock, 55 (3). pp. 379-387
Morris J, Letson H, McEwen P, Biros E, Dlaska C, Hazratwala K, Wilkinson M and Dobson G (2021) Comparison of intra?articular administration of adenosine, lidocaine and magnesium solution and tranexamic acid for alleviating postoperative inflammation and joint fibrosis in an experimental model of knee arthroplasty. Journal of Orthopaedic Surgery and Research, 16.
Morris J, Letson H, McEwen P, Biros E, Dlaska C, Hazratwala K, Wilkinson M and Dobson G (2021) Intra-articular Adenosine, Lidocaine and Magnesium (ALM) solution decreases postoperative joint fibrosis in an experimental knee implant model. Translational Medicine Communications, 6.

More: ResearchOnline@JCU stores 107+ research outputs authored by Prof Geoffrey Dobson from 2001 onwards.

Current Funding

Current and recent Research Funding to JCU is shown by funding source and project.

United States Department of Defence - DoD Peer Reviewed Orthopaedic Research Program (PRORP) - Applied Research Award

ALM Drug Therapy to reduce inflammation and scar formation after ACL reconstruction surgery: Targeting earlier return to active duty.

Indicative Funding: $1,061,864 over 3 years
Summary: Two complications of anterior cruciate ligament (ACL) reconstruction surgery are cartilage degeneration and scarring within the joint, which can prolong healing, promote pain and restrict knee movement. Our project will evaluate a new therapy known as ALM solution that can be administrered during ACL reconstruction surgery to dampen inflammation, protect cartilage and promote tissue healing within the joint. Our study has the potential to expedite a patient's return to an active duty with fewer complications.
Investigators: Geoffrey Dobson, Peter McEwen, Jodie Morris, Hayley Letson and Erik Biros (College of Medicine & Dentistry)
Keywords: ACL Injury; ACL Reconstruction surgery; Scarring; Osteoarthritis; Inflammation; Therapeutics

Emergency Medicine Foundation - Leading Edge

Classifying the Type and Severtiy of Traumatic Injury in North Queensland: A Multicentre Retrospective Study

Indicative Funding: $97,580 over 2 years (administered by Queensland Health)
Summary: Queenslanders living in regional, rural and remote areas having a higher incidence of traumatic injury and are disadvantaged by prolonged prehospital times. The aim of this project is to define and describe trauma patients transported by aeromedical emergency services to and between Townsville, Cairns, Mt Isa and Mackay hospitals over a 3 - year period (2016-2018). A key objective is to conduct a comprehensive analysis of clinical interventions and therapies from point-of-injury to hospital admission, and patient outcomes to hospital discharge. This data will help inform all stakeholders on the current state of emergency trauma care in the tropics.
Investigators: Clinton Gibbs, Hayley Letson, Geoffrey Dobson, Luke Lawton, Brett Hoggard and Ben Butson in collaboration with Erik Biros, Daniel Lindsay, Richard Murray and Ulrich Orda (Queensland Health, College of Medicine & Dentistry, College of Public Health, Medical & Vet Sciences, Townsville Hospital and Health Services and North West Hospital and Health Service)
Keywords: Injury; Trauma; Prehospital emergency care; Patient transfer; Rural Health; Aeromedical

Townsville Hospital and Health Service - Study Education Research Trust Account (SERTA)

Trauma Care in the Tropics: A Multi-centre Retrospective Analysis.

Indicative Funding: $9,110 over 2 years (administered by Townsville Hospital and Health Service)
Summary: High quality pre-hospital trauma care and timely access to emergency aeromedical retrieval services is paramount for an efficient, sustainable healthcare system in North Queensland. We propose to identify and classify trauma patients in the North Queensland since 2016 to assess the magnitude of the total injury burden and evaluate the chain-of-care from the prehospital environment, through patient transfer, to hospital discharge. The dataset generated will provide valuable insights into patterns of primary retrieval, trauma distribution, and service provisions and gaps.
Investigators: Clinton Gibbs, Geoffrey Dobson and Hayley Letson (Retrieval Services Queensland and College of Medicine & Dentistry)
Keywords: Injury; Trauma; Prehospital Emergency Care; Patient Transfer; Rural Health; Aeromedical

United States Department of Defence - Broad Agency Award

Optimisation of Ultra-Small Volume Adenosine, Lidocaine and Mg2+ (ALM) Fluid Resuscitation and 72hr Stabilisation Drip for Uncontrolled Haemorrhage and TBI

Indicative Funding: $1,746,795 over 4 years
Summary: The resuscitation and stabilisation properties of ALM 'one-two treatment' will be investigated in rats after uncontrolled blood loss ? traumatic brain injury, and a translational arm in pigs followed for 72hrs to mimic prolonged far-forward retrieval delays. The aim is to show improved survival is associated with improved cardiac function, reduced inflammation, less coagulopathy and less secondary 'it' complications. The ALM therapy has the potential to reduce morbidity and mortality on the battlefield by buying time for treatment, stabilisation and preparedness of causalities for safer evacuation. The study also has broad-spectrum public purpose for pre-hospital trauma and aeromedical transport.
Investigators: Geoffrey Dobson and Hayley Letson in collaboration with Asger Granfeldt (College of Medicine & Dentistry and The Aarhus School of Business)
Keywords: Haemorrhage; Traumatic Brain / Head Injury; Pre-hospital; Trauma; Haemorrhagic shock; Inflammation

Supervision

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current

Primary Prevention Implantable Cardiac Defribrillators: A North Queensland Perspective (PhD , Primary Advisor/AM/Adv)

Completed

Warm (32 degrees celcius) polarised arrest: towards a new cardioprotective strategy using normokalaemic adenosine-lignocaine cardioplegia (2017, PhD , Primary Advisor)
Development of a small-volume resuscitation fluid for trauma victims (2017, PhD , Primary Advisor)
Adenosine and lidocaine (AL) as a vasodilator in cardiac procedures and a storage solution for vascular banking (2019, PhD , Primary Advisor/AM/Adv)

Data

These are the most recent metadata records associated with this researcher. To see a detailed description of all dataset records, visit Research Data Australia.

Letson, H. (2017) Adenosine, Lidocaine and Mg2+ (ALM) fluid therapy for treatment of non-compressible uncontrolled haemorrhage. James Cook University

Collaboration

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.