JCU > Research Portfolio > Prof Geoffrey Dobson

About

Research Disciplines: Cardiovascular Medicine and Haematology (1102)

Clinical Sciences (1103)
Socio-Economic Objectives: Clinical Health (9201)

Publications

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

Dobson G and Letson H (2020) Far forward gaps in hemorrhagic shock and prolonged field care: an update of ALM fluid therapy for field use. Journal of Special Operations Medicine, 20 (3), pp. 128-134.
Dobson G, Morris J, Davenport L and Letson H (2020) Traumatic-induced coagulopathy as a systems failure: a new window into hemostasis. Seminars in Thrombosis and Hemostasis, 46 (2), pp. 199-214, DOI:10.1055/s-0039-1701018.
Letson H and Dobson G (in press) Buprenorphine analgesia reduces survival with ALM resuscitation in a rat model of uncontrolled hemorrhage: concerns for trauma-related research. Shock, , DOI:10.1097/SHK.0000000000001630.
Letson H, Granfeldt A, Jensen T, Mattson T and Dobson G (2020) Adenosine, lidocaine, and magnesium support a high flow, hypotensive, vasodilatory state with improved oxygen delivery and cerebral protection in a pig model of noncompressible hemorrhage. Journal of Surgical Research, 253, pp. 127-138, DOI:10.1016/j.jss.2020.03.048.
Tobin J, Gavitt B, Nomellini V, Dobson G, Letson H and Shackelford S (2020) Immunotherapeutic options for inflammation in trauma. Journal of Trauma and Acute Care Surgery, 89 (25), pp. S77-S82, DOI:10.1097/TA.0000000000002810.
Davenport L, Dobson G and Letson H (2019) A new model for standardising and treating thermal injury in the rat. MethodsX, 6, pp. 2021-2027, DOI:10.1016/j.mex.2019.09.006.
Davenport L, Dobson G and Letson H (2019) The role of invasive monitoring in the resuscitation of major burns: a systematic review and meta-analysis. International Journal of Burns and Trauma, 9 (2), pp. 28-40.
Letson H, Morris J, Biros E and Dobson G (2019) Conventional and specific-pathogen free rats respond differently to anesthesia and surgical trauma. Scientific Reports, 9, Article: 9399, DOI:10.1038/s41598-019-45871-z.
Letson H, Morris J, Biros E and Dobson G (2019) ALM fluid therapy leads to 72 hr survival after hemorrhagic shock. Journal of Trauma and Acute Care Surgery, 87 (3), pp. 606-613, DOI:10.1097/TA.0000000000002397.
McCutchan A, Dobson G, Stewart N, Letson H, Grant A, Jovanovic I, Hazratwala K, Wilkinson M, McEwen P and Morris J (2019) Absence of cytotoxic and inflammatory effects following in vitro exposure of chondrogenically-differentiated human mesenchymal stem cells to adenosine, lidocaine and Mg2+ solution. Journal of Experimental Orthopaedics, 6, Article: 16, DOI:10.1186/s40634-019-0185-5.
Morris J, Letson H, Gillman R, Hazratwala K, Wilkinson M, McEwen P and Dobson G (2019) The CNS theory of osteoarthritis: opportunities beyond the joint. Seminars in Arthritis and Rheumatism, 49 (3), pp. 331-336, DOI:10.1016/j.semarthrit.2019.03.008.
Arsyad A, Sokoya E and Dobson G (2018) Adenosine and lidocaine (AL) combination dilates intimally damaged rat thoracic aortic rings and guinea pig mesenteric arteries: possible significance to cardiac surgery. American Journal of Translational Research, 10 (6), pp. 1841-1851.

More: ResearchOnline@JCU stores 88+ research outputs authored by Prof Geoffrey Dobson from 2001 onwards.

Current Funding

Current and recent Research Funding to JCU is shown by funding source and project.

United States Department of Defence - DoD Peer Reviewed Orthopaedic Research Program (PRORP) - Applied Research Award

ALM Drug Therapy to reduce inflammation and scar formation after ACL reconstruction surgery: Targeting earlier return to active duty.

Indicative Funding: $1,061,864 over 4 years
Summary: Two complications of anterior cruciate ligament (ACL) reconstruction surgery are cartilage degeneration and scarring within the joint, which can prolong healing, promote pain and restrict knee movement. Our project will evaluate a new therapy known as ALM solution that can be administrered during ACL reconstruction surgery to dampen inflammation, protect cartilage and promote tissue healing within the joint. Our study has the potential to expedite a patient's return to an active duty with fewer complications.
Investigators: Geoffrey Dobson, Peter McEwen, Jodie Morris, Hayley Letson and Erik Biros (College of Medicine & Dentistry)
Keywords: ACL Injury; ACL Reconstruction surgery; Scarring; Osteoarthritis; Inflammation; Therapeutics

Townsville Hospital and Health Service - Study Education Research Trust Account (SERTA)

Trauma Care in the Tropics: A Multi-centre Retrospective Analysis

Indicative Funding: $10,795 (administered by Townsville Hospital and Health Service)
Summary: High quality pre-hospital trauma care and timely access to emergency aeromedical retrievl services is paramount for an efficient, sustainable healthcare system in North Queensland. We propose to identify and classify trauma patients in the North Queensland since 2016 to assess the magnitude of the total injury burden and evaluate the chain-of-care from the prehospital environment, through patient transfer, to hospital discharge. The dataset generated will provide valuable insights into patterns of primary retrieval, trauma distribution, and service provisions and gaps.
Investigators: Clinton Gibbs, Geoffrey Dobson and Hayley Letson (Retrieval Services Queensland and College of Medicine & Dentistry)
Keywords: Injury; Trauma; Prehospital Emergency Care; Patient Transfer; Rural Health; Aeromedical

United States Department of Defence - Broad Agency Award

Optimisation of Ultra-Small Volume Adenosine, Lidocaine and Mg2+ (ALM) Fluid Resuscitation and 72hr Stabilisation Drip for Uncontrolled Haemorrhage and TBI

Indicative Funding: $1,746,795 over 5 years
Summary: The resuscitation and stabilisation properties of ALM 'one-two treatment' will be investigated in rats after uncontrolled blood loss ? traumatic brain injury, and a translational arm in pigs followed for 72hrs to mimic prolonged far-forward retrieval delays. The aim is to show improved survival is associated with improved cardiac function, reduced inflammation, less coagulopathy and less secondary 'it' complications. The ALM therapy has the potential to reduce morbidity and mortality on the battlefield by buying time for treatment, stabilisation and preparedness of causalities for safer evacuation. The study also has broad-spectrum public purpose for pre-hospital trauma and aeromedical transport.
Investigators: Geoffrey Dobson and Hayley Letson in collaboration with Asger Granfeldt (College of Medicine & Dentistry and The Aarhus School of Business)
Keywords: Haemorrhage; Traumatic Brain / Head Injury; Pre-hospital; Trauma; Haemorrhagic shock; Inflammation

Supervision

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current

Primary Prevention Implantable Cardiac Defribrillators: A North Queensland Perspective (PhD , Primary Advisor/AM/Adv)

Completed

Warm (32 degrees celcius) polarised arrest: towards a new cardioprotective strategy using normokalaemic adenosine-lignocaine cardioplegia (2017, PhD , Primary Advisor)
Development of a small-volume resuscitation fluid for trauma victims (2017, PhD , Primary Advisor)
Adenosine and lidocaine (AL) as a vasodilator in cardiac procedures and a storage solution for vascular banking (2019, PhD , Primary Advisor/AM/Adv)

Data

These are the most recent metadata records associated with this researcher. To see a detailed description of all dataset records, visit the JCU Research Data Catalogue.

Letson, H. (2017) Adenosine, Lidocaine and Mg2+ (ALM) fluid therapy for treatment of non-compressible uncontrolled haemorrhage. James Cook University

Collaboration

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.