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Validate - Pump-Priming Grant

Evaluation of BCG?BCG1419c:ESAT6-PE25SS in immunocompetent and immunocompromised mouse models of TB

Indicative Funding
$98,016 over 1 year
Summary
Tuberculosis (TB) is a major public health concern that causes more than 1.5 million deaths each year. Vaccination is considered one of the most effective ways to eliminate TB. However, the only licensed TB vaccine, called BCG, provides limited protection against the disease in adults and can cause dangerous side effects in people with weaker immune systems. This project aims to investigate whether a new vaccine candidate can induce a stronger immune response and better protection against tuberculosis in mice with normal immune systems and is well-tolerated in mice with compromised immune systems, when compared with the original BCG vaccine.
Investigators
Ana Maria Valencia Hernandez, Socorro Miranda-Hernandez, Guangzu Zhao, Andreas Kupz and Mario Alberto Flores-Valdez (Australian Institute of Tropical Health & Medicine and CIATEJ)
Keywords
Mycobacterium Tuberculosis; Vaccine Development; Immunology; Bcg; Infectious deseases
Collaboration

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.

  • 5+ collaborations
  • 4 collaborations
  • 3 collaborations
  • 2 collaborations
  • 1 collaboration
  • Indicates the Tropics (Torrid Zone)

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