Dr James Phie ~ Postdoctoral Research Fellow (Research Scientist)

As a researcher with the Queensland Research Center for Peripheral Vascular Disease I investigate therapeutic interventions in novel clinically relevant pre-clinical models of abdominal aortic aneurysm and intermittent claudication. My research utilizes micro-vascular surgical techniques to model infrarenal aortic aneurysm and multi-stage surgical procedures to induce sustained hind limb ischemia and intermittent claudication in rodents, as well as in vitro cell culture studies to support and inform this work. Routine analytical techniques associated with this work include histology/IHC/IF, western blotting, magnetic bead assays, ELISA and RT-PCR.

Research Disciplines

• Cardiovascular medicine and haematology (3201)
• Pharmacology and pharmaceutical sciences (3214)

Socio-Economic Objectives

• Expanding knowledge (2801)
• Clinical health (2001)

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

• Phie J, Thanigaimani S and Golledge J (in press) Systematic review and meta-analysis of interventions to slow progression of abdominal aortic aneurysm in mouse models. Arteriosclerosis, Thrombosis and Vascular Biology, , DOI:10.1161/ATVBAHA.121.315942.
• Phie J, Krishna S, Kinobe R, Moxon J, Andrade-Lima A, Morton S, Lazzaroni S, Huynh P and Golledge J (2021) Effects of quercetin on exercise performance, physical activity and blood supply in a novel model of sustained hind-limb ischaemia. BJS Open, 5 (1), Article: zraa059, DOI:10.1093/bjsopen/zraa059.
• Thanigaimani S, Phie J, Sharma C, Wong S, Ibrahim M, Huynh P, Moxon J, Jones R and Golledge J (2021) Network meta?analysis comparing the outcomes of treatments for intermittent claudication tested in randomized controlled trials. Journal of the American Heart Association, 10 (9), Article: e019672, DOI:10.1161/JAHA.120.019672.
• Thanigaimani S, Phie J, Krishna S, Moxon J and Golledge J (2021) Effect of disease modifying anti-rheumatic drugs on major cardiovascular events: a meta-analysis of randomized controlled trials. Scientific Reports, 11, p. 6627.
• Huynh P, Phie J, Krishna S and Golledge J (2020) Systematic review and meta-analysis of mouse models of diabetes-associated ulcers. BMJ Open Diabetes Research & Care, 8 (1), Article: e000982, DOI:10.1136/bmjdrc-2019-000982.
• Thanigaimani S, Phie J and Golledge J (2020) Animal models of ischemic limb ulcers: a systematic review and meta-analysis. BMJ Open Diabetes Research & Care, 8, Article: e001676, DOI:10.1136/bmjdrc-2020-001676.
• Hem N, Phie J, Chilton L and Kinobe R (2019) A volume-pressure tail cuff method for hemodynamic parameters: comparison of restraint and light isoflurane anesthesia in normotensive male Lewis rats. Journal of Pharmacological and Toxicological Methods, 100, Article: 106601, DOI:10.1016/j.vascn.2019.106601.
• Langdon K, Phie J, Thapa C, Biros E, Loukas A and Haleagrahara N (2019) Helminth-based therapies for rheumatoid arthritis: a systematic review and meta-analysis. International Immunopharmacology, 66, pp. 366-372, DOI:10.1016/j.intimp.2018.11.034.
• Phie J, Moxon J, Krishna S, Kinobe R, Morton S and Golledge J (2018) A diet enriched with tree nuts reduces severity of atherosclerosis but not abdominal aneurysm in angiotensin II-infused apolipoprotein E deficient mice. Atherosclerosis, 277, pp. 28-33, DOI:10.1016/j.atherosclerosis.2018.08.004.
• Phie J, Krishna S, Moxon J, Omer S, Kinobe R and Golledge J (2017) Flavonols reduce aortic atherosclerosis lesion area in apolipoprotein E deficient mice: a systematic review and meta-analysis. PLoS ONE, 12 (7), Article: e0181832, pp. 1-13, DOI:10.1371/journal.pone.0181832.
• Phie J, Haleagrahara N, Newton P, Constantinoiu C, Sarnyai Z, Chilton L and Kinobe R (2015) Prolonged subcutaneous administration of oxytocin accelerates angiotensin II-induced hypertension and renal damage in male rats. PLoS ONE, 10 (9), Article: e0138048, pp. 1-19, DOI:10.1371/journal.pone.0138048.

Other research outputs

• Kinobe R, Phie J, Haleagrahara N and Chilton L (2016) Carbon monoxide releasing molecule-3 alleviates angiotensin II-induced hypertrophy and apoptosis by inhibiting oxidative and endoplasmic reticulum stress in H9c2 cardiomyocytes. FASEB Journal, 30 (1), DOI:10.1096/fj.1530-6860.

These are the most recent metadata records associated with this researcher. To see a detailed description of all dataset records, visit Research Data Australia.

• Phie, J. (2020) Utilising novel clinically relevant mouse models to test new therapeutic interventions for peripheral artery diseases: linear mixed effects model statistical outputs for all data. James Cook University