I obtained my PhD in 2011 at University of Valencia (Spain) with high honours under the supervision of Dr. Rafael Toledo and J. Guillermo Esteban. My interests during my PhD were the host-parasite interactions at a proteomics and immunological level in the Echinostoma-rodent. In 2012 I was appointed as a Postdoctoral Research Fellow at James Cook University at the laboratory of Alex Loukas. 

My research focus is the analysis of the proteomes and secretomes of parasites and how they orchestrate a parasitic existence. I am also interested in the host-parasite relationships, with a particular emphasis on soil-transmitted helminths (e.g. hookworms, whipworms, roundworms) and water-borne trematodes such as Schistosoma spp. I have described the excretory-secretory proteins of different helminths and have been involved in in analyses of large-scale sequence datasets generated from a range of parasites (i.e. transcriptomes). I recently focused my attention to study small-secreted parasitic vesicles (exosomes) and their implication in parasite-host communication and the modulation of the host’s immune response.

Interests

Research

• Proteomics of helminths
• Host-parasite interactions

Experience

• 2013 to present - Postdoctoral Research Fellow, James Cook University (Cairns, Australia)
• 2012 to 2013 - Proteomics Laboratory Manager, James Cook University (Cairns, Australia)
• 2006 to 2010 - PhD student, University of Valencia (Valencia, Spain)
• 2008 - Visiting scientist, The Queen's University of Belfast (Belfast, Northern Ireland)

Research Disciplines

• Medical microbiology (3207)
• Bioinformatics and computational biology (3102)

Socio-Economic Objectives

• Clinical health (2001)

Fellowships

• 2006 to 2010 - PhD fellowship by Ministry of Education (Spain)
• 2004 to 2005 - Honours student fellowship

Memberships

• 2013 - Current member of the Australian Society for Parasitology
• 2008 - Current member of the Spanish Society for Proteomics
• 2006 - Curent member of the Spanish Society for Parasitology

Other

• 2013 - Reviewer for scientific journals such as PLoS NTD and Journal of Helminthology
• 2011 to 2012 - Grant reviewer for the Spanish Agency of Evaluation and Research (ANEP)

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

• Bouchery T, Volpe B, Doolan R, Coakley G, Moyat M, Esser-von Bieren J, Wickramasinghe L, Hibbs M, Sotillo J, Camberis M, Le Gros G, Khan N, Williams D and Harris N (2022) ?-Glucan receptors on IL-4 activated macrophages are required for hookworm larvae recognition and trapping. Immunology and Cell Biology, 100 (4). pp. 223-234
• Chaiyadet S, Sotillo J, Krueajampa W, Thongsen S, Smout M, Brindley P, Laha T and Loukas A (2022) Silencing of Opisthorchis viverrini Tetraspanin Gene Expression Results in Reduced Secretion of Extracellular Vesicles. Frontiers in Cellular and Infection Microbiology, 12.
• De Sousa K, Potriquet J, Mulvenna J, Sotillo-Gallego J, Groves P, Loukas A, Apte S and Doolan D (2022) Proteomic identification of the contents of small extracellular vesicles from in vivo Plasmodium yoelii infection. International Journal for Parasitology, 52 (1). pp. 35-45
• Khudhair Z, Alhallaf R, Eichenberger R, Field M, Krause L, Sotíllo J and Loukas A (2022) Administration of Hookworm Excretory/Secretory Proteins Improves Glucose Tolerance in a Mouse Model of Type 2 Diabetes. Biomolecules, 12 (5).
• Mekonnen G, Tedla B, Pearson M, Becker L, Field M, Amoah A, van Dam G, Corstjens P, Mduluza T, Mutapi F, Loukas A and Sotillo J (2022) Characterisation of tetraspanins from Schistosoma haematobium and evaluation of their potential as novel diagnostic markers. PLoS Neglected Tropical Diseases, 16 (1).
• Quinzo M, Perteguer M, Brindley P, Loukas A and Sotillo J (2022) Transgenesis in parasitic helminths: a brief history and prospects for the future. Parasites and Vectors, 15 (1).
• Khudhair Z, Alhallaf R, Eichenberger R, Whan J, Kupz A, Field M, Krause L, Wilson D, Daly N, Giacomin P, Sotillo J and Loukas A (2021) Gastrointestinal helminth infection improves insulin sensitivity, decreases systemic inflammation, and alters the composition of gut microbiota in distinct mouse models of Type 2 diabetes. Frontiers in Endocrinology, 11.
• Montaño K, Loukas A and Sotillo J (2021) Proteomic approaches to drive advances in helminth extracellular vesicle research. Molecular Immunology, 131. pp. 1-5
• Pearson M, Tedla B, Mekonnen G, Proietti C, Becker L, Nakajima R, Jasinskas A, Doolan D, Amoah A, Knopp S, Rollinson D, Ali S, Kabole F, Hokke C, Adegnika A, Field M, van Dam G, Corstjens P, Mduluza T, Mutapi F, Oeuvray C, Greco B, Chaiyadet S, Laha T, Cai P, McManus D, Bottazzi M, Felgner P, Sotillo J and Loukas A (2021) Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis: a biomarker identification study. The Lancet Microbe, 2 (11). pp. e617-e626
• Pearson M, Tedla B, Becker L, Nakajima R, Jasinskas A, Mduluza T, Mutapi F, Oeuvray C, Greco B, Sotillo J, Felgner P and Loukas A (2021) Immunomics-guided antigen discovery for praziquantel-induced vaccination in urogenital human schistosomiasis. Frontiers in Immunology, 12.
• Arunsan P, Chaidee A, Cochran C, Mann V, Tanno T, Kumkhaek C, Smout M, Karinshak S, Rodpai R, Sotillo J, Loukas A, Laha T, Brindley P and Ittiprasert W (2020) Liver fluke granulin promote extracellular vesicle-mediated crosstalk and cellular microenvironment conducive to cholangiocarcinoma. Neoplasia, 22 (5). pp. 203-216
• Bouchery T, Moyat M, Sotillo J, Silverstein S, Volpe B, Coakley G, Tsourouktsoglou T, Becker L, Shah K, Kulagin M, Guiet R, Camberis M, Schmidt A, Seitz A, Giacomin P, Le Gros G, Papayannopoulos V, Loukas A and Harris N (2020) Hookworms evade host immunity by secreting a deoxyribonuclease to degrade neutrophil extracellular traps. Cell Host & Microbe, 27 (2). pp. 277-289.e6

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ResearchOnline@JCU stores 80+ research outputs authored by Dr Javier Sotillo-Gallego from 2008 onwards.

Current and recent Research Funding to JCU is shown by funding source and project.

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Completed

• Schistosoma mansoni extracellular vesicles: immunobiology and vaccine efficacy (2020, PhD , Secondary Advisor)
• Characterisation of the proteomic composition of Schistosoma haematobium extracellular vesicles: towards the development of vaccine and diagnostic candidate antigens (2020, PhD , Primary Advisor)
• Impact of hookworms and their secreted proteins on the microbiota and subsequent development of type 2 diabetes in mice (2020, PhD , Secondary Advisor)
• Characterisation of Necator americanus excretory/secretory products (2020, PhD , Secondary Advisor)

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.