Associate Professor John Miles was awarded BSc Hons in 2001 and a PhD in 2008 from the University of Queensland. His work involves understanding basic immune processes which determine the host’s response to infectious disease and chronic conditions. 

He has been awarded a NHMRC Dora Lush Biomedical Postgraduate Scholarship, a NHMRC Overseas Biomedical Fellowship, Welcome Trust VIP Award, WORD Medical Research Fellowship and NHMRC Career Development Fellowships Level 1 and Level 2 (2017-2020). Other awards include the Young Tall Poppy Science Award from the Australian Institute of Policy and Science and Centenary Medal from the Australian Government and her Majesty Queen Elizabeth for Distinguished Service to Medical Research and the Community. John spent 2008-2012 researching immunomonitoring and immune engineering technologies at Cardiff University and was promoted Head of the Human Immunity Laboratory at the QIMR Berghofer Medical Research Institute from 2012-2016. In 2016, John joined the Australian Institute of Tropical Health and Medicine is currently a Principal Research Fellow in Molecular Immunology at the Centre for Biodiscovery and Molecular Development of Therapeutics and the Centre for Biosecurity and Tropical Infectious Diseases. His research has been funded by 12 national and international schemes including Perpetual, NHMRC and ARC.

Experience

• 2016 to present - Consultant, QIMR Berghofer Medical Research Institute (Herston, Australia)
• 2016 to present - Principal Research Fellow & NHMRC Career Development Fellow, Molecular Immunology, Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine (James Cook University, Australia)
• 2008 to present - Research Officer, Cellular Immunology Laboratory, The Queensland Institute of Medical Research (QIMR) (Herston, Australia)
• 2012 to 2016 - Group Leader & NHMRC Career Development Fellow, QIMR Berghofer Medical Research Institute (Herston, Australia)
• 2010 to 2011 - WORD Senior Research Fellow, T Cell Modulation Laboratory, School of Medicine, Department of Infection and Immunity (Cardiff University, Cardiff, United Kingdom)
• 2008 to 2010 - Research Fellow, T Cell Modulation Laboratory, School of Medicine, Department of Infection and Immunity (Cardiff University, Cardiff, United Kingdom)
• 2004 to 2008 - Doctor of Philosophy in Immunology, The University of Queensland (Brisbane, Australia)
• 2002 to 2004 - Research Assistant, Cellular Immunology Laboratory, The Queensland Institute of Medical Research (QIMR) (Herston, Australia)
• 2001 to 2002 - Consultant, The Queensland Department of Primary Industries (DPI); Tick Fever Research Center (TFRC) & Animal Research Institute (ARI) (Brisbane, Australia)
• 2001 - Bachelor of Science (Honours), Microbiology Major, The University of Queensland (Brisbane, Australia)
• 1998 to 2000 - Bachelor of Science, Microbiology and Physiology Majors, The University of Queensland (Brisbane, Australia)

Research Disciplines

• Immunology (1107)

Socio-Economic Objectives

• Clinical Health (9201)

Awards

• National Health and Medical Research Council (NHMRC) Traveling Award for Research Training
• Wellcome Trust VIP Award, ranked 1st in category
• Centenary Medal from the Australian Government and her Majesty Queen Elizabeth II for Distinguished Service to Medical Research and the Community
• Australian Society for Immunology (ASI) Post-doctoral International Travel Award
• The University of Queensland Award for Outstanding Record of Research Performance and Publication; Comprising Certificate and Cash Prize
• Queensland Institute of Medical Research (QIMR) International Travel Award
• Queensland Institute of Medical Research (QIMR) International Postgraduate Travel Award
• Australian Society for Immunology (ASI) Postgraduate International Travel Award
• Health and Medical Research Council (NHMRC) Dora Lush Biomedical Postgraduate Scholarship
• Australian Society for Immunology (ASI) Best Article Prize
• Young Tall Poppy Science Award 2013 from the Australian Institute of Policy and Science.
• Williams Morgan Thomas Bequest Award
• British Society for Immunology (BSI) International Travel Award
• Queensland Cancer Fund (QCF) International Travel Award

Fellowships

• National Health and Medical Research Council (NHMRC) Biomedical Fellowship
• National Health and Medical Research Council (NHMRC) Career Development Fellowship Level 2
• National Health and Medical Research Council (NHMRC) Career Development Fellowship Level 1
• Wales Office of Research and Development (WORD) Medical Research Fellowship

Memberships

• 2017 - Organizing committee, The Australian Tropical Health Conference 2017
• 2015 - Organizing committee, The Brisbane Immunology Group (BIG) Annual Conference 2015
• 2015 - Organizing committee, 46th Australian Society for Immunology Annual meeting 2017
• 2015 - Organizing committee, The 6th Australasian Vaccines & Immunotherapeutics Development Meeting 2016
• 2005 - The Australian Society of Medical Research (ASMR)
• 2003 - The Queensland Institute of Medical Research (QIMR) Information Technology Committee
• 2002 - International Epstein-Barr Virus Association
• 2002 - The Australian Society for Immunology (ASI)
• 2008 to 2012 - The British Society of Immunology (BSI)
• 2001 to 2004 - The Australian Society for Microbiology (ASM)

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

• McGuire H, Watkins T, Field M, Taylor S, Yasuyama N, Farmer A, Miles J and Fazekas de St. Groth B (2018) TCR deep sequencing of transgenic RAG-1-deficient mice reveals endogenous TCR recombination: a cause for caution. Immunology and Cell Biology, 96 (6). pp. 642-645
• Miles J, Tan M, Dolton G, Edwards E, Galloway S, Laugel B, Clement M, Makinde J, Ladell K, Matthews K, Watkins T, Tungatt K, Wong Y, Lee H, Clark R, Pentier J, Attaf M, Lissina A, Ager A, Gallimore A, Rizkallah P, Grass S, Rossjohn J, Burrows S, Cole D, Price D and Sewell A (2018) Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation, 128 (4). pp. 1569-1580
• Tungatt K, Dolton G, Morgan S, Attaf M, Fuller A, Whalley T, Hemmink J, Porter E, Szomolay B, Montoya M, Hammond J, Miles J, Cole D, Townsend A, Bailey M, Rizkallah P, Charleston B, Tchilian E and Sewell A (2018) Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. PLoS Pathogens, 14 (5).
• Cole D, Fuller A, Dolton G, Zervoudi E, Legut M, Miles K, Blanchfield L, Madura F, Holland C, Bulek A, Bridgeman J, Miles J, Schauenburg A, Beck K, Evavold B, Rizkallah P and Sewell A (2017) Dual molecular mechanisms govern escape at immunodominant HLA A2-restricted HIV epitope. Frontiers in Immunology, 8.
• Cole D, Van Den Berg H, Lloyd A, Crowther M, Beck K, Ekeruche-Makinde J, Miles J, Bulek A, Dolton G, Schauenburg A, Wall A, Fuller A, Clement M, Laugel B, Rizkallah P, Wooldridge L and Sewell A (2017) Structural mechanism underpinning cross-reactivity of a CD8(+) T-cell clone that recognizes a peptide derived from human telomerase reverse transcriptase. Journal of Biological Chemistry, 292 (3). pp. 802-813
• Minoda Y, Virshup I, Rojas I, Haigh O, Wong Y, Miles J, Wells C and Radford K (2017) Human CD141(+) dendritic cell and CD1c(+) dendritic cell undergo concordant early genetic programming after activation in humanized mice in vivo. Frontiers in Immunology, 8.
• Panagides N, Jackson T, Ikonomopoulou M, Arbuckle K, Pretzler R, Yang D, Ali S, Koludarov I, Dobson J, Sanker B, Asselin A, Santana R, Hendrikx I, van der Ploeg H, Tai-A-Pin J, van den Bergh R, Kerkkamp H, Vonk F, Naude A, Strydom M, Jacobsz L, Dunstan N, Jaeger M, Hodgson W, Miles J and Fry B (2017) How the cobra got its flesh-eating venom: cytotoxicity as a defensive innovation and its co-evolution with hooding, aposematic marking, and spitting. Toxins, 9 (3).
• Smallwood T, Giacomin P, Loukas A, Mulvenna J, Clark R and Miles J (2017) Helminth immunomodulation in autoimmune disease. Frontiers in Immunology, 8.
• Blake S, Dougall W, Miles J, Teng M and Smyth M (2016) Molecular pathways: targeting CD96 and TIGIT for cancer immunotherapy. Clinical Cancer Research, 22 (21). pp. 5183-5188
• Blake S, Stannard K, Liu J, Allen S, Yong M, Mittal D, Aguilera A, Miles J, Lutzky V, Ferrari de Andrade L, Martinet L, Colonna M, Takeda K, Kühnel F, Gurlevik E, Bernhardt G, Teng M and Smyth M (2016) Suppression of metastases using a new lymphocyte checkpoint target for cancer immunotherapy. Cancer Discovery, 6 (4). pp. 446-459
• Cole D, Bulek A, Dolton G, Schauenberg A, Szomolay B, Rittase W, Trimby A, Jothikumar P, Fuller A, Skowera A, Rossjohn J, Zhu C, Miles J, Peakman M, Wooldridge L, Rizkallah P and Sewell A (2016) Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation, 126 (6). pp. 2191-2204
• Dasari V, Schuessler A, Smith C, Wong Y, Miles J, Smyth M, Ambalathingal G, Francis R, Campbell S, Chambers D and Khanna R (2016) Prophylactic and therapeutic adenoviral vector-based multivirus-specific T-cell immunotherapy for transplant patients. Molecular Therapy: methods & clinical development, 3. pp. 1-9

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ResearchOnline@JCU stores 89+ research outputs authored by A/Prof John Miles from 2003 onwards.

Current and recent Research Funding to JCU is shown by funding source and project.

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current

• Deconstructing the Immunopathogenesis of Pathogenic Lung Infections (PhD , Primary Advisor/AM)
• C. Fleckeri Mode of Action Investigation (Masters , Secondary Advisor)
• First aid of tropical jellyfish stings (PhD , Advisor Mentor)
• High-Throughput and High-Definition Breakdown of Human T Cell Repertoires in Health and Disease (PhD , Primary Advisor/AM)

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.