About

Associate Professor John Miles was awarded BSc Hons in 2001 and a PhD in 2008 from the University of Queensland. His work involves understanding basic immune processes which determine the host’s response to infectious disease and chronic conditions. 

He has been awarded a NHMRC Dora Lush Biomedical Postgraduate Scholarship, a NHMRC Overseas Biomedical Fellowship, Welcome Trust VIP Award, WORD Medical Research Fellowship and NHMRC Career Development Fellowships Level 1 and Level 2 (2017-2020). Other awards include the Young Tall Poppy Science Award from the Australian Institute of Policy and Science and Centenary Medal from the Australian Government and her Majesty Queen Elizabeth for Distinguished Service to Medical Research and the Community. John spent 2008-2012 researching immunomonitoring and immune engineering technologies at Cardiff University and was promoted Head of the Human Immunity Laboratory at the QIMR Berghofer Medical Research Institute from 2012-2016. In 2016, John joined the Australian Institute of Tropical Health and Medicine is currently a Principal Research Fellow in Molecular Immunology at the Centre for Biodiscovery and Molecular Development of Therapeutics and the Centre for Biosecurity and Tropical Infectious Diseases. His research has been funded by 12 national and international schemes including Perpetual, NHMRC and ARC.

Experience
  • 2016 to present - Consultant, QIMR Berghofer Medical Research Institute (Herston, Australia)
  • 2016 to present - Principal Research Fellow & NHMRC Career Development Fellow, Molecular Immunology, Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine (James Cook University, Australia)
  • 2008 to present - Research Officer, Cellular Immunology Laboratory, The Queensland Institute of Medical Research (QIMR) (Herston, Australia)
  • 2012 to 2016 - Group Leader & NHMRC Career Development Fellow, QIMR Berghofer Medical Research Institute (Herston, Australia)
  • 2010 to 2011 - WORD Senior Research Fellow, T Cell Modulation Laboratory, School of Medicine, Department of Infection and Immunity (Cardiff University, Cardiff, United Kingdom)
  • 2008 to 2010 - Research Fellow, T Cell Modulation Laboratory, School of Medicine, Department of Infection and Immunity (Cardiff University, Cardiff, United Kingdom)
  • 2004 to 2008 - Doctor of Philosophy in Immunology, The University of Queensland (Brisbane, Australia)
  • 2002 to 2004 - Research Assistant, Cellular Immunology Laboratory, The Queensland Institute of Medical Research (QIMR) (Herston, Australia)
  • 2001 to 2002 - Consultant, The Queensland Department of Primary Industries (DPI); Tick Fever Research Center (TFRC) & Animal Research Institute (ARI) (Brisbane, Australia)
  • 2001 - Bachelor of Science (Honours), Microbiology Major, The University of Queensland (Brisbane, Australia)
  • 1998 to 2000 - Bachelor of Science, Microbiology and Physiology Majors, The University of Queensland (Brisbane, Australia)
Research Disciplines
Socio-Economic Objectives
Honours
Awards
  • National Health and Medical Research Council (NHMRC) Traveling Award for Research Training
  • Wellcome Trust VIP Award, ranked 1st in category
  • Centenary Medal from the Australian Government and her Majesty Queen Elizabeth II for Distinguished Service to Medical Research and the Community
  • Australian Society for Immunology (ASI) Post-doctoral International Travel Award
  • The University of Queensland Award for Outstanding Record of Research Performance and Publication; Comprising Certificate and Cash Prize
  • Queensland Institute of Medical Research (QIMR) International Travel Award
  • Queensland Institute of Medical Research (QIMR) International Postgraduate Travel Award
  • Australian Society for Immunology (ASI) Postgraduate International Travel Award
  • Health and Medical Research Council (NHMRC) Dora Lush Biomedical Postgraduate Scholarship
  • Australian Society for Immunology (ASI) Best Article Prize
  • Young Tall Poppy Science Award 2013 from the Australian Institute of Policy and Science.
  • Williams Morgan Thomas Bequest Award
  • British Society for Immunology (BSI) International Travel Award
  • Queensland Cancer Fund (QCF) International Travel Award
Fellowships
  • National Health and Medical Research Council (NHMRC) Biomedical Fellowship
  • National Health and Medical Research Council (NHMRC) Career Development Fellowship Level 2
  • National Health and Medical Research Council (NHMRC) Career Development Fellowship Level 1
  • Wales Office of Research and Development (WORD) Medical Research Fellowship
Memberships
  • 2017 - Organizing committee, The Australian Tropical Health Conference 2017
  • 2015 - Organizing committee, The Brisbane Immunology Group (BIG) Annual Conference 2015
  • 2015 - Organizing committee, 46th Australian Society for Immunology Annual meeting 2017
  • 2015 - Organizing committee, The 6th Australasian Vaccines & Immunotherapeutics Development Meeting 2016
  • 2005 - The Australian Society of Medical Research (ASMR)
  • 2003 - The Queensland Institute of Medical Research (QIMR) Information Technology Committee
  • 2002 - International Epstein-Barr Virus Association
  • 2002 - The Australian Society for Immunology (ASI)
  • 2008 to 2012 - The British Society of Immunology (BSI)
  • 2001 to 2004 - The Australian Society for Microbiology (ASM)
Publications

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles
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ResearchOnline@JCU stores 89+ research outputs authored by A/Prof John Miles from 2003 onwards.

Current Funding

Current and recent Research Funding to JCU is shown by funding source and project.

NHMRC - Career Development Fellowship

Understanding and modulating the human immune system. RD Wright Biomedical Career Development Fellowship Level 2

Indicative Funding
$476,728 over 4 years
Summary
T cells are central in the surveillance and clearance of infectious challenges and cancer. T cells are also engines behind autoimmunity and graft rejection. Understanding and controlling this powerful immune lineage has the potential to unlock new treatments across hundreds of human diseases. This research aims to draw on powerful new technologies including high-dimensional phenotyping and high throughput sequencing to analyse the T cell compartment in high detail. The overarching goals of the research are a better comprehension of the human T cell compartment and the generation of new tools that can control its form and function.
Investigators
John Miles (Australian Institute of Tropical Health & Medicine)
Keywords
T cells; Immune System; infectious disease; chronic conditions

NHMRC - Project Grant

Using Methods in Genetic Epidemiology to Elucidate the Relationship Between Viral Infection and Risk of Autoimmune Disease

Indicative Funding
$412,038 over 2 years (administered by University of Queensland)
Summary
The aim of this project is to investigate a possible causal link between six ubiquitous human viruses and the development of four autoimmune diseases. Should our results be consistent with a causal relationship, we expect that approaches aimed at controlling viral infection through vaccination, antiviral drugs or treatment with virus-specific T cell infusions may become effective treatments or preventative strategies against autoimmune diseases in the future.
Investigators
David Evans, John Miles, George Smith and Nicole Warrington (The University of Queensland, Australian Institute of Tropical Health & Medicine and University of Bristol)
Keywords
Virus; Autoimmune Disease

NHMRC - Project Grant

The bioactivity and binding partners of Irukandji and Box Jellyfish venom

Indicative Funding
$605,307 over 3 years
Summary
Venom from the Box Jellyfish and Irukandji jellyfish are considered the most lethal known to science yet precious little is known on the nature of these secretions or how they harm humans. This study aims to fully characterise bioactive proteins in jellyfish venom and attempt to block their activity using regulatory-approved and experimental drugs.
Investigators
John Miles, Jason Mulvenna and Irina Vetter (Australian Institute of Tropical Health & Medicine, Queensland Institute of Medical Research and The University of Queensland)
Keywords
Venom; Cytokine production; Inflammation

Paragen Bio Pty Ltd - Contract Research

Paragen Bio Research Contract

Indicative Funding
$698,763
Summary
The first tranche funds 6 months of a two-year development program to (1) generate a novel biologic for the treatment of inflammation, and (2) create a pipeline of related biologics with distinct MoAs and potentially for use in different indications. At the completion of the 2 year program we anticipate the lead biologic will be at a stage that is ready to commence a pilot clinical trial. The first tranche will specifically fund: 1. pre-clinical development of hookworm AIP proteins and peptides as the therapeutics for colitis 2. develop a pipeline of new hookworm-derived therapeutics for treating inflammation.
Investigators
Alex Loukas, John Miles, Paul Giacomin and Norelle Daly in collaboration with Darren Pickering, Roland Ruscher, Stephanie Ryan and Geraldine Buitrago (Australian Institute of Tropical Health & Medicine)
Keywords
Hookworm; Protein; Inflammatory Bowel Disease; Biotechnology; Autoimmunity; Anti-inflammatory

NHMRC - Project Grant

Defining the molecular and functional features of protective HIV-specific T cells

Indicative Funding
$60,000 (administered by Monash University)
Summary
Human immunodeficiency virus (HIV) directly attacks our immune system, impairing our natural defence against infection and disease. HIV has claimed over 39 million lives worldwide since its discovery, and no vaccine is currently available. Despite this, there are some individuals with a particular genetic advantage able to control HIV infection who never get sick. Understanding how these individuals are able to naturally control HIV may lead to novel treatments or potential vaccines against this disease.
Investigators
Stephanie Gras, David M Price and John Miles (Monash University, Cardiff University and Australian Institute of Tropical Health & Medicine)
Keywords
T Cell Immunity; T Cell Receptors; HIV

NHMRC - Project Grant

A new approach to the design and evaluation of T cell vaccines for cancer and infectious disease

Indicative Funding
$16,250 over 2 years (administered by University of Queensland)
Summary
There is irrefutable evidence that effective cytotoxic T lymphocytes (CTL) are essential for the eradication of cancers and many pathogens for which there are no effective vaccines. Dendritic cells (DC) are rare white blood cells that play a pivotal role in the induction of CTL. We will develop a novel strategy for inducing high quality human CTL by manipulating the key DC subtype responsible for initiating these responses. We originally characterised the human CD141+ DC subtype that are widely considered to be the most clinically relevant human DC subset for inducing CTL and are therefore prime targets for vaccine development. Antibodies (Ab) that engage cell surface receptors expressed on DC can be used as vehicles to carry antigenic cargo directly to DC in vivo. We discovered the novel C-type lectin like receptor, CLEC9A, that is specifically expressed by CD141+ DC. We propose that anti-CLEC9A Ab can be used to deliver antigen (Ag) directly to CD141+ DC in vivo and exploited as a new vaccine platform. We have already demonstrated proof of-concept of this approach in mouse models and now aim to translate this platform to humans.
Investigators
Kristin Radford, Mireille Lahoud, David M Price and John Miles (The University of Queensland, Monash University, Cardiff University and Australian Institute of Tropical Health & Medicine)
Keywords
Vaccine design; Cytotoxic T lymphocyte (CTL) evaluation; Immunotherapy

NHMRC - Project Grant

Following the T cell repertoire over the human life course

Indicative Funding
$61,537
Summary
T cells are critical to human health being our second and last line against infectious disease and cancer. However, we know very little about how this important immune compartment operates on a top-down scale. This project will use new technology to resolve this immune compartment to high detail. We will then use this new method to track the T cell compartment from early life and across years of adult life to see how this vital immune compartment evolves along the human life course.
Investigators
John Miles and Scott Burrows (Australian Institute of Tropical Health & Medicine and Queensland Institute of Medical Research)
Keywords
T Cell Immunity; T Cell Receptors; T Cell development
Supervision

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current
  • Deconstructing the Immunopathogenesis of Pathogenic Lung Infections (PhD , Primary Advisor/AM)
  • C. Fleckeri Mode of Action Investigation (Masters , Secondary Advisor)
  • First aid of tropical jellyfish stings (PhD , Advisor Mentor)
  • High-Throughput and High-Definition Breakdown of Human T Cell Repertoires in Health and Disease (PhD , Primary Advisor/AM)
Collaboration

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.

  • 5+ collaborations
  • 4 collaborations
  • 3 collaborations
  • 2 collaborations
  • 1 collaboration
  • Indicates the Tropics (Torrid Zone)

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Email
Phone
Location
  • E5.109, AITHM Cairns (Cairns campus)
Advisory Accreditation
Advisor Mentor

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