Prof John Miles ~ Professorial Research Fellow, Molecular Immunology
Australian Institute of Tropical Health & Medicine
- About
-
- Experience
-
- 2016 to present - Consultant, QIMR Berghofer Medical Research Institute (Herston, Australia)
- 2016 to present - Principal Research Fellow & NHMRC Career Development Fellow, Molecular Immunology, Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine (James Cook University, Australia)
- 2008 to present - Research Officer, Cellular Immunology Laboratory, The Queensland Institute of Medical Research (QIMR) (Herston, Australia)
- 2012 to 2016 - Group Leader & NHMRC Career Development Fellow, QIMR Berghofer Medical Research Institute (Herston, Australia)
- 2010 to 2011 - WORD Senior Research Fellow, T Cell Modulation Laboratory, School of Medicine, Department of Infection and Immunity (Cardiff University, Cardiff, United Kingdom)
- 2008 to 2010 - Research Fellow, T Cell Modulation Laboratory, School of Medicine, Department of Infection and Immunity (Cardiff University, Cardiff, United Kingdom)
- 2004 to 2008 - Doctor of Philosophy in Immunology, The University of Queensland (Brisbane, Australia)
- 2002 to 2004 - Research Assistant, Cellular Immunology Laboratory, The Queensland Institute of Medical Research (QIMR) (Herston, Australia)
- 2001 to 2002 - Consultant, The Queensland Department of Primary Industries (DPI); Tick Fever Research Center (TFRC) & Animal Research Institute (ARI) (Brisbane, Australia)
- 2001 - Bachelor of Science (Honours), Microbiology Major, The University of Queensland (Brisbane, Australia)
- 1998 to 2000 - Bachelor of Science, Microbiology and Physiology Majors, The University of Queensland (Brisbane, Australia)
- Research Disciplines
- Socio-Economic Objectives
Associate Professor John Miles was awarded BSc Hons in 2001 and a PhD in 2008 from the University of Queensland. His work involves understanding basic immune processes which determine the host’s response to infectious disease and chronic conditions.
He has been awarded a NHMRC Dora Lush Biomedical Postgraduate Scholarship, a NHMRC Overseas Biomedical Fellowship, Welcome Trust VIP Award, WORD Medical Research Fellowship and NHMRC Career Development Fellowships Level 1 and Level 2 (2017-2020). Other awards include the Young Tall Poppy Science Award from the Australian Institute of Policy and Science and Centenary Medal from the Australian Government and her Majesty Queen Elizabeth for Distinguished Service to Medical Research and the Community. John spent 2008-2012 researching immunomonitoring and immune engineering technologies at Cardiff University and was promoted Head of the Human Immunity Laboratory at the QIMR Berghofer Medical Research Institute from 2012-2016. In 2016, John joined the Australian Institute of Tropical Health and Medicine is currently a Principal Research Fellow in Molecular Immunology at the Centre for Biodiscovery and Molecular Development of Therapeutics and the Centre for Biosecurity and Tropical Infectious Diseases. His research has been funded by 12 national and international schemes including Perpetual, NHMRC and ARC.
- Honours
-
- Awards
-
- Centenary Medal from the Australian Government and her Majesty Queen Elizabeth II for Distinguished Service to Medical Research and the Community
- Wellcome Trust VIP Award, ranked 1st in category
- National Health and Medical Research Council (NHMRC) Traveling Award for Research Training
- Australian Society for Immunology (ASI) Post-doctoral International Travel Award
- The University of Queensland Award for Outstanding Record of Research Performance and Publication; Comprising Certificate and Cash Prize
- Queensland Institute of Medical Research (QIMR) International Travel Award
- Young Tall Poppy Science Award 2013 from the Australian Institute of Policy and Science.
- Australian Society for Immunology (ASI) Postgraduate International Travel Award
- Health and Medical Research Council (NHMRC) Dora Lush Biomedical Postgraduate Scholarship
- Australian Society for Immunology (ASI) Best Article Prize
- Williams Morgan Thomas Bequest Award
- British Society for Immunology (BSI) International Travel Award
- Queensland Cancer Fund (QCF) International Travel Award
- Queensland Institute of Medical Research (QIMR) International Postgraduate Travel Award
- Fellowships
-
- Wales Office of Research and Development (WORD) Medical Research Fellowship
- National Health and Medical Research Council (NHMRC) Career Development Fellowship Level 1
- National Health and Medical Research Council (NHMRC) Career Development Fellowship Level 2
- National Health and Medical Research Council (NHMRC) Biomedical Fellowship
- Memberships
-
- 2017 - Organizing committee, The Australian Tropical Health Conference 2017
- 2015 - Organizing committee, The Brisbane Immunology Group (BIG) Annual Conference 2015
- 2015 - Organizing committee, 46th Australian Society for Immunology Annual meeting 2017
- 2015 - Organizing committee, The 6th Australasian Vaccines & Immunotherapeutics Development Meeting 2016
- 2005 - The Australian Society of Medical Research (ASMR)
- 2003 - The Queensland Institute of Medical Research (QIMR) Information Technology Committee
- 2002 - The Australian Society for Immunology (ASI)
- 2002 - International Epstein-Barr Virus Association
- 2008 to 2012 - The British Society of Immunology (BSI)
- 2001 to 2004 - The Australian Society for Microbiology (ASM)
- Publications
-
These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.
- Journal Articles
-
- Wong Y, Meehan M, Burrows S, Doolan D and Miles J (2022) Estimating the global burden of Epstein–Barr virus?related cancers. Journal of Cancer Research and Clinical Oncology, 148. pp. 31-46
- Haigh O, Grant E, Nguyen T, Kedzierska K, Field M and Miles J (2021) Genetic bias, diversity indices, physiochemical properties and CDR3 motifs divide auto-reactive from allo-reactive T-Cell repertoires. International Journal of Molecular Sciences, 22 (4).
- Hewavisenti R, Ferguson A, Gasparini G, Ohashi T, Braun A, Watkins T, Miles J, Elliott M, Sierro F, Feng C, Britton W, Gebhardt T, Tangye S and Palendira U (2021) Tissue-resident regulatory T cells accumulate at human barrier lymphoid organs. Immunology & Cell Biology, 99 (8). pp. 894-906
- Moral-Sanz J, Fernandez-Rojo M, Potriquet J, Mukhopadhyay P, Brust A, Wilhelm P, Smallwood T, Clark R, Fry B, Alewood P, Waddell N, Miles J, Mulvenna J and Ikonomopoulou M (2021) ERK and mTORC1 Inhibitors Enhance the Anti-Cancer Capacity of the Octpep-1 Venom-Derived Peptide in Melanoma BRAF(V600E) Mutations. Toxins, 13 (2).
- Ryan R, Fernandez A, Wong Y, Miles J and Cock I (2021) The medicinal plant Tabebuia impetiginosa potently reduces pro-inflammatory cytokine responses in primary human lymphocytes. Scientific Reports, 11 (1).
- Saggiomo S, Firth C, Wilson D, Seymour J, Miles J and Wong Y (2021) The geographic distribution, venom components, pathology and treatments of stonefish (Synanceia spp.) venom. Marine Drugs, 19 (6).
- Smallwood T, Navarro S, Cristofori-Armstrong B, Watkins T, Tungatt K, Ryan R, Haigh O, Lutzky V, Mulvenna J, Rosengren K, Loukas A, Miles J and Clark R (2021) Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo. Journal of Biological Chemistry, 297 (1).
- Watkins T and Miles J (2021) The human T-cell receptor repertoire in health and disease and potential for omics integration. Immunology and Cell Biology, 99 (2). pp. 135-145
- Weerakoon H, Straube J, Lineburg K, Cooper L, Lane S, Smith C, Alabbas S, Begun J, Miles J, Hill M and Lepletier A (2021) Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity. Clinical and Translational Immunology, 10 (9).
- Pearson F, Tullett K, Leal-Rojas I, Haigh O, Masterman K, Walpole C, Bridgeman J, McLaren J, Ladell K, Miners K, Llewellyn-Lacey S, Price D, Tunger A, Schmitz M, Miles J, Lahoud M and Radford K (2020) Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1?specific CD8+ T cells. Clinical and Translational Immunology, 9 (6).
- Piontek M, Seymour J, Wong Y, Gilstrom T, Potriquet J, Jennings E, Nimmo A and Miles J (2020) The pathology of Chironex fleckeri venom and known biological mechanisms. Toxicon, 6.
- Ratnatunga C, Lutzky V, Kupz A, Doolan D, Reid D, Field M, Bell S, Thomson R and Miles J (2020) The rise of non-tuberculosis mycobacterial lung disease. Frontiers in Immunology, 11.
- More
-
ResearchOnline@JCU stores 119+ research outputs authored by Prof John Miles from 2003 onwards.
- Current Funding
-
Current and recent Research Funding to JCU is shown by funding source and project.
Tropical Australian Academic Health Centre Limited - Contract Research
Can portable genome sequencing provide a rapid, comprehensive, point-of-care diagnostic test for Far North Queensland hospitals and healthcare centres?
- Indicative Funding
- $49,987 over 2 years
- Summary
- Respiratory disease, fevers, and sepsis are common in FNQ and treatment often requires admission to hospital. These infections have many different causes, and diagnosing them requires multiple tests that take weeks to perform. Consequently, patients are treated with broad-spectrum antibiotics before a pathogen is identified, leading to poorer outcomes for the patient and contributing to the spread of antibiotic-resistant infections. We will trial new genome sequencing technology as a point-of-care diagnostic test for fever, sepsis, and pneumonia at Cairns Hospital, and test the hypothesis that this approach will increase the proportion of infections that are diagnosed and reduce the time-to-diagnosis.
- Investigators
- John McBride, Cadhla Firth, Simon Smith, Joshua Hanson, Matt Field, Emma McBryde, John Miles, Damon Eisen and Chris Heather (College of Medicine & Dentistry, Australian Institute of Tropical Health & Medicine and Queensland Health)
- Keywords
- Genomics; Healthcare; pathogens
National Health & Medical Research Council - Development Grant
Hookworm peptide therapeutic for oral treatment of IBD
- Indicative Funding
- $732,700 over 2 years
- Summary
- We intend to develop an orally delivered peptide that can modulate the immune system and be developed as a therapeutic for inflammatory bowel disease. We have identified a peptide, derived from a hookworm protein, that alleviates the clinical symptoms of experimental colitis when orally administered to mice. The peptide has bioactivity with human cells ex vivo and displays desirable drug-like properties. The aim of this project is to acquire further data on the mechanism of action and formulation conditions to facilitate formal product development prior to licensing and clinical trials.
- Investigators
- Alex Loukas, Norelle Daly, Paul Giacomin, John Miles, Roland Ruscher, Keith Dredge, Istvan Toth, Mariusz Skwarczynski, Matthew Moyle, Ashley Waardenberg, John Croese, Matt Field and Tony Rahman (Australian Institute of Tropical Health & Medicine, The University of Queensland and The Prince Charles Hospital)
- Keywords
- Inflammatory Bowel Disease; Peptide; therapeutic; Hookworm; Oral delivery
Australian Research Council - Linkage - Infrastructure (L-IEF)
An integrated, multi-model bio-layer interferometry facility
- Indicative Funding
- $945,000 over 1 year (administered by University of Queensland)
- Summary
- Biomolecular interaction research in Australia is currently constrained by low-throughput, labour intensive techniques that impede research progress and often forces it overseas. This project aims to develop a world class, integrated, multi-node bio-layer interferometry facility. This project expects to generate new knowledge in diverse areas of research ranging from biodiscovery to agricultural vaccine technology. Using biolayer interferometry, the leading-edge biomolecular interaction technique will provide significant benefits by developing high-significant assay techniques, thus enabling diverse streams of national benefit research and propelling Australia to the forefront of biomolecular interaction research.
- Investigators
- Brian Fry, Godwin Ayoko, Brett Collins, Scott Cummins, Norelle Daly, Denise Doolan, Luke Guddat, Emad Kiriakous, Alex Loukas, Stephen Mahler, John Miles, Bernd Rehm, Tomer Ventura, Irina Vetter and Wang Tianfang (The University of Queensland, Queensland University of Technology, University of the Sunshine Coast, Australian Institute of Tropical Health & Medicine and Griffith University)
- Keywords
- Protein Interactions; interferometry; Therapeutics
National Health & Medical Research Council - Career Development Fellowship
Understanding and modulating the human immune system. RD Wright Biomedical Career Development Fellowship Level 2
- Indicative Funding
- $476,728 over 4 years
- Summary
- T cells are central in the surveillance and clearance of infectious challenges and cancer. T cells are also engines behind autoimmunity and graft rejection. Understanding and controlling this powerful immune lineage has the potential to unlock new treatments across hundreds of human diseases. This research aims to draw on powerful new technologies including high-dimensional phenotyping and high throughput sequencing to analyse the T cell compartment in high detail. The overarching goals of the research are a better comprehension of the human T cell compartment and the generation of new tools that can control its form and function.
- Investigators
- John Miles (Australian Institute of Tropical Health & Medicine)
- Keywords
- T cells; Immune System; infectious disease; chronic conditions
National Health & Medical Research Council - Project Grant
Using Methods in Genetic Epidemiology to Elucidate the Relationship Between Viral Infection and Risk of Autoimmune Disease
- Indicative Funding
- $412,038 over 3 years (administered by University of Queensland)
- Summary
- The aim of this project is to investigate a possible causal link between six ubiquitous human viruses and the development of four autoimmune diseases. Should our results be consistent with a causal relationship, we expect that approaches aimed at controlling viral infection through vaccination, antiviral drugs or treatment with virus-specific T cell infusions may become effective treatments or preventative strategies against autoimmune diseases in the future.
- Investigators
- David Evans, John Miles, George Smith and Nicole Warrington (The University of Queensland, Australian Institute of Tropical Health & Medicine and University of Bristol)
- Keywords
- Virus; Autoimmune Disease
National Health & Medical Research Council - Project Grant
The bioactivity and binding partners of Irukandji and Box Jellyfish venom
- Indicative Funding
- $605,307 over 3 years
- Summary
- Venom from the Box Jellyfish and Irukandji jellyfish are considered the most lethal known to science yet precious little is known on the nature of these secretions or how they harm humans. This study aims to fully characterise bioactive proteins in jellyfish venom and attempt to block their activity using regulatory-approved and experimental drugs.
- Investigators
- John Miles, Jason Mulvenna and Irina Vetter (Australian Institute of Tropical Health & Medicine, QIMR Berghofer and The University of Queensland)
- Keywords
- Venom; Cytokine production; Inflammation
- Supervision
-
These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.
- Completed
-
- Deconstructing the immunopathogenesis of lung infections (2019, PhD , Primary Advisor/AM/Adv)
- High-throughput and high-definition analysis of human T cell repertoires in health and disease (2020, PhD , Primary Advisor/AM/Adv)
- Collaboration
-
The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.- 5+ collaborations
- 4 collaborations
- 3 collaborations
- 2 collaborations
- 1 collaboration
- Indicates the Tropics (Torrid Zone)
Connect with me
- Phone
- Location
-
- E5.109, AITHM Cairns (Cairns campus)
- Find me on…
-
My research areas
Similar to me
-
Dr Roland RuscherAustralian Institute of Tropical Health & Medicine
-
Prof Denise DoolanAustralian Institute of Tropical Health & Medicine
-
A/Prof Catherine RushCollege of Public Health, Medical & Vet Sciences
-
Dr Hillary VandervenCollege of Public Health, Medical & Vet Sciences
-
Prof Andreas LopataCollege of Public Health, Medical & Vet Sciences