About

Professor Jonathan Golledge is Head of the Queensland Research Centre for Peripheral Vascular Disease and its pre-clinical arm The Vascular Biology Unit (VBU) at the School of Medicine and Dentistry, James Cook University. Professor Golledge joined JCU in 2002 and established the Vascular Biology Unit with the aim of carrying out research intended to be translated into improved management of aortic aneurysm and other peripheral vascular conditions. We continue to seek high quality students and researchers to join our group. Trained as a vascular specialist, Professor Golledge took 2 years out of specialist training to obtain experience in research techniques as part of a Cambridge MChir (Doctoral equivalent), UK. His research commitment is illustrated by a large number of presentations at International and National meetings and publications in peer-reviewed journals, including a large number in top specialised journals.

Professor Golledge holds a conjoint position between the School of Medicine and Dentistry and Queensland Health, where he works as a vascular surgeon. In addition to providing a high quality clinical service his principal aspiration is to improve management of peripheral vascular diseases. The research impact of this is evidenced by external grant support from the NIH, NHMRC, Queensland Government, NHF and other bodies. Of note in 2010 Professor Golledge led a successful bid to establish a NHMRC funded centre of research excellence for Peripheral Vascular Disease.

Research Disciplines
Socio-Economic Objectives
Honours
Fellowships
  • 2002 - Fellow of the Royal Australasian College of Surgeons
  • 1994 - Fellow of the Royal College of Surgeons of England
Memberships
  • 2012 - Editorial board member, Arteriosclerosis, Thrombosis and Vascular Biology
  • 2009 - Member of The Australian and International Stroke Genetics Collaboration
  • 2009 - Member of The Research Committee of the Faculty Medicine, Health and Molecular Sciences
  • 2007 - Member of the Board of Surgical Research of the Royal Australasian College of Surgeons
  • 2002 - Member of the Australian Vascular Biology Society
  • 2002 - Member of the School of Medicine Research Committee, James Cook University
  • 1996 - Member of the European Society of Vascular Surgery
  • 2002 to 2009 - Member of the ethics committee, The Mater Hospital, Townsville
  • 2003 to 2004 - Member of the Biological Sciences selection panel for internal grants, James Cook University
  • 1996 to 2001 - Member of the Vascular Surgical Society of Great Britain and Ireland
Other
  • 2012 - Editorial board Arteriosclerosis, Thrombosis and Vascular Biology
  • 2011 - Credentialling Committee The Townsville Hospital
  • 2007 - Editorial board member Atherosclerosis
  • 2003 - Reviewer The Lancet, Circulation, Arteriosclerosis, Thrombosis and Vascular Biology, Atherosclerosis, Journal of Vascular Surgery, European Journal of Vascular and Endovascular Surgery, American Journal of Cardiology, American Journal of Pathology
  • 2003 - External reviewer for numerous granting bodies including the National Health and Medical Research Council, National Heart Foundation and other international funding bodies such as the Welcome Trust
  • 2002 - Chairman of the Austalian and New Zealand Society of Vascular Surgery Research Group
  • 2000 - Reviewer Stroke
  • 1997 - Reviewer The Journal of Vascular Surgery and the European Journal of Vascular and Endovascular Surgery
  • 2003 to 2009 - Language Editor European Journal of Vascular and Endovascular Surgery
  • 2002 to 2007 - Chairman of the BMedSci Committee, James Cook University
Publications

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles
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ResearchOnline@JCU stores a total of 233 research outputs authored by Prof Jon Golledge from 2003 onwards.

Current Funding

Current and recent Research Funding is shown by funding source and project.

NHMRC - Project Grant

Assessment of the Efficacy of a Brief Behaviour Intervention Designed to Improve Physical Activithy in Patients with Peripheral Artery Disease

Indicative Funding
$662,912 over 5 years
Summary
The primary aim of the current study is to assess the efficacy of a Brief Behavioural Intervention (BBI) delivered by allied health workers in health facilities to improve physical activity in patients with PAD over 24 months. Secondary aims of this study are to examine the effect of the BBI on participants functional capacity, revascularisation rate, resource use, and to perform an economic evaluation of the BBI compared to usual care.
Investigators
Jon Golledge, Nicola Burton, Phil Walker, Paul Norman, Anthony Leicht and Zanfina Ademi, with the help of Richard Holdsworth, Ronan O'Carroll, Belinda Parmenter and Christopher Reid (College of Medicine & Dentistry, The University of Queensland, The University of Western Australia, College of Healthcare Sciences, The University of Melbourne, Forth Valley Royal Hospital, University of Stirling, The University of New South Wales and Monash University)
Keywords
Peripheral Arterial Disease; Physical Activity; Intermittent Claudication; Behavioural Medicine

NHMRC - Project Grant

Upregulating kallistatin to limit abdominal aortic aneurysm

Indicative Funding
$648,021 over 3 years
Summary
Abdominal aortic aneurysms are present in ~100,000 Australians and easily identified at an early stage. Currently there is no effective treatment for small aneurysms since early surgical therapies do not improve outcomes and there are currently no effective drugs which inhibit aortic aneurysm progression. Patients with small aneurysms are simply managed by repeat imaging at intervals but up to 70% of small aneurysms later expand to a size requiring surgery. Repeat imaging and surgery of abdominal aortic aneurysm are estimated to cost Australia ~$80 million/ year. We present preliminary data suggesting that the protein kallistatin can inhibit aneurysm progression and that it can be upregulated by the drug fenofibrate. The aim of the current study are to assess if mice overexpressing kallistatin are protected from abdominal aortic aneurysm and if administration of 145mg of fenofibrate can increase serum kallistatin in patients with small abdominal aortic aneurysms. We will assess these hypotheses in mice models and within a randomized controlled trial of patients that have small abdominal aortic aneurysms. We have established appropriate mice models, reproducible outcome assessments methods and identified patients to examine these aims. This study represents vital next steps in the assessment of a potential new medical therapy target for abdominal aortic aneurysm.
Investigators
Jon Golledge and Phillip Walker, with the help of Bernard Bourke, Christopher Reid and Jiang-Xing Ma (College of Medicine & Dentistry, The University of Queensland, Gosford Hospital, Monash University and Oklahoma State University - Stillwater)
Keywords
Peripheral Arterial Disease; Aortic Aneurysm

NHMRC - Project Grant

The Role of Angiotensin converting enzyme in limiting complications of aortic aneurysm

Indicative Funding
$663,475 over 3 years
Summary
Bursting or tearing of the main artery leading from the heart kills approximately 1300 Australians each year. In this study we will assess the role of a novel pathway in artery weakening. Improved understanding of he mechanisms causing artery degeneration is crucial to develop better ways to treat this common problem.
Investigators
Jon Golledge, Christos Tikellis and Phillip Walker, with the help of Paul Norman, Merlin Thomas and Carla Ewels (College of Medicine & Dentistry, Baker IDI Heart & Diabetes Institute, The University of Queensland, The University of Western Australia, College of Public Health and Medical & Vet Sciences)
Keywords
Peripheral Arterial Disease; Aortic Aneurysm

NHMRC - Project Grant

Interaction between parathyroid hormone, sclerostin and the wingless pathway in abdominal aortic aneurysm

Indicative Funding
$698,300 over 5 years
Summary
Approximately 5% of men and 1% of women aged over 60 years develop weakening of the main abdominal artery. Currently the management of artery weakening is focused on surgery with no effective medications available. In this study we will assess the role of a novel pathway in artery weakening. Improved understanding of the mechanisms causing artery degeneration is crucial to target the development of better ways to treat this common problem.
Investigators
Jonathan Golledge, Paul Norman, Catherine Rush, Phillip Walker, Craig Jeffrey, Reinhold Muller, Anthony Dear, Timothy Buckenham and Gabby Loots (College of Medicine & Dentistry, The University of Western Australia, College of Public Health, Medical & Vet Sciences, The University of Queensland, Monash University, Christchurch Hospital and Lawrence Livermore National Laboratory)
Keywords
Abdominal aortic aneurysm; Pathogenesis; Therapy; Patient management; Peripheral vascular disease; Cardiovascular Diseases

NHMRC - Project Grant

Telmisartan in the management of abDominal aortic aneurYsm (TEDY)

Indicative Funding
$1,105,894 over 5 years
Summary
Approximately 5% of men and 1% of women aged over 60 years develop weakening of the main abdominal artery. Currently the management of artery weakening is focused on surgery with no effective medications available. In this trial we will examine the value of a promising drug therapy. If proved effective this medication could reduce the requirement for surgery by controlling artery weakening at an early stage in its development.
Investigators
Jonathan Golledge, Paul Norman, Phillip Walker, Anna Ahimastos, Ronald Dalman, Robert Fitridge, Andrew Tonkin, Christopher Reid, Reinhold Muller, Frank Quigley, Graeme Hankey, Bernard Bourke, Anthony Dear and Bronwyn Kingwell (College of Medicine & Dentistry, The University of Western Australia, The University of Queensland, Baker IDI Heart & Diabetes Institute, Stanford University, University of Adelaide, Monash University, College of Public Health, Medical & Vet Sciences and Gosford Hospital)
Keywords
Abdominal aortic aneurysm; Pathogenesis; thrapy; Patient management; Peripheral vascular disease; Cardiovascular Diseases

NHMRC - Practitioner Fellowship

Mechanisms, biomarkers and new therapies for abdominal aortic aneurysm

Indicative Funding
$523,726 over 5 years
Summary
Approximately 100,000 Australians and 5 million people worldwide have abdominal aortic aneurysms (AAAs). Management is currently focused on imaging based diagnosis and prognosis, and surgical methods of treatment. This approach has a number of limitations including limited ability to diagnose AAAs early and accurately predict progression, and no effective means to treat small AAAs. There is also no way to reduce the progression of AAA to a stage when surgery is required.This fellowship will directly address current management deficiencies for AAA. The specific aims are: 1. To improve understanding of AAA pathogenesis and associated complications in order to identify strategies for medical management of AAA; 2. To identify novel diagnostic and prognostic markers for AAA and assess their value in rationalising current management; 3. To assess the safety and efficacy of novel therapies for AAA within carefully designed clinical trials. UtiliSing data from significant preliminary studies, validated pre-clinical models, patient cohorts, established project funding and collaborative networks, it is envisaged work during this fellowship will substantially advance management of AAA.
Investigators
Jonathan Golledge (College of Medicine & Dentistry)
Keywords
Abdominal aortic aneurysm; Pathogenesis; Therapy; Patient management; Peripheral Arterial Disease; Cardiovascular Diseases

Townsville Hospital and Health Service - Research Grant

Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME)-2

Indicative Funding
$100,000
Summary
The current project is a randomised study to assess if fenofibrate can limit key pathological mechanisms in abdominal aortic aneurysm in patients with small aneurysms.
Investigators
Jon Golledge (College of Medicine & Dentistry)
Keywords
Abdominal Aortic Aneurysm; Fenofibrate

NHMRC - Equipment Grant

NHMRC Equipment Grant 2014

Indicative Funding
$26,094
Summary
This equipment purchased will be used to assess pre-clinical models used in a number of NHMRC projects (1079369; 1079193; 1021416) and work contributing to a centre of research excellence (1000967). The equipment will: (1) allow assessments not currently possible at JCU (2) can be used on a rnage of projects (3) was not available in Australia and therefore has to be imported.
Investigators
Jon Golledge (College of Medicine & Dentistry)
Keywords
Abdominal Aortic Aneurysm; Peripheral Arterial Disease

Townsville Health Service District - Private Practice Study, Research & Education Trust Fund

The effects of exercise therapy on biomarkers of abdominal aortic aneurysm presence and outcome.

Indicative Funding
$107,960 over 3 years
Summary
The aim of this project is to assess the effect of a supervised exercise regimen on circulating markers of AAA and cardiovascular risk. This project offers the opportunity of identifying a novel effective therapy for a common and potentially devastating condition.
Investigators
Jonathan Golledge and Anthony Leicht, with the help of Elise Pappas (College of Medicine & Dentistry and College of Healthcare Sciences)
Keywords
Abdominal aortic aneurysm; Biomarkers; supervised exercise

Queensland Health - Senior Clinical Research Fellowships

Peripheral Arterial Disease

Indicative Funding
$4,250,000 over 5 years
Summary
Developing novel therapies ad management pathways for Peripheral Arterial Disease. Aim 1. to assess the safety and efficacy of novel medications for PAD within carefully designed clinical trials and registries; Aim 2. to utilise clinical risk factors and novel biomarkers to develop models to better predict outcomes for PAD: Aim 3. To develop appropriate guidelines for the evidence-based management of PAD in Australia and assess novel ways to implement them within Queensland.
Investigators
Jonathan Golledge, with the help of Paul Norman, Timothy Buckenham, Robert Fitridge, Bernard Bourke, Mark Nelson, Reinhold Muller, Anthony Leicht, Frances Quirk, Paula Clancy, Erik Biros, Corey Moran, Lesley Stainkey, Phillip Walker, Craig McLachlan, Yew Toh Wong and Melina Wilson (College of Medicine & Dentistry, The University of Western Australia, Christchurch Hospital, Queen Elizabeth Hospital, Gosford Hospital, Menzies School of Health Research, College of Public Health, Medical & Vet Sciences, College of Healthcare Sciences, Townsville - Mackay Medicare Local, The University of Queensland, University of Technology, Sydney, Southmead Hospital, Bristol and St George's Hospital Medical School)
Keywords
Peripheral Arterial Disease

NHMRC - Project Grant

The role of the clotting cascade in aortic aneurysm and associated cardiovascular events

Indicative Funding
$619,911 over 5 years
Summary
Weakening of the main abdominal artery is responsible for approximately 100 deaths/ year in Australia. Most weakened arteries are identified at an early stage but there is no current therapy which limits the progression of artery weakening. There is also no model which predicts the complications associated with weakened arteries. In the current project we proposed the importance of clot in progression and complications of weakened arteries. We will undertake studies to identify new therapies and a predictive model for weakened arteries.
Investigators
Jonathan Golledge, Catherine Rush, Phillip Walker, Robert Fitridge, Reinhold Muller, Corey Moran and Paula Clancy, with the help of Robert Andrews, Lajos Gera, Benjamin Herbert, Katherine High, Paul Norman, Thomas Renne and Douglas Tollefsen (College of Medicine & Dentistry, College of Public Health, Medical & Vet Sciences, The University of Queensland, QEII Jubilee Hospital, Monash University, University of Colorado - Boulder, Macquarie University, Academy of National Sciences of Philadelphia, The University of Western Australia, Karolinska Institute and Washington University in St. Louis)
Keywords
Cardiovascular Diseases; Thrombosis; Abdominal aortic aneurysm; Biological Markers; Thrombin

Bellberry Limited - Donation

Examining aPathway Which Protects the Aorta from Weakening

Indicative Funding
$80,000
Summary
Bursting or tearing of the main artery leading from the heart kills approximately 1300 Australians each year. In this study we will assess the role of a novel pathway in artery weakening. Improved understanding of the mechanisms causing artery degeneration is crucial to develop better ways to treat this common problem.
Investigators
Jon Golledge (College of Medicine & Dentistry)
Keywords
Perpheral Vascular Disease; Abdominal Aortic Aneurysm; Angiotensin; Aortic Aneurysm; angiotensin-converting enzyme; Surgery
Supervision

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current
  • The Role of Vitamin D in Abdominal Aortic Aneurysm Development and Progression. (PhD, Primary Advisor)
  • The Role of Angiotensin Convertine Enzyme 2 (ACE2) in a Novel Mouse Model of Critical Lower Limb Ischemia. (PhD, Primary Advisor)
  • Plantar Pressure and Gait Characteristics of Type II diabetic/Plantar Ulcer/Non Ulcer Patients and Correlations of Ulceration to Histopathological and Haematological Findings (PhD, Primary Advisor)
  • Small Animal Model of Intracranial Cerebral Aneurysms. (Masters, Co-Advisor)
  • The Association and Predictive Value of Circulating Leucocytes with Cardovascular Outcomes in Peripheral Arterial Occlusive Disease (Masters, Primary Advisor)
  • Laparoscopic Techniques Improve Management of Rectal Adenocarcinoma. (PhD, Co-Advisor)
  • Effect of Angiopoietin-2 on Abdominal Aortic Aneurysm Development in a Mouse Model (PhD, Primary Advisor)
Completed
Data

These are the most recent metadata records associated with this researcher. To see a detailed description of all dataset records, visit the JCU Research Data Catalogue.

Collaboration

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.

  • 5+ collaborations
  • 4 collaborations
  • 3 collaborations
  • 2 collaborations
  • 1 collaboration
  • Indicates the Tropics (Torrid Zone)

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Email
Phone
Location
  • Townsville
Advisory Accreditation
Level 1
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