About

Professor Jonathan Golledge is Head of the Queensland Research Centre for Peripheral Vascular Disease and its pre-clinical arm The Vascular Biology Unit (VBU) at the School of Medicine and Dentistry, James Cook University. Professor Golledge joined JCU in 2002 and established the Vascular Biology Unit with the aim of carrying out research intended to be translated into improved management of aortic aneurysm and other peripheral vascular conditions. We continue to seek high quality students and researchers to join our group. Trained as a vascular specialist, Professor Golledge took 2 years out of specialist training to obtain experience in research techniques as part of a Cambridge MChir (Doctoral equivalent), UK. His research commitment is illustrated by a large number of presentations at International and National meetings and publications in peer-reviewed journals, including a large number in top specialised journals.

Professor Golledge holds a conjoint position between the School of Medicine and Dentistry and Queensland Health, where he works as a vascular surgeon. In addition to providing a high quality clinical service his principal aspiration is to improve management of peripheral vascular diseases. The research impact of this is evidenced by external grant support from the NIH, NHMRC, Queensland Government, NHF and other bodies. Of note in 2010 Professor Golledge led a successful bid to establish a NHMRC funded centre of research excellence for Peripheral Vascular Disease.

Research Disciplines
Socio-Economic Objectives
Honours
Fellowships
  • 2002 - Fellow of the Royal Australasian College of Surgeons
  • 1994 - Fellow of the Royal College of Surgeons of England
Memberships
  • 2012 - Editorial board member, Arteriosclerosis, Thrombosis and Vascular Biology
  • 2009 - Member of The Australian and International Stroke Genetics Collaboration
  • 2009 - Member of The Research Committee of the Faculty Medicine, Health and Molecular Sciences
  • 2007 - Member of the Board of Surgical Research of the Royal Australasian College of Surgeons
  • 2002 - Member of the Australian Vascular Biology Society
  • 2002 - Member of the School of Medicine Research Committee, James Cook University
  • 1996 - Member of the European Society of Vascular Surgery
  • 2002 to 2009 - Member of the ethics committee, The Mater Hospital, Townsville
  • 2003 to 2004 - Member of the Biological Sciences selection panel for internal grants, James Cook University
  • 1996 to 2001 - Member of the Vascular Surgical Society of Great Britain and Ireland
Other
  • 2012 - Editorial board Arteriosclerosis, Thrombosis and Vascular Biology
  • 2011 - Credentialling Committee The Townsville Hospital
  • 2007 - Editorial board member Atherosclerosis
  • 2003 - Reviewer The Lancet, Circulation, Arteriosclerosis, Thrombosis and Vascular Biology, Atherosclerosis, Journal of Vascular Surgery, European Journal of Vascular and Endovascular Surgery, American Journal of Cardiology, American Journal of Pathology
  • 2003 - External reviewer for numerous granting bodies including the National Health and Medical Research Council, National Heart Foundation and other international funding bodies such as the Welcome Trust
  • 2002 - Chairman of the Austalian and New Zealand Society of Vascular Surgery Research Group
  • 2000 - Reviewer Stroke
  • 1997 - Reviewer The Journal of Vascular Surgery and the European Journal of Vascular and Endovascular Surgery
  • 2003 to 2009 - Language Editor European Journal of Vascular and Endovascular Surgery
  • 2002 to 2007 - Chairman of the BMedSci Committee, James Cook University
Publications

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles
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ResearchOnline@JCU stores 495+ research outputs authored by Prof Jon Golledge from 2003 onwards.

Current Funding

Current and recent Research Funding to JCU is shown by funding source and project.

CRC for Developing Northern Australia - Grant

Tele-DFD: Remotely providing effective healthcare for diabetic foot disease

Indicative Funding
$840,000 over 4 years, in partnership with the Townsville Hospital and Health Service ($120,000)
Summary
Current models of care for diabetes-associated foot disease (DFD) management are not sustainable due to the recurring nature of this condition and lead to enormous social and economic burden (~$24 million / year). Models of healthcare that are financially viable and effective at meeting the challenges of the dispersed population of Northern Australia are urgently needed to reduce the rates of DFD-related amputations, and costs associated with preventable hospital admissions and ongoing treatment. This project will test whether a telehealth model of care (Tele-DFD) is more effective at achieving secondary prevention than the current usual face to face consultation model. If effective this model offers the potential of improved health outcomes and substantially reducing geographic disparity and social and economic burden from DFD.
Investigators
Jon Golledge in collaboration with Rebecca Evans and Joseph Moxon (College of Medicine & Dentistry)
Keywords
Prevention; Complications; Diabetes; Peripheral artery disease; Risk Factors

Commonwealth Department of Health - Medical Research Future Fund - Cardiovascular Health Mission

Improving clinical pathways for abdominal aortic aneurysm through incorporating biomarkers

Indicative Funding
$1,000,000 over 3 years
Summary
20 million people worldwide have weakening of their main abdominal artery (abdominal aortic aneurysm; AAA) and are at high risk of both major adverse cardiovascular events (MACE) and AAA related events (AAA repair and rupture-related death). Most AAAs are identified at a small size when their risk of rupture is low. Management of small AAA focuses on repeat aortic imaging every 6 months to identify when the threshold diameter (50mm in women and 55mm in men) is reached for elective surgical AAA repair. Most small AAAs continue to grow in size and eventually undergo repair. No drugs have been shown to limit AAA growth and the clinical pathway focuses on identifying those needing surgery rather than medical management. There are no established means to individualise care. Our interviews with patients and health professionals indicate that the number one deficiency in current AAA management is the lack of individualising medical management to reduce the high incidence of MACE and AAA related events. Our international AAA alliance is uniquely placed due to our resources (biobank-registry) and IP (bioinformatics, clinical, engineering software, genomics, biomarkers, machine learning and pathogenesis) to addresses this unmet clinical need.
Investigators
Jon Golledge, Clare Arnott, Thomas Gasser, Rebecca Evans, Joseph Moxon, Matt Field, Jenna Pinchbeck, Aaron Drovandi, Dylan Morris, Svetha Venkatesh, Truyen Tran, Catherine Rush, Aletta Schutte, Robyn Clay-Williams and Geoffrey Jones (College of Medicine & Dentistry, The George Institute for Global Health, KTH Royal Institute of Technology, College of Public Health, Medical & Vet Sciences, Townsville Hospital and Health Services, Deakin University, The University of New South Wales, Macquarie University and University of Otago)
Keywords
Prevention; Complications; Peripheral artery disease; Risk Factors

Commonwealth Department of Health - Medical Research Future Fund - Dementia, Ageing and Aged Care

METformin for treating peripheral artery disease Related walking Impairment Trial (MERIT)

Indicative Funding
$1,215,182 over 3 years
Summary
Peripheral artery disease (PAD) is a very common chronic cardiovascular disease of ageing affecting approximately 1 million older Australians and causing substantial leg pain on walking (intermittent claudication), marked functional impairment, reduced quality of life (QOL) and very high risk of major adverse cardiovascular and limb events. Vulnerable populations (e.g. regional or remote, lower income and Aboriginal and Torres Strait Islander populations) have much greater PAD-related burden. Our past consultations with patients indicate that improvements in walking is their number one priority. The only widely available PAD treatment in Australia is revascularisation but this does not improve walking distance and has substantial safety concerns. Multiple lines of evidence suggest that metformin safely improves leg blood supply. MERIT is a placebo-controlled randomised trial performed across 7 sites. The importance of the trial has been endorsed by patients, Heart Foundation, Queensland Health and Australian and New Zealand Society for Vascular Surgery and Alliance for Cardiovascular Trials. If positive, MERIT will identify a cheap, safe and widely available drug to improve the function and QOL of millions of older adults worldwide who have PAD.
Investigators
Jon Golledge, Clare Arnott, Edward Strivens, Belinda Parmenter, Clare Heal, Christopher Reid, Aaron Drovandi, Joseph Moxon, Jenna Pinchbeck, Richard Norman, Dylan Morris, Christopher Askew, Sarah Larkins, Rachel Quigley and Yvonne Cadet-James (College of Medicine & Dentistry, The George Institute for Global Health, The University of New South Wales, Curtin University of Technology, Townsville Hospital and Health Services, University of the Sunshine Coast and Indigenous Education & Research Centre)
Keywords
Prevention; Complications; Peripheral artery disease; Risk Factors

Heart Foundation - Vanguard Grant

Testing a 5' adenosine monophosphate-activated protein kinase inhibitor in models of the two main clinical presentations of peripheral artery disease.

Indicative Funding
$150,000 over 2 years
Summary
250 million people worldwide (>1 million Australians) have legartery blockage (peripheral artery disease; PAD). Thecommonest clinical presentations of PAD are: a) leg pain on walking which limits daily function and reduces quality of life; b) ischemic ulceration which is associated with a high risk of major amputation. The only widely available PAD treatment in Australia is surgery to improve leg blood supply (revascularisation) but this has limited effectiveness and safety concerns. There are currently no drug therapies for these clinical presentations of PAD. A major limitation with past efforts to develop PAD drugs has been the absence of clinically-relevant animal models. We have developed mouse models representative of the two main clinical presentations of PAD. Based on the findings of our extensive preliminary research, this project tests a promising drug therapy (SBI-0206965) in these models. This study has real potential to discover a clinically valuable drug and will further validate valuable laboratory models.
Investigators
Jon Golledge and Norelle Daly (College of Medicine & Dentistry and Australian Institute of Tropical Health & Medicine)
Keywords
Peripheral artery disease; Complications; Prevention; Risk Factors; amputation

Townsville Hospital and Health Service - SERTA Research Capacity Grant

Improving outcomes for people with peripheral artery diseases

Indicative Funding
$140,000 over 2 years
Summary
Peripheral artery disease (PAD) is a collection of occlusive and aneurysmal vascular diseases associated with high risks of major adverse cardiovascular (myocardial infarction, stroke, cardiovascular death; MACE) and limb (revascularisation surgery or amputation) events [1,2]. >1 million Australians and 30,000 North Queenslanders have PAD which causes ~20,000 hospital admissions at a cost of ~$1 billion/year [1-3]. PAD disproportionally affects regional and Aboriginal and Torres Strait Islander populations [4,5]. PAD treatment focuses on surgery but this is associated with complications and alone is not effective at reducing the long-term risk of adverse events nor improving quality of life (QOL) [1,2]. This program develops new PAD management options and builds research capacity.
Investigators
Jon Golledge (College of Medicine & Dentistry)
Keywords
Prevention; Complications; Peripheral artery disease; Risk Factors

Tropical Australian Academic Health Centre Limited - Research Seed Grants

Metformin for treating peripheral artery disease-related walking impairment (MERIT)

Indicative Funding
$50,000 over 2 years
Summary
Blockage of the leg arteries (peripheral artery disease; PAD) leads to severe pain, walking impairment and a substantial risk of leg amputation and death. Over 20,000 North Queenslanders have PAD which is overrepresented in regional, remote and rural populations. There are currently no effective PAD medications. Multiple lines of evidence suggest that metformin, a cheap and safe medication, promotes formation of new vessels, improves microcirculation and muscle function and limits PAD-related pain. This placebo-controlled, randomised clinical trial, run by a North Queensland vascular research collaboration, will examine the efficacy of metformin in improving walking ability of PAD patients.
Investigators
Jon Golledge, Alkira Venn and Joseph Moxon (College of Medicine & Dentistry)
Keywords
Prevention; Complications; Preipheral artery disease; Risk Factors

Townsville Hospital and Health Service - Study Education Research Trust Account (SERTA)

Metformin for treating peripheral artery disease-related walking impairment (MERIT)

Indicative Funding
$50,000 over 3 years
Summary
lBockage of the leg arteries (peripheral artery disease; PAD) leads to severe pain, walking impairment, and a substantial risk of leg amputation and death. Over 20,000 North Queenslanders have blocked leg arteries and the problem is over-represented in rural, remote and Aboriginal and Torres Strait Islander People. There are currently no effective PAD medications. Multiple lines of evidence suggest that metformin, a cheap and safe medication, promotes formation of new vessels, improves microcirculation and muscle function and limits pain. This placebo-controlled, randomised clinical trial will examine the efficacy of metformin in improving walking ability in patients with blocked leg arteries.
Investigators
Jon Golledge (College of Medicine & Dentistry)
Keywords
Prevention; Complications; Peripheral Arterial Disease; Risk Factors

Heart Foundation - Secondary Prevention Strategic Grant

Peripheral Arterial Disease- a holistic medical management program

Indicative Funding
$1,000,000 over 3 years
Summary
Approximately 200 million people worldwide and 1 million Australians have blockage of their lower limb arteries. Leg artery blockage causes substantial leg pain, walking impairment and reduced health-related quality of life and leads to a high risk of heart attack, stroke, hospital admission, amputation and death. Prior clinical trials have demonstrated that a range of secondary prevention treatments including medications and exercise therapy can substantially improve quality of life and physical performance and reduce the risk of adverse events. Our previous research shows that these treatments are not effectively implemented in Australians that have leg artery blockage. Based on a systematic review of the available evidence and our prior research, we have developed the PAD-medical program. This program consists of personalised treatments sessions delivered via telehealth to monitor control of key risk factors, optimise prescribed medications, supervise an exercise program and provide behaviour support counselling aimed to educate and aid achieving exercise goals and support smoking abstinence. This controlled, randomised clinical trialwill examine the efficacy of PAD-medical in improving control of the key risk factor for adverse events, quality of life and physical performance in people with blocked leg arteries over six months. The trial will also include a health economic assessment. Positive findings fromthis trial will identify a new treatment for a problem that affects 10% of adults. If shown to be effective, an application will be made to the Medical Services Advisory Committee to seek national funding for the program. PAD-medical can be potentially implemented across Australia to any locality withWiFi access, in order to substantially reduce the frequency of adverse events and improve quality of life of the large number of people who have blocked leg arteries.
Investigators
Jon Golledge in collaboration with Belinda Parmenter, Bruce Neale, Clare Arnott, Toby Richards, Gemma Figtree, Richard Norman, Robyn Gallagher, Christopher Askew and Gian Luca Di Tanna (College of Medicine & Dentistry, The University of New South Wales, The University of Western Australia, University of Sydney, Curtin University of Technology and University of the Sunshine Coast)
Keywords
Peripheral artery disease; Complications; Prevention; Risk factors

National Health & Medical Research Council - Clinical Trials and Cohort Studies

The Metformin Aneurisym Trial (MAT)

Indicative Funding
$4,997,653 over 5 years
Summary
20 million people worldwide and 100,000 Australians have an abdominal aortic aneurysm (AAA). The main complication of AAA, aortic rupture, leads to 200,000 deaths/year worldwide. AAA prevalence and mortality rates in Australasia are 4-fold higher than the world average, so research to improve management is a key priorty. Most AAAs are detected when theya re small, when an effective treatment would prevent the need for surgery. There is currently no effective drug therapy for AA, and 70% of small AAAs grow to a size requiring surgical repair which carries inherent risks of death and major complications. A large amount of observational data from patients and laboratory models suggest that metformin may be an effective drug therapy for AAA. The metformin aneurysm trial (MAT) will be a large-scale, multi-centre randomised trail done as a collaboration between investigators in Australia, New Zealand, Swden and the United Kingdom across 55 sites over a 5 year trial period. Patients with AAA measuring between 39 and 49mmm in diameter will be enrolled over 24 months, assiged at random to 1500mn of metformin extended release (XR) or placebo each day followed for a mean of 3.5 years. The primary outcome will be AAA rupture or repair. The sample size of 1,954 will provide 90% pwer (p=0.05) to detect a 25% or greater reduction in the relative risk of the primary outcome. A positive finding from MAT would identify metformin as the first effective medical treatment for AAA. Since metformin is low cost, safe and available worldwide, the trial will have direct clinical implications for tens of millions of people around the world for whom no preventative therapy is currently available.
Investigators
Jon Golledge, Bruce Neal, Qiang Li, Gregory Jones, Matthew Bown, Anders Wanhainen, Richard Norman, Helen Monaghan, Dylan Morris and Joseph Moxon (College of Medicine & Dentistry, The George Institute for International Health, University of Otago, University of Leicester, University of Uppsala, Curtin University of Technology and Townsville Hospital and Health Services)
Keywords
Clinical Trial; Abdominal Aortic Aneurysm; Metformin

Diabetes Australia - General Grant

Assessing a novel drug therapy for ischaemic ulceration

Indicative Funding
$70,000 over 1 year
Summary
Ischemic foot disease is the main cause of diabetes-related leg amputation. This project uses a unique rodent model to investigate a novel drug therapy for ischemic ulceration. The main aim is to assess if administration of a 5' adenosine monophosphate-activated protein kinase (AMPK) inhibitor will promote ischemic foot ulceration healing in a mouse model. The study will also examine if ulcer healing is greater with peri-ulcer compared to systemic administration of the AMPK inhibitor.
Investigators
Jon Golledge (College of Medicine & Dentistry)
Keywords
Prevention; Complications; Diabetes; Risk Factors

Queensland Health - Senior Clinical Research Fellowships

Peripheral Arterial Disease

Indicative Funding
$4,250,000 over 12 years
Summary
Developing novel therapies ad management pathways for Peripheral Arterial Disease. Aim 1. to assess the safety and efficacy of novel medications for PAD within carefully designed clinical trials and registries; Aim 2. to utilise clinical risk factors and novel biomarkers to develop models to better predict outcomes for PAD: Aim 3. To develop appropriate guidelines for the evidence-based management of PAD in Australia and assess novel ways to implement them within Queensland.
Investigators
Jonathan Golledge in collaboration with Paul Norman, Timothy Buckenham, Robert Fitridge, Bernard Bourke, Mark Nelson, Reinhold Muller, Anthony Leicht, Frances Quirk, Paula Clancy, Erik Biros, Corey Moran, Lesley Stainkey, Phillip Walker, Craig McLachlan, Yew Toh Wong and Melina Wilson (College of Medicine & Dentistry, The University of Western Australia, Christchurch Hospital, Queen Elizabeth Hospital, Gosford Hospital, Menzies School of Health Research, College of Public Health, Medical & Vet Sciences, College of Healthcare Sciences, Townsville - Mackay Medicare Local, The University of Queensland, University of Technology, Sydney, Southmead Hospital, Bristol and St George's Hospital Medical School)
Keywords
Peripheral Arterial Disease

Tropical Australian Academic Health Centre Limited - Research Seed Grants

(COMFITE) Efficacy, acceptability and adherence with custom-made footwear in people with a history of diabetes-related foot disease.

Indicative Funding
$50,000 over 2 years
Summary
Approximately 8% (n=80,000) of Northern Australians have diabetes of whom about a quarter (n=20,000) will develop foot disease putting them at risk of amputation and death and costing ~$24 million each year. The most common cause of diabetes-related foot complications is excessive pressure on an area of an insensate foot. Footwear designed to limit pressure on the feet has been shown to reduce the risk of foot ulcers. The most appropriate type of footwear is however unknown. This pilot clinical trial examines the efficacy and acceptability of footwear designed to the shape of an individuals? feet using three-dimensional printing.
Investigators
Jon Golledge and Joseph Moxon (College of Medicine & Dentistry)
Keywords
Diabetes Foot Disease; Diabetes; Aboriginal And Torres Strait Health; Podiatry
Supervision

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current
  • Developing a Risk Score to predict the Risk of Major Adverse Cardiovascular events in Patients with Abdominal Aortic Aneurysm (Masters , Primary Advisor)
  • Burden of diabetes-related foot disease in North Queensland, Australia (PhD , Primary Advisor/AM/Adv)
  • Assessment and Intervention of Dietary Patterns in Patients with Peripheral Arterial Disease and Abdominal Aortic Aneurysm (PhD , Primary Advisor/AM/Adv)
  • Development and Implementation of Plasma Polymer Thin Films for Enhanced Biocompatibility in Medical Implants (PhD , Secondary Advisor)
  • IDENTIFICATION OF MEDIATORS IMPORTANT IN DETERMINING CAROTID PLAQUE INSTABILITY (PhD , Secondary Advisor)
Completed
Data

These are the most recent metadata records associated with this researcher. To see a detailed description of all dataset records, visit Research Data Australia.

Collaboration

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.

  • 5+ collaborations
  • 4 collaborations
  • 3 collaborations
  • 2 collaborations
  • 1 collaboration
  • Indicates the Tropics (Torrid Zone)

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