Prof Jon Golledge ~ Distinguished Professor
College of Medicine & Dentistry
- About
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- Research Disciplines
- Socio-Economic Objectives
Professor Jonathan Golledge is Head of the Queensland Research Centre for Peripheral Vascular Disease and its pre-clinical arm The Vascular Biology Unit (VBU) at the School of Medicine and Dentistry, James Cook University. Professor Golledge joined JCU in 2002 and established the Vascular Biology Unit with the aim of carrying out research intended to be translated into improved management of aortic aneurysm and other peripheral vascular conditions. We continue to seek high quality students and researchers to join our group. Trained as a vascular specialist, Professor Golledge took 2 years out of specialist training to obtain experience in research techniques as part of a Cambridge MChir (Doctoral equivalent), UK. His research commitment is illustrated by a large number of presentations at International and National meetings and publications in peer-reviewed journals, including a large number in top specialised journals.
Professor Golledge holds a conjoint position between the School of Medicine and Dentistry and Queensland Health, where he works as a vascular surgeon. In addition to providing a high quality clinical service his principal aspiration is to improve management of peripheral vascular diseases. The research impact of this is evidenced by external grant support from the NIH, NHMRC, Queensland Government, NHF and other bodies. Of note in 2010 Professor Golledge led a successful bid to establish a NHMRC funded centre of research excellence for Peripheral Vascular Disease.
- Honours
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- Fellowships
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- 2002 - Fellow of the Royal Australasian College of Surgeons
- 1994 - Fellow of the Royal College of Surgeons of England
- Memberships
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- 2012 - Editorial board member, Arteriosclerosis, Thrombosis and Vascular Biology
- 2009 - Member of The Australian and International Stroke Genetics Collaboration
- 2009 - Member of The Research Committee of the Faculty Medicine, Health and Molecular Sciences
- 2007 - Member of the Board of Surgical Research of the Royal Australasian College of Surgeons
- 2002 - Member of the Australian Vascular Biology Society
- 2002 - Member of the School of Medicine Research Committee, James Cook University
- 1996 - Member of the European Society of Vascular Surgery
- 2002 to 2009 - Member of the ethics committee, The Mater Hospital, Townsville
- 2003 to 2004 - Member of the Biological Sciences selection panel for internal grants, James Cook University
- 1996 to 2001 - Member of the Vascular Surgical Society of Great Britain and Ireland
- Other
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- 2012 - Editorial board Arteriosclerosis, Thrombosis and Vascular Biology
- 2011 - Credentialling Committee The Townsville Hospital
- 2007 - Editorial board member Atherosclerosis
- 2003 - Reviewer The Lancet, Circulation, Arteriosclerosis, Thrombosis and Vascular Biology, Atherosclerosis, Journal of Vascular Surgery, European Journal of Vascular and Endovascular Surgery, American Journal of Cardiology, American Journal of Pathology
- 2003 - External reviewer for numerous granting bodies including the National Health and Medical Research Council, National Heart Foundation and other international funding bodies such as the Welcome Trust
- 2002 - Chairman of the Austalian and New Zealand Society of Vascular Surgery Research Group
- 2000 - Reviewer Stroke
- 1997 - Reviewer The Journal of Vascular Surgery and the European Journal of Vascular and Endovascular Surgery
- 2003 to 2009 - Language Editor European Journal of Vascular and Endovascular Surgery
- 2002 to 2007 - Chairman of the BMedSci Committee, James Cook University
- Publications
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These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.
- Journal Articles
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- Chasland L, Knuiman M, Divitini M, Murray K, Handelsman D, Flicker L, Hankey G, Almeida O, Golledge J, Ridgers N, Naylor L, Green D and Yeap B (2019) Higher circulating androgens and higher physical activity levels are associated with less central adiposity and lower risk of cardiovascular death in older men. Clinical Endocrinology, 90 (2). pp. 375-383
- Almeida O, Ford A, Hankey G, Yeap B, Golledge J and Flicker L (2018) Risk of dementia associated with psychotic disorders in later life: the health in men study (HIMS). Psychological Medicine, 49 (2). pp. 232-242
- Almeida O, Hankey G, Yeap B, Golledge J and Flicker L (2018) Older men with bipolar disorder diagnosed in early and later life: physical health morbidity and general hospital service use. Journal of Affective Disorders, 241. pp. 269-274
- Bailey T, Perissiou M, Windsor M, Schulze K, Nam M, Magee R, Leicht A, Green D, Greaves K, Golledge J and Askew C (2018) Effects of acute exercise on endothelial function in abdominal aortic aneurysm patients. American Journal of Physiology-Heart and Circulatory Physiology, 314 (1). pp. H19-H30
- Chan Y, Alfonso H, Chubb S, Ho K, Fegan P, Hankey G, Golledge J, Flicker L and Yeap B (2018) Higher IGFBP3 is associated with increased incidence of colorectal cancer in older men independently of IGF1. Clinical Endocrinology, 88 (2). pp. 333-340
- Dewdney B, Trollope A, Moxon J, Thomas Manapurathe D, Biros E and Golledge J (2018) Circulating microRNAs as biomarkers for acute ischemic stroke: a systematic review Journal of Stroke and Cerebrovascular Diseases. Journal of stroke and cerebrovascular diseases, 27 (3). pp. 522-530
- Dunster-Jones M, Steicke M, Mackie J, Guthrie R, Nguyen Dinh T, Ahmady F, Golledge J and Wang Y (2018) The concentration of ethanol affects its penetration rate in bovine cardiac and hepatic tissues. Folia Histochemica et Cytobiologica, 56 (2). pp. 92-97
- Ford A, Yeap B, Flicker L, Hankey G, Chubb S, Golledge J and Almeida O (2018) Sex hormones and incident dementia in older men: the health in men study. Psychoneuroendocrinology, 98. pp. 139-147
- Ford A, Hankey G, Yeap B, Golledge J, Flicker L and Almeida O (2018) Hearing loss and the risk of dementia in later life. Maturitas, 112. pp. 1-11
- Golledge J, Hankey G, Almeida O, Flicker L, Norman P and Yeap B (2018) Plasma free thyroxine in the upper quartile is associated with an increased incidence of major cardiovascular events in older men that do not have thyroid dysfunction according to conventional criteria. International Journal of Cardiology, 254. pp. 316-321
- Krishna S, Moxon J, Jose R, Sahebkar A, Hatamipour M, Liu D and Golledge J (2018) Anionic nanoliposomes reduced atherosclerosis progression in Low Density Lipoprotein Receptor (LDLR) deficient mice fed a high fat diet. Journal of Cellular Physiology, 233 (10). pp. 6951-6964
- Meneses A, Nam M, Bailey T, Magee R, Golledge J, Hellsten Y, Keske M, Greaves K and Askew C (2018) Leg blood flow and skeletal muscle microvascular perfusion responses to submaximal exercise in peripheral arterial disease. American Journal of Physiology-Heart and Circulatory Physiology, 315 (5). pp. H1425-H1433
- More
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ResearchOnline@JCU stores 350+ research outputs authored by Prof Jon Golledge from 2003 onwards.
- Current Funding
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Current and recent Research Funding to JCU is shown by funding source and project.
Queensland Health - Senior Clinical Research Fellowships
Peripheral Arterial Disease
- Indicative Funding
- $4,250,000 over 8 years
- Summary
- Developing novel therapies ad management pathways for Peripheral Arterial Disease. Aim 1. to assess the safety and efficacy of novel medications for PAD within carefully designed clinical trials and registries; Aim 2. to utilise clinical risk factors and novel biomarkers to develop models to better predict outcomes for PAD: Aim 3. To develop appropriate guidelines for the evidence-based management of PAD in Australia and assess novel ways to implement them within Queensland.
- Investigators
- Jonathan Golledge in collaboration with Paul Norman, Timothy Buckenham, Robert Fitridge, Bernard Bourke, Mark Nelson, Reinhold Muller, Anthony Leicht, Frances Quirk, Paula Clancy, Erik Biros, Corey Moran, Lesley Stainkey, Phillip Walker, Craig McLachlan, Yew Toh Wong and Melina Wilson (College of Medicine & Dentistry, The University of Western Australia, Christchurch Hospital, Queen Elizabeth Hospital, Gosford Hospital, Menzies School of Health Research, College of Public Health, Medical & Vet Sciences, College of Healthcare Sciences, Townsville - Mackay Medicare Local, The University of Queensland, University of Technology, Sydney, Southmead Hospital, Bristol and St George's Hospital Medical School)
- Keywords
- Peripheral Arterial Disease
National Health & Medical Research Council - Practitioner Fellowship
Developing improved management for peripheral artery diseases
- Indicative Funding
- $569,219 over 5 years
- Summary
- This fellowship aims to address current deficiencies in the care of PAD patients by: Aim 1: Testing new PAD treatments in patient-relevant pre-clinical models; Aim 2: Examining the efficacy of new treatments in human clinical trials; Aim 3: Discovering novel targets for diagnostic tests, prognostic markers and treatments.
- Investigators
- Jon Golledge (College of Medicine & Dentistry)
- Keywords
- Peripheral Arterial Disease; Aortic Aneurysm
Townsville Hospital and Health Service - Study Education Research Trust Account (SERTA)
Peak Wall Stress as a prognostic indicator of abdominal Aortic Aneurysm rupture risk
- Indicative Funding
- $50,000 over 2 years
- Summary
- Abdominal Aortic Aneurysm (AAA) affects 20 million people worldwide and 100,000 people in Australia. Annually, AAA rupture leads to 200,000 deaths worldwide and 2000 deaths in Australia. In clinical practice, maximum AAA diameter is the preferred surrogate measure for disease progression and rupture risk, and is used to guide surgical intervention. Approximately 10% of AAAs will rupture before they reach the current threshold for repair, whereas 60% of large AAAs remain stable during their lifetime, suggesting that diameter alone is an imperfect tool to decide which AAAs require surgical intervention. The specific aims of the project are Aim 1: To investigate if PWS is greater in patients with ruptured compared to intact AAAs matched for diameter; Aim 2: To evaluate the impact of a common anti-hypertensive medication {Telmisartan) on PWS and rupture risk in patients with small AAAs.
- Investigators
- Tejas Singh, Jon Golledge and Joseph Moxon in collaboration with Thomas Gasser (College of Medicine & Dentistry and Royal Institute of Technology)
- Keywords
- Metformin; Abdominal Aortic Aneurysm; Ruptures
Townsville Hospital and Health Service - Study Education Research Trust Account (SERTA)
Assessment of the efficacy of a novel treatment for Peripheral Artery Disease (PAD)
- Indicative Funding
- $50,000 over 2 years
- Summary
- Blockage of leg arteries (peripheral artery disease - PAD) leads to severe exertional leg pain (intermittent claudication), impaired walking ability, reduced health-related quality of life, and high risk of amputation and death. Multiple lines of evidence suggest that metformin, a cheap and safe medication, promotes formation of new vessels, improves microcirculation and muscle function,s and limits pain.
- Investigators
- Jon Golledge, Joseph Moxon, Tejas Singh, Rachel Wong, Kunwargit Sangla and Veronica White (College of Medicine & Dentistry and Townsville Hospital and Health Services)
- Keywords
- Metformin; peripheral artery disease; Intermittent Claudication
Royal Australasian College of Surgeons RACS - James Ramsay Project Grant
Metformin in the management of abdominal aortic aneurysm (MAGIC)
- Indicative Funding
- $78,000 over 2 years
- Summary
- MAGIC will be the first trial to assess the value of metformin wiuth significant preliminary data to suggest it can slow AAA growth. This trial offers the possibility of identifying a new treatment modality for an increasingly common condition, which would markedly change clinical practice.
- Investigators
- Jon Golledge, Dylan Morris, Paul Norman, Joseph Moxon, Zanfina Ademi, Rachel Neale, Anders Wanhainen, Ronald Dalman, Robert Hinchliffe and Matthew Bown in collaboration with Anthony Dear, Bernard Bourke, Christopher Reid, Jason Jenkins, Derek Chew, Rachael Jones, Richard Norman and Stephen Colagiuri (College of Medicine & Dentistry, University of Oxford, The University of Western Australia, Monash University, Queensland Institute of Medical Research, University of Uppsala, Stanford University, University of Bristol, University of Leicester, Gosford Hospital, The University of Queensland, Flinders University, Curtin University of Technology and The University of Sydney)
- Keywords
- Aortic Aneurysm; Clinical Trials; Surgery
Vascular Foundation - Project Grant
Metformin in the management of abdominal aortic aneurysm (MAGIC)
- Indicative Funding
- $50,000
- Summary
- MAGIC will be the first trial to assess the value of metformin with significant preliminary data to suggest it can slow AAA growth. The trial offers the possibility of identifying a new treatment modality for an increasingly common condition, which would markedly change clinical practice.
- Investigators
- Jon Golledge and Paul Norman (College of Medicine & Dentistry and The University of Western Australia)
- Keywords
- Aortic Aneurysm; clinical trials; Surgery
Queensland Health - Junior Research Fellowship
Coding and non-coding circulating RNAs associated with the presence and rapid expansion of abdominal aortic aneurysms
- Indicative Funding
- $250,000 over 2 years
- Summary
- Deoxyribonucleic Acid, or DNA is the molecule that comprises genes. The mix of genes you have may mean you are likely to have, or be more prone to develop, particular conditions. The way the information encoded by DNA is converted into outcomes (such as a medical condition) is via the action of Ribonucleic Acid, or RNA. This project aims to identify RNAs in blood associated with the presence or rapid growth of abdominal aortic aneurysms - potentially lethal balloonings of the largest artery in the abdomen, the abdominal aorta. This may yield new methods of diagnosing and treating aneurysms.
- Investigators
- Vikram Iyer and Jon Golledge (College of Medicine & Dentistry)
- Keywords
- Abdominal Aortic Aneurysm; RNAs
National Health & Medical Research Council - Project Grant
Blocking the factor XII-kallikrein pathway to limit abdominal aortic aneurysm
- Indicative Funding
- $686,995 over 3 years
- Summary
- Abdominal aortic aneurysm (AAA) is estimated to be responsible for 2000 sudden deaths each year in Australia. AAAs can be readily identified when they are small but there are currently no effective medical therapies to limit complications in patients that have such AAAs. We hypothesise that interventions inhibiting the FXII-kallikrein pathway will limit progression of established AAAs within pre-clinical models and have other important secondary benefits such as the reduction of atherosclerosis progression.
- Investigators
- Jon Golledge and Corey Moran in collaboration with Daniel Sexton, Rhondda Jones, Paul Norman and Kosta Panousis (College of Medicine & Dentistry, Dyax Corporation, Division of Tropical Health & Medicine, The University of Western Australia and CSL)
- Keywords
- Abdominal Aortic Aneurysm; mouse models; Peripheral Vascular Disease; Biology; treatment planning
National Health & Medical Research Council - Project Grant
Upregulating kallistatin to limit abdominal aortic aneurysm
- Indicative Funding
- $648,021 over 3 years
- Summary
- Abdominal aortic aneurysms are present in ~100,000 Australians and easily identified at an early stage. Currently there is no effective treatment for small aneurysms since early surgical therapies do not improve outcomes and there are currently no effective drugs which inhibit aortic aneurysm progression. Patients with small aneurysms are simply managed by repeat imaging at intervals but up to 70% of small aneurysms later expand to a size requiring surgery. Repeat imaging and surgery of abdominal aortic aneurysm are estimated to cost Australia ~$80 million/ year. We present preliminary data suggesting that the protein kallistatin can inhibit aneurysm progression and that it can be upregulated by the drug fenofibrate. The aim of the current study are to assess if mice overexpressing kallistatin are protected from abdominal aortic aneurysm and if administration of 145mg of fenofibrate can increase serum kallistatin in patients with small abdominal aortic aneurysms. We will assess these hypotheses in mice models and within a randomized controlled trial of patients that have small abdominal aortic aneurysms. We have established appropriate mice models, reproducible outcome assessments methods and identified patients to examine these aims. This study represents vital next steps in the assessment of a potential new medical therapy target for abdominal aortic aneurysm.
- Investigators
- Jon Golledge in collaboration with Bernard Bourke, Christopher Reid, Jiang-Xing Ma and Jason Jenkins (College of Medicine & Dentistry, Gosford Hospital, Monash University, Oklahoma State University - Stillwater and Royal Brisbane & Women's Hospital)
- Keywords
- Peripheral Arterial Disease; Aortic Aneurysm
National Health & Medical Research Council - Project Grant
Assessment of the Efficacy of a Brief Behaviour Intervention Designed to Improve Physical Activity in Patients with Peripheral Artery Disease
- Indicative Funding
- $662,912 over 5 years
- Summary
- The primary aim of the current study is to assess the efficacy of a Brief Behavioural Intervention (BBI) delivered by allied health workers in health facilities to improve physical activity in patients with PAD over 24 months. Secondary aims of this study are to examine the effect of the BBI on participants functional capacity, revascularisation rate, resource use, and to perform an economic evaluation of the BBI compared to usual care.
- Investigators
- Jon Golledge, Nicola Burton, Paul Norman, Anthony Leicht and Zanfina Ademi in collaboration with Richard Holdsworth, Ronan O'Carroll, Belinda Parmenter, Christopher Reid and Jason Jenkins (College of Medicine & Dentistry, The University of Queensland, The University of Western Australia, College of Healthcare Sciences, The University of Melbourne, Forth Valley Royal Hospital, University of Stirling, The University of New South Wales, Monash University and Royal Brisbane & Women's Hospital)
- Keywords
- Peripheral Arterial Disease; Physical Activity; Intermittent Claudication; Behavioural Medicine
National Health & Medical Research Council - Project Grant
The Role of Angiotensin converting enzyme in limiting complications of aortic aneurysm
- Indicative Funding
- $663,475 over 3 years
- Summary
- Bursting or tearing of the main artery leading from the heart kills approximately 1300 Australians each year. In this study we will assess the role of a novel pathway in artery weakening. Improved understanding of he mechanisms causing artery degeneration is crucial to develop better ways to treat this common problem.
- Investigators
- Jon Golledge and Christos Tikellis in collaboration with Carla Ewels, Merlin Thomas, Paul Norman and Jason Jenkins (College of Medicine & Dentistry, Baker Heart & Diabetes Institute, College of Public Health, Medical & Vet Sciences, The University of Western Australia and Royal Brisbane & Women's Hospital)
- Keywords
- Peripheral Arterial Disease; Aortic Aneurysm
Heart Foundation - Vanguard Grant
Association of Vitamin D insufficiency with presence, growth and biomarkers of abdominal aortic aneurysm
- Indicative Funding
- $75,000
- Summary
- In this study we examine if vitamin D insufficiency is associated with aortic aneurysm presence and growth and investigate likely mechanisms by which this may occur.
- Investigators
- Jon Golledge, Paul Norman, Rachel Neale and Michael Clarke (College of Medicine & Dentistry, The University of Western Australia and Queensland Institute of Medical Research)
- Keywords
- Abdominal Aortic Aneurysm; Vitamin D; Cardiovascular
- Supervision
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Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.
These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.
- Current
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- Identification of Mediators Important in Determining Carotid Plaque Instability (PhD , Secondary Advisor)
- Individualized Laparoscopic and Related Technique in Rectal Cancer Surgery (PhD , Secondary Advisor)
- A Small Animal Model for the Creation of Intracranial Aneurysms (Masters , Secondary Advisor)
- Measuring Person-Centred Healthcare (PhD , Advisor Mentor)
- Designing a home based Exercise Program for Patients who are affected with Peripheral Arterial Disease (PhD , Primary Advisor/AM)
- Assessment and Intervention of Dietary Patterns in Patients with Peripheral Arterial Disease and Abdominal Aortic Aneurysm (PhD , Primary Advisor/AM)
- Peak Wall Stress as a Prognostic Indicator of Abdominal Aortic Aneurysm Rupture Risk (PhD , Primary Advisor/AM)
- The effects of aspects of the Mediterranean diet on Peripheral Artery Disease in mice (PhD , Primary Advisor/AM)
- A new mouse model of lower limb ischaemia: development, validation and assessment of therapeutic targets and interventions (PhD , Primary Advisor/AM)
- The Role of Vitamin D in the Pathogenesis and Progression of Abdominal Aortic Aneurysm. (PhD , Primary Advisor/AM)
- Completed
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- The role of angiopoietin-2 in experimental abdominal aortic aneurysm development (2015, PhD , Primary Advisor)
- The role of kinin receptors in abdominal aortic aneurysm (2015, PhD , Primary Advisor)
- Regulation of transforming growth factor beta (TGFβ) at the level of nuclear entry (2016, PhD , Secondary Advisor)
- The gait features & plantar pressures of people with diabetic peripheral neuropathy & plantar foot ulcers (2017, PhD , Primary Advisor)
- Behavioural and neurobiological changes mediated by TNF-α signalling in the CNS (2014, PhD , Secondary Advisor)
- Data
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These are the most recent metadata records associated with this researcher. To see a detailed description of all dataset records, visit the JCU Research Data Catalogue.
- Fernando, M. (2017) Plantar pressures are elevated in people with longstanding diabetes-related foot ulcers during follow-up . James Cook University
- Fernando, M. (2016) Plantar pressures are higher in cases with diabetic foot ulcers compared to controls despite a longer stance phase duration. James Cook University
- Moxon, J. (2012) Data for: Comparison of the serum lipidome in patients with abdominal aortic aneurysm and peripheral artery disease. James Cook University
- Collaboration
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The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.- 5+ collaborations
- 4 collaborations
- 3 collaborations
- 2 collaborations
- 1 collaboration
- Indicates the Tropics (Torrid Zone)
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Dr Joseph MoxonCollege of Medicine & Dentistry