JCU > Research Portfolio > Dr Joseph Moxon

About

Biog:

I received my PhD from the University of Wales Aberystwyth (UK) in 2008 after completing a research program which utilised proteomics and bioinformatics to identify molecular markers for parasite infection. After graduation I joined the JCU Vascular Biology Unit as a junior post-doctoral scientist, to conduct proteomic and bioinformatic research in peripheral artery disease (PAD). In 2011, I was appointed to the position of Senior Scientist within the Vascular Biology Unit leading a team of scientists who conduct a range of clinical and pre-clinical investigations to improve our understanding of PAD. In 2017, I was promoted to my current academic C position within the College of Medicine and Dentistry, and also work closely with the newly established Australian Institute of Tropical Health and Medicine.

Research:

My research focuses on PAD, predominatly complications arising from lower limb atherosclerosis and abdominal aortic aneurysm. Upon joining JCU, I was surprised to learn how common PAD is within the general population. Approximately one-quarter of the adult population will develop PAD, and this significantly increases the risk of suffering major cardiovascular events (such as heart attack and stroke), and increases the rate of functional decline. My research primarily focuses on identifying novel drug, diagnostic and prognostic targets for PAD and associated complications, with a specific emphasis on translating findings from the laboratory to the patient.

In 2017 I was awarded a competitive Advance Queensland Fellowship to further my studies into the management of cardiovascular complications. Notably, this funding has allowed me to expand my research into the development of rapid diagnostics for ischaemic stroke, with the scope of building additional skills in statistical modelling and economic analysis.

Student Supervision:

Student supervision is one of the aspects of my job that I most enjoy and I have been privileged to work with some talented students since joining JCU. To date, I have (co)-supervised 1 PhD student, and 3 honours students to successful completion. Students under my supervision have performed well evidenced by publication of multiple papers and conference presentations, award of academic medals and receipt of competitive grants including an NHF Summer Scholarship and a John Monash Scholarship.

I currently co-supervise 2 honours and 4 PhD students, and am always happy to hear from any prospective students interested in becoming involved in peripheral artery disease research. I am also the MBBS honours co-ordinator for the Townsville campus, and welcome any enquiries from medical students hoping to gain research experience.

Other Academic Activities:

Editorial board member of the International Journal of Molecular Sciences (molecular pathology section). Achievements in this position include:

Co-editor of a special issue titled 'Advances in Peripheral artery disease' (see http://www.mdpi.com/journal/ijms/special_issues/peripheral_artery_disease);

Appointed and editor of the IJMS 'Feature Reviews in Molecular Biology' collection.

Reviewer for a range of journals including PLoS, Circulation Cardiovascular Genetics, Scientific Reports and Molecular and Cellular Proteomics.

Grant reviewer for a range of funding bodies including philanthropic organisations and JCU schemes.

Teaching

MD1010: Introduction to Integrated Medical Studies Part 1 of 2 (Level 1; TSV)

Interests

Professional

Vascular Disease
Parasitology

Research

Abdominal Aortic Aneurysm
Peripheral Artery Disease
Proteomics
Lipidomics
Bioinformatics
Biostatistics
Biomarker Discovery
Molecular Pathology
Predictive modelling
Stroke
Cardiovascular complications
Clinical research

Teaching

Research Methods
Postgraduate Mentoring

Experience

2017 to present - Senior Research Fellow, The College of Medicine and Dentistry, (Australia)
2011 to 2016 - Senior Scientist, The College of Medicine and Dentistry, James Cook University (Australia)
2008 to 2011 - Post-doctoral Scientist, The College of Medicine and Dentistry, James Cook University (Australia)
2008 - Research Assistant, The University of Wales Aberystwyth (UK)
2004 to 2008 - PhD Student, The University of Wales Aberystwyth (UK)

Research Disciplines

Socio-Economic Objectives

Honours

Awards

2016 to 2017 - The Townsville Hospital SERTA grant. 'Physical activity, sedentary behaviour, physical performance and frailty in patients with peripheral artery disease.' $40,000. Golledge J, Moxon JV, Leicht A, Mudge A, Biros E, Best S, Yip L.
2016 to 2017 - The Townsville Hospital SERTA grant . 'The role of circulating blood markers to diagnose endoleak after endovascular repair of abdominal aortic aneurysm (EVAR)'. $14,000. Velu R, Ng E, Golledge J, Moxon JV, Biros E, Lazzaroni S, Fitridge R, Boult M
2016 to 2017 - The Townsville Hospital SERTA grant . 'Developing a case-control cohort to examine the treatment targets for peripheral vascular diseases.' $169,306. Biros E, Field M, Golledge J, Krishna S, Leicht A, Moxon J, Woodward L.
2016 - Travel grant to attend and present at the 2016 meeting of the European Atherosclerosis Society (Innsbruck, Austria; total value: $1,250).
2016 - Research Infrastructure Building Grant 'Part time clinical trials co-ordinator' ($39,110)
2016 - The Townsville Hospital SERTA grant 'Identifying lipid markers to predict outcomes for patients with peripheral artery disease' ($10,000)
2016 - Travel grant from the International Journal of Molecular Sciences ($650).
2015 to 2016 - Development Grant 'Is inositol a potential therapy for abdominal aortic aneurysm? Building the case to support external funding applications' $80,000, Chief Investigator)
2015 to 2016 - Bridging the Gap grant 'The effect of hookworm proteins on abdominal aortic aneurysm' ($20,000 - Chief Investigator).
2015 - Research Infrastructure Funding ($77,000 - James Cook University RIBG and AITHM, Chief Investigator)
2014 to 2015 - Faculty Administered Internal Grant 'Peripheral arterial disease in Aboriginal and Torres Strait Islanders' ($9,646 - Chief Investigator)
2014 to 2015 - JCU Rising Stars Award - Competitive award given to emerging JCU research leaders ($15,000)
2013 to 2014 - Faculty Administered Internal Grant 'Proteomic and bioinformatic characterisation of the ageing aorta' ($11,500 - Chief Investigator)
2013 - CASS Foundation Early Career Researcher Travel Grant ($3,000)
2012 to 2013 - School of Medicine and Dentistry Internal Administered Grant 'Contribution of ACE2 to human AAA' ($7,500 - Co-investigator)
2012 to 2013 - School of Medicine and Dentistry Internal Administered Grant 'Lipid biomarkers for aneurysm disease' ($7,500 - Chief Investigator)
2011 to 2012 - Competitive Research Incentive Grant - Personal award for highly ranked application to the ARC ($10,000)
2011 to 2012 - Faculty Administered Internal Grant 'Stem cell therapy for aortic aneurysms' ($3,000 - Chief Investigator)
2010 to 2011 - Faculty Administered Internal Grant 'Biomarkers of abdominal aortic aneurysm' ($8,000 - Chief Investigator)
2010 - Research Infrastructure Funding ($12,500 - Chief Investigator)
2009 to 2010 - Faculty Administered Internal Grant 'Aneurysm proteomics: Biomarker discovery' ($7,650 - Chief Investigator)
2009 - Research Infrastructure Funding ($12,800 - Chief Investigator)

Fellowships

2017 to 2020 - Advance Queensland Mid Career Fellowship - 'Clinical and economic evaluation of novel blood tests for stroke'.

Memberships

2016 - The Australian Institute of Tropical Health and Medicine
2015 - The European Atherosclerosis Society
2015 - The Australian Atherosclerosis Society
2015 - The Australian Cardiovascular Alliance
2011 - The Australasian Vascular Biology Society

Publications

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

Dewdney B, Trollope A, Moxon J, Thomas Manapurathe D, Biros E and Golledge J (2018) Circulating microRNAs as biomarkers for acute ischemic stroke: a systematic review Journal of Stroke and Cerebrovascular Diseases. Journal of stroke and cerebrovascular diseases, 27 (3). pp. 522-530
Golledge J, Maarij K, Moxon J, Beard J, Girold S, Wrang H and Morris D (2018) Systematic review and meta-analysis of clinical trials examining the benefit of exercise programmes using Nordic walking in patients with peripheral artery disease. European Journal of Vascular and Endovascular Surgery, 56 (4). pp. 534-543
Krishna S, Moxon J, Jose R, Sahebkar A, Hatamipour M, Liu D and Golledge J (2018) Anionic nanoliposomes reduced atherosclerosis progression in Low Density Lipoprotein Receptor (LDLR) deficient mice fed a high fat diet. Journal of Cellular Physiology, 233 (10). pp. 6951-6964
Morris D, Skalina T, Singh T, Moxon J and Golledge J (2018) Association of computed tomographic leg muscle characteristics with lower limb and cardiovascular events in patients with peripheral artery disease. Journal of the American Heart Association, 7 (20).
Moxon J, Ng E, Lazzaroni S, Boult M, Velu R, Fitridge R and Golledge J (2018) Circulating biomarkers are not associated wtih endoleaks after endovascular repair of abdominal aortic aneurysms. Journal of Vascular Surgery, 67 (3). pp. 770-777
Nastasi D, Smith J, Moxon J, Trollope A and Golledge J (2018) Prescription of pharmacotherapy and the incidence of stroke in patients with symptoms of peripheral artery disease. Stroke, 49 (12).
Phie J, Moxon J, Krishna S, Kinobe R, Morton S and Golledge J (2018) A diet enriched with tree nuts reduces severity of atherosclerosis but not abdominal aneurysm in angiotensin II-infused apolipoprotein E deficient mice. Atherosclerosis, 277. pp. 28-33
Pinchbeck J, Moxon J, Rowbotham S, Bourke M, Lazzaroni S, Morton S, Matthews E, Hendy K, Jones R, Bourke B, Jaeggi R, Favot D, Quigley F, Jenkins J, Reid C, Velu R and Golledge J (2018) A randomized placebo-controlled trial assessing the effect of 24 weeks fenofibrate therapy on circulating markers of abdominal aortic aneurysm: outcomes from the FAME-2 trial. Journal of the American Heart Association, 7 (19).
Singh T, Skallina T, Nour D, Murali A, Morrison S, Moxon J and Golledge J (2018) A meta-analysis of the efficacy of allopurinol in reducing the incidence of myocardial infarction following coronary artery bypass grafting. BMC Cardiovascular Disorders, 18.
Singh T, Moxon J, Healy G, Cadet-James Y and Golledge J (2018) Presentation and outcomes of indigenous Australians with peripheral artery disease. BMC Cardiovascular Disorders, 18 (94).
Golledge J, Moxon J, Pinchbeck J, Anderson G, Rowbotham S, Jenkins J, Bourke M, Bourke B, Dear A, Buckenham T, Jones R and Norman P (2017) Metformin prescription is associated with reduced abdominal aortic aneurysm growth in three cohorts. British Journal of Surgery, 104 (11). pp. 1486-1493
Krishna S, Seto S, Jose R, Li J, Moxon J, Clancy P, Crossman D, Norman P, Emeto T and Golledge J (2017) High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency promotes angiotensin-II induced aneurysm in mice. Clinical Science, 131 (12). pp. 1261-1281

More: ResearchOnline@JCU stores 58+ research outputs authored by Dr Joseph Moxon from 2006 onwards.

Current Funding

Current and recent Research Funding to JCU is shown by funding source and project.

Townsville Hospital and Health Service - Study Education Research Trust Account (SERTA)

Peak Wall Stress as a prognostic indicator of abdominal Aortic Aneurysm rupture risk

Indicative Funding: $50,000 over 2 years
Summary: Abdominal Aortic Aneurysm (AAA) affects 20 million people worldwide and 100,000 people in Australia. Annually, AAA rupture leads to 200,000 deaths worldwide and 2000 deaths in Australia. In clinical practice, maximum AAA diameter is the preferred surrogate measure for disease progression and rupture risk, and is used to guide surgical intervention. Approximately 10% of AAAs will rupture before they reach the current threshold for repair, whereas 60% of large AAAs remain stable during their lifetime, suggesting that diameter alone is an imperfect tool to decide which AAAs require surgical intervention. The specific aims of the project are Aim 1: To investigate if PWS is greater in patients with ruptured compared to intact AAAs matched for diameter; Aim 2: To evaluate the impact of a common anti-hypertensive medication {Telmisartan) on PWS and rupture risk in patients with small AAAs.
Investigators: Tejas Singh, Jon Golledge and Joseph Moxon in collaboration with Thomas Gasser (College of Medicine & Dentistry and Royal Institute of Technology)
Keywords: Metformin; Abdominal Aortic Aneurysm; Ruptures

Townsville Hospital and Health Service - Study Education Research Trust Account (SERTA)

Assessment of the efficacy of a novel treatment for Peripheral Artery Disease (PAD)

Indicative Funding: $50,000 over 2 years
Summary: Blockage of leg arteries (peripheral artery disease - PAD) leads to severe exertional leg pain (intermittent claudication), impaired walking ability, reduced health-related quality of life, and high risk of amputation and death. Multiple lines of evidence suggest that metformin, a cheap and safe medication, promotes formation of new vessels, improves microcirculation and muscle function,s and limits pain.
Investigators: Jon Golledge, Joseph Moxon, Tejas Singh, Rachel Wong, Kunwargit Sangla and Veronica White (College of Medicine & Dentistry and Townsville Hospital and Health Services)
Keywords: Metformin; peripheral artery disease; Intermittent Claudication

Royal Australasian College of Surgeons RACS - James Ramsay Project Grant

Metformin in the management of abdominal aortic aneurysm (MAGIC)

Indicative Funding: $78,000 over 2 years
Summary: MAGIC will be the first trial to assess the value of metformin wiuth significant preliminary data to suggest it can slow AAA growth. This trial offers the possibility of identifying a new treatment modality for an increasingly common condition, which would markedly change clinical practice.
Investigators: Jon Golledge, Dylan Morris, Paul Norman, Joseph Moxon, Zanfina Ademi, Rachel Neale, Anders Wanhainen, Ronald Dalman, Robert Hinchliffe and Matthew Bown in collaboration with Anthony Dear, Bernard Bourke, Christopher Reid, Jason Jenkins, Derek Chew, Rachael Jones, Richard Norman and Stephen Colagiuri (College of Medicine & Dentistry, University of Oxford, The University of Western Australia, Monash University, Queensland Institute of Medical Research, University of Uppsala, Stanford University, University of Bristol, University of Leicester, Gosford Hospital, The University of Queensland, Flinders University, Curtin University of Technology and The University of Sydney)
Keywords: Aortic Aneurysm; Clinical Trials; Surgery

Diabetes Australia - General Grant

Testing a novel treatment for diabetes-associated ischemic foot ulceration

Indicative Funding: $60,000
Summary: 5000 Australians with diabetes have a leg amputations each year. This project investigates a novel drug therapy approach to reducing the need for leg amputations within an established rodent model. The aim of the study is to assess if administration of a direct activator of adenosine-5'-monophosphate (AMP)-activated protein kinase (AMPK) will promote healing within a rat model of diabetes and limb ischaemia-associated foot ulceration
Investigators: Jon Golledge, Smriti Krishna and Joseph Moxon in collaboration with Jon Oakhill, Michelle Keske and Valerie Schini-Kerth (College of Medicine & Dentistry, St Vincent's Institute of Medical Research, Deakin University and Universite Louis Pasteur - Strasbourg I)
Keywords: peripheral artery disease; Diabetes; rodent model

Heart Foundation - Vanguard Grant

Metformin for treating peripheral artery disease-related walking impairment (MERIT)

Indicative Funding: $75,000
Summary: Blockage of the lower limb arteries (peripheral artery disease; PAD) leads to severe leg pain, walking impairment, and a substantial risk of leg amputation and death. Approximately 200 million people worldwide and approximately 1 million Australians have blocked leg arteries. This problem has recognised treatment deficiencies in comparison to other common diseases, including the absence of effective medications to increase blood supply to the legs, reduce leg pain, improve walking ability and reduce the risk of major amputation. Multiple lines of evidence suggest that metformin, a cheap and safe medication, promotes formation of new vessels, improves microcirculation and muscle function, and limits pain. In preliminary studies, metformin significantly increased blood supply to the limb of a pre-clinical model of blocked leg arteries. We have also associated metformin prescription with a 4-fold reduction in the rate of major lower limb amputation in patients with blocked arteries. This placebo-controlled, randomised clinical trial will examine the efficacy of metformin in improving walking ability in patients with blocked leg arteries over 6 months. Positive findings from this trial will identify a new treatment for a problem that affects 10-20% of adults aged over 50 years.
Investigators: Jon Golledge, Dylan Morris and Joseph Moxon (College of Medicine & Dentistry and University of Oxford)
Keywords: peripheral artery disease; Clinical Trial; Medication

QLD Department of Science, Information, Technology and Innovation - Advance Queensland Research Fellowship

Clinical and economic evaluation of novel blood tests for stroke

Indicative Funding: $300,000 over 3 years
Summary: This clinical study aims to test the ability for 2 novel blood borne markers to 1) diagnose stroke and 2) predict patient outcomes 90 days after stroke onset. In partnership with the Townsville Hospital, I will recruit presenting patients suffering suspected stroke and collect blood samples at presentation and after 24 hours as part of their usual care. Blood will be analysed for circulating concentrations of the novel markers which will be statistically compared to current gold standards in stroke assessment. Patients will be followed up at 3 months to assess disability, and perform economic analyses to quantify healthcare costs.
Investigators: Joseph Moxon (College of Medicine & Dentistry)
Keywords: Stroke; Diagnosis; Economic Analysis; Blood tests; Prognosis

Supervision

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current

Peak Wall Stress as a Prognostic Indicator of Abdominal Aortic Aneurysm Rupture Risk (PhD , Secondary Advisor)
The effects of aspects of the Mediterranean diet on Peripheral Artery Disease in mice (PhD , Secondary Advisor)
Diabetic foot disease and prevention of its complications (PhD , Secondary Advisor)
The Role of Vitamin D in the Pathogenesis and Progression of Abdominal Aortic Aneurysm. (PhD , Secondary Advisor)
Assessment and Intervention of Dietary Patterns in Patients with Peripheral Arterial Disease and Abdominal Aortic Aneurysm (PhD , Secondary Advisor)
A New Mouse model of Peripheral Artery Disease: development, validation and assessment of a potential intervention and a therapeutic target (PhD , Secondary Advisor)

Data

These are the most recent metadata records associated with this researcher. To see a detailed description of all dataset records, visit the JCU Research Data Catalogue.

Moxon, J. (2012) Data for: Comparison of the serum lipidome in patients with abdominal aortic aneurysm and peripheral artery disease. James Cook University

Collaboration

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.