About

Biog:

I received my PhD from the University of Wales Aberystwyth (UK) in 2008 after completing a research program which utilised proteomics and bioinformatics to identify molecular markers for parasite infection. After graduation I joined the JCU Vascular Biology Unit as a junior post-doctoral scientist, to conduct proteomic and bioinformatic research in peripheral artery disease (PAD). In 2011, I was appointed to the position of Senior Scientist within the Vascular Biology Unit leading a team of scientists who conduct a range of clinical and pre-clinical investigations to improve our understanding of PAD. In 2017, I was promoted to my current academic C position within the College of Medicine and Dentistry, and also work closely with the newly established Australian Institute of Tropical Health and Medicine.

Research: 

My research focuses on PAD, predominatly complications arising from lower limb atherosclerosis and abdominal aortic aneurysm. Upon joining JCU, I was surprised to learn how common PAD is within the general population. Approximately one-quarter of the adult population will develop PAD, and this significantly increases the risk of suffering major cardiovascular events (such as heart attack and stroke), and increases the rate of functional decline. My research primarily focuses on identifying novel drug, diagnostic and prognostic targets for PAD and associated complications, with a specific emphasis on translating findings from the laboratory to the patient.

In 2017 I was awarded a competitive Advance Queensland Fellowship to further my studies into the management of cardiovascular complications. Notably, this funding has allowed me to expand my research into the development of rapid diagnostics for ischaemic stroke, with the scope of building additional skills in statistical modelling and economic analysis.

Student Supervision:

Student supervision is one of the aspects of my job that I most enjoy and I have been privileged to work with some talented students since joining JCU. To date, I have (co)-supervised 1 PhD student, and 3 honours students to successful completion.  Students under my supervision have performed well evidenced by publication of multiple papers and conference presentations, award of academic medals and receipt of competitive grants including an NHF Summer Scholarship and a John Monash Scholarship.

I currently co-supervise 2 honours and 4 PhD students, and am always happy to hear from any prospective students interested in becoming involved in peripheral artery disease research. I am also the MBBS honours co-ordinator for the Townsville campus, and welcome any enquiries from medical students hoping to gain research experience.

Other Academic Activities:

Editorial board member of the International Journal of Molecular Sciences (molecular pathology section). Achievements in this position include:

  • Co-editor of a special issue titled 'Advances in Peripheral artery disease' (see http://www.mdpi.com/journal/ijms/special_issues/peripheral_artery_disease);
  • Appointed and editor of the IJMS 'Feature Reviews in Molecular Biology' collection.

Reviewer for a range of journals including PLoS, Circulation Cardiovascular Genetics, Scientific Reports and Molecular and Cellular Proteomics.

Grant reviewer for a range of funding bodies including philanthropic organisations and JCU schemes.

Teaching
  • MD1010: Introduction to Integrated Medical Studies Part 1 of 2 (Level 1; TSV)
Interests
Professional
  • Vascular Disease
  • Parasitology
Research
  • Abdominal Aortic Aneurysm
  • Peripheral Artery Disease
  • Proteomics
  • Lipidomics
  • Bioinformatics
  • Biostatistics
  • Biomarker Discovery
  • Molecular Pathology
  • Predictive modelling
  • Stroke
  • Cardiovascular complications
  • Clinical research
Teaching
  • Research Methods
  • Postgraduate Mentoring
Experience
  • 2017 to present - Senior Research Fellow, The College of Medicine and Dentistry, (Australia)
  • 2011 to 2016 - Senior Scientist, The College of Medicine and Dentistry, James Cook University (Australia)
  • 2008 to 2011 - Post-doctoral Scientist, The College of Medicine and Dentistry, James Cook University (Australia)
  • 2008 - Research Assistant, The University of Wales Aberystwyth (UK)
  • 2004 to 2008 - PhD Student, The University of Wales Aberystwyth (UK)
Research Disciplines
Socio-Economic Objectives
Honours
Awards
  • 2016 to 2017 - The Townsville Hospital SERTA grant. 'Physical activity, sedentary behaviour, physical performance and frailty in patients with peripheral artery disease.' $40,000. Golledge J, Moxon JV, Leicht A, Mudge A, Biros E, Best S, Yip L.
  • 2016 to 2017 - The Townsville Hospital SERTA grant . 'The role of circulating blood markers to diagnose endoleak after endovascular repair of abdominal aortic aneurysm (EVAR)'. $14,000. Velu R, Ng E, Golledge J, Moxon JV, Biros E, Lazzaroni S, Fitridge R, Boult M
  • 2016 to 2017 - The Townsville Hospital SERTA grant . 'Developing a case-control cohort to examine the treatment targets for peripheral vascular diseases.' $169,306. Biros E, Field M, Golledge J, Krishna S, Leicht A, Moxon J, Woodward L.
  • 2016 - Travel grant to attend and present at the 2016 meeting of the European Atherosclerosis Society (Innsbruck, Austria; total value: $1,250).
  • 2016 - Research Infrastructure Building Grant 'Part time clinical trials co-ordinator' ($39,110)
  • 2016 - The Townsville Hospital SERTA grant 'Identifying lipid markers to predict outcomes for patients with peripheral artery disease' ($10,000)
  • 2016 - Travel grant from the International Journal of Molecular Sciences ($650).
  • 2015 to 2016 - Development Grant 'Is inositol a potential therapy for abdominal aortic aneurysm? Building the case to support external funding applications' $80,000, Chief Investigator)
  • 2015 to 2016 - Bridging the Gap grant 'The effect of hookworm proteins on abdominal aortic aneurysm' ($20,000 - Chief Investigator).
  • 2015 - Research Infrastructure Funding ($77,000 - James Cook University RIBG and AITHM, Chief Investigator)
  • 2014 to 2015 - Faculty Administered Internal Grant 'Peripheral arterial disease in Aboriginal and Torres Strait Islanders' ($9,646 - Chief Investigator)
  • 2014 to 2015 - JCU Rising Stars Award - Competitive award given to emerging JCU research leaders ($15,000)
  • 2013 to 2014 - Faculty Administered Internal Grant 'Proteomic and bioinformatic characterisation of the ageing aorta' ($11,500 - Chief Investigator)
  • 2013 - CASS Foundation Early Career Researcher Travel Grant ($3,000)
  • 2012 to 2013 - School of Medicine and Dentistry Internal Administered Grant 'Contribution of ACE2 to human AAA' ($7,500 - Co-investigator)
  • 2012 to 2013 - School of Medicine and Dentistry Internal Administered Grant 'Lipid biomarkers for aneurysm disease' ($7,500 - Chief Investigator)
  • 2011 to 2012 - Competitive Research Incentive Grant - Personal award for highly ranked application to the ARC ($10,000)
  • 2011 to 2012 - Faculty Administered Internal Grant 'Stem cell therapy for aortic aneurysms' ($3,000 - Chief Investigator)
  • 2010 to 2011 - Faculty Administered Internal Grant 'Biomarkers of abdominal aortic aneurysm' ($8,000 - Chief Investigator)
  • 2010 - Research Infrastructure Funding ($12,500 - Chief Investigator)
  • 2009 to 2010 - Faculty Administered Internal Grant 'Aneurysm proteomics: Biomarker discovery' ($7,650 - Chief Investigator)
  • 2009 - Research Infrastructure Funding ($12,800 - Chief Investigator)
Fellowships
  • 2017 to 2020 - Advance Queensland Mid Career Fellowship - 'Clinical and economic evaluation of novel blood tests for stroke'.
Memberships
  • 2016 - The Australian Institute of Tropical Health and Medicine
  • 2015 - The European Atherosclerosis Society
  • 2015 - The Australian Atherosclerosis Society
  • 2015 - The Australian Cardiovascular Alliance
  • 2011 - The Australasian Vascular Biology Society
Publications

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles
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ResearchOnline@JCU stores 68+ research outputs authored by Dr Joseph Moxon from 2006 onwards.

Current Funding

Current and recent Research Funding to JCU is shown by funding source and project.

National Health & Medical Research Council - Clinical Trials and Cohort Studies

The Metformin Aneurisym Trial (MAT)

Indicative Funding
$4,997,653 over 5 years
Summary
20 million people worldwide and 100,000 Australians have an abdominal aortic aneurysm (AAA). The main complication of AAA, aortic rupture, leads to 200,000 deaths/year worldwide. AAA prevalence and mortality rates in Australasia are 4-fold higher than the world average, so research to improve management is a key priorty. Most AAAs are detected when theya re small, when an effective treatment would prevent the need for surgery. There is currently no effective drug therapy for AA, and 70% of small AAAs grow to a size requiring surgical repair which carries inherent risks of death and major complications. A large amount of observational data from patients and laboratory models suggest that metformin may be an effective drug therapy for AAA. The metformin aneurysm trial (MAT) will be a large-scale, multi-centre randomised trail done as a collaboration between investigators in Australia, New Zealand, Swden and the United Kingdom across 55 sites over a 5 year trial period. Patients with AAA measuring between 39 and 49mmm in diameter will be enrolled over 24 months, assiged at random to 1500mn of metformin extended release (XR) or placebo each day followed for a mean of 3.5 years. The primary outcome will be AAA rupture or repair. The sample size of 1,954 will provide 90% pwer (p=0.05) to detect a 25% or greater reduction in the relative risk of the primary outcome. A positive finding from MAT would identify metformin as the first effective medical treatment for AAA. Since metformin is low cost, safe and available worldwide, the trial will have direct clinical implications for tens of millions of people around the world for whom no preventative therapy is currently available.
Investigators
Jon Golledge, Bruce Neal, Qiang Li, Gregory Jones, Matthew Bown, Anders Wanhainen, Richard Norman, Helen Monaghan, Dylan Morris and Joseph Moxon (College of Medicine & Dentistry, The George Institute for International Health, University of Otago, University of Leicester, University of Uppsala, Curtin University of Technology and Townsville Hospital and Health Services)
Keywords
Clinical Trial; Abdominal Aortic Aneurysm; Metformin

Heart Foundation - Vanguard Grant

Metformin for treating peripheral artery disease-related walking impairment (MERIT)

Indicative Funding
$75,000
Summary
Blockage of the lower limb arteries (peripheral artery disease; PAD) leads to severe leg pain, walking impairment, and a substantial risk of leg amputation and death. Approximately 200 million people worldwide and approximately 1 million Australians have blocked leg arteries. This problem has recognised treatment deficiencies in comparison to other common diseases, including the absence of effective medications to increase blood supply to the legs, reduce leg pain, improve walking ability and reduce the risk of major amputation. Multiple lines of evidence suggest that metformin, a cheap and safe medication, promotes formation of new vessels, improves microcirculation and muscle function, and limits pain. In preliminary studies, metformin significantly increased blood supply to the limb of a pre-clinical model of blocked leg arteries. We have also associated metformin prescription with a 4-fold reduction in the rate of major lower limb amputation in patients with blocked arteries. This placebo-controlled, randomised clinical trial will examine the efficacy of metformin in improving walking ability in patients with blocked leg arteries over 6 months. Positive findings from this trial will identify a new treatment for a problem that affects 10-20% of adults aged over 50 years.
Investigators
Jon Golledge, Dylan Morris and Joseph Moxon (College of Medicine & Dentistry and University of Oxford)
Keywords
peripheral artery disease; Clinical Trial; Medication

QLD Department of Science, Information, Technology and Innovation - Advance Queensland Research Fellowship

Clinical and economic evaluation of novel blood tests for stroke

Indicative Funding
$300,000 over 3 years
Summary
This clinical study aims to test the ability for 2 novel blood borne markers to 1) diagnose stroke and 2) predict patient outcomes 90 days after stroke onset. In partnership with the Townsville Hospital, I will recruit presenting patients suffering suspected stroke and collect blood samples at presentation and after 24 hours as part of their usual care. Blood will be analysed for circulating concentrations of the novel markers which will be statistically compared to current gold standards in stroke assessment. Patients will be followed up at 3 months to assess disability, and perform economic analyses to quantify healthcare costs.
Investigators
Joseph Moxon (College of Medicine & Dentistry)
Keywords
Stroke; Diagnosis; Economic Analysis; Blood tests; Prognosis

Townsville Hospital and Health Service - Study Education Research Trust Account (SERTA)

Peak Wall Stress as a prognostic indicator of abdominal Aortic Aneurysm rupture risk

Indicative Funding
$50,000 over 2 years
Summary
Abdominal Aortic Aneurysm (AAA) affects 20 million people worldwide and 100,000 people in Australia. Annually, AAA rupture leads to 200,000 deaths worldwide and 2000 deaths in Australia. In clinical practice, maximum AAA diameter is the preferred surrogate measure for disease progression and rupture risk, and is used to guide surgical intervention. Approximately 10% of AAAs will rupture before they reach the current threshold for repair, whereas 60% of large AAAs remain stable during their lifetime, suggesting that diameter alone is an imperfect tool to decide which AAAs require surgical intervention. The specific aims of the project are Aim 1: To investigate if PWS is greater in patients with ruptured compared to intact AAAs matched for diameter; Aim 2: To evaluate the impact of a common anti-hypertensive medication {Telmisartan) on PWS and rupture risk in patients with small AAAs.
Investigators
Tejas Singh, Jon Golledge and Joseph Moxon in collaboration with Thomas Gasser (College of Medicine & Dentistry and Royal Institute of Technology)
Keywords
Metformin; Abdominal Aortic Aneurysm; Ruptures

Townsville Hospital and Health Service - Study Education Research Trust Account (SERTA)

Assessment of the efficacy of a novel treatment for Peripheral Artery Disease (PAD)

Indicative Funding
$50,000 over 2 years
Summary
Blockage of leg arteries (peripheral artery disease - PAD) leads to severe exertional leg pain (intermittent claudication), impaired walking ability, reduced health-related quality of life, and high risk of amputation and death. Multiple lines of evidence suggest that metformin, a cheap and safe medication, promotes formation of new vessels, improves microcirculation and muscle function,s and limits pain.
Investigators
Jon Golledge, Joseph Moxon, Tejas Singh, Rachel Wong, Kunwargit Sangla and Veronica White (College of Medicine & Dentistry and Townsville Hospital and Health Services)
Keywords
Metformin; peripheral artery disease; Intermittent Claudication

Royal Australasian College of Surgeons RACS - James Ramsay Project Grant

Metformin in the management of abdominal aortic aneurysm (MAGIC)

Indicative Funding
$156,000 over 2 years
Summary
MAGIC will be the first trial to assess the value of metformin wiuth significant preliminary data to suggest it can slow AAA growth. This trial offers the possibility of identifying a new treatment modality for an increasingly common condition, which would markedly change clinical practice.
Investigators
Jon Golledge, Dylan Morris, Paul Norman, Joseph Moxon, Zanfina Ademi, Rachel Neale, Anders Wanhainen, Ronald Dalman, Robert Hinchliffe and Matthew Bown in collaboration with Anthony Dear, Bernard Bourke, Christopher Reid, Jason Jenkins, Derek Chew, Rachael Jones, Richard Norman and Stephen Colagiuri (College of Medicine & Dentistry, University of Oxford, The University of Western Australia, Monash University, Queensland Institute of Medical Research, University of Uppsala, Stanford University, University of Bristol, University of Leicester, Gosford Hospital, The University of Queensland, Flinders University, Curtin University of Technology and The University of Sydney)
Keywords
Aortic Aneurysm; Clinical Trials; Surgery

Diabetes Australia - General Grant

Testing a novel treatment for diabetes-associated ischemic foot ulceration

Indicative Funding
$60,000
Summary
5000 Australians with diabetes have a leg amputations each year. This project investigates a novel drug therapy approach to reducing the need for leg amputations within an established rodent model. The aim of the study is to assess if administration of a direct activator of adenosine-5'-monophosphate (AMP)-activated protein kinase (AMPK) will promote healing within a rat model of diabetes and limb ischaemia-associated foot ulceration
Investigators
Jon Golledge, Smriti Krishna and Joseph Moxon in collaboration with Jon Oakhill, Michelle Keske and Valerie Schini-Kerth (College of Medicine & Dentistry, St Vincent's Institute of Medical Research, Deakin University and Universite Louis Pasteur - Strasbourg I)
Keywords
peripheral artery disease; Diabetes; rodent model
Supervision

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current
  • Peak Wall Stress as a Prognostic Indicator of Abdominal Aortic Aneurysm Rupture Risk (PhD , Secondary Advisor)
  • Utilising novel clinically relevant mouse models to test new therapeutic interventions for peripheral artery diseases (PhD , Secondary Advisor)
  • The Efficacy of the DeStress for Success Education program on Attenuating Depressive Symptomatology in Adolescents (PhD , Secondary Advisor)
  • Assessment and Intervention of Dietary Patterns in Patients with Peripheral Arterial Disease and Abdominal Aortic Aneurysm (PhD , Secondary Advisor)
  • Diabetic foot disease and prevention of its complications (PhD , Secondary Advisor)
Completed
Data

These are the most recent metadata records associated with this researcher. To see a detailed description of all dataset records, visit the JCU Research Data Catalogue.

Collaboration

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.

  • 5+ collaborations
  • 4 collaborations
  • 3 collaborations
  • 2 collaborations
  • 1 collaboration
  • Indicates the Tropics (Torrid Zone)

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  • 47.109D, Pharmacy and Medical Research (Townsville campus)
Advisory Accreditation
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