Biog:

I received my PhD from the University of Wales Aberystwyth (UK) in 2008 after completing a research program which utilised proteomics and bioinformatics to identify molecular markers for parasite infection. After graduation I joined the JCU Vascular Biology Unit as a junior post-doctoral scientist, to conduct proteomic and bioinformatic research in peripheral artery disease (PAD). In 2011, I was appointed to the position of Senior Scientist within the Vascular Biology Unit leading a team of scientists who conduct a range of clinical and pre-clinical investigations to improve our understanding of PAD. In 2017, I was promoted to my current academic C position within the College of Medicine and Dentistry, and also work closely with the newly established Australian Institute of Tropical Health and Medicine.

Research: 

My research focuses on PAD, predominatly complications arising from lower limb atherosclerosis and abdominal aortic aneurysm. Upon joining JCU, I was surprised to learn how common PAD is within the general population. Approximately one-quarter of the adult population will develop PAD, and this significantly increases the risk of suffering major cardiovascular events (such as heart attack and stroke), and increases the rate of functional decline. My research primarily focuses on identifying novel drug, diagnostic and prognostic targets for PAD and associated complications, with a specific emphasis on translating findings from the laboratory to the patient.

In 2017 I was awarded a competitive Advance Queensland Fellowship to further my studies into the management of cardiovascular complications. Notably, this funding has allowed me to expand my research into the development of rapid diagnostics for ischaemic stroke, with the scope of building additional skills in statistical modelling and economic analysis.

Student Supervision:

Student supervision is one of the aspects of my job that I most enjoy and I have been privileged to work with some talented students since joining JCU. To date, I have (co)-supervised 1 PhD student, and 3 honours students to successful completion.  Students under my supervision have performed well evidenced by publication of multiple papers and conference presentations, award of academic medals and receipt of competitive grants including an NHF Summer Scholarship and a John Monash Scholarship.

I currently co-supervise 2 honours and 4 PhD students, and am always happy to hear from any prospective students interested in becoming involved in peripheral artery disease research. I am also the MBBS honours co-ordinator for the Townsville campus, and welcome any enquiries from medical students hoping to gain research experience.

Other Academic Activities:

Editorial board member of the International Journal of Molecular Sciences (molecular pathology section). Achievements in this position include:

• Co-editor of a special issue titled 'Advances in Peripheral artery disease' (see http://www.mdpi.com/journal/ijms/special_issues/peripheral_artery_disease);

• Appointed and editor of the IJMS 'Feature Reviews in Molecular Biology' collection.

Reviewer for a range of journals including PLoS, Circulation Cardiovascular Genetics, Scientific Reports and Molecular and Cellular Proteomics.

Grant reviewer for a range of funding bodies including philanthropic organisations and JCU schemes.

Interests

Professional

• Vascular Disease
• Parasitology

Research

• Abdominal Aortic Aneurysm
• Peripheral Artery Disease
• Proteomics
• Lipidomics
• Bioinformatics
• Biostatistics
• Biomarker Discovery
• Molecular Pathology
• Predictive modelling
• Stroke
• Cardiovascular complications
• Clinical research

Teaching

• Research Methods
• Postgraduate Mentoring

Experience

• 2017 to present - Senior Research Fellow, The College of Medicine and Dentistry, (Australia)
• 2011 to 2016 - Senior Scientist, The College of Medicine and Dentistry, James Cook University (Australia)
• 2008 to 2011 - Post-doctoral Scientist, The College of Medicine and Dentistry, James Cook University (Australia)
• 2008 - Research Assistant, The University of Wales Aberystwyth (UK)
• 2004 to 2008 - PhD Student, The University of Wales Aberystwyth (UK)

Research Disciplines

• Cardiovascular Medicine and Haematology (1102)

Socio-Economic Objectives

• Clinical Health (9201)

Awards

• 2016 to 2017 - The Townsville Hospital SERTA grant. 'Physical activity, sedentary behaviour, physical performance and frailty in patients with peripheral artery disease.' $40,000. Golledge J, Moxon JV, Leicht A, Mudge A, Biros E, Best S, Yip L.
• 2016 to 2017 - The Townsville Hospital SERTA grant . 'The role of circulating blood markers to diagnose endoleak after endovascular repair of abdominal aortic aneurysm (EVAR)'. $14,000. Velu R, Ng E, Golledge J, Moxon JV, Biros E, Lazzaroni S, Fitridge R, Boult M
• 2016 to 2017 - The Townsville Hospital SERTA grant . 'Developing a case-control cohort to examine the treatment targets for peripheral vascular diseases.' $169,306. Biros E, Field M, Golledge J, Krishna S, Leicht A, Moxon J, Woodward L.
• 2016 - Travel grant to attend and present at the 2016 meeting of the European Atherosclerosis Society (Innsbruck, Austria; total value: $1,250).
• 2016 - Research Infrastructure Building Grant 'Part time clinical trials co-ordinator' ($39,110)
• 2016 - The Townsville Hospital SERTA grant 'Identifying lipid markers to predict outcomes for patients with peripheral artery disease' ($10,000)
• 2016 - Travel grant from the International Journal of Molecular Sciences ($650).
• 2015 to 2016 - Development Grant 'Is inositol a potential therapy for abdominal aortic aneurysm? Building the case to support external funding applications' $80,000, Chief Investigator)
• 2015 to 2016 - Bridging the Gap grant 'The effect of hookworm proteins on abdominal aortic aneurysm' ($20,000 - Chief Investigator).
• 2015 - Research Infrastructure Funding ($77,000 - James Cook University RIBG and AITHM, Chief Investigator)
• 2014 to 2015 - Faculty Administered Internal Grant 'Peripheral arterial disease in Aboriginal and Torres Strait Islanders' ($9,646 - Chief Investigator)
• 2014 to 2015 - JCU Rising Stars Award - Competitive award given to emerging JCU research leaders ($15,000)
• 2013 to 2014 - Faculty Administered Internal Grant 'Proteomic and bioinformatic characterisation of the ageing aorta' ($11,500 - Chief Investigator)
• 2013 - CASS Foundation Early Career Researcher Travel Grant ($3,000)
• 2012 to 2013 - School of Medicine and Dentistry Internal Administered Grant 'Contribution of ACE2 to human AAA' ($7,500 - Co-investigator)
• 2012 to 2013 - School of Medicine and Dentistry Internal Administered Grant 'Lipid biomarkers for aneurysm disease' ($7,500 - Chief Investigator)
• 2011 to 2012 - Competitive Research Incentive Grant - Personal award for highly ranked application to the ARC ($10,000)
• 2011 to 2012 - Faculty Administered Internal Grant 'Stem cell therapy for aortic aneurysms' ($3,000 - Chief Investigator)
• 2010 to 2011 - Faculty Administered Internal Grant 'Biomarkers of abdominal aortic aneurysm' ($8,000 - Chief Investigator)
• 2010 - Research Infrastructure Funding ($12,500 - Chief Investigator)
• 2009 to 2010 - Faculty Administered Internal Grant 'Aneurysm proteomics: Biomarker discovery' ($7,650 - Chief Investigator)
• 2009 - Research Infrastructure Funding ($12,800 - Chief Investigator)

Fellowships

• 2017 to 2020 - Advance Queensland Mid Career Fellowship - 'Clinical and economic evaluation of novel blood tests for stroke'.

Memberships

• 2016 - The Australian Institute of Tropical Health and Medicine
• 2015 - The European Atherosclerosis Society
• 2015 - The Australian Atherosclerosis Society
• 2015 - The Australian Cardiovascular Alliance
• 2011 - The Australasian Vascular Biology Society

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

• Dewdney B, Trollope A, Moxon J, Thomas Manapurathe D, Biros E and Golledge J (2018) Circulating microRNAs as biomarkers for acute ischemic stroke: a systematic review Journal of Stroke and Cerebrovascular Diseases. Journal of stroke and cerebrovascular diseases, 27 (3). pp. 522-530
• Golledge J, Moxon J, Pinchbeck J, Anderson G, Rowbotham S, Jenkins J, Bourke M, Bourke B, Dear A, Buckenham T, Jones R and Norman P (2017) Metformin prescription is associated with reduced abdominal aortic aneurysm growth in three cohorts. British Journal of Surgery, 104 (11). pp. 1486-1493
• Krishna S, Seto S, Jose R, Li J, Moxon J, Clancy P, Crossman D, Norman P, Emeto T and Golledge J (2017) High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency promotes angiotensin-II induced aneurysm in mice. Clinical Science, 131 (12). pp. 1261-1281
• Matthews E, Rowbotham S, Moxon J, Jones R, Vega de Ceniga M and Golledge J (2017) Meta-analysis of the association between peripheral artery disease and growth of abdominal aortic aneurysms. British Journal of Surgery, 104 (13). pp. 1765-1774
• Moran C, Biros E, Krishna S, Wang Y, Tikellis C, Moxon J, Cooper M, Norman P, Burrell L, Thomas M and Golledge J (2017) Resveratrol inhibits growth of experimental abdominal aortic aneurysm associated with upregulation of angiotensin-converting enzyme 2. Arteriosclerosis Thrombosis and Vascular Biology, 37 (11). pp. 2195-2218
• Morris D, Singh T, Moxon J, Smith A, Stewart F, Jones R and Golledge J (2017) Assessment and validation of a novel angiographic scoring system for peripheral artery disease. British Journal of Surgery, 104. pp. 544-554
• Moxon J, Ng E, Lazzaroni S, Boult M, Velu R, Fitridge R and Golledge J (in press) Circulating biomarkers are not associated wtih endoleaks after endovascular repair of abdominal aortic aneurysms. Journal of Vascular Surgery, pp. 1-8
• Moxon J, Jones R, Wong G, Weir J, Mellett N, Kingwell B, Meikle P and Golledge J (2017) Baseline serum phosphatidylcholine plasmalogen concentrations are inversely associated with incident myocardial infarction in patients with mixed peripheral artery disease presentations. Atherosclerosis, 263. pp. 301-308
• Phie J, Krishna S, Moxon J, Omer S, Kinobe R and Golledge J (2017) Flavonols reduce aortic atherosclerosis lesion area in apolipoprotein E deficient mice: a systematic review and meta-analysis. PLoS ONE, 12 (7). pp. 1-13
• Rowbotham S, Pinchbeck J, Anderson G, Bourke B, Bourke M, Gasser T, Jaeggi R, Jenkins J, Moran C, Morton S, Reid C, Velu R, Yip L, Moxon J and Golledge J (2017) Inositol in the MAnaGemENt of abdominal aortic aneurysm (IMAGEN): study protocol for a randomised controlled trial. Trials, 18.
• Rowbotham S, Cavaye D, Jaeggi R, Jenkins J, Moran C, Moxon J, Pinchbeck J, Quigley F, Reid C and Golledge J (2017) Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME): study protocol for a randomised controlled trial. Trials, 18 (1). pp. 1-8
• Singh T, Morris D, Smith S, Moxon J and Golledge J (2017) A systematic review and meta-analysis of the association between C-reactive protein and major cardiovascular events in patients with peripheral artery disease. European Journal of Vascular and Endovascular Surgery, 54 (2). pp. 220-233

More

ResearchOnline@JCU stores 50+ research outputs authored by Dr Joseph Moxon from 2006 onwards.

Current and recent Research Funding to JCU is shown by funding source and project.

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current

• The effects of aspects of the Mediterranean diet on Peripheral Artery Disease in mice (PhD , Secondary Advisor)
• A new mouse model of lower limb ischaemia: development, validation and assessment of therapeutic targets and interventions (PhD , Secondary Advisor)
• The Role of Vitamin D in the Pathogenesis and Progression of Abdominal Aortic Aneurysm. (PhD , Secondary Advisor)
• Assessment and Intervention of Dietary Patterns in Patients with Peripheral Arterial Disease and Abdominal Aortic Aneurysm (PhD , Secondary Advisor)

Completed

• Urocortin 2: an interesting role in human abdominal aortic aneurysm (2013, PhD , Associate Advisor)

These are the most recent metadata records associated with this researcher. To see a detailed description of all dataset records, visit the JCU Research Data Catalogue.

• Moxon, J. (2012) Data for: Comparison of the serum lipidome in patients with abdominal aortic aneurysm and peripheral artery disease. James Cook University

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.