About

Letitia completed her studies at the University of Melbourne, focusing on human disease, genetics and immunology. She subsequently worked in the Genetic Epidemiology Laboratory under the supervision of Prof Melissa Southey. During this time she investigated the genetic causes of breast, ovarian, colorectal and prostate cancers within various population- and clinic-based studies.  

Since joining Molecular & Cell Biology at JCU, Letitia has worked on projects investigating gene expression in immune cells in Multiple Sclerosis and immune cell development using microarray technology.

She is currently a clinical researcher for the Queensland Genomic Health Alliance (QGHA), aiming to improve molecular diagnostics and provision of treatment for North Queensland cancer patients. 

Research Disciplines
Socio-Economic Objectives
Publications

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles
  • Broeks A, Schmidt M, Sherman M, Couch F, Hopper J, Dite G, Apicella C, Smith L, Hammet F, Southey M, Van 't Veer L, de Groot R, Smit V, Fasching P, Beckmann M, Jud S, Ekici A, Hartmann A, Hein A, Schulz-Wendtland R, Burwinkel B, Marme F, Schneeweiss A, Sinn H, Sohn C, Tchatchou S, Bojesen S, Nordestgaard B, Flyger H, Ørsted D, Kaur-Knudsen D, Milne R, Pérez J, Zamora P, Menéndez Rodríguez P, Benítez J, Brauch H, Justenhoven C, Ko Y, Hamann U, Fischer H, Brüning T, Pesch B, Chang-Claude J, Wang-Gohrke S, Bremer M, Karstens J, Hillemanns P, Dörk T, Nevanlinna H, Heikkinen T, Heikkilä P, Blomqvist C, Aittomäki K, Aaltonen K, Lindblom A, Margolin S, Mannermaa A, Kosma V, Kauppinen J, Kataja V, Auvinen P, Eskelinen M, Soini Y, Chenevix-Trench G, Spurdle A, Beesley J, Chen X, Holland H, Lambrechts D, Claes B, Vandorpe T, Neven P, Wildiers H, Flesch-Janys D, Hein R, Löning T, Kosel M, Fredericksen Z, Wang X, Giles G, Baglietto L, Severi G, McLean C, Haiman C, Henderson B, Le Marchand L, Kolonel L, Alnæs G, Kristensen V, Børresen-Dale A, Hunter D, Hankinson S, Andrulis I, Mulligan A, O'Malley F, Devilee P, Huijts P, Tollenaar R, Van Asperen C, Seynaeve C, Chanock S, Lissowska J, Brinton L, Peplonska B, Figueroa J, Yang X, Hooning M, Hollestelle A, Oldenburg R, Jager A, Kriege M, Ozturk B, van Leenders G, Hall P, Czene K, Humphreys K, Liu J, Cox A, Connley D, Cramp H, Cross S, Balasubramanian S, Reed M, Dunning A, Easton D, Humphreys M, Caldas C, Blows F, Driver K, Provenzano E, Lubinski J, Jakubowska A, Huzarski T, Byrski T, Cybulski C, Gorski B, Gronwald J, Brennan P, Sangrajrang S, Gaborieau V, Shen C, Hsiung C, Yu J, Chen S, Hsu G, Hou M, Huang C, Anton-Culver H, Ziogas A, Pharoah P, Garcia-Closas M, The Genica Network , kConFab and AOCS (2011) Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium. Human Molecular Genetics, 20 (16). pp. 3289-3303
  • Milne R, Lorenzo-Bermejo J, Burwinkel B, Malats N, Ignacio Arias J, Pilar Zamora M, Benítez J, Humphreys M, García-Closas M, Chanock S, Lissowska J, Sherman M, Mannermaa A, Kataja V, Kosma V, Nevanlinna H, Heikkinen T, Aittomäki K, Blomqvist C, Anton-Culver H, Ziogas A, Devilee P, van Asperen C, Tollenaar R, Seynaeve C, Hall P, Czene K, Liu J, Irwanto A, Kang D, Yoo K, Noh D, Couch F, Olson J, Wang X, Fredericksen Z, Nordestgaard B, Bojesen S, Flyger H, Margolin S, Lindblom A, Fasching P, Schulz-Wendtland R, Ekici A, Beckmann M, Wang-Gohrke S, Shen C, Yu J, Hsu H, Wu P, Giles G, Severi G, Baglietto L, English D, Cox A, Brock I, Elliott G, Reed M, Beesley J, Chen X, Fletcher O, Gibson L, Silva I, Peto J, Frank B, Heil J, Meindl A, Chang-Claude J, Hein R, Vrieling A, Flesch-Janys D, Southey M, Smith L, Apicella C, Hopper J, Dunning A, Pooley K, Pharoah P, Hamann U, Pesch B, Ko Y, Easton D, Chenevix-Trench G, kConFab Investigators , AOCS Group and The GENICA Network (2011) 7q21-rs6964587 and breast cancer risk: an extended case–control study by the Breast Cancer Association Consortium. Journal of Medical Genetics, 48 (10). pp. 698-702
  • Smith L, Tesoriero A, Wong E, Ramus S, O'Malley F, Mulligan A, Terry M, Senie R, Santella R, John E, Andrulis I, Ozcelik H, Daly M, Godwin A, Buys S, Fox S, Goldgar D, Giles G, Hopper J and Southey M (2011) Contribution of large genomic BRCA1 alterations to early-onset breast cancer selected for family history and tumour morphology: a report from The Breast Cancer Family Registry. Breast Cancer Research, 13 (1).
  • Southey M, Ramus S, Dowty J, Smith L, Tesoriero A, Wong E, Dite G, Jenkins M, Byrnes G, Winship I, Phillips K, Giles G and Hopper J (2011) Morphological predictors of BRCA1 germline mutations in young women with breast cancer. British Journal of Cancer, 104 (6). pp. 903-909
  • van Vliet C, Dowty J, van Vliet J, Smith L, Mead L, Macrae F, St John D, Giles G, Southey M, Jenkins M, Velan G and Hopper J (2011) Dependence of colorectal cancer risk on the parent-of-origin of mutations in DNA mismatch repair genes. Human Mutation, 32 (2). pp. 207-212
  • Yang X, Chang-Claude J, Goode E, Couch F, Nevanlinna H, Milne R, Gaudet M, Schmidt M, Broeks A, Cox A, Fasching P, Hein R, Spurdle A, Blows F, Driver K, Flesch-Janys D, Heinz J, Sinn P, Vrieling A, Heikkinen T, Aittomäki K, Heikkilä P, Blomqvist C, Lissowska J, Peplonska B, Chanock S, Figueroa J, Brinton L, Hall P, Czene K, Humphreys K, Darabi H, Liu J, Van 't Veer L, Van Leeuwen F, Andrulis I, Glendon G, Knight J, Mulligan A, O'Malley F, Weerasooriya N, John E, Beckmann M, Hartmann A, Weihbrecht S, Wachter D, Jud S, Loehberg C, Baglietto L, English D, Giles G, McLean C, Severi G, Lambrechts D, Vandorpe T, Weltens C, Paridaens R, Smeets A, Neven P, Wildiers H, Wang X, Olson J, Cafourek V, Fredericksen Z, Kosel M, Vachon C, Cramp H, Connley D, Cross S, Balasubramanian S, Reed M, Doerk T, Bremer M, Meyer A, Karstens J, Ay A, Park-Simon T, Hillemanns P, Arias Pérez J, Menéndez Rodríguez P, Zamora P, Benítez J, Ko Y, Fischer H, Hamann U, Pesch B, Brüning T, Justenhoven C, Brauch H, Eccles D, Tapper W, Gerty S, Sawyer E, Tomlinson I, Jones A, Kerin M, Miller N, McInerney N, Anton-Culver H, Ziogas A, Shen C, Hsiung C, Wu P, Yang S, Yu J, Chen S, Hsu G, Haiman C, Henderson B, Le Marchand L, Kolonel L, Lindblom A, Margolin S, Jakubowska A, Lubiński J, Huzarski T, Byrski T, Górski B, Gronwald J, Hooning M, Hollestelle A, van den Ouweland A, Jager A, Kriege M, Tilanus-Linthorst M, Collée M, Wang-Gohrke S, Pylkäs K, Jukkola-Vuorinen A, Mononen K, Grip M, Hirvikoski P, Winqvist R, Mannermaa A, Kosma V, Kauppinen J, Kataja V, Auvinen P, Soini Y, Sironen R, Bojesen S, Ørsted D, Kaur-Knudsen D, Flyger H, Nordestgaard B, Holland H, Chenevix-Trench G, Manoukian S, Barile M, Radice P, Hankinson S, Hunter D, Tamimi R, Sangrajrang S, Brennan P, Mckay J, Odefrey F, Gaborieau V, Devilee P, Huijts P, Tollenaar R, Seynaeve C, Dite G, Apicella C, Hopper J, Hammet F, Tsimiklis H, Smith L, Southey M, Humphreys M, Easton D, Pharoah P, Sherman M and Garcia-Closas M (2011) Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies. Journal of the National Cancer Institute, 103 (3). pp. 250-263
  • Fletcher O, Johnson N, Silva I, Orr N, Ashworth A, Nevanlinna H, Heikkinen T, Aittomäki K, Blomqvist C, Burwinkel B, Bartram C, Meindl A, Schmutzler R, Cox A, Brock I, Elliott G, Reed M, Southey M, Smith L, Spurdle A, Hopper J, Couch F, Olson J, Wang X, Fredericksen Z, Schürmann P, Waltes R, Bremer M, Dörk T, Devilee P, van Asperen C, Tollenaar R, Seynaeve C, Hall P, Czene K, Humphreys K, Liu J, Ahmed S, Dunning A, Maranian M, Pharoah P, Chenevix-Trench G, Beesley J, Bogdanova N, Antonenkova N, Zalutsky I, Anton-Culver H, Ziogas A, Brauch H, Ko Y, Hamann U, Fasching P, Strick R, Ekici A, Beckmann M, Giles G, Severi G, Baglietto L, English D, Milne R, Benítez J, Ignacio Arias J, Pita G, Nordestgaard B, Bojesen S, Flyger H, Kang D, Yoo K, Noh D, Mannermaa A, Kataja V, Kosma V, Garcia-Closas M, Chanock S, Lissowska J, Brinton L, Chang-Claude J, Wang-Gohrke S, Broeks A, Schmidt M, van Leeuwen F, Van't Veer L, Margolin S, Lindblom A, Humphreys M, Morrison J, Platte R, Easton D, Peto J, kConFab Investigators , AOCS Group , GENICA Consortium and Breast Cancer Association Consortium (2010) Missense variants in ATM in 26,101 breast cancer cases and 29,842 controls. Cancer Epidemiology, Biomarkers & Prevention, 19 (9). pp. 2143-2151
  • Royce S, Alsop K, Haydon A, Mead L, Smith L, Tesoriero A, Giles G, Jenkins M, Hopper J and Southey M (2010) The role of SMAD4 in early-onset colorectal cancer. Colorectal Disease, 12 (3). pp. 213-219
  • Ahmed S, Thomas G, Ghoussaini M, Healey C, Humphreys M, Platte R, Morrison J, Maranian M, Pooley K, Luben R, Eccles D, Evans D, Fletcher O, Johnson N, dos Santos Silva I, Peto J, Stratton M, Rahman N, Jacobs K, Prentice R, Anderson G, Rajkovic A, Curb J, Ziegler R, Berg C, Buys S, McCarty C, Feigelson H, Calle E, Thun M, Diver W, Bojesen S, Nordestgaard B, Flyger H, Dörk T, Schürmann P, Hillemanns P, Karstens J, Bogdanova N, Antonenkova N, Zalutsky I, Bermisheva M, Fedorova S, Khusnutdinova E, Kang D, Yoo K, Noh D, Ahn S, Devilee P, van Asperen C, Tollenaar R, Seynaeve C, Garcia-Closas M, Lissowska J, Brinton L, Peplonska B, Nevanlinna H, Heikkinen T, Aittomäki K, Blomqvist C, Hopper J, Southey M, Smith L, Spurdle A, Schmidt M, Broeks A, van Hien R, Cornelissen S, Milne R, Ribas G, González-Neira A, Benitez J, Schmutzler R, Burwinkel B, Bartram C, Meindl A, Brauch H, Justenhoven C, Hamann U, Chang-Claude J, Hein R, Wang-Gohrke S, Lindblom A, Margolin S, Mannermaa A, Kosma V, Kataja V, Olson J, Wang X, Fredericksen Z, Giles G, Severi G, Baglietto L, English D, Hankinson S, Cox D, Kraft P, Vatten L, Hveem K, Kumle M, Sigurdson A, Doody M, Bhatti P, Alexander B, Hooning M, van den Ouweland A, Oldenburg R, Schutte M, Hall P, Czene K, Liu J, Li Y, Cox A, Elliott G, Brock I, Reed M, Shen C, Yu J, Hsu G, Chen S, Anton-Culver H, Ziogas A, Andrulis I, Knight J, Beesley J, Goode E, Couch F, Chenevix-Trench G, Hoover R, Ponder B, Hunter D, Pharoah P, Dunning A, Chanock S and Easton D (2009) Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nature Genetics, 41 (5). pp. 585-590
  • Milne R, Benitez J, Nevanlinna H, Heikkinen T, Aittomäki K, Blomqvist C, Arias J, Zamora M, Burwinkel B, Bartram C, Meindl A, Schmutzler R, Cox A, Brock I, Elliott G, Reed M, Southey M, Smith L, Spurdle A, Hopper J, Couch F, Olson J, Wang X, Fredericksen Z, Schürmann P, Bremer M, Hillemanns P, Dörk T, Devilee P, van Asperen C, Tollenaar R, Seynaeve C, Hall P, Czene K, Liu J, Li Y, Ahmed S, Dunning A, Maranian M, Pharoah P, Chenevix-Trench G, Beesley J, Bogdanova N, Antonenkova N, Zalutsky I, Anton-Culver H, Ziogas A, Brauch H, Justenhoven C, Ko Y, Haas S, Fasching P, Strick R, Ekici A, Beckmann M, Giles G, Severi G, Baglietto L, English D, Fletcher O, Johnson N, dos Santos Silva I, Peto J, Turnbull C, Hines S, Renwick A, Rahman N, Nordestgaard B, Bojesen S, Flyger H, Kang D, Yoo K, Noh D, Mannermaa A, Kataja V, Kosma V, Garcia-Closas M, Chanock S, Lissowska J, Brinton L, Chang-Claude J, Wang-Gohrke S, Pashen C, Wang H, Yu J, Chen S, Bermisheva M, Nikolaeva T, Khusnutdinova E, Humphreys M, Morrison J, Platte R, Easton D, kConFab Investigators , AOCS Group and Breast Cancer Association Consortium (2009) Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042. Journal of the National Cancer Institute, 101 (14). pp. 1012-1018
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