Dr Lisa Chilton ~ Senior Lecturer
Biomedical Sciences and Molecular Biology
- About
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- Teaching
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- BM1001: Introduction to Biomedicine (Level 1; TSV)
- BM1003: Biomedicine in the Tropics (Level 1; TSV)
- BM5001: Professional Placement 1 (Level 5; TSV)
- BM5002: Professional Placement 2 (Level 5; TSV)
- BM5003: Clinical Measurements 1 (Level 5; TSV)
- MD1020: Introduction to Integrated Medical Studies Part 2 of 2 (Level 1; TSV)
- MD2011: Integrated Human System Pathophysiology Part 1 of 2 (Level 2; TSV)
- MD2012: Integrated Human System Pathophysiology Part 2 of 2 (Level 2; TSV)
- NS2881: Nursing Practice 3 (Level 2; CNS & TSV)
- PP2101: Medical Physiology 1 (Level 2; TSV)
- PP3101: Advanced and Integrated Physiology (Level 3; TSV)
- PP3251: Systemic Pathophysiology and Therapeutics (Level 3; TSV)
- PP5101: Advanced and Integrated Physiology (Level 5; TSV)
- PP5251: Systemic Pathophysiology and Therapeutics (Level 5; TSV)
- Interests
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- Research
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- The cardiovascular system
- The role of scar-forming fibroblasts and myofibroblasts in electrical connectivity in the heart following heart attack
- Cardiac electrophysiology
- Functional studies of manipulating the membrane potential and K+ channel function in cardiac fibroblasts and myofibroblasts
- Characteristics and control of contractility in cardiac myofibroblasts
- Effect of ischaemia/reperfusion injury and ischaemic preconditioning on fibroblast to myofibroblast differentiation
- Role of epicardial adipose tissue in health and disease, with particular interest in diabetic patients with or without obesity.
- Experience
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- 2015 - Research Sabbatical, Glasgow University (Glasgow, Scotland)
- 2004 to 2006 - Postdoctoral Research Fellow, Glasgow University (Glasgow, Scotland)
- 2002 to 2004 - Postdoctoral Research Fellow, University of Calgary (Calgary, Alberta, Canada)
- 2003 - Visiting Scientist, Oxford University (Oxford, England)
- 2002 - Visiting Scientist, Pfizers Research Facility (Sandwich, Kent, England)
- 1998 to 2002 - PhD, University of Calgary (Calgary, Alberta, Canada)
- Research Disciplines
- Socio-Economic Objectives
Dr Lisa Chilton has been studying the cardiovascular system throughout her research career. She studied how the intestinal circulation was impared with cirrhosis of the liver, the role of ATP-sensitive potassium channels in cardiac stunning, the role of membrane potential in activation of white blood cells, the role of potassium channels in controling blood vessel diameter, and the electrophysiology of cardiac fibroblasts. She has degrees from the University of Calgary in Canada, and did a postdoctoral fellowship at Glasgow University in Scotland. She was also a visiting scientist in Pfizer's sexual health division in Sandwich, Kent, England, and in Professor Fran Ashcroft's lab in Oxford, England.
Dr Chilton has maintained her collaborations with colleagues in Canada and the UK. She is involved in research projects studying epicardial adipose tissue, diabetes, obesity, cardiovascular diseases including rheumatic heart disease and heart failure, & ischaemic preconditioning at James Cook University.
- Honours
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- Awards
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- 1999 to 2001 - Izaak Walton Killam Memorial Scholarship
- 1999 to 2001 - Alberta Heritage Foundation for Medical Research Doctoral Studentship
- 1999 to 2000 - Dr Monica Scarabello Memorial Scholarship
- 1999 - Heart and Stroke Foundation of Canada Doctoral Studentship
- Fellowships
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- 2012 to 2015 - Australian National Health and Medical Research Council Project Grant in collaboration with Professor Ketheesan and Dr Cathy Rush
- 2005 to 2006 - British Heart Foundation Project Grant
- 2002 to 2004 - Alberta Heritage Foundation for Medical Research Postdoctoral Fellowship
- 2002 to 2004 - Heart and Stroke of Canada Postdoctoral Fellowship
- Publications
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These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.
- Journal Articles
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- Krishnan A, Sharma H, Yuan D, Trollope A and Chilton L (2022) The Role of Epicardial Adipose Tissue in the Development of Atrial Fibrillation, Coronary Artery Disease and Chronic Heart Failure in the Context of Obesity and Type 2 Diabetes Mellitus: A Narrative Review. Journal of Cardiovascular Development and Disease, 9.
- Krishnan A, Chilton E, Raman J, Saxena P, McFarlane C, Trollope A, Kinobe R and Chilton L (2021) Are interactions between epicardial adipose tissue, cardiac fibroblasts and cardiac myocytes instrumental in atrial fibrosis and atrial fibrillation? Cells, 10 (9).
- McArthur L, Riddell A, Chilton L, Smith G and Nicklin S (2020) Regulation of connexin 43 by interleukin 1 beta in adult rat cardiac fibroblasts and effects in an adult rat cardiac myocyte: fibroblast co-culture model. Heliyon, 6 (1).
- Hem N, Phie J, Chilton L and Kinobe R (2019) A volume-pressure tail cuff method for hemodynamic parameters: comparison of restraint and light isoflurane anesthesia in normotensive male Lewis rats. Journal of Pharmacological and Toxicological Methods, 100.
- Pertiwi K, Hillman R, Scott C and Chilton L (2019) Ischemia Reperfusion Injury Produces, and Ischemic Preconditioning Prevents, Rat Cardiac Fibroblast Differentiation: Role of KATP Channels. Journal of Cardiovascular Development and Disease, 6 (2).
- Gorton D, Sikder S, Williams N, Chilton L, Rush C, Govan B, Cunningham M and Ketheesan N (2016) Repeat exposure to group A streptococcal M protein exacerbates cardiac damage in a rat model of rheumatic heart disease. Autoimmunity, 49 (8). pp. 563-570
- McArthur L, Chilton L, Smith G and Nicklin S (2015) Electrical consequences of cardiac myocyte: fibroblast coupling. Biochemical Society Transactions, 43. pp. 513-518
- Phie J, Haleagrahara N, Newton P, Constantinoiu C, Sarnyai Z, Chilton L and Kinobe R (2015) Prolonged subcutaneous administration of oxytocin accelerates angiotensin II-induced hypertension and renal damage in male rats. PLoS ONE, 10 (9). pp. 1-19
- Chilton L, Smirnov S, Loutzenhiser K, Wang X and Loutzenhiser R (2011) Segment-specific differences in the inward rectifier K+ current along the renal interlobular artery. Cardiovascular Research, 92 (1). pp. 169-177
- Freed D, Chilton L, Li Y, Dangerfield A, Raizman J, Rattan S, Visen N, Hryshko L and Dixon I (2011) Role of myosin light chain kinase in cardiotrophin-1-induced cardiac myofibroblast cell migration. American Journal of Physiology-Heart and Circulatory Physiology, 301. pp. H514-H522
- Book Chapters
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- MacCannell K, Chilton L, Smith G and Giles W (2015) Mathematical simulations of sphingosine-1-phosphate actions on mammalian ventricular myofibroblasts and myocytes. In: Cardiac Fibrosis and Heart Failure: cause or effect?. Advances in Biochemistry in Health and Disease. Springer, Cham, Switzerland, pp. 299-322
- Conference Papers
- More
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ResearchOnline@JCU stores 22+ research outputs authored by Dr Lisa Chilton from 2005 onwards.
- Current Funding
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Current and recent Research Funding to JCU is shown by funding source and project.
Townsville Hospital and Health Service - Study Education Research Trust Account (SERTA)
Establishing the North Queensland Diabetic muscle stem cell library.
- Indicative Funding
- $50,000 over 3 years (administered by Townsville Hospital and Health Service)
- Summary
- This project will develop a North Queensland Diabetic Muscle Library. Muscle tissue will be resected from patients and fixed and frozen. The tissues will also be dissociated and cultured to make primary myoblast cultures that will be used in future experiments in drug trials, sequencing and biochemical assays.
- Investigators
- Pankaj Saxena, Craig McFarlane, Lionel Hebbard, Lisa Chilton, Zaaem Ahmed and Jaishankar Raman (Townsville Hospital and Health Service, College of Public Health and Medical & Vet Sciences)
- Keywords
- Diabetes; metabolism; myogenesis
- Collaboration
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The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.- 5+ collaborations
- 4 collaborations
- 3 collaborations
- 2 collaborations
- 1 collaboration
- Indicates the Tropics (Torrid Zone)
Connect with me
- Phone
- Location
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- 87.222, Veterinary & Biomedical Sciences (Townsville campus)
- Advisory Accreditation
- Secondary Advisor
- Find me on…
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My research areas
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