About

Dr Jordan is an NHMRC/MSRA (Betty Cuthbert) research fellow having completed a PhD in Immunogenetics at James Cook University, Townsville under the supervision of Professor Alan Baxter. She has extensive years of experience in Immunogenetics dissecting the genetics of Type 1 Diabetes, SLE, experimental autoimmune gastritis and Multiple Sclerosis. She has been a member of the Australasian Society for Immunology (ASI) since 1998 and the Australsian Genomic Technologies Association (AGTA, formally AMATA) since 2010. She is a Grant Reviewer for National Health and Medical Research Council (NHMRC), Diabetes Australia Research Trust (DART),  Rebecca L. Cooper Foundation  and Multiple Sclerosis Research Australia (MSRA) and is a member of the Queensland branch of the ASI committee. She is a reviewer for Clinical and Experimental Immunology Journal and has been an abstract reviewer for the International Congress of the Immunology of Diabetes Society and Brisbane Immunology Group meeting. Her work is funded by the NHMRC, MSRA, the Rebecca L. Cooper Foundation and the Lions Club. Dr Jordan became Honours' co-ordinator (Molecular and Cell Biology) in 2013 and Director of Research (Molecular and Cell Biology) in 2015, both roles of which are still current.  She also serves on the Animal Ethics Commitee and is an ethics monitor for the Human Ethics Committee.

 Specialties

Her current research focus is the identification of multiple sclerosis genes in man using gene expression arrays on sorted white blood cells. She has also utilised genetic linkage analyses and congenic mouse strains for gene expression microarray profiling to identify disease-associated candidate genes in other autoimmune dideases, such as SLE, T1D and autoimmune gastritis.  She has identified genes controlling the immunoregulatory subset, NKT cells, whose candidacy she subsequently confirmed  by producing transgenic and knock out strains. In addition, she is proficient in qPCR, sequencing and microsatellite/SNP typing. She has extensive experience working with DNA, RNA and proteins, cell preparations for flow cytometry, immunofluorescence and immunohistochemistry.screening of numerical aberrations.

In addition, Dr Jordan has 11.5 years experience as a Medical Scientist in Cytogentics becoming expert in identifying chromosome anomalies in human blood, bone-marrow, amniotic fluid and CVS samples. She established/cryopreserved and deposited human EBV-transformed cell lines in Coriell Cell Repositories; extracted DNA for population studies of peoples of Sub-Saharan origin; prepared centomeric probes and chromosome paints. She was instrumental in establishing the FISH division within the Cytogenetics Unit, S.A.I.M.R. which facilitated further research of patient samples to better define translocations and the interphase analysis of numerical anomalies.

Teaching
  • BC3102: Molecular Basis of Disease (Level 3; TSV)
  • BC3202: Special Topics in Biochemistry and Molecular Biology (Level 3; TSV)
  • BC5102: Advanced Molecular Basis of Disease (Level 5; TSV)
  • BC5202: Advanced Laboratory Practice in Molecular and Cell Biology (Level 5; TSV)
  • BC5312: Research and Dissertation in Molecular and Cell Biology (Level 5; TSV)
  • PC3102: Health Care for Pharmacists (Level 3; TSV)
Interests
Research
  • Multiple Sclerosis (MS)
  • Type 1 Diabetes (T1D)
  • Systemic Lupus Erythematosis (SLE)
  • Autoimmunity
  • Autoimmune Gastritis
  • Genetics
  • Genomics
  • Immunogenetics
  • Genetics of Immune Regulation
Experience
  • 2015 to present - Director of Research (Molecular and Cell Biology), James Cook University (Townsville, Australia)
  • 2015 to present - AEC Member, James Cook University (Townsville, Australia)
  • 2014 to present - Senior Research Fellow, CGC, James Cook University (Townsville, Australia)
  • 2014 to present - Human Ethic Monitor, James Cook University (Townsville, Australia)
  • 2013 to present - Honours co-ordinator (Molecular and Cell Biology), James Cook University (Townsville, Australia)
  • 2003 to 2013 - Research Fellow, CGC, James Cook University (Townsville, Australia)
  • 1998 to 2003 - Research Assistant, Centenary Institute for Molecular Biology and Cancer Research (Sydney, Australia)
  • 1997 to 1998 - Hospital Scientist, New Childrens's Hospital (Sydney Australia)
  • 1997 - Cytogeneticist, Sydney Genetics (Sydney, Australia)
  • 1986 to 1997 - Medical Scientist, South African Institute for Medical Research (Johannesburg, South Africa)
Research Disciplines
Socio-Economic Objectives
Honours
Awards
  • 2016 to 2018 - MSRA (Multiple Sclerosis Research Australia) Project grant
  • 2016 - International travel award from ICG (International congress genetics) to attend ICG, 2016, Dalian, People's Republic of China
  • 2014 to 2016 - AI on NHMRC grant #1061580 (Novel posttranscriptional pathways that control Tfh cell numbers. CIA Prof Carola Vinuesa CIB Dr Julia Ellyard, ANU $626 226.00
  • 2014 to 2015 - Rising Stars ECR Leadership Program grant
  • 2014 - Rebecca L. Cooper Research Foundation Grant
  • 2013 - ASI Travel grant to attend ICI (International congress of immunology), Milan, Italy 2013
  • 2013 - Wellcome Trust international travel award to attend The Genomics of Common Diseases conference, Oxford, UK.
  • 2013 - Competitive Research Incentive grant (CRIG)
  • 2013 - JCU MHMS Faculty travel grant to attend “Science Pathways” Conference, 17-18 October 2013, AMREP Education Centre, Melbourne, VIC.
  • 2013 - Equipment grant
  • 2012 to 2013 - FAIG (Medicine, Health & Molecular Sciences Grants Scheme 2012 (Early Career Researchers)
  • 2010 - AMATA Travel award
  • 2009 - FIMSA/ASI Travel award
  • 2007 - ASI-BIG Medal for Best Poster Presentation
  • 2007 - Logan Foundation Travel Scholarship
  • 2006 - Science Communicators Award for Best Oral Presentation, ThymOz
  • 2006 - JDRF Travel award
  • 2006 - ASI-BIG Medal for Best Poster Presentation
  • 2006 - ASI International Travel Award
  • 2006 - Townsville festival of Life Sciences Poster prize
  • 2005 - ASI National Travel award
Fellowships
  • 2013 to 2016 - NHMRC/MSRA Betty Cuthbert Fellowship
Memberships
  • 2015 - Animal Ethics Committee member
  • 2014 - Human Ethics Research monitor
  • 2012 - ASI Queensland commitee member
  • 2010 - Member of Australian Microarray Associated Technologies Association (AMATA) now AGTA (Australian Genome Technologies association)
  • 1998 - Member of the Australasian Society for Immunology
  • 1986 to 1997 - Member of the South African Society for Human Genetics
Other
  • 2015 - Grant reviewer for HDR student research grants
  • 2014 - Organizer of "Day of Immunology" events, Townsville
  • 2014 - Grant reviewer for National Health & Medical Research Council (NHMRC)
  • 2014 - Grant reviewer for Rebecca L Cooper foundation
  • 2014 - Selected as NHMRC project grant panel observer
  • 2013 - Grant reviewer for Multiple Sclerosis Research Australia (MSRA)
  • 2012 - Grant reviewer for Diabetes Australia Research Trust ( DART)
  • 2012 - Faculty representitive of the Gender Equity Working Group (GEWG)
  • 2011 - Editorial responsibilities with Clinical and Experimental Immunology Journal
  • 2016 - Invitation to deliver an oral presentation at ICG, Dalian, People's Republic of China
  • 2015 - Judge for oral presentations: Townsville Health Symposium, Townsville Hospital
  • 2014 - Session chair for ECR session BIG conference, Gold Coast
  • 2013 - Invited speaker MS Angels event, Brisbane, April, 2013
  • 2013 - Invited speaker MS Angels event, Brisbane, November, 2013
  • 2009 - Invited speaker BIG (Brisbane Immunology Group) meeting
  • 1986 to 1998 - Registration with the Medical Scientist Association
Publications

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles
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ResearchOnline@JCU stores 25+ research outputs authored by Dr Margaret Jordan from 1995 onwards.

Current Funding

Current and recent Research Funding to JCU is shown by funding source and project.

Multiple Sclerosis Research Australia - Project Grant

An immune transcriptional regulatory network approach to Multiple Sclerosis

Indicative Funding
$240,000 over 3 years
Summary
Multiple Sclerosis (MS) is an autoimmune disease resulting from a complex interaction between genetic and environmental factors. In an attempt to understand the integration of both sets of risk factors, we have compared mRNA transcripts between relapsing/remitting (RR) MS patients and healthy controls in 5 leukocyte subsets: CD4 and CD8 T cells, B cells, NK cells and monocytes. A gene co-expression network was generated based on correlation of expression levels across >700 gene expression microarrays, and a major co-ordinately regulated sub-network (module) of mRNA transcripts that is differentially expressed in the monocytes of RR-MS patients was identified. This project validates, characterizes and attempts to manipulate this transcriptional module in human cells ex-vivo and in the experimental autoimmune encephalomyelitis (EAE) model of central nervous system (CNS) autoimmunity. These results should provide greater explanatory power than the analyses of individual risk factors separately and may provide a multi-faceted target for intervention.
Investigators
Alan Baxter, Margaret Jordan, Helmut Butzkueven and Louise Laverick in collaboration with Letitia Smith (College of Public Health, Medical & Vet Sciences and The University of Melbourne)
Keywords
Autoimmunity; Cellular Immunology; Immunogenetics; Multiple Sclerosis; mouse models; humans

Rebecca L Cooper Medical Research Foundation - Research Grant

Causes of multiple scelerosis: A functional genomics approach

Indicative Funding
$22,000
Summary
Multiple sclerosis (MS) is a chronic disease that damages the brain and spinal cord and can cause numbness, muscle weakness, difficulties with coordination and balance, problems with speech and swallowing, visual problems, fatigue and bladder and bowel difficulties. After a worldwide effort, a large number of multiple sclerosis genes have been localised in the human genome. This project examines two of these genes in more detail with the aim of identifying exactly how they contribute to the risk of developing MS.
Investigators
Margaret Jordan, Alan Baxter and Adrian Gemiarto (College of Public Health and Medical & Vet Sciences)
Keywords
Multiple Sclerosis; Autoimmunity; Susceptibiity genes; Animal model; Innate immunity

NHMRC - Early Career Fellowship

Causes of Multiple Sclerosis: a functional genomics approach

Indicative Funding
$299,564 over 4 years
Summary
The locations of genes causing Multiple Sclerosis (MS) have been recently identified. The remaining challenge is to determine how these genetic locations contribute to risk. We have adopted a strategy to identify candidate genes (protein coding units) based on their differential expression in relevant immunocyte subsets. This project tests the candidate genes RGS1, HHEX and THEMIS.
Investigators
Margaret Jordan (Australian Institute of Tropical Health & Medicine)
Keywords
Multiple Sclerosis; Susceptibility genes; in vitro; Animal model; Innate immunity
Supervision

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current
  • Causes of Multiple Sclerosis: A Functional Genomics Approach. (PhD , Secondary Advisor)
  • NKT Cell Development and Regulatory Factors in Non-Obese Diabetic Mice (PhD , Secondary Advisor)
Collaboration

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.

  • 5+ collaborations
  • 4 collaborations
  • 3 collaborations
  • 2 collaborations
  • 1 collaboration
  • Indicates the Tropics (Torrid Zone)

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Email
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Location
  • 21.012B, Molecular Sciences (Townsville campus)
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