Dr Mark Pearson ~ Research Fellow

After the completion of a PhD in 2005, Mark was appointed the senior research scientist of the Queensland Institute of Medical Research arm of the Human Helminth Vaccine Initiative, a multi-national collaborative effort funded by the Bill and Melinda Gates Foundation to develop recombinant vaccines against the human parasitic worms, Necator americanus and Schistosoma mansoni.

In 2009, Mark was granted an NHMRC training fellowship to study how molecules in parasite secretions and on the parasite surface influence the host-parasite relationship with a view to develop anti-worm vaccines and novel therapies for autoimmune disorders. Mid-way through 2011 Mark completed part of this work at the Institute of Infection and Immunology Research at the University of Edinburgh and is now continuing this research at James Cook University.

Interests

Research

• Mark’s major research focus involves looking at the functions of proteins from human parasites (specifically helminths, or worms) and how these molecules interact with the host immune system.I am particularly interested in understanding these processes in the context of developing vaccines against parasites of third world populations and finding novel therapies for autoimmune disorders such as asthma.

Experience

• 2011 to present - Research Fellow, James Cook University (Cairns, Qld, Australia)
• 2009 to 2011 - Research Fellow, University of Edinburgh (Edinburgh, UK)
• 2006 to 2010 - Research Officer, Queensland institute of Medical Research (Brisbane, Qld, Australia)
• 2001 to 2005 - PhD Student, Queensland institute of Medical Research (Brisbane, Qld, Australia)

Research Disciplines

• Medical Microbiology (1108)
• Clinical Sciences (1103)

Socio-Economic Objectives

• Clinical Health (9201)
• Public Health (9204)

Awards

• 2011 - Finalist - Australian Museum Eureka Prizes
• 2010 - Research Australia Griffith University Discovery Award

Fellowships

• 2009 to 2013 - NHMRC Early Career Training Fellowship

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

• Bouchery T, Filbey K, Shepherd A, Chandler J, Patel D, Schmidt A, Camberis M, Peignier A, Smith A, Johnston K, Painter G, Pearson M, Giacomin P, Loukas A, Bottazzi M, Hotez P and LeGros G (2018) A novel blood-feeding detoxification pathway in Nippostrongylus brasiliensis L3 reveals a potential checkpoint for arresting hookworm development. PLoS Pathogens, 14 (3).
• Mekonnen G, Pearson M, Loukas A and Sotillo J (2018) Extracellular vesicles from parasitic helminths and their potential utility as vaccines. Expert Review of Vaccines, 17 (3). pp. 197-205
• Singh A, McBride W, Govan B and Pearson M (2018) Potential animal reservoir of Mycobacterium ulcerans: a systematic review. Tropical Medicine and Infectious Disease, 3 (2).
• Sundaraneedi M, Eichenberger R, Al-Hallaf R, Yang D, Sotillo J, Rajan S, Wangchuk P, Giacomin P, Keene F, Loukas A, Collins J and Pearson M (2018) Polypyridylruthenium(II) complexes exert in vitro and in vivo nematocidal activity and show significant inhibition of parasite acetylcholinesterases. International Journal for Parasitology: Drugs and Drugs Resistance, 8 (1). pp. 1-7
• Wendt G, Collins J, Pei J, Pearson M, Bennett H, Loukas A, Berriman M, Grishin N and Collins III J (2018) Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni. eLife, 7.
• Sundaraneedi M, Tedla B, Eichenberger R, Becker L, Pickering D, Smout M, Rajan S, Wangchuk P, Keene F, Loukas A, Collins J and Pearson M (2017) Polypyridylruthenium(II) complexes exert anti-schistosome activity and inhibit parasite acetylcholinesterases. PLoS Neglected Tropical Diseases, 11 (12).
• Sundaraneedi M, Ammit A, Tedla B, Pearson M, Loukas A, Keene F and Collins J (2017) Tetranuclear polypyridylruthenium(II) complexes as inhibitors and down-regulators of phosphatase enzymes. ChemistrySelect, 2 (33). pp. 10668-10672
• Driguez P, Li Y, Gaze S, Pearson M, Nakajima R, Trieu A, Doolan D, Felgner P, Hou X, Cardoso F, Jasinskas A, Gobert G, Loukas A and McManus D (2016) Antibody signatures reflect different disease pathologies in patients with schistosomiasis due to Schistosoma japonicum. Journal of Infectious Diseases, 213 (1). pp. 122-130
• Driguez P, McWilliam H, Gaze S, Piedrafita D, Pearson M, Nakajima R, Duke M, Trieu A, Doolan D, Cardoso F, Jasinskas A, Gobert G, Felgner P, Loukas A, Meeusen E and McManus D (2016) Specific humoral response of hosts with variable schistosomiasis susceptibility. Immunology and Cell Biology, 94. pp. 52-65
• Sotillo J, Pearson M, Potriquet J, Becker L, Pickering D, Mulvenna J and Loukas A (2016) Extracellular vesicles secreted by Schistosoma mansoni contain protein vaccine candidates. International Journal for Parasitology, 46 (1). pp. 1-5
• Susilawati T, Jex A, Cantacessi C, Pearson M, Navarro S, Susianto A, Loukas A and McBride W (2016) Deep sequencing approach for investigating infectious agents causing fever. European Journal of Clinical Microbiology and Infectious Diseases, 35 (7). pp. 1137-1149
• Wangchuk P, Giacomin P, Pearson M, Smout M and Loukas A (2016) Identification of lead chemotherapeutic agents from medicinal plants against blood flukes and whipworms. Scientific Reports, 6. pp. 1-10

More

ResearchOnline@JCU stores 47+ research outputs authored by Dr Mark Pearson from 2002 onwards.

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current

• Investigation of Potential Environmental Reservoirs of Mycobacterium Ulcerans in North Queensland. (PhD , Secondary Advisor)
• Characterization of the excretory/secretory molecules and extracellular vesicles from Schistosoma haematobium and their role in host-parasite relationships (PhD , Secondary Advisor)
• Schistosome exosomes - immunobiology and vaccine efficacy (PhD , Secondary Advisor)
• Rational Vaccine Development for Malaria from Genomic Sequence Information (PhD , Secondary Advisor)
• Targeting Schistosome Cholinesterases for Vaccine & Drug Development (PhD , Primary Advisor)

Completed

• Hookworm Na-ASP-2- Putative Functions, Allergenicity and Implications for Vaccine Development (2015, PhD , Associate Advisor)

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.