Dr. Paul Giacomin is currently a Senior Research Fellow in the Australian Institute of Tropical Health and Medicine at JCU Cairns. Since completing his PhD studies at the University of Adelaide in 2008, his research interests have focussed on understanding the molecular and cellular mechanisms by which immune responses to parasitic helminths (worms) are initiated and regulated. Dr. Giacomin underwent his postdoctoral training at the University of Pennsylvania between 2008 and 2012 in the laboratory of Dr. David Artis, where he was awarded fellowships from the American-Australian Association, as well as the NHMRC, to conduct his research. Dr. Giacomin continued his fellowship at JCU Cairns in 2012, where he continues to investigate the key immune cells and cytokines involved in immunity to intestinal worms, as well as exploring the potential beneficial effects that worm infection may have in alleviating inflammation associated with autoimmune diseases.

Interests

Research

• Immunity to gastrointestinal helminths
• Epithelial regulation of Type 2 inflammatory responses to parasites and allergens
• Therapeutic roles for helminths and helminth-derived proteins for treating allergic or autoimmune diseases

Experience

• 2016 to 2019 - Advance QLD Mid-Career Fellow, James Cook Univers (Australia)
• 2012 to 2015 - NHMRC CJ Martin Research Fellow, James Cook University, Cairns (Australia)
• 2010 to 2012 - NHMRC CJ Martin Research Fellow, University of Pennsylvania (USA)
• 2009 - Research Fellow, University of Pennsylvania (USA)
• 2008 to 2009 - Sir Keith Murdoch Fellow, University of Pennsylvania (USA)
• 2003 to 2008 - PhD candidate, University of Adelaide (Australia)
• 2002 - BSc (Hons), University of Adelaide (Australia)
• 1999 to 2002 - BSc (Biomedical Science), University of Adelaide (Australia)

Research Disciplines

• Immunology (3204)
• Medical microbiology (3207)
• Microbiology (3107)

Socio-Economic Objectives

• Clinical health (2001)

Fellowships

• 2010 to 2014 - NHMRC CJ Martin Fellow
• 2008 to 2009 - Sir Keith Murdoch Fellow, American Australian Association

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

• Chapman P, Llewellyn S, Jennings H, Becker L, Giacomin P, McDougall R, Robson J, Loukas A and McCarthy J (2022) The production of Necator americanus larvae for use in experimental human infection. Parasites & Vectors, 15.
• Cobos C, Bansal P, Wilson D, Jones L, Zhao G, Field M, Eichenberger R, Pickering D, Ryan R, Ratnatunga C, Miles J, Ruscher R, Giacomin P, Navarro S, Loukas A and Daly N (2022) Peptides derived from hookworm anti-inflammatory proteins suppress inducible colitis in mice and inflammatory cytokine production by human cells. Frontiers in Medicine, 9.
• Langdon K, Buitrago G, Pickering D, Giacomin P, Loukas A and Haleagrahara N (2022) Na-AIP-1 secreted by human hookworms suppresses collagen-induced arthritis. Inflammopharmacology, 30 (2). pp. 527-535
• Ryan S, Ruscher R, Johnston W, Pickering D, Kennedy M, Smith B, Jones L, Buitrago G, Field M, Esterman A, McHugh C, Browne D, Cooper M, Ryan R, Doolan D, Engwerda C, Miles K, Mitreva M, Croese J, Rahman T, Alexandrov K, Giacomin P and Loukas A (2022) Novel antiinflammatory biologics shaped by parasite–host coevolution. Proceedings of the National Academy of Sciences of the United States of America, 119 (36).
• Shalash A, Becker L, Yang J, Giacomin P, Pearson M, Hussein W, Loukas A, Toth I and Skwarczynski M (2022) Development of a peptide vaccine against hookworm infection: Immunogenicity, efficacy, and immune correlates of protection. Journal of Allergy and Clinical Immunology, 150 (1). pp. 157-169.e10
• Buitrago G, Pickering D, Ruscher R, Cobos Caceres C, Jones L, Cooper M, Van Waardenberg A, Ryan S, Miles K, Field M, Dredge K, Daly N, Giacomin P and Loukas A (2021) A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis. Translational Research, 232. pp. 88-102
• Chapman P, Giacomin P, Loukas A and McCarthy J (2021) Experimental human hookworm infection: a narrative historical review. PLoS Neglected Tropical Diseases, 15 (12).
• Chapman P, Webster R, Giacomin P, Llewellyn S, Becker L, Pearson M, De Labastida Rivera F, O’Rourke P, Engwerda C, Loukas A and McCarthy J (2021) Vaccination of human participants with attenuated Necator americanus hookworm larvae and human challenge in Australia: a dose-finding study and randomised, placebo-controlled, phase 1 trial. Lancet Infectious Diseases, 21 (12). pp. 1725-1736
• Douglas B, Oyesola O, Cooper M, Posey A, Tait Wojno E, Giacomin P and Herbert D (2021) Immune system investigation using parasitic helminths. Annual Review of Immunology, 39. pp. 639-665
• Khudhair Z, Alhallaf R, Eichenberger R, Whan J, Kupz A, Field M, Krause L, Wilson D, Daly N, Giacomin P, Sotillo J and Loukas A (2021) Gastrointestinal helminth infection improves insulin sensitivity, decreases systemic inflammation, and alters the composition of gut microbiota in distinct mouse models of Type 2 diabetes. Frontiers in Endocrinology, 11.
• Shalash A, Becker L, Yang J, Giacomin P, Pearson M, Hussein W, Loukas A, Skwarczynski M and Toth I (2021) Oral peptide vaccine against hookworm infection: correlation of antibody titers with protective efficacy. Vaccines, 9.
• Bouchery T, Moyat M, Sotillo J, Silverstein S, Volpe B, Coakley G, Tsourouktsoglou T, Becker L, Shah K, Kulagin M, Guiet R, Camberis M, Schmidt A, Seitz A, Giacomin P, Le Gros G, Papayannopoulos V, Loukas A and Harris N (2020) Hookworms evade host immunity by secreting a deoxyribonuclease to degrade neutrophil extracellular traps. Cell Host & Microbe, 27 (2). pp. 277-289.e6

More

ResearchOnline@JCU stores 69+ research outputs authored by Dr Paul Giacomin from 2002 onwards.

Current and recent Research Funding to JCU is shown by funding source and project.

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current

• Airway Resident Memory T Cell Development and Persistence: The Key to Induction of Sterile Immunity against Pulmonary Tuberculosis? (PhD , Secondary Advisor)
• Hookworm Extracellular Vesicle microRNAs target Mammalian Host Genes involved in Inflammation (PhD , Secondary Advisor)
• Understanding Immunogenicity, Safety and Protective Efficacy of next-generation Vaccines for Tuberculosis (PhD , Secondary Advisor)
• Novel type 2 diabetes therapeutics from recombinant human hookworm secretome (PhD , Secondary Advisor)
• The Role of Intestinal T Cells in Gut Homeostasis and Disease (PhD , Secondary Advisor)

Completed

• Regulation of immunity and inflammation during parasitic helminth infection by inflammasomes (2019, PhD , Primary Advisor)
• Investigating the immunomodulatory properties of the hookworm recombinant secretome (2019, PhD , Secondary Advisor)
• Molecular profiling of immunity to infectious disease using human challenge models (2020, PhD , Secondary Advisor)
• Characterisation of Necator americanus excretory/secretory products (2020, PhD , Secondary Advisor)
• The anti-colitic properties of hookworm protein Na-AIP-1 (2020, PhD , Secondary Advisor)
• Quantitative assessment of covariants of root canal treatment efficacy in human teeth (2018, PhD , Secondary Advisor)
• Experimental Hookworm Infection in Humans with Metabolic Disease (2022, PhD , Primary Advisor)

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.