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Current and recent Research Funding to JCU is shown by funding source and project.

Townsville Hospital and Health Service - Study Education Research Trust Account (SERTA)

Measuring aspirinand its biometabolites penetration into synovial fluid to assess its potential for prevention of prosthetic joint infection using I vintro and experimental animal models

Indicative Funding
$15,800 over 2 years
Summary
Aspirin has biofilm inhibiting activity which may be useful in prevention or treatment of prosthetic joint infection. Such infections are extremely difficult to treat and are unlikely to be cured. We will investigate whether combinations of this drug with antibacterials breaks down biofilms. In vitro assays measuring changes in biofilm measured by EISA readers will be used to determine which bacteria and drug combination to use in animal mode studies. Mice will have an infected surgical device inserted into the leg to emulate joint infection. Treatment consisting of preventative aspirin and a single dose of antibiotic will be used to assess the amount ad type of infection present. Positive results could see aspirin added in combination with antibiotics for treatment and prevention of prosthetic joint infection.
Investigators
Damon Eisen and Peter Mulvey (College of Medicine & Dentistry and Australian Institute of Tropical Health & Medicine)
Keywords
Biofilms; Infection; Aspirin; In Vitro; Mouse Model
Supervision

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current
  • Effectiveness of Salicylic Acid and Ibuprofen in Disrupting Bacterial Biofilm Formation (PhD , External Advisor)

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