Dr Sacha Jensen ~ Senior Lecturer
Biomedical Sciences and Molecular Biology
- About
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- Teaching
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- BC3102: Molecular Basis of Disease (Level 3; TSV)
- BC3201: Bioengineering (Level 3; TSV)
- BC3202: Special Topics in Biochemistry and Molecular Biology (Level 3; TSV)
- BC5102: Advanced Molecular Basis of Disease (Level 5; TSV)
- BC5201: Advanced Bioengineering (Level 5; TSV)
- BM1000: Introductory Biochemistry and Microbiology (Level 1; TSV)
- BM3000: Advanced Projects in Biomedicine (Level 3; TSV)
- BM5000: Advanced Projects in Biomedicine (Level 5; TSV)
- TV1102: Cell Biology and Biochemistry for Veterinary Science and Agriculture (Level 1; TSV)
- Research Disciplines
- Socio-Economic Objectives
- Publications
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These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.
- Journal Articles
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- Meng Y, Sanlidag S, Jensen S, Burnap S, Struwe W, Section A, Feng X, Mittal S, Sansom M, Sahlgren C and Handford P (2022) An N-glycan on the C2 domain of JAGGED1 is important for Notch activation. Science Signaling, 15 (755).
- Jensen S, Atwa O and Handford P (2021) Assembly assay identifies a critical region of human fibrillin-1 required for 10 - 12 nm diameter microfibril biogenesis. PLoS ONE, 16 (3).
- Del Cid J, Isik Reed N, Molnar K, Liu S, Dang B, Jensen S, DeGrado W, Handford P, Sheppard D and Sundaram A (2019) A disease associated mutation in fibrillin-1 differentially regulates integrin mediated cell adhesion. Journal of Biological Chemistry, 294 (48). pp. 18232-18243
- Pfeffer I, Brewitz L, Krojer T, Jensen S, Kochan G, Kershaw N, Hewitson K, McNeill L, Kramer H, Münzel M, Hopkinson R, Oppermann U, Handford P, McDonough M and Schofield C (2019) Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern. Nature Communications, 10.
- Robertson I, Dias H, Osuch I, Lowe E, Jensen S, Redfield C and Handford P (2017) The N-terminal region of Fibrillin-1 mediates a bipartite interaction with LTBP1. Structure, 25 (8). pp. 1208-1221.e5
- Jensen S and Handford P (2016) New insights into the structure, assembly and biological roles of 10–12 nm connective tissue microfibrils from fibrillin-1 studies. Biochemical Journal, 473 (7). pp. 827-838
- Jensen S, Iqbal S, Bulsiewicz A and Handford P (2015) A microfibril assembly assay identifies different mechanisms of dominance underlying Marfan syndrome, stiff skin syndrome and acromelic dysplasias. Human Molecular Genetics, 24 (15). pp. 4454-4463
- Jensen S, Aspinall G, Handford P and (2014) C-terminal propeptide is required for fibrillin-1 secretion and blocks premature assembly through linkage to domains cbEGF41-43. Proceedings of the National Academy of Sciences of the United States of America, 111 (28). pp. 10155-10160
- Current Funding
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Current and recent Research Funding to JCU is shown by funding source and project.
The Marfan Foundation - Research Grant
Mechanisms determining Marfan syndrome severity
- Indicative Funding
- $100,000 over 3 years
- Summary
- Marfan syndrome (MFS), caused by defects in the protein fibrillin-1, has a wide spectrum of severity with symptoms affecting the heart, bones and eyes. The cause of this variation in severity is unclear. Severe, neonatal MFS and Beal's syndrome result from mutations in corresponding parts of the proteins fibrilin-1 and fibrillin-2. Using clues from these diseases, this project will use new cell engineering techniques to determine why some fibrillin mutations are more severe than others. The results are relevant not only to understanding MFS, but also to understanding how the tissues in our bodies are developed and maintained.
- Investigators
- Sacha Jensen (College of Public Health and Medical & Vet Sciences)
- Keywords
- Marfan Syndrome; Extracellular Matrix; Microfibrils; Pathogenesis; Genome editing; Fibrillin
- Supervision
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Advisory Accreditation: I can be on your Advisory Panel as a Secondary Advisor.
These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.
- Current
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- Striking Gold - Determining the genetic Drivers of Gold Coloration in Barramundi (PhD , Secondary Advisor)
- Synthesis of GFP-tagged fibrillin-2 to study the pathogenesis of congenital contractural arachnodactyly (CCA) (Masters , Secondary Advisor)
- Completed
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- Development of a high-throughput HIV-1 integrase drug screening platform (2023, Masters , External Advisor)
- Defining the ancestral replication fork trap in Tus-dependent bacteria (2021, Masters , External Advisor)
- Collaboration
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The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.- 5+ collaborations
- 4 collaborations
- 3 collaborations
- 2 collaborations
- 1 collaboration
- Indicates the Tropics (Torrid Zone)
Connect with me
- Phone
- Location
- Advisory Accreditation
- Secondary Advisor
- Find me on…
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