Dr Shiv Thanigaimani ~ Post-Doctoral Research Scientist

Biography:

I was trained in biotechnology at Flinders University and received a Ph.D. in Medicine from the University of Adelaide after completing a research program investigating reverse atrial remodeling in a hypertensive large animal model. I continued to explore the prevention of atrial remodeling with small animal models during my work as a postdoctoral fellow. Later, I joined Prof. Jonathan Golledge group at the Queensland Research Centre for Peripheral Artery Diseases and currently appointed as a postdoctoral research scientist.

Research:

My broad research interests span within vascular biology, specifically in understanding the mechanisms of abdominal aortic aneurysm and peripheral vascular diseases. My primary focus is to unravel the mechanisms involved in vascular inflammation and endothelial injury of these diseases using in vitro and pre-clinical models and identifying novel biomarkers for early detection in clinical diagnostics, thereby improving quality of life in patients and their subsequent management.

Currently, I am investigating the potential for the DMARD class of drugs to limit AAA progression. I would welcome any inquiries from students interested in gaining research experience or undertaking honors or Ph.D. research projects in vascular biology.

Scientific contribution:

Reviewer for a number of peer-reviewed journals including International Journal of Medical Sciences (IJMS), Journal of Clinical Medicine (JCM), Current Molecular Medicine (CMM), Current Vascular Pharmacology (CVP), Current Biotechnology, Molecules, Materials, Medical sciences, Cells, and Letters for drug design & discovery.

Interests

Professional

• Vascular biology

Research

• Abdominal aortic aneurysm
• Peripheral artery disease
• Vascular inflammation
• Endothelial injury
• Clinical research
• Statistics

Experience

• 2019 to present - Postdoctoral Research Scientist, James Cook University (Australia)
• 2016 to 2018 - Postdoctoral fellow, University of Adelaide (Australia)
• 2014 to 2016 - Research Assistant, University of Adelaide (Australia)

Awards

• 2016 - Second prize: Young Investigator award – Asia Pacific Heart rhythm society. Seoul, South Korea
• 2016 - Finalist: Ralph reader prize – Cardiac Society of Australia and New Zealand. Adelaide, Australia
• 2015 - Winner: Victorian government educational grant allowance – Asia Pacific Heart rhythm society. Melbourne, Australia.
• 2015 - Finalist: Young Investigator award – Asia Pacific Heart rhythm society. Melbourne, Australia
• 2014 - Dean’s commendation for doctoral thesis excellence: University of Adelaide
• 2014 - Finalist: Best oral presentation Asia Pacific Heart rhythm society. New Delhi, India

Other

• 2016 - Discipline of Medicine Travel grant, The University of Adelaide
• 2013 - Discipline of Medicine Travel grant, The University of Adelaide
• 2011 to 2014 - The University of Adelaide full fee waiver scholarship
• 2011 to 2014 - Peter Hetzel electrophysiology scholarship

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

• Phie J, Thanigaimani S and Golledge J (in press) Systematic review and meta-analysis of interventions to slow progression of abdominal aortic aneurysm in mouse models. Arteriosclerosis, Thrombosis and Vascular Biology, , DOI:10.1161/ATVBAHA.121.315942.
• Golledge J, Rowbotham S, Velu R, Quigley F, Jenkins J, Bourke M, Bourke B, Thanigaimani S, Chan D and Watts G (2020) Association of serum lipoprotein (a) with the requirement for a peripheral artery operation and the incidence of major adverse cardiovascular events in people with peripheral artery disease. Journal of the American Heart Association, 9 (6), Article: e015355, DOI:10.1161/JAHA.119.015355.
• Thanigaimani S, Phie J and Golledge J (2020) Animal models of ischemic limb ulcers: a systematic review and meta-analysis. BMJ Open Diabetes Research & Care, 8, Article: e001676, DOI:10.1136/bmjdrc-2020-001676.
• Dharmaprani D, McGavigan A, Chapman D, Kutlieh R, Thanigaimani S, Dykes L, Kalman J, Sanders P, Pope K, Kuklik P and Ganesan A (2019) Temporal stability and specificity of high bipolar electrogram entropy regions in sustained atrial fibrillation: implications for mapping. Journal of Electrocardiology, 53, pp. 18-27, DOI:10.1016/j.jelectrocard.2018.11.014.
• Thanigaimani S, McLennan E, Linz D, Mahajan R, Agbaedeng T, Lee G, Kalman J, Sanders P and Lau D (2017) Progression and reversibility of stretch induced atrial remodeling: characterization and clinical implications. Progress in Biophysics and Molecular Biology, 130, pp. 376 - 386, DOI:10.1016/j.pbiomolbio.2017.07.010.
• Thanigaimani S, Brooks A, Kuklik P, Twomey D, Franklin S, Noschka E, Chapman D, Pathak R, Mahajan R, Sanders P and Lau D (2017) Spatiotemporal characteristics of atrial fibrillation electrograms: a novel marker for arrhythmia stability and termination. Journal of Arrhythmia, 33 (1), pp. 40-48, DOI:10.1016/j.joa.2016.05.009.
• Thanigaimani S, Lau D, Agbaedeng T, Elliott A, Mahajan R and Sanders P (2017) Molecular mechanisms of atrial fibrosis: implications for the clinic. Expert Review of Cardiovascular Therapy, 15 (4), pp. 247-256.
• Mahajan R, Lau D, Brooks A, Shipp N, Manavis J, Wood J, Finnie J, Samuel C, Royce S, Twomey D, Thanigaimani S, Kalman J and Sanders P (2015) Electrophysiological, electroanatomical, and structural remodeling of the atria as consequences of sustained obesity. Journal of the American College of Cardiology, 66 (1), pp. 1-11, DOI:10.1016/j.jacc.2015.04.058.
• Ganesan A, Kuklik P, Lau D, Brooks A, Baumert M, Lim W, Thanigaimani S, Nayyar S, Mahajan R, Kalman J, Roberts-Thomson K and Sanders P (2013) Bipolar electrogram Shannon entropy at sites of rotational activation implications for ablation of atrial fibrillation. Circulation: Arrhythmia and Electrophysiology, 6 (1), pp. 48-57, DOI:10.1161/CIRCEP.112.976654.
• Lau D, Shipp N, Kelly D, Thanigaimani S, Neo M, Kuklik P, Lim H, Zhang Y, Drury K, Wong C, Chia N, Brooks A, Dimitri H, Saint D, Brown L and Sanders P (2013) Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing. PLoS ONE, 8 (8), Article: e72416, DOI:10.1371/journal.pone.0072416.
• Thanigaimani S, Kichenadasse G and Mangoni A (2011) The emerging role of vascular endothelial growth factor (VEGF) in vascular homeostasis: Lessons from recent trials with anti-VEGF drugs. Current Vascular Pharmacology, 9 (3), pp. 358-380, DOI:10.2174/157016111795495503.

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