Dr Shiv Thanigaimani ~ Research Fellow, Peripheral Vascular Disease (PVD)

Biography:

I was trained in biotechnology at Flinders University and received PhD in Medicine from the University of Adelaide after completing a research program investigating reverse atrial remodeling in a hypertensive large animal model. I continued to explore the prevention of atrial remodeling with small animal models during my work as a postdoctoral fellow. Later, I joined as a postdoctoral research scientist at the Queensland Research Centre for Peripheral Artery Diseases. In 2023, I was promoted as Research fellow (Peripheral vascular disease).

Research:

My broad research interests span within vascular biology, specifically in understanding the risk factors and mechanisms of peripheral artery diseases. I primarily perform pre-clinical and in vitro studies involving development of PAD animal models via microsurgery, tissue culture and a number of molecular biology techniques. Clinically, I am involved in determining risk factors of PAD through various statistical techniques using prospectively collected patient data. My research aim is to enable direct translation of my work towards improving patient management.

I would welcome any inquiries from students interested in gaining research experience or undertaking honors or PhD research projects in topics including abdominal aortic aneurysm, limb ischemia and limb ulcers.

Scientific contribution:

International advisory board member - CIMSER, Loyola college, India.

Grant reviewer - Diabetes Australia.

Editorial board member - BMC cardiovascular disorders, BMC research notes, Cardiovascular therapeutics.

Review editor - Frontiers (General Cardiovascular Medicine, Atherosclerosis and Vascular Medicine, Aortic surgery and endovascular repair).

Peer reviewer - European Journal of Pharmacology, International Journal of Medical Sciences (IJMS), Cells, Journal of Clinical Medicine (JCM), Current Molecular Medicine (CMM), Current Vascular Pharmacology (CVP) and Molecules.

Interests

Professional

• Vascular biology

Research

• Abdominal aortic aneurysm
• Limb ischemia
• Statistical techniques

Experience

• 2023 to present - Research fellow, James Cook University (Australia)
• 2019 to 2022 - Postdoctoral Research Scientist, James Cook University (Australia)
• 2016 to 2018 - Postdoctoral fellow, University of Adelaide (Australia)
• 2014 to 2016 - Research Assistant, University of Adelaide (Australia)

Research Disciplines

• Cardiovascular medicine and haematology (3201)

Socio-Economic Objectives

• Clinical health (2001)

Awards

• 2016 - Second prize: Young Investigator award – Asia Pacific Heart rhythm society. Seoul, South Korea
• 2016 - Finalist: Ralph reader prize – Cardiac Society of Australia and New Zealand. Adelaide, Australia
• 2015 - Winner: Victorian government educational grant allowance ($1,000) – Asia Pacific Heart rhythm society. Melbourne, Australia.
• 2015 - Finalist: Young Investigator award – Asia Pacific Heart rhythm society. Melbourne, Australia
• 2014 - Dean’s commendation for doctoral thesis excellence: University of Adelaide
• 2014 - Finalist: Best oral presentation Asia Pacific Heart rhythm society. New Delhi, India

Memberships

• 2021 - Queensland Cardiovascular Research Network

Other

• 2022 - Incentive grant ($4500), College of Medicine & Dentistry, James Cook University
• 2016 - Discipline of Medicine Travel grant ($2,000), The University of Adelaide
• 2013 - Discipline of Medicine Travel grant ($2,000), The University of Adelaide
• 2011 to 2014 - Peter Hetzel electrophysiology scholarship ($122,500 for 3.5 years)
• 2011 to 2014 - The University of Adelaide full fee waiver scholarship ($98,000 for 3.5 years)

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

• Golledge J, Thanigaimani S, Barratt K and Fadini G (in press) Recent developments in targets for ischemic foot disease. Diabetes/Metabolism Research and Reviews,
• Alahakoon C, Thanigaimani S, Seng L, Fernando M, Lazzarini P and Golledge J (2023) A Systematic Review and Meta-Analysis of the Incidence and Risk Factors for Re-admission to Hospital in People with Diabetes Related Foot Disease. European Journal of Vascular and Endovascular Surgery, 66 (2). pp. 195-202
• Golledge J, Thanigaimani S, Powell J and Tsao P (2023) Pathogenesis and management of abdominal aortic aneurysm. European Heart Journal, 44 (29). pp. 2682-2697
• Sharma C, Singh T, Thanigaimani S, Nastasi D and Golledge J (2023) A Systematic Review and Meta-Analysis of the Incidence and Risk Factors for Major Adverse Cardiovascular Events in Patients with Unrepaired Abdominal Aortic Aneurysms. Biomedicines, 11 (4).
• Thanigaimani S, Jin H, Ahmad U, Anbalagan R and Golledge J (2023) Comparative efficacy of growth factor therapy in healing diabetes-related foot ulcers: A network meta-analysis of randomized controlled trials. Diabetes/Metabolism Research and Reviews, 39 (5).
• Thanigaimani S, Iyer V, Bingley J, Browne D, Phie J, Doolan D and Golledge J (2023) Association Between Serum MicroRNAs and Abdominal Aortic Aneurysm Diagnosis and Growth. European Journal of Vascular and Endovascular Surgery, 65 (4). pp. 573-581
• Golledge J and Thanigaimani S (2022) Role of Sclerostin in Cardiovascular Disease. Arteriosclerosis, Thrombosis and Vascular Biology, 42. pp. e187-e202
• Matthews E, Moxon J, Singh T, Thanigaimani S, Jones R, Gasser T, Fitridge R, Lindeman J, Dalman R and Golledge J (2022) Athero-occlusive disease appears to be associated with slower abdominal aortic aneurysm growth: an exploratory analysis of the TEDY trial. European Journal of Vascular and Endovascular Surgery, 63 (4). pp. 632-640
• Phie J, Thanigaimani S, Huynh P, Anbalagan R, Moran C, Kinobe R, Moxon J, Field M, Krishna S and Golledge J (2022) Colchicine Does Not Reduce Abdominal Aortic Aneurysm Growth in a Mouse Model. Cardiovascular Therapeutics, 2022.
• Thanigaimani S, Phie J, Quigley F, Bourke M, Bourke B, Velu R, Jenkins J and Golledge J (2022) Immunosuppressive drugs for nontransplant comorbidities are not associated with abdominal aortic aneurysm growth. JVS: Vascular Science, 3. pp. 306-313
• Thanigaimani S, Ibrahim M and Golledge J (2022) Potential of Disease-Modifying Anti-Rheumatic Drugs to Limit Abdominal Aortic Aneurysm Growth. Biomedicines, 10 (10).
• Thanigaimani S, Jin H, Silva M and Golledge J (2022) Network Meta-Analysis of Trials Testing If Home Exercise Programs Informed by Wearables Measuring Activity Improve Peripheral Artery Disease Related Walking Impairment. Sensors, 22 (20).

More

ResearchOnline@JCU stores 36+ research outputs authored by Dr Shiv Thanigaimani from 2011 onwards.

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current

• Evaluation of the Effect of a Direct 5' Adenosine Monophosphate-activated protein (AMP) Kinase (AMPK) Activator in Inhibiting Abdominal Aortic Aneurysms (AAA) in Mouse Model (PhD , Secondary Advisor)
• Using rodent models to develop new treatments for aortic aneurysm (PhD , Secondary Advisor)
• Developing a Risk Score to predict the Risk of Major Adverse Cardiovascular events in Patients with Abdominal Aortic Aneurysm (Masters , Secondary Advisor)
• Investigating a novel potential therapy for abdominal aortic aneurysm (PhD , Secondary Advisor)
• Effect of interleukin-6 blocking antibody on aneurysm growth in an elastase-BAPN induced abdominal aortic aneurysm mouse model (PhD , Secondary Advisor)

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.