Role and responsibilities within the QRC-PVD:

Currently, I lead one of the preclinical team within the QRC-PVD with a special focus on development and use of preclinical models of blocked arteries (peripheral arterial diseases; PAD) and weakened arteries (abdominal aortic aneurysms; AAA). Translational research involves applying insights and discoveries generated by basic scientific inquiry for the treatment or prevention of human diseases. The long-term objective of the translational research program in the QRC-PVD is to develop new treatments for PAD and AAA. One of the limitations of preclinical work is the lack of appropriate pre-clinical models covering important aspects of the human disease. To address this problem, one focus of the research within the QRC-PVD has been examining the clinical relevance of pre-clinical models. The models currently being assessed within the QRC-PVD include various models of AAA, lower limb ischemia and stroke.

I am also involved in the QRC-PVD Management and Biobank Sample committees to facilitate goal oriented progress of the team. I currently co-supervise 4 PhD students that are working on the topics of therapeutic revascularisation in lower limb ischemia and nutritional intervention in AAA. I invite expressions of interest from capable and committed prospective students interested in becoming involved in peripheral artery research.

I was awarded a PhD in 2006 in Cancer Biology from the Laboratory of Tumour Immunology and Functional Genomics in Regional Cancer Centre, India. The project focused on the viral and environmental interaction of various cell-cycle regulatory proteins which lead to cancer. The work identified crucial molecular pathways which are affected by the DNA virus infection and the relation to the response of the patients to anti-cancer therapy. I did my Postdoctoral research in the Immunology Department in the Faculty of Medicine & Health Sciences in UAE University and worked for 3 years in the Molecular Biology & Genetics Laboratory under the Dubai Government as a Senior Research Scientist. My work mainly focused on analysis of gene expression patterns and epigenetic silencing of genes under physiological and environmental stress. The research involved sophisticated molecular biology techniques including development of cDNA libraries, BAC libraries, SNP analysis and microarray analysis. I joined the QRC-PVD in 2009 and continued researching on the genetic and epigenetic alterations leading to the development of PAD.

Research/projects:

My primary interest is translational research aimed at better understanding the molecular and cellular mechanisms involved in development and progression of PAD and AAA.

Specific interests include:

1. Developing and refining Preclinical models of PAD and AAA.

2. Testing therapeutic interventions in preclinical models;

3. Genetic and epigenetic alterations in the pathology of PAD and AAA. 

Teaching

• MD1010: Introduction to Integrated Medical Studies Part 1 of 2 (Level 1; TSV)
• MD3011: Introduction to Clinical Healthcare Part 1 of 2 (Level 3; TSV)

Interests

Research

• Atherosclerosis, cardiovascular, Vascular, ischemia, angiogenesis, epigenetics, funtional genomics, nutrigenomics

Research Disciplines

• Cardiovascular Medicine and Haematology (1102)

Socio-Economic Objectives

• Clinical Health (9201)

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

• Krishna S, Moran C, Jose R, Lazzaroni S, Huynh P and Golledge J (2019) Depletion of CD11c+ dendritic cells in apolipoprotein E-deficient mice limits angiotensin II-induced abdominal aortic aneurysm formation and growth. Clinical Science, 133 (21), Article: 7, pp. 2203-2215, DOI:10.1042/CS20190924.
• Krishna S (2019) Vitamin D as a protector of arterial health: potential role in peripheral arterial disease formation. International Journal of Molecular Sciences, 20 (19), Article: 4907, DOI:10.3390/ijms20194907.
• Thomas Manapurathe D, Moxon J, Krishna S, Rowbotham S, Quigley F, Jenkins J, Bourke M, Bourke B, Jones R and Golledge J (2019) Cohort study examining the association between blood pressure and cardiovascular events in patients with peripheral artery disease. Journal of the American Heart Association, 8, Article: e010748, DOI:10.1161/JAHA.118.010748.
• Krishna S, Moxon J, Jose R, Sahebkar A, Hatamipour M, Liu D and Golledge J (2018) Anionic nanoliposomes reduced atherosclerosis progression in Low Density Lipoprotein Receptor (LDLR) deficient mice fed a high fat diet. Journal of Cellular Physiology, 233 (10), pp. 6951-6964, DOI:10.1002/jcp.26610.
• Phie J, Moxon J, Krishna S, Kinobe R, Morton S and Golledge J (2018) A diet enriched with tree nuts reduces severity of atherosclerosis but not abdominal aneurysm in angiotensin II-infused apolipoprotein E deficient mice. Atherosclerosis, 277, pp. 28-33, DOI:10.1016/j.atherosclerosis.2018.08.004.
• Rowbotham S, Krishna S, Moran C and Golledge J (2018) Fenofibrate and telmisartan in the management of abdominal aortic aneurysm. Current Drug Targets, 19 (11), pp. 1241-1246, DOI:10.2174/1389450119666171227224655.
• Krishna S, Seto S, Jose R, Li J, Morton S, Biros E, Wang Y, Nsengiyumva V, Lindeman J, Loots G, Rush C, Craig J and Golledge J (2017) Wnt signaling pathway inhibitor sclerostin inhibits angiotensin II-induced aortic aneurysm and atherosclerosis. Arteriosclerosis, Thrombosis and Vascular Biology, 37 (3), pp. 553-566, DOI:10.1161/ATVBAHA.116.308723.
• Krishna S, Seto S, Jose R, Li J, Moxon J, Clancy P, Crossman D, Norman P, Emeto T and Golledge J (2017) High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency promotes angiotensin-II induced aneurysm in mice. Clinical Science, 131 (12), pp. 1261-1281, DOI:10.1042/CS20160970.
• Moran C, Biros E, Krishna S, Wang Y, Tikellis C, Moxon J, Cooper M, Norman P, Burrell L, Thomas M and Golledge J (2017) Resveratrol inhibits growth of experimental abdominal aortic aneurysm associated with upregulation of angiotensin-converting enzyme 2. Arteriosclerosis Thrombosis and Vascular Biology, 37 (11), pp. 2195-2218, DOI:10.1161/ATVBAHA.117.310129.
• Moran C, Seto S, Krishna S, Sharma S, Jose R, Biros E, Wang Y, Morton S and Golledge J (2017) Parenteral administration of factor Xa/IIa inhibitors limits experimental aortic aneurysm and atherosclerosis. Scientific Reports, 7, Article: 43079, pp. 1-12, DOI:10.1038/srep43079.
• Phie J, Krishna S, Moxon J, Omer S, Kinobe R and Golledge J (2017) Flavonols reduce aortic atherosclerosis lesion area in apolipoprotein E deficient mice: a systematic review and meta-analysis. PLoS ONE, 12 (7), Article: e0181832, pp. 1-13, DOI:10.1371/journal.pone.0181832.
• Thomas Manapurathe D, Krishna S, Dewdney B, Moxon J, Biros E and Golledge J (2017) Effect of blood pressure lowering medication on peripheral artery disease: a meta-analysis of randomised controlled trials. PLoS ONE, 12 (6), Article: e0178713, pp. 1-12, DOI:10.1371/journal.pone.0178713.

Current and recent Research Funding to JCU is shown by funding source and project.

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current

• Utilising novel clinically relevant mouse models to test new therapeutic interventions for peripheral artery diseases (PhD , Secondary Advisor)
• Assessment and Intervention of Dietary Patterns in Patients with Peripheral Arterial Disease and Abdominal Aortic Aneurysm (PhD , Secondary Advisor)
• Development and Implementation of Plasma Polymer Thin Films for Enhanced Biocompatibility in Medical Implants (PhD , Secondary Advisor)

Completed

• The role of vitamin D in the development and progression of experimental abdominal aortic aneurysm (2020, PhD , Secondary Advisor)
• A new mouse model of peripheral artery disease: development, validation and assessment of a potential intervention and a therapeutic target (2019, PhD , Secondary Advisor)

The map shows research collaborations by institution from the past 7 years.
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