Dr Stephan Karl ~ Senior Research Fellow, Malaria and Vector Biology
Australian Institute of Tropical Health & Medicine
- About
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- Research Disciplines
- Socio-Economic Objectives
Dr Karl has a M. Sc. in Biological Process Engineering (2007) and a PhD in biophysics (University of Western Australia, 2012). He has done postdocs in vector-borne diseases epidemiology and entomology at Walter and Eliza Hall Institute , James Cook University and PNG Institute of Medical Research. He is currently a Senior Research Officer in the Australian Institute of Tropical Health and Medicine at JCU and laboratory head of the entomology section at the PNG Institute of Medical Research. He has 65 research papers mainly in the field of vector-borne tropical diseases, a 14 year collaborative history with the PNG Institute of Medical Research and more than 5 years of full-time in-country research experience in PNG.
Dr Karl is currently a project leader in the NIH-funded Asia-Pacific Centre of Excellence in Malaria Research in PNG (2017-2023) and a program director in an Australian Department of Foreign Affairs and Trade-funded program to strengthen surveillance and control of malaria and arboviruses in PNG (Strive PNG, 2018-2020). Dr Karl is also leading the Global Fund to Fight Aids, Malaria and Tuberculosis-funded mosquito monitoring activities in PNG (since 2017) as well as various studies funded by the Bill and Melinda Gates Foundation, Australian National Health and Medical Research Council and the Commonwealth Scientific and Industrial Research Organisation.
- Publications
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These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.
- Journal Articles
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- Gruenberg M, Hofmann N, Nate E, Karl S, Robinson L, Lanke K, Smith T, Bousema T and Felger I (2020) qRT-PCR versus IFA-based quantification of male and female gametocytes in low-density Plasmodium falciparum infections and their relevance for transmission. Journal of Infectious Diseases, 221 (4), pp. 598-607, DOI:10.1093/infdis/jiz420.
- Demok S, Endersby-Harshman N, Vinit R, Timinao L, Robinson L, Susapu M, Makita L, Laman M, Hoffmann A and Karl S (2019) Insecticide resistance status of Aedes aegypti and Aedes albopictus mosquitoes in Papua New Guinea. Parasites & Vectors, 12, Article: 333, DOI:10.1186/s13071-019-3585-6.
- Keven J, Katusele M, Vinit R, Koimbu G, Vincent N, Thomsen E, Karl S, Reimer L and Walker E (2019) Species abundance, composition, and nocturnal activity of female Anopheles (Diptera: Culicidae) in malaria-endemic villages of Papua New Guinea: assessment with barrier screen sampling. Malaria Journal, 18, Article: 96, DOI:10.1186/s12936-019-2742-x.
- Nguitragool W, Karl S, White M, Koepfli C, Felger I, Singhasivanon P, Mueller I and Sattabongkot J (2019) Highly heterogeneous residual malaria risk in western Thailand. International Journal for Parasitology, 49 (6), pp. 455-462, DOI:10.1016/j.ijpara.2019.01.004.
- Ome-Kaius M, Kattenberg J, Zaloumis S, Siba M, Kiniboro B, Jally S, Razook Z, Mantila D, Sui D, Ginny J, Rosanas-Urgell A, Karl S, Obadia T, Barry A, Rogerson S, Laman M, Tisch D, Felger I, Kazura J, Mueller I and Robinson L (2019) Differential impact of malaria control interventions on P. falciparum and P. vivax infections in young Papua New Guinean children. BMC Medicine, 17, Article: 220, DOI:10.1186/s12916-019-1456-9.
- Quah Y, Waltmann A, Karl S, White M, Vahi V, Darcy A, Pitakaka F, Whittaker M, Tisch D, Barry A, Barnadas C, Kazura J and Mueller I (2019) Molecular epidemiology of residual Plasmodium vivax transmission in a paediatric cohort in Solomon Islands. Malaria Journal, 18, Article: 106, DOI:10.1186/s12936-019-2727-9.
- Unger H, Hansa A, Buffet C, Hasang W, Teo A, Randall L, Ome-Kaius M, Karl S, Anuan A, Beeson J, Mueller I, Stock S and Rogerson S (2019) Sulphadoxine-pyrimethamine plus azithromycin may improve birth outcomes through impacts on inflammation and placental angiogenesis independent of malarial infection. Scientific Reports, 9, Article: 2260, DOI:10.1038/s41598-019-38821-2.
- Koimbu G, Czeher C, Katusele M, Sakur M, Kilepak L, Tandrapah A, Hetzel M, Pulford J, Robinson L and Karl S (2018) Status of insecticide resistance in Papua New Guinea: an update from nation-wide monitoring of Anopheles mosquitoes. American Journal of Tropical Medicine and Hygiene, 98 (1), pp. 162-165, DOI:10.4269/ajtmh.17-0454.
- Waltmann A, Koepfli C, Tessier N, Karl S, Fola A, Darcy A, Wini L, Harrison G, Barnadas C, Jennison C, Karunajeewa H, Boyd S, Whittaker M, Kazura J, Bahlo M, Mueller I and Barry A (2018) Increasingly inbred and fragmented populations of Plasmodium vivax associated with the eastward decline in malaria transmission across the Southwest Pacific. PLoS Neglected Tropical Diseases, 12 (1), DOI:10.1371/journal.pntd.0006146.
- Schofield L, Ioannidis L, Karl S, Robinson L, Tan Q, Poole D, Betuela I, Hill D, Siba P, Hansen D, Mueller I and Eriksson E (2017) Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of gamma delta T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea. BMC Medicine, 15, Article: 114, DOI:10.1186/s12916-017-0883-8.
- Karl S, Laman M, Moore B, Benjamin J, Salib M, Lorry L, Maripal S, Siba P, Robinson L, Mueller I and Davis T (2016) Risk factors for Plasmodium falciparum and Plasmodium vivax gametocyte carriage in Papua New Guinean children with uncomplicated malaria. Acta Tropica, 160, pp. 1-8, DOI:10.1016/j.actatropica.2016.04.002.
- Waltmann A, Karl S, Chiu C and Mueller I (2016) Limited degradation of the Plasmodium falciparum gametocyte marker pfs25 mRNA exposed to tropical temperatures: considerations for malaria transmission field studies. American Journal of Tropical Medicine and Hygiene, 94 (4), pp. 886-889, DOI:10.4269/ajtmh.15-0531.
- More
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ResearchOnline@JCU stores 20+ research outputs authored by Dr Stephan Karl from 2014 onwards.
- Current Funding
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Current and recent Research Funding to JCU is shown by funding source and project.
Macfarlane Burnet Institute for Medical Research and Public Health - Contract Research
Newly adopted tools and network against disease transmission (NATNAT)
- Indicative Funding
- $479,827 over 4 years
- Summary
- The proposed consortia and the NATNAT project, will support the Papua New Guinea Institute of Medical Research (PNGIMR) and PNG NDoH to adopt a 'framework for rapid assessment and adoption of new vector control tools' (VCTs) [1] for PNG and the South Pacific Region, including VCTs targeted at controlling Anopheline and Aedine populations.
- Investigators
- Stephan Karl in collaboration with Leanne Robinson and Moses LAMAN (Australian Institute of Tropical Health & Medicine, Burnet Institute and Institute of Medical Research (PNG))
- Keywords
- Capacity Building; Quality Control; Papua New Guinea; Education; Resistance; Empowerment
Government Department of Foreign Affairs and Trade - Pacific Infectious Disease Prevention (PIDP) Program
Building Capacity for Evidence Based Sustainable Vector Surveillance and Control in the Pacific
- Indicative Funding
- $5,124,884 over 2 years
- Summary
- This proposal will build the capacity of country-led programs for Aedes and anopheline borne disease control across Pacific Island countries to implement sustainable best practice surveillance and response plans based on a foundation of improved capacity and community engagement
- Investigators
- Tom Burkot, Tanya Russell, Stephan Karl, Kyran Staunton, Tessa Knox, Rabindra Abeyasinghe, Angela Merianos, Gregor Devine, Michael Nunan, Gerard Kelly, Lisa Natoli, Veronica Bell, Moses LAMAN, Adam Craig, Nigel Beebe and Leanne Robinson (Australian Institute of Tropical Health & Medicine, College of Public Health, Medical & Vet Sciences, World Health Organisation (Switzerland), Queensland Institute of Medical Research, Beyond Essential Systems, Red Cross Australia, Institute of Medical Research (PNG), The University of New South Wales, The University of Queensland and Burnet Insitute)
- Keywords
- Dengue; Aedes; Capacity Building; Ministry of Health; Pacific region; Anopheles
Government Department of Foreign Affairs and Trade - DFAT Stronger Systems For Health Security
Stronger surveillance and systems support for rapid identification and containment of resurgent or resistant vector borne pathogens in Papua New Guinea.
- Indicative Funding
- $121,016 over 3 years (administered by Burnet Institute)
- Summary
- This project is aimed at stronger surveillance and systems support for rapid identification and containment of resurgent or resistant vector borne pathogens in Papua New Guinea. The subcontract to JCU includes a specific work package on arbovirus and malaria mosquito surveillance.
- Investigators
- Leanne Robinson, Stephan Karl, Alyssa Barry, Nigel Beebe and Jack Richards in collaboration with Moses LAMAN, Ivo Mueller, Evelyn Lavu, Lucy John, Christopher Morgan, Freya Fowkes, David Williams, Leo Makita, Nakapi Tefuarani, Nick Scott, Paul Horwood, Qin Cheng, Richard Price, Tom Burkot and William Pomat (Burnet Insitute, Papua New Guinea Institute of Medical Research, Walter & Eliza Hall Institute of Medical Research, Central Public Health Laboratory, National Department of Health (PNG), Australian Institute of Tropical Health & Medicine, The University of Queensland, Commonwealth Scientific & Industrial Research Organisation, University of Papua New Guinea, College of Public Health, Medical & Vet Sciences, Army Malaria Institute and Menzies Health Institute Queensland)
- Keywords
- Papua New Guinea; Health System Strengthening; Malaria; Arbovirus; Surveillance; Control
National Health & Medical Research Council - Career Development Fellowship
Plasmodium vivax transmission blocking studies in the South Pacific
- Indicative Funding
- $437,034 over 4 years
- Summary
- This project is aimed at better understanding transmission of P. vivax, the world's most widely spread malaria parasite. Using a newly established experimental platform that enables us to feed P. vivax infected blood to Anopheles farauti mosquitoes, we can start researching factors in human blood that determine P. vivax infection success, test new vaccine and drug candidates for their ability to block transmission and thus significantly advance science surrounding this neglected parasite.
- Investigators
- Stephan Karl in collaboration with Louis Schofield, Tom Burkot, Vicky Avery, Ivo Mueller and Laman Moses (Australian Institute of Tropical Health & Medicine, Griffith University, Walter & Eliza Hall Institute of Medical Research and Institute of Medical Research (PNG))
- Keywords
- Plasmodium Vivax; Anopheles Farauti; Malaria Vaccines; antimalarial drugs; transmission blocking immunity; Papua New Guinea
ACIAR - Research Grant
A one health approach to establish surveillance strategies for Japanese encephalitis and zoonotic arboviruses in Papua New Guinea
- Indicative Funding
- $23,700 over 2 years (administered by CSIRO)
- Summary
- The project aim is to establish surveillance for JEV and other zoonotic arboviruses that affect the rural population of PNG. The major objectives are to: 1. Evaluate current detection methods to detect zoonotic arboviruses in the field and laboratory, and build capacity where gaps are identified. 2. Establish surveillance at selected sites using sentinel animal (pigs, chickens) and mosquito trapping 3. Develop linkages and coordination between human and animal health agencies. The primary outputs are to develop surveillance activities that contribute to early warning for public health and provide a better understanding of the ecological drivers of arboviruses in PNG.
- Investigators
- David Williams, Leanne Robinson, Paul Horwood, Stephan Karl and Dagmar Meyer Steiger (Australian Animal Health Laboratory, Burnet Insitute and Australian Institute of Tropical Health & Medicine)
- Keywords
- Japanese encephalitis virus; Arbovirus; Papua New Guinea; Mosquito; Vector; Zoonotic
National Health & Medical Research Council - Project Grant
Field-based evaluation of a novel magneto-optical technique to diagnose malaria
- Indicative Funding
- $204,975 over 4 years
- Summary
- This project is aimed at field testing a novel method to diagnose malaria using magneto-optics. The method is to be applied in Papua New Guinea, in collaboration with the PNG Institute of Medical Research. The project is 2 years into its 3 year duration and has so far successfully tested 1000 patients in PNG.
- Investigators
- Stephan Karl, Istvan Kezsmarki, Moses LAMAN, Malcolm Jones and Peter Metaxas in collaboration with Timothy Davis, Timothy St Pierre, Brioni Moore and Ivo Mueller (Australian Institute of Tropical Health & Medicine, Budapest University of Technology & Economics, Papua New Guinea Institute of Medical Research, The University of Queensland, The University of Western Australia and Walter & Eliza Hall Institute of Medical Research)
- Keywords
- Plasmodium Vivax; Malaria diagnosis; Plasmodium Falciparum; Papua New Guinea; magneto-optical
- Supervision
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Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.
These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.
- Current
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- Defining transmission of malaria parasites from humans to mosquitos in Papua New Guinea (PhD , Primary Advisor)
- Collaboration
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The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.- 5+ collaborations
- 4 collaborations
- 3 collaborations
- 2 collaborations
- 1 collaboration
- Indicates the Tropics (Torrid Zone)
Connect with me
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Similar to me
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Dr Tanya RussellAustralian Institute of Tropical Health & Medicine
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Prof Tom BurkotAustralian Institute of Tropical Health & Medicine
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Prof Louis SchofieldAustralian Institute of Tropical Health & Medicine
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Dr Adeshina AdekunleAustralian Institute of Tropical Health & Medicine
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Prof Maxine WhittakerCollege of Public Health, Medical & Vet Sciences