Dr Stephanie M. Ryan ~ Research Fellow

Dr Stephanie Ryan is currently an Early Career Post-Doctoral Research Fellow at the Australian Institute of Tropical Health and Medicine at JCU Cairns.

Before her PhD studies, Dr Ryan underwent immunoparasitology training at the University of Edinburgh between 2011 and 2014 in the laboratory of Professor Rick Maizels investigating the link between parasitic worm proteins and allergies. Her PhD studies at JCU focussed on the search for an alternative to live hookworm therapy for autoimmune diseases. Developing a high-throughput bioinformatics analysis pipeline to profile, identify and rapidly express candidates to assess their anti-inflammatory properties in models of inflammation. Since completing her PhD in 2019, her research interests involve exploring the use of worm proteins as novel anti-inflammatories to the treatment of allergic and autoimmune disorders and the mechanisms by which key immune cells and cytokines are altered. In 2020, Stephanie was chosen as a recipient of the Dean's Award for Higher Degree by Research Excellence. 

Teaching

• DS1101: Dental Science Part 1 of 2 (Level 1; CNS)

Interests

Research

• Therapeutic roles for helminths and their secretomes for treating allergic or autoimmune diseases

Experience

• 2019 to 2022 - Research Fellow, James Cook University (Australia)
• 2015 to 2019 - PhD Candidate, James Cook University (Australia)
• 2011 to 2014 - Research Assistant, University of Edinburgh (Scotland, U.K.)
• 2010 to 2011 - MSc Biomedical Science, Edinburgh Napier University (Scotland, U.K.)
• 2005 to 2009 - BSc (Hons) Biomedical Science, University of London (England, U.K.)

Research Disciplines

• Medical Microbiology (1108)
• Genetics (0604)
• Immunology (1107)

Socio-Economic Objectives

• Clinical Health (9201)
• Public Health (9204)

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU.

Journal Articles

• Ryan S, Eichenberger R, Ruscher R, Giacomin P and Loukas A (2020) Harnessing helminth-driven immunoregulation in the search for novel therapeutic modalities. PLoS Pathogens, 16 (5), Article: e1008508, DOI:10.1371/journal.ppat.1008508.
• Tedla B, Sotillo J, Pickering D, Eichenberger R, Ryan S, Becker L, Loukas A and Pearson M (2019) Novel cholinesterase paralogs of Schistosoma mansoni have perceived roles in cholinergic signaling and drug detoxification and are essential for parasite survival. PLoS Pathogens, 15 (12), Article: e1008213, DOI:10.1371/journal.ppat.1008213.
• Eichenberger R, Ryan S, Jones L, Buitrago G, Polster R, Montes de Oca M, Zuvelek J, Giacomin P, Dent L, Engwerda C, Field M, Sotillo J and Loukas A (2018) Hookworm secreted extracellular vesicles interact with host cells and prevent inducible colitis in mice. Frontiers in Immunology, 9, DOI:10.3389/fimmu.2018.00850.
• Lau C, Sheridan S, Ryan S, Roineau M, Andreosso A, Fuimaono S, Tufa J and Graves P (2017) Detecting and confirming residual hotspots of lymphatic filariasis transmission in American Samoa 8 years after stopping Mass Drug Administration. PLoS Neglected Tropical Diseases, 11 (9), Article: e0005914, DOI:10.1371/journal.pntd.0005914.
• Navarro S, Pickering D, Ferreira I, Jones L, Ryan S, Troy S, Leech A, Hotez P, Zhan B, Laha T, Prentice R, Sparwasser T, Croese J, Engwerda C, Upham J, Julia V, Giacomin P and Loukas A (2016) Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma. Science Translational Medicine, 8 (362), Article: 362ra143, DOI:10.1126/scitranslmed.aaf8807.
• Farnell E, Tyagi N, Ryan S, Chalmers I, Pinot de Moira A, Jones F, Wawrzyniak J, Fitzsimmons C, Tukahebwa E, Furnham N, Maizels R and Dunne D (2015) Known allergen structures predict Schistosoma mansoni IgE-binding antigens in human infection. Frontiers in Immunology, 6, Article: 26, pp. 1-14, DOI:10.3389/fimmu.2015.00026.
• Tyagi N, Farnell E, Fitzsimmons C, Ryan S, Tukahebwa E, Maizels R, Dunne D, Thornton J and Furnham N (2015) Comparisons of allergenic and metazoan parasite proteins: allergy the price of immunity. PLoS Computational Biology, 11 (10), Article: e1004546, pp. 1-24, DOI:10.1371/journal.pcbi.1004546.

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.