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Emeritus Professor Richard Keene

Experience

keeneA graduate of the University of Adelaide in inorganic chemistry, Richard Keene has been on the staff at James Cook University since 1978.  His research interests centre around stereochemistry of metallosupramolecular assemblies, with particular application to the effect of molecular geometry on intramolecular electron transfer, and its influence on the selective interaction of such metal complexes with biological molecules. Richard has published 160 journal articles (h-index 44), 6 book chapters and has a patent on his present work on the selective toxicity of ruthenium(II) complexes to drug-resistant pathogens.  Richard has received a number of awards for his research - including a DSc by the University of Adelaide in 1998, and being conferred as a Distinguished Professor by JCU in 2010. He was granted Emeritus status on his retirement form JCU at the end of 2012, and is currently an Adjunct Professor in the School of Pharmacy & Molecular Sciences at JCU.

Current Research Projects

  • The selective toxicity of ruthenium(II) complexes to drug-resistant pathogens
  • Mechanism of cytotoxicity and cellular uptake of lipophilic inert dinuclear polypyridylruthenium (II) complexes to cancer cells and bacteria
  • Structure- and sequence-selectivity in the interaction of metal complexes with nucleic acids
  • Stereochemical aspects of intramolecular electron transfer in metallosupramolecular assemblies.

Grants

ARC-Discovery grant. C.I.’s FR Keene and JG Collins; P.I. PJ Steel: 2009-2011 - $320,000 over three years.

ARC-Discovery grant. C.I. FR Keene; P.I.’s PJ Steel and JT Hupp: 2004-2006 - $240,000 over three years.

ARC-Discovery grant. C.I.’s FR Keene, JG Collins and JR Aldrich-Wright; P.I. Y. Tor: 2003-2005 - $300,000 over three years.

ARC-Large grant. C.I. FR Keene: 2001-2003 - $131,000 over three years.

Marsden Research Grant (New Zealand). C.I. PJ Steel; A.I. FR Keene: 2011-2013 - $885,000 over three years.

Marsden Research Grant (New Zealand). C.I. PJ Steel; A.I. FR Keene: 2004-2006

Awards and Honours

  • Rennie Medal of the Royal Australian Chemical institute (1979)
  • Fulbright Fellowship (1983-84)
  • Elected Fellow of Royal Australian Chemical Institute (1986) and Fellow of Royal Society of Chemistry, U.K. (2001)
  • Awarded Personal Chair, James Cook University (1997)
  • Commonwealth Fellow, Bede Morris Scheme - Australian Academy of Science (1998)
  • Awarded DSc by University of Adelaide (1998)
  • Erskine Visiting Research Fellow, University of Canterbury, Christchurch, N.Z.  (2000)
  • Visiting Scientist Award {Australian Academy of Science/Japan Society for Promotion of Science; Osaka University and Tokyo Institute of Technology (Japan)} (2009)
  • Erasmus Mundus Fellow and Invited Professor, Univeristät Leipzig (Germany) (2012)
  • Conferred title of James Cook University Distinguished Professor (2010)
  • Honorary Visiting Research Fellow, University of Adelaide (appointed 2012)
  • Invited as Visiting Professor over the last two decades to Stanford University and the University of North Carolina at Chapel Hill (U.S.A.); Oxford University (U.K.), Université Louis Pasteur de Strasbourg and Université Paul Sabatier, Toulouse (France); Université de Fribourg (Switzerland); Universität Leipzig (Germany); and the University of Canterbury (Christchuch, New Zealand).
  • Appointed Visiting Professor, UNSW Canberra (February-May, 2013)

Key Publications

  1. “Groove binding ruthenium(II) complexes as probes of DNA recognition”, J.A. Smith, J.G. Collins and F.R. Keene,  in “Metal Complexes - DNA interactions” (Eds, N. Hadjiliadis and E. Sletten), Blackwell Publishing, Oxford, UK (2009); pps. 319-346.
  2. “Metal Complexes as Structure-Selective Binding Agents for Nucleic Acids”, F.R.Keene, J.A. Smith and J.G. Colllins, Coord. Chem. Rev. 2009, 253, 2021-2035.
  3. Chlorido-containing ruthenium(II) and iridium(III) complexes as antimicrobial agents” M. Pandrala, F. Li, M. Feterl, Y. Mulyana, J. M. Warner, L. Wallace, F.R. Keene, and J.G. Collins, Dalton Trans. 2013, 42, 4686-4694.
  4. “In vitro susceptibility and cellular uptake for a new class of antimicrobial agents: dinuclear ruthenium(II) complexes”, F. Li, M. Feterl, Y. Mulyana, J.M. Warner, J.G. Collins and F.R. Keene, J. Antimicrob. Chemother. 2012, 67, 2686-2695.
  5. “An approach to therapeutic agents through selective targeting of destabilised nucleic acid duplex sequences”, F. Li, D.K. Weber, J.L. Morgan, J.G. Collins and F.R. Keene, Dalton Trans. 2012, 41, 6528-6535.
  6. ” Nucleic acid binding and cytotoxicity of the labile oligonuclear ruthenium(II) complexes”, Y. Mulyana, J.G. Collins and F.R. Keene, J. Incl. Phenom. Macrocycl. Chem. 2011 71, 371-379.
  7. “The antimicrobial activity of inert oligonuclear polypyridylruthenium(II) complexes against pathogenic bacteria, including MRSA”, F. Li, Y. Mulyana, M. Feterl, J. Warner, J.G. Collins and F.R. Keene, Dalton Trans. 2011, 40, 5032-5038.
  8. “Mechanism of cytotoxicity and cellular uptake of lipophilic inert dinuclear polypyridylruthenium(II) complexes”, M.J. Pisani, P.D. Fromm, R.J. Clarke, Y. Mulyana, K. Heimann, J.G. Collins and F.R. Keene, ChemMedChem 2011, 6, 848-858.
  9. “Oligonuclear Polypyridylruthenium(II) Complexes Incorporating Flexible Polar and Non-  Polar Bridges:  Synthesis, DNA-Binding and Cytotoxicity”, Y. Mulyana, D.K. Weber, J.G.     Collins and F.R. Keene, Dalton Trans. 2011, 40, 1510-1523.
  10. “Sequence and duplex structure determinants of the binding of flexibly-linked dinuclear ruthenium(II) complexes to adenine-bulged DNA duplexes”, D.P. Buck, J.A. Paul, M.J. Pisani, J.G. Collins  and F.R. Keene, Aust. J. Chem. 2010, 63, 1365-1375.
  11. “Selective Mitochodrial Accumulation of Cytotoxic Dinuclear Polypyridyl Ruthenium(II) Complexes”, M.J. Pisani, D.K. Weber, K. Heimann, J.G. Collins and F.R. Keene, Metallomics 2010, 2393-396.
  12. “Cucurbit[10]uril binding of dinuclear platinum(II) and ruthenium(II) complexes: association/dissociation rates from seconds to hours”, M.J. Pisani, Y. Zhao, L. Wallace, C.E. Woodward, F.R. Keene, A.I. Day and J.G. Collins, Dalton Trans. 2010, 39, 2078-2086.
  13. “Anionic PAMAM dendrimers as drug delivery vehicles for transition metal-based anticancer drugs”, M.J. Pisani, N.J. Wheate, F.R. Keene, J.R. Aldrich-Wright, and J.G. Collins, J. Inorg. Biochem. 2009, 103, 373-380.
  14. “Binding of a dinuclear ruthenium(II) complex to the TAR region of the HIV-AIDS viral RNA”, D.P. Buck, C.B. Spillane, J.G. Collins and F.R. Keene, Molecular BioSystems 2008, 4, 851-854.
  15. “The Dichotomy in the DNA-Binding Behaviour of Ruthenium(II) Complexes Bearing Benzoxazole and Benzothiazole Groups”,  C.B. Spillane, M.N.V. Dabo, N.C. Fletcher, J.L. Morgan, F.R. Keene,  I. Haq, and N.J.  Buurma, J. Inorg. Biochem. 2008, 102, 673-683.
  16. “Dinuclear ruthenium(II) complexes as potential probes for RNA bulge sites”, C.B. Spillane, J.A. Smith, D.P. Buck, J.G. Collins and F.R. Keene, Dalton Trans. 2007, 5290-5296.
  17. “Benzothiazole bipyridine complexes of Ruthenium(II) with Cytotoxic Activity”, C.B. Spillane, N.C. Fletcher,  S. Roundtree, H. van den Berg, S. Chanduloy, J.L. Morgan and F.R. Keene,  J. Inorg. Biol. Chem. 2007, 12, 797-807.
  18. “Dinuclear ruthenium(II) complexes with flexible bridges as DNA bulge-selective probes”,  J.L. Morgan, C.B. Spillane, J.A. Smith, D.P. Buck, J. G. Collins and F.R. Keene, Dalton Trans. 2007, 4333-4342.
  19. “DNA Affinity Binding Studies using a Fluorescent Dye Displacement Technique – the Dichotomy of the Binding Site” C.B. Spillane, J.A. Smith, J.L. Morgan and F.R. Keene, J. Inorg. Biol. Chem. 2007, 12, 819-824.
  20. “Selectivity at a Three-base Bulge Site in the DNA Binding of Delta,Delta-[{Ru(phen)2}2(mu-dppm)]4+ {dppm = 4,6-bis(2-pyridyl)pyrimidine; phen = 1,10-phenanthroline}”, J.L. Morgan, D.P. Buck, A.G. Turley, J.G. Collins and F.R. Keene, J. Biol. Inorg. Chem. 2006, 11, 824-834.
  21. Meso-[{Ru(phen)2}2(m-HAT)]4+:  a high-affinity DNA hairpin probe (HAT = 1,4,5,8,9,12-hexaazatriphenylene; phen = 1,10-phenantroline)”, J.A. Smith, J.L. Morgan, A.G. Turley, J.G. Collins, and F.R. Keene, Dalton Trans. 2006, 3179-3187.
  22. “Separation of stereoisomers of dinuclear metal complexes by binding affinity chromatography using non-duplex DNA”, J.A. Smith and F.R. Keene, Chem. Commun. 2006, 2583-2585.
  23. “Inert benzothiazole functionalised ruthenium(II) complexes; potential DNA hairpin binding agents”, C.B. Spillane, J.L. Morgan, N.C. Fletcher, J.G. Collins and F.R. Keene, Dalton Trans. 2006, 3122-3133.
  24. Meso-[{Ru(phen)2}2(mu-bpm)]4+: a high-affinity DNA bulge probe {bpm = 2,2’-bipyrimidine; phen = 1,10-phenanthroline}”, J.L. Morgan, D.P. Buck, A.G. Turley, J.G. Collins and F.R. Keene, Inorg. Chim. Acta 2006, 359, 888-898.
  25. “Total Enantioselectivity in the DNA Binding of the Dinuclear Ruthenium(II) Complex [{Ru(Me2bpy)2}2(mu-bpm)]4+ {bpm = 2,2'-bipyrimidine; Me2bpy = 4,4'-dimethyl-2,2'-bipyridine}”,  J.A. Smith, J.G. Collins, B.T. Patterson and F.R. Keene, Dalton Trans. 2004, 1277-1283.
  26. "Dinuclear Ruthenium(II) Complexes as Probes for DNA Bulge Sites ",  B.T. Patterson, J.G. Collins, F.M. Foley and F.R. Keene, J. Chem. Soc., Dalton Trans. 2002, 4343-4350.
  27. "The DNA Binding of the Delta,Delta-, Delta,Lambda- and Lambda,Lambda-Stereoisomers of [{Ru(Me2bpy)2}2(mu-bpm)]4+", F.M. Foley, F.R. Keene and J.G. Collins, J. Chem. Soc., Dalton Trans. 2001, 2968-2974.

JCU eResearch Publication List.

Contact Information

Telephone:

(08) 8338 4323

+61 8 8338 4323 (International)

Mobile:

0416 275 161

+61 416 275 161 (International)

Email:

richard.keene@jcu.edu.au

 

Address:

2/15 Short Crescent

Beaumont, South Australia 5066