Research Data

Potential allergens of the Pacific Oyster (Crassostrea gigas)

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General
Title
Potential allergens of the Pacific Oyster (Crassostrea gigas)
Type
Dataset
Date Record Created
2017-01-30
Date Record Modified
2017-03-24
Language
English
Coverage
Date Coverage
(no information)
Time Period
(no information)
Geospatial Location
(no information)
Description
Descriptions
  1. Type: full

    The increasing production and consumption of molluscs are associated with a rise in the prevalence of mollusc allergy worldwide, currently affecting 0.2% to 1.3% of the general population. However, the elucidation of mollusc allergens, crucial for better diagnostics, still lags behind other seafood groups such as fish and crustacean. Genomic data have previously been utilized for the improved identification of non-food allergens by performing similarity searches using the BLAST program. Based on the published genome of the Pacific oyster (Crassostrea gigas) we aimed to identify the repertoire of potential allergen using bioinformatics analysis and sought to validate allergenicity using a combination of immuno-chemical methods and proteomic analysis. A repertoire of 25,982 genome-derived proteomes of the Pacific oyster were aligned with 2117 allergen sequences resulting in over 800 protein homologues. Of those, 95 proteins were potentially cross-reactive allergens due to high identity with known allergens (>50% identity). Analysis of the transcriptomic data showed the proteins were differentially expressed across tissue of the oyster.

  2. Type: note

    This dataset consists of a spreadsheet in MS Excel (.xlsx) and Open Document formats (.ods)

Related Publications
  1. Nugraha, Roni, Zenger, Kyall, Kamath, Sandip D. and Lopota, Andreas L. (2015). In-silico bioinformatics approach for the identification and characterisation of allergens from the Pacific oyster (Crassotrea gigas). Internal Medicine Journal, 45 (Suppl. 4). pp. 9.
    ASCIA-2015 Published Abstract
Related Websites
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Related Data
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Related Services
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Technical metadata
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People
Creators
  1. Managed by: Prof Andreas Lopata , andreas.lopata@jcu.edu.au , Discipline of Biochemistry & Molecular Biology (6272), Centre for Biodiscovery and Molecular Development of Therapeutics, Centre for Sustainable Tropical Fisheries and Aquaculture
  2. Managed by: Dr Sandip Kamath , sandip.kamath@jcu.edu.au , Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Medicine (6205), Discipline of Biochemistry & Molecular Biology (6272)
  3. Aggregated by: Mr Roni Nugraha , roni.nugraha@my.jcu.edu.au , Discipline of Biochemistry & Molecular Biology (6272), Centre for Tropical Biodiversity and Climate Change
Primary Contact
A/Prof Andreas Lopata, andreas.lopata@jcu.edu.au
Supervisors
  1. Prof Andreas Lopata , andreas.lopata@jcu.edu.au
  2. Dr Sandip Kamath , sandip.kamath@jcu.edu.au
  3. Dr Kyall Zenger , kyall.zenger@jcu.edu.au
Collaborators
  1. Prof. Jennifer M Rolland, Department of Immunology and Pathology, Monash University, Melbourne, Victoria, Australia
  2. Prof. Robyn E. O'Hehir, Department of Immunology and Pathology, Monash University, Melbourne, Victoria, Australia
Subject
Fields of Research
  1. 110701 - Allergy (110701)
  2. 110106 - Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics) (110106)
Socio-Economic Objective
  1. 920108 - Immune System and Allergy (920108)
  2. 920203 - Diagnostic Methods (920203)
Keywords
  1. food allergens
  2. oyster
  3. genomic
  4. in-silico
  5. immunoinformatics
Research Activity
(no information)
Research Themes
Industries and Economies in the Tropics
Tropical Health, Medicine and Biosecurity
Rights
License
CC BY-NC: Attribution-Noncommercial 3.0 AU
License - Other
(no information)
Access Rights/Conditions
Please contact the data manager or nominated primary contact to negotiate access to this data. If you have difficulty, please contact researchdata@jcu.edu.au for assistance.
Type
conditional
Rights
Once access to the data has been obtained via negotiation with the data manager, use of the dataset is governed by the CC-BY-NC AU licence.
Data
Data Location
Online Locations
Stored At
Secure data section of the Tropical Data Hub (TDH) archive - eResearch Centre, James Cook University, Townsville, Queensland, Australia
Citation
Cite:
Lopata, A.; Kamath, S.; Nugraha, R. (2017). Potential allergens of the Pacific Oyster (Crassostrea gigas). James Cook University. (dataset). http://dx.doi.org/10.4225/28/588ebc2ca00e2
Digital Object Identifier (DOI):
10.4225/28/588ebc2ca00e2