Research Data

Adenosine, Lidocaine and Mg2+ (ALM) fluid therapy for treatment of non-compressible uncontrolled haemorrhage

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General
Title
Adenosine, Lidocaine and Mg2+ (ALM) fluid therapy for treatment of non-compressible uncontrolled haemorrhage
Type
Dataset
Date Record Created
2017-09-16
Date Record Modified
2020-08-13
Language
English
Coverage
Date Coverage
2015-09-01 to 2016-11-30
Time Period
(no information)
Geospatial Location
Description
Descriptions
  1. Type: full

    Systemic inflammation and coagulopathy are major drivers of injury progression following haemorrhagic trauma. Our aim was to examine the effect of small-volume 3% NaCl adenosine, lidocaine and Mg2+ (ALM) bolus and 0.9% NaCl/ALM 'drip' on inflammation and coagulation in a rat model of haemorrhagic shock. Male Sprague-Dawley rats were randomly assisned to: 1) shams, 2) no-treatment, 3) saline controls, 4) ALM therapy, and 5) Hextend. Haemorrhage was induced in anaesthetized and ventilated animals by liver resection (60% left lateral lobe and 50% medial lobe). After 15 min, a bolus of 3% NaCl +/- ALM (0.7 ml/kg) was administered intravenously (Phase 1) followed 60 min later by 4 hours infusion of 0.9% NaCl +/- ALM (0.5 ml/kg/hr) with 60 min monitoring (Phase 2). Plasma cytokines were measured on Magpix and coagulation using Stago/Rotational Thromboelastometry.

  2. Type: note

    This dataset is available as 7 files saved in .sav (SPSS) and comma-separated values (CSV) formats.

Related Publications
  1. Letson, Hayley, and Dobson, Geoffrey (2017) 3% NaCl adenosine, lidocaine, Mg2+ (ALM) bolus and 4 hours "drip" infusion reduces noncompressible hemorrhage by 60% in a rat model. Journal of Trauma and Acute Care Surgery, 82 (6). pp. 1063-1072.
Related Websites
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Related Data
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Related Services
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Technical metadata
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People
Creators
  1. Owned by: Miss Hayley Letson , hayley.letson@jcu.edu.au , Biomedical Sciences, Medicine
  2. Owned by: Prof Geoffrey Dobson , geoffrey.dobson@jcu.edu.au , Biomedical Sciences, Medicine
Primary Contact
Miss Hayley Letson, hayley.letson@jcu.edu.au
Supervisors
(no information)
Collaborators
(no information)
Subject
Fields of Research
  1. 119999 - Medical and Health Sciences not elsewhere classified (119999)
Socio-Economic Objective
  1. 920199 - Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified (920199)
Keywords
  1. non-compressible hemorrhage
  2. trauma
  3. surgery
  4. truncal
  5. inflammation
  6. shock
  7. immune
  8. platelet
  9. coagulopathy
  10. ROTEM
Research Activity
(no information)
Research Themes
Tropical Health, Medicine and Biosecurity
Rights
License
CC BY 4.0: Attribution 4.0 International
License - Other
(no information)
Access Rights/Conditions
Open access. If the data is not feely accessible via the link provided, please contact the nominated data manager or researchdata@jcu.edu.au for assistance.
Type
open
Rights
(no information)
Data
Data Location
Online Locations
Attachments
  1. Hem_Stago.sav (Data File, Public)
  2. Hem_Luminex.sav (Data File, Public)
  3. Hem_Luminex.csv (Data File, Public)
  4. Hem_ROTEM_Phase_1.csv (Data File, Public)
  5. Hem_RBC.csv (Data File, Public)
  6. Hem_PAP.csv (Data File, Public)
  7. Hem_Stago.csv (Data File, Public)
  8. Hem_PLT.sav (Data File, Public)
  9. Hem_RBC.sav (Data File, Public)
  10. Hem_PAP.sav (Data File, Public)
  11. Hem_ROTEM_Phase_2.csv (Data File, Public)
  12. Hem_ROTEM_Phase_1.sav (Data File, Public)
  13. Hem_ROTEM_Phase_2.sav (Data File, Public)
  14. Hem_PLT.csv (Data File, Public)
Stored At
(no information)
Citation
Cite:
Letson, H.; Dobson, G. (2017). Adenosine, Lidocaine and Mg2+ (ALM) fluid therapy for treatment of non-compressible uncontrolled haemorrhage. James Cook University. (dataset). http://dx.doi.org/10.4225/28/59c446100467b
Digital Object Identifier (DOI):
10.4225/28/59c446100467b