Research Data

Detecting sub-clinical change in tissue compressibility and free fluid in the lower limbs of young people living in an LF endemic area in Myanmar


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Detecting sub-clinical change in tissue compressibility and free fluid in the lower limbs of young people living in an LF endemic area in Myanmar
Date Record Created
Date Record Modified
Date Coverage
2014-10-14 to 2015-06-17
Time Period
(no information)
Geospatial Location
  • Central Myanmar
  1. Type: brief

    SPSS data set for physical measures taken at 3 time points using 4 devices and publications relating to the data analysis.

    Abstract [Related Publication]: When normal lymphatic function is hampered, imperceptible subcutaneous edema can develop and progress to overt lymphedema. Low-cost reliable devices for objective assessment of lymphedema are well accepted in clinical practice and research on breast-cancer related lymphedema but are untested in populations with lymphatic filariasis (LF). This is a cross-sectional analysis of baseline data in a longitudinal study on asymptomatic, LF antigen-positive and -negative young people in Myanmar. Rapid field screening was used to identify antigen-positive cases and a group of antigen-negative controls of similar age and gender were invited to continue in the study. Tissue compressibility was assessed with three tissue tonometers, and free fluids were assessed using bio-impedance spectroscopy (BIS). Infection status was confirmed by Og4C3 antigen assay. At baseline (n= 98), antigen-positive cases had clinically relevant increases in tissue compressibilityat the calf using a digital Indurometer (11.1%, p = 0.021), and in whole-leg free fluid using BIS (9.2%, p = 0.053). Regression analysis for moderating factors (age, gender, hydration) reinforced the between-infection group differences. Results demonstrate that sub-clinical changes associated with infection can be detected in asymptomatic cases. Further exploration of these low-cost devices in clinical and research settings on filariasis-related lymphedema are warranted.

    The full methodology is available in the publications from the Related Publications links below.


Related Publications
  1. Douglass, Janet, Graves, Patricia, and Gordon, Susan (2017) Intrarater reliability of tonometry and bio-impedance spectroscopy to measure tissue compressibility and extracellular fluid in the legs of healthy young people in Australia and Myanmar. Lymphatic Biology and Research, 15 (1). pp. 57-63.
    Reliability study includes a detailed description of data collection methods
  2. Douglass, Janet, Graves, Patricia, Lindsay, Daniel, Becker, Luke, Mason, Jesse, Aye, Ni Ni, Win, San San, Wai, Tint, Win, Yi Yi, and Gordon, Susan (2017) Lymphatic filariasis increases tissue compressibility and extracellular fluid in lower limbs of asymptomatic young people in Central Myanmar. Tropical Medicine and Infectious Disease, 2 (4).
    Open Access
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  1. Owned by: Mrs Janet Douglass , , College of Healthcare Sciences, College of Public Health, Medical & Vet Sciences, Australian Institute of Tropical Health & Medicine
Primary Contact
Ms Janet Douglass,
  1. Dr Susan Gordon ,
  2. Dr Patricia Graves ,
  3. Prof Peter Leggat ,
  1. Vector Borne Disease Control, Myanmar Ministry of Health and Sports
  2. Department of Medical Research, Myanmar Ministry of Health and Sports
Fields of Research
  1. 1117 - Public Health and Health Services (1117)
Socio-Economic Objective
(no information)
  1. lymphoedema
  2. lymphedema
  3. filariasis
  4. indurometer
  5. bio-impedance spectroscopy
Research Activity
(no information)
Research Themes
People and Societies in the Tropics
CC BY-NC 4.0: Attribution-Noncommercial 4.0 International
License - Other
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Access Rights/Conditions
Open access. If the data is not freely accessible via the link provided, please contact the nominated data manager or for assistance.
(no information)
Data Location
Online Locations
  1. DOUGLASS PhD LF research data Myanmar.sav (Data File, Public)
  2. DOUGLASS PhD LF research data Myanmar.csv (Data File, Public)
  3. Codebook.pdf (Data File, Public)
Stored At
(no information)
Douglass, J. (2020): Detecting sub-clinical change in tissue compressibility and free fluid in the lower limbs of young people living in an LF endemic area in Myanmar. James Cook University. (dataset).
Digital Object Identifier (DOI):