Research Data

Data for: Comparison of the serum lipidome in patients with abdominal aortic aneurysm and peripheral artery disease

Details

Print this Page Print this Page
Show all sections
General
Title
Data for: Comparison of the serum lipidome in patients with abdominal aortic aneurysm and peripheral artery disease
Type
Dataset
Date Record Created
2012-11-12
Date Record Modified
2012-12-13
Language
English
Coverage
Date Coverage
2011-01-01 to 2012-06-01
Time Period
(no information)
Geospatial Location
(no information)
Description
Descriptions
  1. Type: brief

    Dyslipidemia is a common risk factor for cardiovascular disease although the relationship between circulating lipids and abdominal aortic aneurysm (AAA) is unclear. We conducted a lipidomic analysis with the objective of identifying serum lipid species associated with AAA presence. Secondary analyses assessed the ability of models incorporating lipidomic features to improve stratification of AAA patients from controls with peripheral artery disease (PAD) beyond traditional risk factors.

  2. Type: full

    Liquid-chromatography tandem mass spectrometry (LC-MS/MS) was used to profile serum lipids from patients with AAA (n=91) or PAD (n=103). Adjusted binary logistic regression was used to identify lipids associated with AAA. Classification models were created based on a combination of 1) traditional cardiovascular risk factors only, or 2) lipidomic features and traditional risk factors. Receiver operator characteristic (ROC) curves were generated to assess the performance of the models. Of 314 identified lipids, 4 diacylglycerol and 10 triacylglycerol lipid species were associated with AAA after adjusting for other risk factors and correcting for multiple comparisons. Stratification of AAA patients from PAD controls was significantly improved when combining lipidomic features with clinical characteristics (mean area under ROC curve: 0.775; 95% CI: 0.770 – 0.780) compared to clinical features alone (mean area under ROC curve: 0.735; 95% CI: 0.729 - 0.741). Conclusion: We identified a group of linoleic acid-containing triacylglycerols and diacylglycerols to be significantly associated with AAA presence. Inclusion of these lipids in a multivariate analysis significantly improved prediction of the presence of AAA compared to traditional risk factors alone.

  3. Type: brief

    Data is in an excel spreadsheet.

Related Publications
(no information)
Related Websites
(no information)
Related Data
(no information)
Related Services
(no information)
Technical metadata
(no information)
People
Creators
  1. Managed by: Dr Joseph Moxon , School of Medicine & Dentistry
  2. Aggregated by: Mrs Barbara Bradshaw , School of Medicine & Dentistry
  3. Enriched by: Prof Jon Golledge , School of Medicine & Dentistry
  4. Enriched by: Dr David Liu , School of Medicine & Dentistry
Primary Contact
Dr Joseph Moxon, joseph.moxon@jcu.edu.au
Supervisors
(no information)
Collaborators
  1. Wong, Gerard. Baker IDI Heart and Diabetes Research Institute, Melbourne, Victoria, Australia
  2. Weir, Jacquelyn, M. Baker IDI Heart and Diabetes Research Institute, Melbourne, Victoria, Australia
  3. Behl-Gilhotr, Ratnesh. Baker IDI Heart and Diabetes Research Institute, Melbourne, Victoria, Australia
  4. Kingwell, Bronwyn, A. Baker IDI Heart and Diabetes Research Institute, Melbourne, Victoria, Australia
  5. Meikle, Peter, J. Baker IDI Heart and Diabetes Research Institute, Melbourne, Victoria, Australia
Subject
Fields of Research
  1. 110299 - Cardiovascular Medicine and Haematology not elsewhere classified (110299) (110299)
Socio-Economic Objective
  1. 920103 - Cardiovascular System and Diseases (920103) (920103)
Keywords
  1. plasma lipidomic analysis
  2. linoleic acid
  3. liquid-chromatography tandem mass spectrometry
  4. abdominal aortic aneurysm
  5. peripheral artery disease
  6. multivariate analysis
  7. serum lipidome
  8. lipids
  9. risk factors
Research Activity
(no information)
Research Themes
Tropical Health, Medicine and Biosecurity
Rights
License
(no information)
License - Other
(no information)
Access Rights/Conditions
Contact owner for access
Type
conditional
Rights
(no information)
Data
Data Location
Online Locations
Stored At
The Vascular Biology Unit, School of Medicine & Dentistry, James Cook University, Townsville Qld Australia 4811, Tel: 07 4781 6232, International: +61 7 4781 6232, Fax: 07 4781 6986
Citation
Cite:
Moxon, Joseph.; Bradshaw, Barbara.; Golledge, Jon.; Liu, David Dawei.; Wong, Gerard.; Weir, Jacquelyn.; Behl-Gilhotr, Ratnesh.; Kingwell, Bronwyn.; Meikle, Peter. (2012). Data for: Comparison of the serum lipidome in patients with abdominal aortic aneurysm and peripheral artery disease. James Cook University. (dataset). jcu.edu.au/tdh/collection/4e4c5a4e-a39d-4f35-9c54-12ef55117f7b