Dr. Phurpa Wangchuk is a Research Fellow at JCU. He was an Australian Endeavour Award Holder in 2010-2014 and completed his PhD in Natural Products Chemistry with examiners' special commendation for ‘Outstanding Thesis’ from the University of Wollongong, NSW, Australia. His research project on the phytochemical analysis, bioassays and the identification of drug lead compounds from the medicinal plants resulted into numerous awards, research papers and a patent on the novel antimalarial drug lead compound.

Currently, his research at Professor Alex Loukas Laboratory involve the metabolomics, biodiscovery and molecular characterisation of the anti-inflammatory and anthelmintic small molecules from worms, medicinal plants and entomopathogenic fungi using HPLC, MALDI-MS, GCMS, NMR, and the in vitro, in vivo and ex vivo experimental models. His NHMRC EC Fellowship (2015-2019) enabled him to work on pre-clinical evaluation of anti-inflammatory small molecules from hookworms, which resulted in the identification of 83 metabolites for the first time from helminths, and the publications of three research articles. 

Dr. Phurpa Wangchuk completed his M.Sc. in Medicinal Chemistry by Research from the University of Wollongong, which resulted in the discovery of new alkaloids and three high impact journal articles. He obtained his Post Graduate Diploma in Research Methodology (Clinical Research) from the DBL-Centre for Health Research and Development, Faculty of Life Sciences, Copenhagen University, Denmark under DANIDA fellowship. He obtained his Bachelor of Bioscience (Chemistry, Botany and Zoology as majors) from Sherubtse College with an award conferred for ‘Overall Academic Excellence’.

Prior to his appointment at JCU, he worked for 12 years in Bhutan at various capacities as a Research Officer, Chemist, Product Manager and as a Head of the Research and Development Section of the Manjong Sorig Pharmaceuticals. As a Head of the R&D, he lead a team comprising ethnobotanist, pharmacognosist, traditional physician and external technical consultants from Europe, Japan, India and Thailand. He implemented many World Health Organisation grants and was an executive team member involved in deciding and executing million Euros European Union Medicinal Plants Project in Bhutan. He also did laboratory demonstrations to the first year chemistry students at the University of Wollongong.

He has published more than 40 journal papers, 2 books, 3 book chapters, 4 conference proceedings and 1 plant monograph in the areas of natural products involving plants, parasites and metabolomics. He is also an active member, reviewer and editorial boards of few national and international journals. 

Interests

Research

• Parasitology-worms and their anti-inflammatory compounds
• Anti-inflammatory and anthelmintic alkaloids/flavonoids
• Phytochemicals and pharmacology of medicinal and parasitic plants
• Insect-fungi and their bioactive secondary metabolites
• North Queensland Natural Products, their chemistry and therapeutic applications
• Metabolomics and biomarkers of natural compounds and diseases

Experience

• 2015 to 2018 - NHMRC ECR Fellow, James Cook University (Cairns)
• 2014 - Research Officer, James Cook University (Cairns, Australia)
• 2010 to 2014 - PhD Research Candidate, University of Wollongong (NSW, Australia)
• 2008 to 2009 - Editor of Manjong Sorig Journal, Ministry of Health (Bhutan)
• 2008 to 2009 - Editor of Quarterly Morbidity and Activity Report, Ministry of Health (Bhutan)
• 2007 to 2009 - Product Manager, Manjong Sorig Pharmaceuticals, Kawajangsa, Thimphu District, Bhutan (Thimphu, Bhutan)
• 2006 to 2009 - Head of R&D, Manjong Sorig Pharmaceuticals (Thmphu, Bhutan)
• 2006 to 2009 - Executive Team (representing R&D section) of the European Union Project-II, Manjong Sorig Pharmaceuticals, Kawajangsa, Thimphu District, Bhutan (Thimphu, Bhutan)
• 2006 to 2007 - Secretary of Research and Development of Bhutan, MSP/MoH (Bhutan)
• 2006 - DANIDA Research Fellowship, DBL-Centre for Health Research and Development, University of Copenhagen (Denmark)
• 2004 to 2006 - Chemist, Pharmaceutical and Research Unit (Thmphu, Bhutan)
• 2002 to 2004 - M.Sc. Research Candidate, University of Wollongong (NSW, Australia)
• 1999 to 2002 - Research Officer, Pharmaceutical and Research Unit (Thmphu, Bhutan)

Research Disciplines

• Medicinal and Biomolecular Chemistry (0304)
• Organic Chemistry (0305)
• Pharmacology and Pharmaceutical Sciences (1115)

Socio-Economic Objectives

• Expanding Knowledge (9701)
• Clinical Health (9201)
• Health and Support Services (9202)

Awards

• 2018 - Invited Speaker to the International conference in Beijing (fully funded by the conference organiser)
• 2018 - Keynote Speaker Tavel Award -fully funded by the international conference on medicine and health sciences, Indonesia
• 2018 - Special Address/Talk invitation -fully funded by the international conference on JIGNASA 2018 International conference, India
• 2017 - Full conference travel award as an 'Invited Speaker' at Harvard Conference on Health-Body-Mind
• 2017 - Conference travel grant for organising and chairing a biodiscovery panel at ICTAM IX, Germany
• 2016 to 2017 - Australian Institute of Tropical Health and Medicine Capacity Building Grant
• 2016 - Best Poster Presentation Award - awarded in the International Conference on 'Molecular and Cellular Biology of Helminth Parasites X' held at Hydra (4-9 September 2016).
• 2015 - "Invited speaker" Travel Award -International conference on 'Utilising Sub-Himalayan Biological Resources (fully funded by the conference organiser-Dibrugarh University, India)
• 2014 - Examiners' special commendations for outstanding PhD thesis
• 2009 to 2014 - Australian Endeavour Post Graduate Award
• 2013 - KIOM-South Korea keynote speaker full funding award for the International Symposium on Value and Folk Remedy as Traditional Knowledge
• 2013 - Bhutan Royal Civil Service Award for dedicated service (10 years) to the nation and the public
• 2013 - ICTAM VIII Congress Award for attending the conference held every after 4 years
• 2012 - Phytochemical Society of Europe's Best Congress Communication Award
• 2012 - UOW Faculty of Science post graduate conference funding award
• 2011 - UOW 2011 Highly Commended PhD Presentation Award
• 2011 - Royal Australian Chemical Institute (RACI) 2011 Best Oral Presentation Runner up Award
• 2010 - Royal Australian Chemical Institute (RACI) 2010 Best PhD Meritorious Poster Presentation Award
• 2010 - BlueScope Steel Research Innovation Awards 2010
• 2008 - RCSC meritorious promotion
• 2007 - International Centre for Environmental Health and Toxicology Training Award, Thailand
• 2000 - United Nations Industrial Development Organization Training Workshop Award
• 1998 - Graduate Academic Excellence Award

Fellowships

• 2015 to 2018 - National Health and Medical Research Council ECR Grant
• 2010 to 2014 - Australian Endeavour Award-PhD
• 2006 - DANIDA Fellowship for Post Graduate Diploma in Social/Clinical Research Methodology, Denmark.
• 2002 to 2004 - Royal Government of Bhutan M.Sc. Scholarship

Memberships

• 2016 to 2018 - Australia & New Zealand Society for Magnetic Resonance (ANZMAG )
• 2014 - The Australian Society for Parasitology
• 2014 - Editorial Board of the Journal of Biologically Active Products from Nature
• 2013 to 2014 - Council Member of The International Association for the Study of Traditional Asian Medicine
• 2012 to 2014 - Member of the Phytochemical Society of Europe
• 2010 to 2014 - Chemical Society of University of Wollongong
• 2008 to 2009 - Member of the National Scientific Review Committee of Bhutan
• 2008 to 2009 - Organiser and Editor of the Manjong Sorig Journal
• 2008 to 2009 - Editorial Board of the Bhutan Ministry of Health Quarterly and Morbidity Activity Report
• 2005 to 2009 - Research Core Group and Quality Assurance Team of Manjong Sorig Pharmaceuticals
• 2007 to 2008 - Non-Wood Forest Products Task Force
• 2007 - Biodiversity Action Plan Development Technical Committee Member
• 2007 - Ethnobotany

Other

• 2018 - Invited Reviewer for the BMC Infectious Diseases-Impact Factor 2.7
• 2018 - Invited reviewer -Acta Parasitologica
• 2018 - Invited Reviewer of the 'International Wound Journal' -Impact factor-2.8
• 2019 - Invited Reviewer of the PLOS Neglected Tropical Diseases-Impact factor = 4.3
• 2016 to 2019 - Reviewed paper for Phytochemistry Letters-IF=1.5
• 2018 - Invited Reviewer of the Toxins- Impact factor = 3.2
• 2018 - Invited Reviewer of the 'Nutrients'-2017 Impact factor-4.2
• 2018 - Invited Reviewer of the 'Digestive Diseases and Sciences'-2017 Impact factor-2.9
• 2016 to 2018 - Invited Reviewer of the 'Journal of Ethnopharmacology' Elsevier Impact factor-3.11
• 2016 - Reviewed paper for BMC Immunology-IF=2.6
• 2016 - Reviewed paper for Molecules-IF = 3
• 2016 - Reviewed paper for International Journal of Molecular Sciences-IF=3.6
• 2016 - Reviewed paper for International Journal of Parasitology-IF=4.2
• 2015 - Invited Reviewer of the Journal of Pharmaceutical and Biomedical Analysis-Impact factor = 2.97
• 2015 - Invited Reviewer for the Natural Products Research
• 2015 - Invited Reviewer of the Pharmaceutical Biology-impact factor = 1.9
• 2015 - Invited Reviewer of the paper submitted to the Ethnobotany Research & Applications
• 2015 - Invited reviewer for the Journal of Biologically Active Products from Nature
• 2015 - Invited reviewer for Journal of Ethnobiology and Ethnomedicine-Impact factor = 2.1
• 2015 - Invited Reviewer of the BMC Pharmacology and Toxicology-Impact factor = 1.84
• 2015 - Invited Reviewer of the 'BMC Complementary and Alternative Medicine'- 2015 Impact factor-2.12
• 2015 - Invited Reviewer of the 'Scientific Reports'-Nature Publishing Group-2014 Impact factor-5.58.
• 2015 - Invited Reviewer of the paper submitted to the BMC Research Notes.
• 2015 - Invited Reviewer of the 'BMC Ecology'-2014 Impact factor-2.36
• 2015 - Reviewer for a journal paper-Natural Products Communication Impact factor =1
• 2013 - Invited Reviewer of the Natural Product Communications
• 2012 - Guest Reviewer of the Acta Pharmaceutica Sinica B- Impact factor = 6.01

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

• Nugraha A, Pratoko D, Damayanti Y, Lestari N, Laksono T, Addy H, Untari L, Kusumawardani B and Wangchuk P (2019) Antibacterial and anticancer activities of nine lichens of Indonesian Java Island. Journal of Biologically Active Products from Nature, 9 (1). pp. 39-46
• Wangchuk P, Kouremenos K, Eichenberger R, Pearson M, Susianto A, Wishart D, McConville M and Loukas A (2019) Metabolomic profling of the excretory–secretory products of hookworm and whipworm. Metabolomics, 15.
• Wangchuk P, Constantinoiu C, Eichenberger R, Field M and Loukas A (2019) Characterization of tapeworm metabolites and their reported biological activities. Molecules, 24 (8).
• Wangchuk P, Shepherd C, Constantinoiu C, Ryan R, Kouremenos K, Becker L, Jones L, Buitrago G, Giacomin P, Wilson D, Daly N, Mcconville M, Miles J and Loukas A (2019) Hookworm-derived metabolites suppress pathology in a mouse model of colitis and inhibit secretion of key inflammatory cytokines in primary human leukocytes. Infection and Immunity, 87 (4).
• Yeshi K, Gyal Y, Sabernig K, Phuntsho J, Tidwell T, Jamtsho T, Dhondup R, Tokar E and Wangchuk P (2019) An integrated medicine of Bhutan: Sowa Rigpa concepts, botanical identification, and the recorded phytochemical and pharmacological properties of the eastern Himalayan medicinal plants. European Journal of Integrative Medicine, 29.
• Cobos C, Bansal P, Jones L, Wangchuk P, Wilson D, Loukas A and Daly N (2018) Engineering of an anti-inflammatory peptide based on the disulfide-rich linaclotide scaffold. Biomedicines, 6 (4).
• Eichenberger R, Hasanuzzaman T, Field M, Wangchuk P, Giacomin P, Loukas A and Sotillo J (2018) Characterization of Trichuris muris secreted proteins and extracellular vesicles provides new insights into host–parasite communication. Journal of Extracellular Vesicles, 7 (1).
• Shepherd C, Wangchuk P and Loukas A (2018) Of dogs and hookworms: man's best friend and his parasites as a model for translational biomedical research. Parasites & Vectors, 11.
• Shepherd C, Giacomin P, Navarro S, Miller C, Loukas A and Wangchuk P (2018) A medicinal plant compound, capnoidine, prevents the onset of inflammation in a mouse model of colitis. Journal of Ethnopharmacology, 211. pp. 17-28
• Sundaraneedi M, Eichenberger R, Al-Hallaf R, Yang D, Sotillo J, Rajan S, Wangchuk P, Giacomin P, Keene F, Loukas A, Collins J and Pearson M (2018) Polypyridylruthenium(II) complexes exert in vitro and in vivo nematocidal activity and show significant inhibition of parasite acetylcholinesterases. International Journal for Parasitology: Drugs and Drugs Resistance, 8 (1). pp. 1-7
• Wangchuk P, Apte S, Smout M, Groves P, Loukas A and Doolan D (2018) Defined small molecules produced by Himalayan medicinal plants display immunomodulatory properties. International Journal of Molecular Sciences, 19 (11).

Book Chapters

• Wangchuk P (2019) Plant alkaloids: classification, isolation and drug development. In: Medicinal Plants: chemistry, pharmacology and therapeutic applications. Taylor & Francis Ltd, Boca Raton, FL, USA, pp. 131-137

More

ResearchOnline@JCU stores 52+ research outputs authored by Dr Phurpa Wangchuk from 2007 onwards.

Current and recent Research Funding to JCU is shown by funding source and project.

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current

• Biodiscovery of anti-inflammatory drug leads from parasites and medicinal plants of Australian wet tropics. (PhD , Primary Advisor)

Completed

• Exploring low molecular weight molecules produced by hookworms (Ancylostoma caninum) and their use as anti-inflammatory agents (2018, PhD , Secondary Advisor)

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.