About
Teaching
  • BC2023: Molecular Genetics (Level 2; TSV)
  • BC3102: Molecular Basis of Disease (Level 3; TSV)
  • BC3201: Bioengineering (Level 3; TSV)
  • BC5102: Advanced Molecular Basis of Disease (Level 5; TSV)
  • BM1000: Introductory Biochemistry and Microbiology (Level 1; TSV)
  • TV1102: Cell Biology and Biochemistry for Veterinary Science and Agriculture (Level 1; TSV)
Research Disciplines
Socio-Economic Objectives
Publications

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles
Current Funding

Current and recent Research Funding to JCU is shown by funding source and project.

The Marfan Foundation - Research Grant

Mechanisms determining Marfan syndrome severity

Indicative Funding
$100,000 over 2 years
Summary
Marfan syndrome (MFS), caused by defects in the protein fibrillin-1, has a wide spectrum of severity with symptoms affecting the heart, bones and eyes. The cause of this variation in severity is unclear. Severe, neonatal MFS and Beal's syndrome result from mutations in corresponding parts of the proteins fibrilin-1 and fibrillin-2. Using clues from these diseases, this project will use new cell engineering techniques to determine why some fibrillin mutations are more severe than others. The results are relevant not only to understanding MFS, but also to understanding how the tissues in our bodies are developed and maintained.
Investigators
Sacha Jensen (College of Public Health and Medical & Vet Sciences)
Keywords
Marfan Syndrome; Extracellular Matrix; Microfibrils; Pathogenesis; Genome editing; Fibrillin
Supervision

Advisory Accreditation: I can be on your Advisory Panel as a Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current
  • Synthesis of GFP-tagged fibrillin-2 to study the pathogenesis of congenital contractural arachnodactyly (CCA) (Masters , Secondary Advisor)
  • Development of a high-throughput HIV-1 integrase drug screening platform (Masters , External Advisor)
Completed
  • Defining the ancestral replication fork trap in Tus-dependent bacteria (2021, Masters , External Advisor)

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Secondary Advisor

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