Prof Louis Schofield ~ Director, Australian Institute of Tropical Health and Medicine; Distinguished Professor
Australian Institute of Tropical Health & Medicine
- About
-
- Research Disciplines
- Socio-Economic Objectives
Professor Schofield is inaugural Director of the Australian Institute of Tropical Health and Medicine (AITHM). He was for 24 years an NHMRC Research Fellow at the Walter and Eliza Hall Institute in Melbourne, has twice held an International Research Scholarship of the Howard Hughes Medical Institute, and was co-founder of Ancora Pharmaceuticals Inc. A recognised authority in the immunology and pathogenesis of infectious diseases, his research programs cover basic molecular sciences, product development and commercialisation, epidemiology and public health. His approach to malaria has resulted in promising vaccine development programs, and clinical trials in Papua New Guinea and Africa. He has published key articles in the highest ranked international journals and received over 6,500 citations.
- Publications
-
These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.
- Journal Articles
-
- Moraleda C, Aguilar R, Quintó L, Nhampossa T, Renom M, Nhabomba A, Ruperez M, Aponte J, Achtman A, Mañú Pereira M, Schofield L, Alonso P, Macete E and Menéndez C (2021) Pathophysiology of anemia in HIV-infected children exposed to malaria. American Journal of Tropical Medicine and Hygiene, 104 (3). pp. 1003-1012
- Timinao L, Vinit R, Katusele M, Koleala T, Nate E, Czeher C, Burkot T, Schofield L, Felger I, Mueller I, Laman M, Robinson L and Karl S (2021) Infectivity of Symptomatic Malaria Patients to Anopheles farauti Colony Mosquitoes in Papua New Guinea. Frontiers in Cellular and Infection Microbiology, 11.
- Timinao L, Vinit R, Katusele M, Schofield L, Burkot T and Karl S (2021) Optimization of the feeding rate of Anopheles farauti s.s. colony mosquitoes in direct membrane feeding assays. Parasites & Vectors, 14.
- Webster R, Sekuloski S, Odedra A, Woolley S, Jennings H, Amante F, Trenholme K, Healer J, Cowman A, Eriksson E, Sathe P, Penington J, Blanch A, Dixon M, Tilley L, Duffy M, Craig A, Storm J, Chan J, Evans K, Papenfuss A, Schofield L, Griffin P, Barber B, Andrew D, Boyle M, Rivera F, Engwerda C and McCarthy J (2021) Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria updates vaccine. BMC Medicine, 19.
- Kumarasingha R, Ioannidis L, Abeysekera W, Studniberg S, Wijesurendra D, Mazhari R, Poole D, Mueller I, Schofield L, Hansen D and Eriksson E (2020) Transcriptional memory-like imprints and enhanced functional activity in gamma delta T cells following resolution of malaria infection. Frontiers in Immunology, 11.
- Vinit R, Timinao L, Bubun N, Katusele M, Robinson L, Kaman P, Sakur M, Makita L, Reimer L, Schofield L, Pomat W, Mueller I, Laman M, Freeman T and Karl S (2020) Decreased bioefficacy of long-lasting insecticidal nets and the resurgence of malaria in Papua New Guinea. Nature Communications, 11 (7).
- Joseph H, Eriksson E and Schofield L (2019) Early suppression of B cell immune responses by low doses of chloroquine and pyrimethamine: implications for studying immunity in malaria. Parasitology Research, 118 (6). pp. 1987-1992
- Joseph H, Tan Q, Mazhari R, Eriksson E and Schofield L (2019) Vaccine-induced carbohydrate-specific memory B cells reactivate during rodent malaria infection. Frontiers in Immunology, 10.
- Pawliw R, Farrow R, Sekuloski S, Jennings H, Healer J, Phuong T, Sathe P, Pasay C, Evans K, Cowman A, Schofield L, Chen N, McCarthy J and Trenholme K (2018) A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial. Malaria Journal, 17.
- Sampaio N, Kocan M, Schofield L, Pfleger K and Eriksson E (2018) Investigation of interactions between TLR2, MyD88 and TIRAP by bioluminescence resonance energy transfer is hampered by artefacts of protein overexpression. PLoS ONE, 13 (8).
- Sampaio N, Emery S, Garnham A, Tan Q, Sisquella X, Pimentel M, Jex A, Regev-Rudzki N, Schofield L and Eriksson E (2018) Extracellular vesicles from early stage Plasmodium falciparum‐infected red blood cells contain PfEMP1 and induce transcriptional changes in human monocytes. Cellular Microbiology, 20 (5).
- Sampaio N, Eriksson E and Schofield L (2018) Plasmodium falciparum PfEMP1 modulates monocyte/macrophage transcription factor activation and cytokine and chemokine responses. Infection and Immunity, 86 (1).
- More
-
ResearchOnline@JCU stores 51+ research outputs authored by Prof Louis Schofield from 2008 onwards.
- Current Funding
-
Current and recent Research Funding to JCU is shown by funding source and project.
Department of Industry - Australian Tropical Medicine Commercialisation Programme
Commercial Development of a pan-species multistage vaccine for malaria
- Indicative Funding
- $1,057,480 over 3 years
- Summary
- AITHM will use the funding to achieve five sequential aims; 1. Establish a joint venture with WEHI for the commercial development of a pan-species, multi-stage vaccine for the malaria eradication agenda; 2. Undertake process development towards GMP manufacturing of the synthetic saccharide vaccine target; 3. Undertake process development towards GMP conjugation of the synthetic saccharide vaccine target to GMP grade CRM carrier; 4. Undertake rigours stability and pre-clinical toxicology testing of the vaccine product; and 5. Undergo regulatory affairs (TGA/FDA) compliance
- Investigators
- Louis Schofield, Stewart Campbell, Priyanka Sathe, Subash Kapre, Andy Lees and Peter Tapley (Australian Institute of Tropical Health & Medicine, Corden Pharma International Inc, Walter & Eliza Hall Institute of Medical Research, Inventprise LLC, FinaBio Solutions LLC and TetraQ Research Institute)
- Keywords
- Malaria; Plasmodium; Vaccine; Immunology; Trial
- Supervision
-
Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.
These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.
- Completed
-
- Investigating transmission of malaria parasites to Anopheles farauti mosquitoes in Papua New Guinea (2023, PhD , Secondary Advisor/AM)
- Collaboration
-
The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.- 5+ collaborations
- 4 collaborations
- 3 collaborations
- 2 collaborations
- 1 collaboration
- Indicates the Tropics (Torrid Zone)
Connect with me
- Location
- Advisory Accreditation
- Advisor Mentor
- Find me on…
-
My research areas
Similar to me
-
Dr Carla ProiettiAustralian Institute of Tropical Health & Medicine
-
Dr Martha CooperAustralian Institute of Tropical Health & Medicine
-
A/PROF Stephan KarlAustralian Institute of Tropical Health & Medicine
-
Dr Tanya RussellAustralian Institute of Tropical Health & Medicine
-
Prof Tom BurkotAustralian Institute of Tropical Health & Medicine