I am a scientist, employed as a Senior Lecturer in the Department of Molecular and Cell Biology. I completed my PhD in Germany and for my postdoctoral time worked at the University Hospital Zurich, Switzerland and the Burnham Institute for Medical Research, La Jolla, USA. I returned from the USA in 2008 to continue my research in Australia and established a research group at the Westmead Millennium Institute in Sydney. In July 2015 I moved to James Cook University and my current research focuses on the role of adiponectin and its receptors in cancer, liver injury and fibrosis, and metabolism.

I utilise mouse and cellular models for my studies and I am always looking for motivated and hard working students who wish to run with a project. PhD students should be in the position to apply for an Australian Institute for Tropical Health and Medicine (AITHM), Australian Postgraduate Award (APA or JCU) or International (IPRS) Scholarship, or alternatively a scholarship from their home country to support their stay.  Summer studentships are available through the comparative genomics centre and Internships and Masters student applications are encouraged to enquire. Honours students should approach me about their studies.

I have published in high-ranking journals that include: Journal of Cell Biology, Cancer Research, Oncogene, Nature Reviews Gastroenterology & Hepatology, Hepatology, and Journal of Biological Chemistry.

Current Honours/Masters/PhD projects:

1. The role of metabolism in Cancer Stem Cell Function and Liver tumour progression.

2. The influence of adiponectin and its receptor interactions in colon and liver diseases.

3. The function of adiponectin receptors in metabolism.

For PhD scholarship applications see:

https://espaces.edu.au/aithm-scholarships

http://www.jcu.edu.au/grs/scholarships/JCUDEV_014879.html

http://www.jcu.edu.au/grs/scholarships/JCUDEV_014949.html

Throughout my career I have been interested in the role of cellular and molecular interactions in tumour cells. The training I received in these areas equipped me with experience in a wide range of technologies, allowing me to bring together molecular, cell biology, biochemistry, stem cell biology, mouse genetics and metabolomics to achieve my goals. The ultimate goal of my research is to understand how these interactions and in particular factors from adipocytes and their corresponding receptors in other organs can mediate processes like cancer, angiogenesis, inflammation and metabolism, and to generate novel therapeutic approaches to treat disease states.

I have supervised five PhD, one Masters and four Honours students to completion. These students have received competitive PhD scholarships (e.g. Australian Postgraduate Award, NSW Cancer Institute, Saudi PhD scholarships), and won scientific awards (e.g. GESA Student Prizes). Three of the Honours students have completed their Honours with first class. I have also had a number of Interns, Summer students, and European Masters students whom have performed their projects in my lab, from Iran, Denmark, the Netherlands and Switzerland.

Current Funding

Cancer Council Queensland Project Grant: CIA, Clarifying the controversial role of fructose in liver cancer:  $200,000; 2017-8.

CCNSW
 project grant: CIA, Metabolic drivers of liver cancer progression: $360,000; 2014-7.

NHMRC project grant: CIB, Exploiting the pharmacokinetic and pharmacodynamic properties of bile acid receptor agonists to treat liver disease: $628,074, 2015-8. Administered by the University of Sydney.

JCU Intellectual Property Department: CIA, A Novel Therapeutic for Liver Fibrosis? $2,000, 2015.

Comparative Genomics Centre: CIA, The role of fructose in memory and behaviour. $10,000, 2016.

JCU Development Grant:  CIA, A new target for treating liver fibrosis. $70,766, 2016-7.

Previous Funding

NHMRC Project Grant 1049857: CIB, Adiponectin and cholesterol: A driving force in NASH immunopathogenesis: $420,498; 2013-15:

Philantropic Trust: CIB, Development of combinatorial therapies to treat liver cancer $360,000; 2012-14.

NHMRC Project Grant 1006200: CIB, Role of adiponectin in hepatic carcinogenesis: $361,082; 2011-13.

Cancer Council CNSW IG11-27: CIA, Novel molecular targets for treatment of hepatocellular cancer. $100,000, 2011-12.

International Program Development Fund from the University of Sydney. CIA: $20,000, 2011-12

NHMRC Project Grant  632630: CIB, The roleof the adiponectin receptors in liver fibrosis. $379,125, 2010-12:

Philantropic Trust: CIB, Molecular mechanisms for the development and progression of liver cancer. $360,000, 2009-11:

Teaching

• BC2013: Principles of Biochemistry (Level 2; TSV)
• BC2014: Principles of Biochemistry for Pharmacy Students (Level 2; TSV)
• BC3102: Molecular Basis of Disease (Level 3; TSV)
• BC3202: Special Topics in Biochemistry and Molecular Biology (Level 3; TSV)
• BC5102: Advanced Molecular Basis of Disease (Level 5; TSV)
• BC5202: Advanced Laboratory Practice in Molecular and Cell Biology (Level 5; TSV)
• BC5312: Research and Dissertation in Molecular and Cell Biology (Level 5; TSV)
• BM1000: Introductory Biochemistry and Microbiology (Level 1; TSV)
• MD1010: Introduction to Integrated Medical Studies Part 1 of 2 (Level 1; TSV)
• MD1020: Introduction to Integrated Medical Studies Part 2 of 2 (Level 1; TSV)

Interests

Professional

• Gastroenterological Society of Australia (GESA)
• European Society for the Study of the Liver

Research

• Role of metabolism in liver cancer progression
• Targeting liver fibrosis
• Understanding tissue cross-talk in hepatic disease
• Mouse models of cancer
• Cancer Stem Cells

Experience

• 2008 to 2015 - Group Leader, Westmead Millennium Institute (Westmead, Sydney, Australia)
• 2006 to 2008 - Staff Investigator, Burnham Institute (La Jolla, USA)
• 2002 to 2006 - Postdoc, Burnham Institute (La Jolla, USA)
• 1999 to 2002 - Postdoc, University Hospital, Zurich (Switzerland)
• 1995 to 1998 - PhD, Karlsruhe Institute for Technology (Karlrsuhe, Germany)
• 1991 to 1993 - Masters in Science, Griffith University (Brisbane, Australia)
• 1985 to 1991 - Undergrad Science/Economics/Biochemistry, Griffith University and the University of Queensland (Brisbane, Australia)

Research Disciplines

• Oncology and Carcinogenesis (1112)
• Medical Biochemistry and Metabolomics (1101)

Socio-Economic Objectives

• Clinical Health (9201)
• Health (9299)

Awards

• 2017 to 2018 - QLD Cancer Council Project Grant
• 2016 to 2017 - JCU Development Grant
• 2013 to 2017 - NSW Cancer Council Project Grant
• 2016 - 3 Minute Thesis Winner Established Researcher Category
• 2013 - WMI Science prize
• 2011 - NSW Cancer Council Innovation Grant
• 2005 - Career development award from the Fishman Fund

Fellowships

• 2004 - Travel fellowship from the Keystone Conference Foundation
• 1995 to 1999 - PhD Fellowship for doctoral work from the Forschungszentrum Karlsruhe, Germany
• 1992 to 1993 - Fellowship from the Royal Australian College of Physicians for MPhil studies

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

• Han S, Latchoumanin O, Wu G, Zhou G, Hebbard L, George J and Qiao L (2017) Recent clinical trials utilizing chimeric antigen receptor T cells therapies against solid tumors. Cancer Letters, 390. pp. 188-200
• Obeid S, Wankell M, Charrez B, Sternberg J, Kreuter R, Esmaili S, Ramezani-Moghadam M, Devine C, Read S, Bhathal P, Lopata A, Ahlenstiel G, Qiao L, George J and Hebbard L (2017) Adiponectin confers protection from acute colitis and restricts a B cell immune response. Journal of Biological Chemistry, 292 (16). pp. 6569-6582
• Sternberg J, Wankell M, Subramaniam V and Hebbard L (2017) The functional roles of T-cadherin in mammalian biology. AIMS Molecular Science, 4 (1). pp. 62-81
• Wu G, Wilson G, George J, Liddle C, Hebbard L and Liang Q (2017) Overcoming treatment resistance in cancer: current understanding and tactics. Cancer Letters, 387. pp. 69-76
• Charrez B, Qiao L and Hebbard L (2016) Hepatocellular carcinoma and non-alcoholic steatohepatitis: the state of play. World Journal of Gastroenterology, 22 (8). pp. 2494-2502
• Zhou G, Wilson G, Hebbard L, Duan W, Liddle C, George J and Qiao L (2016) Aptamers: a promising chemical antibody for cancer therapy. Oncotarget, 7 (12). pp. 13446-13463
• Heebøll S, Thomsen K, Clouston A, Sundelin E, Radko Y, Christensen L, Ramezani-Moghadam M, Kreutzfeldt M, Pedersen S, Jessen N, George J and Grønbæk H (2015) Effect of resveratrol on experimental non-alcoholic steatohepatitis. Pharmacological research, 95-96. pp. 34-41
• Ramezani-Moghadam M, Wang J, Ho V, Iseli T, Alzahrani B, Xu A, Van der Poorten D, Qiao L, George J and Hebbard L (2015) Adiponectin reduces hepatic stellate cell migration by promoting tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion. Journal of Biological Chemistry, 290 (9). pp. 5533-5542
• Wu G, Wilson G, Zhou G, Hebbard L, George J, Qiao L, and (2015) Oct4 is a reliable marker of liver tumor propagating cells in hepatocellular carcinoma. Discovery Medicine, 20 (110). pp. 219-229
• Alzahrani B, Iseli T and Hebbard L (2014) Non-viral causes of liver cancer: does obesity led inflammation play a role. Cancer Letters, 345 (2). pp. 223-229
• Dai Y, Jiao H, Teng G, Wang W, Zhang R, Wang Y, Hebbard L, George J and Qiao L (2014) Embelin reduces colitis-associated tumorigenesis through limiting IL-6/STAT3 signaling. Molecular Cancer Therapeutics, 13 (5). pp. 1206-1216
• Hebbard L and Ranscht B (2014) Multifaceted roles of adiponectin in cancer. Best practice & research Clinical endocrinology & metabolism, 28 (1). pp. 59-69

More

ResearchOnline@JCU stores 37+ research outputs authored by Dr Lionel Hebbard from 2000 onwards.

Current and recent Research Funding to JCU is shown by funding source and project.

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current

• The Role of Fructose in Liver Cancer (PhD , Primary Advisor)
• The Function and Ligands of G-Protein Coupled Receptors (GPCRs) in Coral Larvae Settlement (PhD , Secondary Advisor)

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.