I completed my PhD in Germany in 1999 and my postdoctoral time was at the University Hospital Zurich, Switzerland and the Burnham Institute for Medical Research, La Jolla, USA.

In 2008 I returned from the USA to establish the" Cancer and Metabolism" research group at the Westmead  Institute of Medical Research in Sydney. In 2015 I moved to James Cook University to a tenured position and my current research focuses on the role of adiponectin and its receptors in cancer, liver injury and fibrosis, and metabolism.

My laboratory utilises mouse and cellular models for our studies and I am always looking for motivated students who wish to run with a project. PhD students can apply for a JCU domestic or International PhD Scholarship, or alternatively a scholarship from their home country to support their stay.  Applications for Internships and Masters Degrees are encouraged to enquire. Honours students should approach me about their studies.

I have published in Journals that include: Journal of Cell Science, Cancer Research, Oncogene, Nature Reviews Gastroenterology & Hepatology, Hepatology,  Journal of Biological Chemistry, PLoS One and BBA.

Current Honours/Masters/PhD projects:

1. The role of DNA repair and cell adhesion in Liver tumour progression.

2. The influence of adiponectin and its receptor interactions in colon and liver diseases.

3. The role of cell adhesion in myogenesis.

For PhD scholarship applications see:

JCU is offering the following Research Scholarships for outstanding Doctorate or Research Masters applicants. Closing September 30, 2019 and see the link:

https://www.jcu.edu.au/graduate-research-school/candidates/postgraduate-research-scholarships

Throughout my career I have been interested in the role of cellular and molecular interactions in tumour cells. The training I received in these areas equipped me with experience in a wide range of technologies, allowing me to bring together molecular, cell biology, biochemistry, stem cell biology, mouse genetics and metabolomics to achieve my goals. The ultimate goal of my research is to understand how these interactions and in particular factors from adipocytes and their corresponding receptors in other organs can mediate processes like cancer, angiogenesis, inflammation and metabolism, and to generate novel therapeutic approaches to treat disease states.

I have supervised six PhD, one Masters and five Honours students to completion. These students have received competitive PhD scholarships (e.g. Australian Postgraduate Award, NSW Cancer Institute, Saudi PhD scholarships), and won scientific awards (e.g. GESA Student Prizes). Four of the Honours students have completed their Honours with first class. I have also had a number of Interns, Summer students, and European Masters students whom have performed their projects in my lab, from Iran, Denmark, China,  Netherlands and Switzerland.

Current group

Postdoc: Dr Miriam Wankell MSc PhD

Adjunct Postdoc: Dr Kylie Lopas BSc Hons PhD MBBS (Townsville Hospital)

PhD Student: Brittany Dewdney BSc MSc

PhD Student: Lauren Taylor BSc Hons Ist Class

Masters Student: Rhys Gillman BSc

Medical Student: Eun Jin Sun (3rd Year) BA

Medical Student: Ravi Marwah (6th Year)

 Former students at JCU:

Berenice Charrez, Jade Sternberg, Roxanne Kreuter, Kaltrina Paloja, Cypriane Dormenval, Casey Toft, Maxine Smith, Skye McGregor, Cong Chen.

Former students at WIMR/USyd/Westmead:

Sarah Walker (PhD), Stephanie Obeid (PhD), Saeed Esmaili (PhD), Badr Alzahrani (PhD), Mohammed Alanazy (PhD), Medhi Ramezani-Moghadam (MPhil), Nikita Deo (Hons 1st Class), James Hendersen (Hons), Kristen Piper (Hons 1st Class), Lewis Tsang (Hons 1st Class).

Current Funding

SERTA Grant with Townsville Hospital Health Service, Oropharyngeal Cancer and Stem Cells, $50,000, 2019-20.

Royal Australian and New Zealand College of Radiologists Research Grant, $20,000, 2019-20.

Cancer Council Queensland Project Grant: CIA, Clarifying the controversial role of fructose in liver cancer:  $200,000; 2017-9.

 

Teaching

• BC2013: Principles of Biochemistry (Level 2; TSV)
• BC2014: Principles of Biochemistry for Pharmacy Students (Level 2; TSV)
• BC3102: Molecular Basis of Disease (Level 3; TSV)
• BC5001: Advanced Readings in Molecular and Cell Biology (Level 5; TSV)
• BC5002: Advanced Research in Molecular and Cell Biology 1 of 2 (Level 5; TSV)
• BC5102: Advanced Molecular Basis of Disease (Level 5; TSV)
• MD1010: Introduction to Integrated Medical Studies Part 1 of 2 (Level 1; TSV)
• MD1020: Introduction to Integrated Medical Studies Part 2 of 2 (Level 1; TSV)

Interests

Professional

• Gastroenterological Society of Australia (GESA)
• European Society for the Study of the Liver

Research

• Role of metabolism in liver cancer progression
• Targeting liver fibrosis
• Muscle development and disease
• Mouse models of cancer
• Cancer Stem Cells

Experience

• 2020 to present - Associate Professor, James Cook University (Townsville, Australia)
• 2018 to present - Associate Dean, Research, James Cook University (Townsville, Australia)
• 2015 to 2019 - Senior Lecturer, James Cook University (Townsville, Australia)
• 2008 to 2015 - Group Leader, University of Sydney, Westmead Institute of Medical Research (Westmead, Sydney, Australia)
• 2006 to 2008 - Staff Investigator, Burnham Institute (La Jolla, USA)
• 2002 to 2006 - Postdoc, Burnham Institute (La Jolla, USA)
• 1999 to 2002 - Postdoc, University Hospital, Zurich (Switzerland)
• 1995 to 1998 - PhD, Karlsruhe Institute for Technology (Karlrsuhe, Germany)
• 1991 to 1993 - MPhil, Griffith University (Brisbane, Australia)
• 1985 to 1991 - Undergrad Science/Economics/Biochemistry, Griffith University and the University of Queensland (Brisbane, Australia)

Research Disciplines

• Oncology and Carcinogenesis (1112)
• Clinical Sciences (1103)

Socio-Economic Objectives

• Clinical Health (9201)
• Health (9299)

Awards

• 2017 to 2019 - QLD Cancer Council Project Grant
• 2016 to 2017 - JCU Development Grant
• 2013 to 2017 - NSW Cancer Council Project Grant
• 2016 - 3 Minute Thesis Winner Established Researcher Category
• 2013 - WMI Science prize
• 2011 - NSW Cancer Council Innovation Grant
• 2005 - Career development award from the Fishman Fund

Fellowships

• 2004 - Travel fellowship from the Keystone Conference Foundation
• 1995 to 1999 - PhD Fellowship for doctoral work from the Forschungszentrum Karlsruhe, Germany
• 1992 to 1993 - Fellowship from the Royal Australian College of Physicians for MPhil studies

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU.

Journal Articles

• Gupta S, Read S, Shackel N, Hebbard L, George J and Ahlenstiel G (2019) The role of micronutrients in the infection and subsequent response to hepatitis C virus. Cells, 8 (6), Article: 603, DOI:10.3390/cells8060603.
• Kreuter R, Wankell M, Ahlenstiel G and Hebbard L (2019) The role of obesity in inflammatory bowel disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1865 (1), pp. 63-72, DOI:10.1016/j.bbadis.2018.10.020.
• Walker S, Wankell M, White R, Ho V, Deo N, Devine C, Dewdney B, Bhathal P, Govaere O, Roskams T, Qiao L, George J and Hebbard L (2019) Targeting mTOR and Src restricts hepatocellular carcinoma growth in a novel murine liver cancer model. PLoS One, 14 (2), Article: e0212860, DOI:10.1371/journal.pone.0212860.
• Alzahrani B, Iseli T, Ramezani-Moghadam M, Ho V, Wankell M, Sun E, Qiao L, George J and Hebbard L (2018) The role of AdipoR1 and AdipoR2 in liver fibrosis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1864 (3), pp. 700-708, DOI:10.1016/j.bbadis.2017.12.012.
• Zhou G, Latchoumanin O, Hebbard L, Duan W, Liddle C, George J and Qiao L (2018) Aptamers as targeting ligands and therapeutic molecules for overcoming drug resistance in cancers. Advanced Drug Delivery Reviews, 134, pp. 107-121, DOI:10.1016/j.addr.2018.04.005.
• Han S, Latchoumanin O, Wu G, Zhou G, Hebbard L, George J and Qiao L (2017) Recent clinical trials utilizing chimeric antigen receptor T cells therapies against solid tumors. Cancer Letters, 390, pp. 188-200, DOI:10.1016/j.canlet.2016.12.037.
• Huo X, Han S, Wu G, Latchoumanin O, Zhou G, Hebbard L, George J and Qiao L (2017) Dysregulated long noncoding RNAs(lncRNAs) in hepatocellular carcinoma: implications for tumorigenesis, disease progression, and liver cancer stem cells. Molecular Cancer Therapeutics, 16, Article: 165, DOI:10.1186/s12943-017-0734-4.
• Obeid S, Wankell M, Charrez B, Sternberg J, Kreuter R, Esmaili S, Ramezani-Moghadam M, Devine C, Read S, Bhathal P, Lopata A, Ahlenstiel G, Qiao L, George J and Hebbard L (2017) Adiponectin confers protection from acute colitis and restricts a B cell immune response. Journal of Biological Chemistry, 292 (16), pp. 6569-6582, DOI:10.1074/jbc.M115.712646.
• Sternberg J, Wankell M, Subramaniam V and Hebbard L (2017) The functional roles of T-cadherin in mammalian biology. AIMS Molecular Science, 4 (1), pp. 62-81, DOI:10.3934/molsci.2017.1.62.
• Wu G, Wilson G, George J, Liddle C, Hebbard L and Liang Q (2017) Overcoming treatment resistance in cancer: current understanding and tactics. Cancer Letters, 387, pp. 69-76, DOI:10.1016/j.canlet.2016.04.018.
• Zhou G, Latchoumanin O, Bagdesar M, Hebbard L, Duan W, Liddle C, George J and Qiao L (2017) Aptamer-based therapeutic approaches to target cancer wtem cells. Theranostics, 7 (16), pp. 3948-3961, DOI:10.7150/thno.20725.
• Charrez B, Qiao L and Hebbard L (2016) Hepatocellular carcinoma and non-alcoholic steatohepatitis: the state of play. World Journal of Gastroenterology, 22 (8), pp. 2494-2502, DOI:10.3748/wjg.v22.i8.2494.

More

ResearchOnline@JCU stores 47+ research outputs authored by A/Prof Lionel Hebbard from 2000 onwards.

Current and recent Research Funding to JCU is shown by funding source and project.

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current

• The Function and Ligands of G-Protein Coupled Receptors (GPCRs) in Coral Larvae Settlement (PhD , Secondary Advisor)
• A new target mediating cell death in liver cancer. (Masters , Primary Advisor/AM/Adv)
• Understanding a new regulator of skeletal muscle myogenesis (PhD , Primary Advisor/AM/Adv)
• The Role of Fructose in Liver Cancer (PhD , Primary Advisor/AM/Adv)

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.