About

Professor Daly was awarded her PhD from the University of Queensland. Her studies involved using NMR spectroscopy to determine the structure of domains of the LDL receptor; a receptor critical for the control of cholesterol levels. Following these studies she was involved in establishing a new field of research involving plant derived cyclic peptides. This work resulted in several granted patents and the establishment of a small biotechnology company associated with The University of Queensland.

Norelle has published more than 120 journal articles, 3 book chapters, been awarded a UQ Research Excellence Award, awarded a National Breast Cancer Foundation Novel Concept award, and held a NHMRC Industry Fellowship, a Queensland Smart State Fellowship and is currently an ARC Future Fellow.

Teaching
  • BC3202: Special Topics in Biochemistry and Molecular Biology (Level 3; TSV)
  • BC5202: Advanced Laboratory Practice in Molecular and Cell Biology (Level 5; TSV)
  • BC5312: Research and Dissertation in Molecular and Cell Biology (Level 5; TSV)
Interests
Research
  • Professor Daly’s research involves exploring the potential of peptides as drug candidates for therapeutic applications. Peptides are of significant interest in drug design as they can be highly potent and specific for a range of different drug targets. However, the inherent poor stability of peptides limits their application. Her research aims to overcome this limitation by using tightly folded scaffolds, such as those found in the venom of spiders, cone snails and scorpions, to improve stability. In addition, plants are a rich source of highly stable peptides including backbone cyclic peptides from the coffee and sunflower families. It is anticipated that these studies will significantly expand the potential of peptides as therapeutics. In particular, peptide-based drug leads for cancer are being explored because of the enormous impact it has on health care in Australia and the urgent need for more effective treatments.
Experience
  • 2008 to 2011 - Queensland Smart State Fellow, The University of Queensland (Brisbane)
  • 2004 to 2008 - NHMRC Industry Fellow, The University of Queensland (Brisbane)
Socio-Economic Objectives
Honours
Fellowships
  • 2012 to 2016 - ARC Future Fellowship
  • 2008 to 2011 - Queensland Smart State Fellowship
  • 2004 to 2008 - NHMRC Industry Fellowship
Other
  • 2004 - The University of Queensland Research Excellence Award
Publications

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles
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ResearchOnline@JCU stores 90+ research outputs authored by Prof Norelle Daly from 2002 onwards.

Current Funding

Current and recent Research Funding to JCU is shown by funding source and project.

Merchant Charitable Foundation - Donation

Pre-clinical development of a liver fluke growth factor for treating non-healing wounds

Indicative Funding
$150,000
Summary
This research proposal aims to develop more effective treatments for wound healing, improving treatment options for diabetic patients in Australia and eventually worldwide. This is likely to alleviate suffering from the disease and also decrease the AUD$3.6 billion financial burden of diabetic wound ulcers on the healthcare system. Although we showed that the liver fluke granulin protein has wound healing properties, it is difficult to produce in recombinant form. We have now developed a minimized version of granulin and produce it as a synthetic peptide that when applied topically displays wound-healing properties as potent as the full-length protein. Using the peptide as a topical agent is ideal because it capitalizes on the potency and specificity often associated with peptide-based drugs but does not require the high levels of bioavailability necessary for orally administered drugs. Our research will also provide advances in the field regarding the structure and folding of Ov-GRN-1, which will be of significant interest to researchers working specifically on growth factors and more broadly for those working on disulphide-rich peptides and proteins. Moreover, we believe that our decision to be guided in drug discovery by millennia of host-parasite coevolution will ensure that the most efficacious and safe drugs are identified and developed.
Investigators
Alex Loukas, Michael Smout, Norelle Daly and Paramjit Bansal (Australian Institute of Tropical Health & Medicine)
Keywords
Liver Fluke; Growth Factor; Wound Repair; Therapeutics; Diabetes

NHMRC - Project Grant

Bio-molecular studies for improved diagnosis and management of Australian children with fish allergy

Indicative Funding
$476,794 over 4 years
Summary
Allergy to fish among children is emerging as a significant healthcare issue in Australia and worldwide, with prevalence rates among childen with food allergy as high as 16% in Australia. Our strong clinical-laboratory interface, bringing together a highly experienced senior team in the areas of molecular and immunological allergen characterization with leading clinicians in paediatric allergy, will significantly improve the management of fish-allergic children in Australia.
Investigators
Andreas Lopata, Dianne Campbell, Norelle Daly and Katrina Allen (College of Public Health, Medical & Vet Sciences, The University of Sydney, Australian Institute of Tropical Health & Medicine and Royal Childrens Hospital)
Keywords
Paediatric; allergy testing; clinical diagnosis; Proteomics; allergen

Australian Research Council - Discovery - Future Fellowships

Development of disulfide-rich peptides for drug design

Indicative Funding
$714,528 over 5 years
Summary
Peptides are an outstanding source of potential drug candidates for therapeutic applications because of their potency and specificity for a range of different drug targets. However, the inherent poor stability of peptides limits their application. This project seeks to overcome this limitation by using tightly folded scaffolds, such as those found in the venom of spiders and scorpions, to improve stability. It is anticipated that these studies will significantly expand the potential of peptides as therapeutics. In particular, peptide-based drug leads for cancer and autoimmune diseases will be explored because of the enormous impact they have on health care in Australia and the urgent need for more effective treatments.
Investigators
Norelle Daly (Australian Institute of Tropical Health & Medicine)
Keywords
peptidesw; Structural Biology; Cancer
Supervision

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current
  • Current Approaches in Manageing Food Allergy Among North Queensland Public Health Sectors (PhD , Secondary Advisor)
  • Exploring Low Molecular Weight Molecules Produced by Hookworms (Ancylostomoa Caninum) and their use as Anti-Inflammatory Agents (PhD , Secondary Advisor)
  • Cardiotoxic pathways of Box Jellyfish {Chironex fleckeri) venom proteins (PhD , Primary Advisor)
  • Structure-Function Relationships of Disulphide-Rich Peptides (PhD , Primary Advisor)
  • Development of Disulfide-Rich Peptides as Potential Drug Leads. (PhD , Primary Advisor)
Collaboration

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.

  • 5+ collaborations
  • 4 collaborations
  • 3 collaborations
  • 2 collaborations
  • 1 collaboration
  • Indicates the Tropics (Torrid Zone)

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Email
Phone
Location
  • E4.112, QLD Tropical Health Alliance (Cairns campus)
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