About

Dr. Paul Giacomin is currently an Advance Queensland Mid-Career Research Fellow in the Australian Institute of Tropical Health and Medicine at JCU Cairns.

Since completing his PhD studies at the University of Adelaide in 2008, his research interests have focussed on understanding the molecular and cellular mechanisms by which immune responses to parasitic helminths (worms) are initiated and regulated.

Dr. Giacomin underwent his postdoctoral training at the University of Pennsylvania between 2008 and 2012 in the laboratory of Dr. David Artis, where he was awarded fellowships from the American-Australian Association, as well as the NHMRC, to conduct his research. Dr. Giacomin continued his fellowship at JCU Cairns in 2012 and continues to investigate the key immune cells and cytokines involved in immunity to intestinal worms, as well as exploring the potential beneficial effects that worm infection may have in alleviating inflammation associated with autoimmune diseases.

Interests
Research
  • Immunity to gastrointestinal helminths
  • Epithelial regulation of Type 2 inflammatory responses to parasites and allergens
  • Therapeutic roles for helminths and helminth-derived proteins for treating allergic or autoimmune diseases
Experience
  • 2016 to 2019 - Advance QLD Mid-Career Fellow, James Cook Univers (Australia)
  • 2012 to 2015 - NHMRC CJ Martin Research Fellow, James Cook University, Cairns (Australia)
  • 2010 to 2012 - NHMRC CJ Martin Research Fellow, University of Pennsylvania (USA)
  • 2009 - Research Fellow, University of Pennsylvania (USA)
  • 2008 to 2009 - Sir Keith Murdoch Fellow, University of Pennsylvania (USA)
  • 2003 to 2008 - PhD candidate, University of Adelaide (Australia)
  • 2002 - BSc (Hons), University of Adelaide (Australia)
  • 1999 to 2002 - BSc (Biomedical Science), University of Adelaide (Australia)
Research Disciplines
Socio-Economic Objectives
Honours
Fellowships
  • 2010 to 2014 - NHMRC CJ Martin Fellow
  • 2008 to 2009 - Sir Keith Murdoch Fellow, American Australian Association
Publications

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles
Book Chapters
More

ResearchOnline@JCU stores 34+ research outputs authored by Dr Paul Giacomin from 2002 onwards.

Current Funding

Current and recent Research Funding to JCU is shown by funding source and project.

NHMRC - Project Grant

Hookworm therapy for Coeliac Disease: A randomised, double blink, placebo-controlled clinical trial

Indicative Funding
$865,000 over 5 years
Summary
Parasitic worms have an amazing ability to manipulate the immune system, and our research group recently discovered how they may hold the key for treating inflammatory diseases such as Coeliac Disease. The aim of this research is to further develop this novel therapy in a clinical trial and study the mechanism of how worms control the immune response, including identifying the molecules that the worm produces that could be produced as a pill-based medication for treating coeliac disease.
Investigators
John Croese, Paul Giacomin, Graham Radford-Smith, Tony Rahman and Louise Marquart (Australian Institute of Tropical Health & Medicine, Queensland Institute of Medical Research and The Prince Charles Hospital)
Keywords
Autoimmunity; Parasite; Inflammation

QLD Department of Science, Information, Technology and Innovation - Advance Queensland Research Fellowship

New therapies for Coeliac Disease: Helminths and their secreted products.

Indicative Funding
$300,000 over 4 years
Summary
Coeliac Disease (CeD) is a common and debilitating autoimmune disorder (affecting 1% of the Queensland population) where gluten ingestion triggers an inflammatory reaction and severe intestinal symptoms. A gluten-free diet is effective for some, but is expensive, inconvenient and inadvertant gluten exposure is common. Hence there is a need for new new treatements for CeD. In a recent clinical trial, our research group demonstrated the efficacy of an unlikely agent to imporive gluten tolerance; parasitic helominths (worms). The overall aim of my research is to translate this movel thereapy into a larger, placebo-controlled clinical trail and study the mechanisms by which worms control the immune response. Identification of the molecules that the worms prodcue to suppress gluten-induced pathology will allow the development of "pill-based" medcations for CeD, and potentially other autoimmune or inflammatory conditions.
Investigators
Paul Giacomin, John Croese, Tony Rahman and Graham Radford Smith (Australian Institute of Tropical Health & Medicine and The Prince Charles Hospital)
Keywords
Autoimmunity; Inflammation; Parasite; Clinical Trial

Coeliac Australia - Project Grant

Hookworm therapy for restoring tolerance in coeliac disease

Indicative Funding
$86,110 over 3 years
Summary
Parasitic worms have an amazing ability to manipulate the immune system, and our research group recently discovered how they may hold the key for treating inflammatory diseases such as Coeliac Disease. The aim of our reseach is to further develop this novel therapy in a clinical trial and study the mechanism of how worms control the immune response, including identifying the molecules that the work produces that could be produced as a pill-based medication for treating coeliac disease.
Investigators
John Croese, Paul Giacomin, Tony Rahman and Alex Loukas (Australian Institute of Tropical Health & Medicine, The Prince Charles Hospital, College of Public Health and Medical & Vet Sciences)
Keywords
Autoimmunity; Parasite; Inflammation
Supervision

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current
  • Quantitative Assessment of Covariants of Root Canal Treatment Efficacy in Human Teeth (PhD , Secondary Advisor)
  • High throughput production and screening of hookworm derived anti-imflammatory proteins. (PhD , Secondary Advisor)
  • Assessing the anti-colitic properties of the hookworm protein Na-AIP-1 (PhD , Secondary Advisor)
  • Molecular Profiling of Immunity to Infections and Chronic Disease in Humans using Sytems Immunology (PhD , Secondary Advisor)
  • TSLP-Dependent Regulation of Memory Immune Responses to Intestinal Pathogens (PhD , Primary Advisor)
Completed
  • Hookworm Na-ASP-2- Putative Functions, Allergenicity and Implications for Vaccine Development (2015, PhD , Associate Advisor)
Collaboration

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.

  • 5+ collaborations
  • 4 collaborations
  • 3 collaborations
  • 2 collaborations
  • 1 collaboration
  • Indicates the Tropics (Torrid Zone)

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Email
Phone
Location
  • E4.107, QLD Tropical Health Alliance (Cairns campus)
Advisory Accreditation
Primary Advisor
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  3. Prof Alex Loukas
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  4. Dr Severine Navarro
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  5. Dr Phurpa Wangchuk
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