Dr. Paul Giacomin is currently an Advance Queensland Mid-Career Research Fellow in the Australian Institute of Tropical Health and Medicine at JCU Cairns.

Since completing his PhD studies at the University of Adelaide in 2008, his research interests have focussed on understanding the molecular and cellular mechanisms by which immune responses to parasitic helminths (worms) are initiated and regulated.

Dr. Giacomin underwent his postdoctoral training at the University of Pennsylvania between 2008 and 2012 in the laboratory of Dr. David Artis, where he was awarded fellowships from the American-Australian Association, as well as the NHMRC, to conduct his research. Dr. Giacomin continued his fellowship at JCU Cairns in 2012 and continues to investigate the key immune cells and cytokines involved in immunity to intestinal worms, as well as exploring the potential beneficial effects that worm infection may have in alleviating inflammation associated with autoimmune diseases.

Interests

Research

• Immunity to gastrointestinal helminths
• Epithelial regulation of Type 2 inflammatory responses to parasites and allergens
• Therapeutic roles for helminths and helminth-derived proteins for treating allergic or autoimmune diseases

Experience

• 2016 to 2019 - Advance QLD Mid-Career Fellow, James Cook Univers (Australia)
• 2012 to 2015 - NHMRC CJ Martin Research Fellow, James Cook University, Cairns (Australia)
• 2010 to 2012 - NHMRC CJ Martin Research Fellow, University of Pennsylvania (USA)
• 2009 - Research Fellow, University of Pennsylvania (USA)
• 2008 to 2009 - Sir Keith Murdoch Fellow, University of Pennsylvania (USA)
• 2003 to 2008 - PhD candidate, University of Adelaide (Australia)
• 2002 - BSc (Hons), University of Adelaide (Australia)
• 1999 to 2002 - BSc (Biomedical Science), University of Adelaide (Australia)

Research Disciplines

• Immunology (1107)
• Medical Microbiology (1108)
• Clinical Sciences (1103)

Socio-Economic Objectives

• Clinical Health (9201)

Fellowships

• 2010 to 2014 - NHMRC CJ Martin Fellow
• 2008 to 2009 - Sir Keith Murdoch Fellow, American Australian Association

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

• Cobos Caceres C, Bansal P, Navarro S, Wilson D, Don L, Giacomin P, Loukas A and Daly N (2017) An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease. Journal of Biological Chemistry, 292 (24). pp. 10288-10294
• Giacomin P, Zakrzewski M, Jenkins T, Su X, Al-Hallaf R, Croese J, De Vries S, Grant A, Mitreva M, Krause L, Loukas A and Cantacessi C (2016) Changes in duodenal tissue-associated microbiota following hookworm infection and consecutive gluten challenges in humans with coeliac disease. Scientific Reports, 6. pp. 1-10
• Navarro S, Pickering D, Ferreira I, Jones L, Ryan S, Troy S, Leech A, Hotez P, Zhan B, Laha T, Prentice R, Sparwasser T, Croese J, Engwerda C, Upham J, Julia V, Giacomin P and Loukas A (2016) Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma. Science Translational Medicine, 8 (362).
• Wangchuk P, Giacomin P, Pearson M, Smout M and Loukas A (2016) Identification of lead chemotherapeutic agents from medicinal plants against blood flukes and whipworms. Scientific Reports, 6. pp. 1-10
• Wangchuk P, Pearson M, Giacomin P, Becker L, Sotillo J, Pickering D, Smout M and Loukas A (2016) Compounds derived from the Bhutanese daisy, Ajania nubigena, demonstrate dual anthelmintic activity against Schistosoma mansoni and Trichuris muris. PLOS Neglected Tropical Diseases, 10 (8). pp. 1-18
• Croese J, Giacomin P, Navarro S, Clouston A, McCann L, Dougall A, Ferreira I, Susianto A, O'Rourke P, Howlett M, McCarthy J, Engwerda C, Jones D and Loukas A (2015) Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease. Journal of Allergy and Clinical Immunology, 135 (2). pp. 508-516
• Giacomin P, Croese J, Krause L, Loukas A and Cantacessi C (2015) Suppression of inflammation by helminths: a role for the gut microbiota. Philosophical Transactions of the Royal Society B: Biological Sciences, 370 (1675). pp. 1-6
• Giacomin P, Moy R, Noti M, Osborne L, Siracusa M, Alenghat T, Liu B, McCorkell K, Troy A, Rak G, Hu Y, May M, Ma H, Fouser L, Sonnenberg G and Artis D (2015) Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity. The Journal of Experimental Medicine, 212 (10). pp. 1513-1528
• Giacomin P, Zakrzewski M, Croese J, Su X, Sotillo J, McCann L, Navarro S, Mitreva M, Krause L, Loukas A and Cantacessi C (2015) Experimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjects. Scientific Reports, 5. pp. 1-8
• Hays R, Esterman A, Giacomin P, Loukas A and McDermott R (2015) Does Strongyloides stercoralis infection protect against type 2 diabetes in humans? Evidence from Australian Aboriginal adults. Diabetes Research and Clinical Practice, 107 (3). pp. 355-361
• Smout M, Sotillo J, Laha T, Papatpremsiri A, Rinaldi G, Pimenta R, Chan L, Johnson M, Turnbull L, Whitchurch C, Giacomin P, Moran C, Golledge J, Daly N, Sripa B, Mulvenna J, Brindley P and Loukas A (2015) Carcinogenic parasite secretes growth factor that accelerates wound healing and potentially promotes neoplasia. PLoS Pathogens, 11 (10). pp. 1-20

Book Chapters

• Loukas A and Giacomin P (2016) Developments in the design of anti-helminth vaccines. In: The Th2 Type Immune Response in Health and Disease: from host defense and allergy to metabolic homeostasis and beyond. Springer, New York, NY, USA, pp. 97-114

More

ResearchOnline@JCU stores 34+ research outputs authored by Dr Paul Giacomin from 2002 onwards.

Current and recent Research Funding to JCU is shown by funding source and project.

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current

• Quantitative Assessment of Covariants of Root Canal Treatment Efficacy in Human Teeth (PhD , Secondary Advisor)
• High throughput production and screening of hookworm derived anti-imflammatory proteins. (PhD , Secondary Advisor)
• Assessing the anti-colitic properties of the hookworm protein Na-AIP-1 (PhD , Secondary Advisor)
• Molecular Profiling of Immunity to Infections and Chronic Disease in Humans using Sytems Immunology (PhD , Secondary Advisor)
• TSLP-Dependent Regulation of Memory Immune Responses to Intestinal Pathogens (PhD , Primary Advisor)

Completed

• Hookworm Na-ASP-2- Putative Functions, Allergenicity and Implications for Vaccine Development (2015, PhD , Associate Advisor)

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.