I am a Research Fellow in the Heart, Trauma and Sepsis Research Laboratory in the College of Medicine and Dentistry, at James Cook University (JCU). After graduating with a University Medal from JCU with a Bachelor of Science majoring in Physiology and Pharmacology and Biochemistry and Molecular Biology, I joined the Heart and Trauma Research Laboratory in 2008 where I undertook an MSc and PhD developing a small-volume resuscitation solution comprising adenosine, lidocaine and magnesium (ALM) for the treatment of traumatic hemorrhagic shock. More recently I completed the first trials of ALM in uncontrolled hemorrhage as well as traumatic brain injury, and continue to work with the US Military to translate ALM resuscitation fluid into the field.

Collaborations:

• Aarhus University Hospital, Denmark
• Orthopaedic Research Institute of Queensland (ORIQL)
• Madigan Army Medical Center, Tacoma, Washington, USA
• US Special Operations Command (USSOCOM), Tampa, Florida
• Naval Mediccal Research Unit San Antonio (NAMRU-SA), Texas, USA
• Naval Medical Research Center (NMRC), Maryland, USA
• US Army Institute of Surgical Research, Ft. Sam, Houston

Engagement:

Guest Lecture University of Leuven, Belgium "Animal Models of Traumatic Injury and Critical Illness"

Australian Brain Alliance EMCR Network Townsville Showcase

Be My Guest Speakers

In the Media:

New Trauma Drug Increases Survival by 'Slowing Time'

 New Drug Providing Hope for Brain Injury Sufferers

Drug to Prolong 'Golden Hour' Could be a Lifesaver

New Australian Treatment Could Save Wounded Soldiers

Breakthrough: Lifesaving Drug to Save Soldiers

Gut Health Key to Effective Biomedical Research

Bloody Battle - Australasian Science

JCU Scientists Develop the First 'Pharmacological' Tourniquet

JCU and the Mater Hospital Join Forces for Better Surgery Outcomes

JCU-US Navy Tackle Battlefield Trauma

Innovative Blood Loss Treatment Awarded

Teaching

• PP3201: Contemporary Research in Physiology (Level 3; TSV)
• PP5201: Contemporary Research in Physiology (Level 5; TSV)

Interests

Research

• Trauma
• Battlefield Medicine
• Emergency Medicine
• Pre-hospital Medicine
• Traumatic Injury
• Shock
• Haemorrhage
• Haemorrhagic Shock
• Traumatic Brain Injury
• Combat Trauma
• Coagulopathy
• Obstetric Haemorrhage
• Inflammation
• Surgery
• Burns
• Cardiovascular Medicine
• Aeromedical Retrieval
• Orthopaedics
• Sepsis
• Cardiac Arrest

Experience

• 2017 to present - Research Fellow, James Cook University (College of Medicine and Dentistry, Townsville)
• 2012 to 2016 - Senior Research Associate, James Cook University (College of Medicine and Dentistry, Townsville)
• 2008 to 2012 - Research Associate, James Cook University (College of Veterinary and Biomedical Sciences, Townsville)

Research Disciplines

• Clinical Sciences (1103)
• Cardiovascular Medicine and Haematology (1102)

Socio-Economic Objectives

• Clinical Health (9201)

Awards

• 2016 - Best Poster Presentation for “Small-Volume ALM Resuscitation Reduces Blood Loss and Mortality in a Rat Model of Severe Uncontrolled Haemorrhagic Shock” Townsville Research Week
• 2015 - Honorable Mention for “Differential Contributions of Platelets and Fibrinogen to Early Hypocoagulopathy during Hemorrhage and Shock, and its Correction with 7.5% NaCl ALM” Military Health System Research Symposium
• 2014 - Medicine Winner for “Treatment With Adenosine, Lidocaine/Mg2+ Induces Reversible Hypotension, Improves Cardiac and Pulmonary Function, and Exerts Anti-Inflammatory Effects in an Endotoxaemic Porcine Model” (Festival of Life Sciences)
• 2013 - Young Investigator Award for “Cardioprotective and Anti-inflammatory Effects of Treatment With Adenosine, Lidocaine/Mg2+ in a Porcine Model of Endotoxemia” presented at the Resuscitation Science Symposium (ReSS) (American Heart Association)
• 2012 - Best Abstract Award (Trauma) at the American Heart Association Resuscitation Science Symposium (ReSS) for “Small-Volume 7.5% NaCl Adenocaine/Mg2+ Preserves Cardiac Function During Hypotensive Resuscitation in the Pig Following Severe Hemorrhagic Shock
• 2012 - “So You Think You Can Research” Winner for “Development of a Revolutionary Small-Volume Resuscitation Fluid for Trauma Victims at North Queensland Festival of Life Sciences
• 2012 - Young Investigator Award for “Rat To Pig Translation: Small-Volume 7.5% NaCl Adenocaine/Mg2+ Has Multiple Physiological Benefits During Hypotensive And Blood Resuscitation In The Porcine Model Of Severe Hemorrhagic Shock” (ReSS; AHA)
• 2011 - Young Investigator Award for “Reversal of Acute Coagulopathy Using Small Volume 7.5% NaCl with Adenocaine and Mg2+ Resuscitation in the Rat Model of Severe Hemorrhagic Shock” (ReSS; AHA)
• 2010 - Best Abstract Award (Trauma) at the AHA ReSS for “7.5% NaCl with Adenosine, Lidocaine and Mg2+ (ALM) improves hypotensive resuscitation in the pressure-controlled rat model of severe hemorrhagic shock”
• 2007 - James Cook University Medal for Academic Excellence
• 2005 - James Cook University School of Biomedical and Molecular Sciences Academic Prize Winner

Memberships

• 2015 - Fresh Science Alumnus, Science in Public, Australia

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

• Davenport L, Dobson G and Letson H (2019) A new model for standardising and treating thermal injury in the rat. MethodsX, 6. pp. 2021-2027
• Davenport L, Dobson G and Letson H (2019) The role of invasive monitoring in the resuscitation of major burns: a systematic review and meta-analysis. International Journal of Burns and Trauma, 9 (2). pp. 28-40
• Elsiwy Y, Jovanovic I, Doma K, Hazratwala K and Letson H (2019) Risk factors associated with cardiac complication after total joint arthroplasty of the hip and knee: a systematic review. Journal of Orthopaedic Surgery and Research, 14.
• Letson H, Morris J, Biros E and Dobson G (2019) Conventional and specific-pathogen free rats respond differently to anesthesia and surgical trauma. Scientific Reports, 9.
• Letson H, Morris J, Biros E and Dobson G (2019) ALM fluid therapy leads to 72 hr survival after hemorrhagic shock. Journal of Trauma and Acute Care Surgery, 87 (3). pp. 606-613
• McCutchan A, Dobson G, Stewart N, Letson H, Grant A, Jovanovic I, Hazratwala K, Wilkinson M, McEwen P and Morris J (2019) Absence of cytotoxic and inflammatory effects following in vitro exposure of chondrogenically-differentiated human mesenchymal stem cells to adenosine, lidocaine and Mg2+ solution. Journal of Experimental Orthopaedics, 6.
• Morris J, Letson H, Grant A, Wilkinson M, Hazratwala K and McEwen P (2019) Experimental model of peri-prosthetic infection of the knee caused by Staphylococcus aureus using biomaterials representative of modern TKA. Biology Open, 8.
• Morris J, Letson H, Gillman R, Hazratwala K, Wilkinson M, McEwen P and Dobson G (in press) The CNS theory of osteoarthritis: opportunities beyond the joint. Seminars in Arthritis and Rheumatism,
• Dobson G, Letson H, Grant A, McEwen P, Hazratwala K, Wilkinson M and Morris J (2018) Defining the osteoarthritis patient: back to the future. Osteoarthritis and Cartilage, 26 (8). pp. 1003-1007
• Dobson G, Letson H, Grant A, McEwen P, Hazratwala K, Wilkinson M and Morris J (2018) Defining the osteoarthritis patient: back to the future. Osteoarthritis and Cartilage, 26 (8). pp. 1003-1007
• Grant A, Letson H, Morris J, McEwen P, Hazratwala K, Wilkinson M and Dobson G (2018) Tranexamic acid is associated with selective increase in inflammatory markers following total knee arthroplasty (TKA): a pilot study. Journal of Orthopaedic Surgery and Research, 13.
• Letson H and Dobson G (2018) Adenosine, lidocaine, and Mg2+ (ALM) resuscitation fluid protects against experimental traumatic brain injury. Journal of Trauma and Acute Care Surgery, 84 (6). pp. 908-916

More

ResearchOnline@JCU stores 46+ research outputs authored by Dr Hayley Letson from 2010 onwards.

Current and recent Research Funding to JCU is shown by funding source and project.

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Completed

• Adenosine and lidocaine (AL) as a vasodilator in cardiac procedures and a storage solution for vascular banking (2019, PhD , Secondary Advisor)

These are the most recent metadata records associated with this researcher. To see a detailed description of all dataset records, visit the JCU Research Data Catalogue.

• Letson, H. (2017) Adenosine, Lidocaine and Mg2+ (ALM) fluid therapy for treatment of non-compressible uncontrolled haemorrhage. James Cook University

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.